LOCUS       NM_001171004            5887 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus protein kinase D3 (Prkd3), transcript variant 1, mRNA.
ACCESSION   NM_001171004
VERSION     NM_001171004.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5887)
  AUTHORS   Waheed-Ullah,Q., Wilsdon,A., Abbad,A., Rochette,S., Bu'Lock,F.,
            Hitz,M.P., Dombrowsky,G., Cuello,F., Brook,J.D. and Loughna,S.
  TITLE     Effect of deletion of the protein kinase PRKD1 on development of
            the mouse embryonic heart
  JOURNAL   J Anat 245 (1), 70-83 (2024)
   PUBMED   38419169
REFERENCE   2  (bases 1 to 5887)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5887)
  AUTHORS   Burciaga,S.D., Saavedra,F., Fischer,L., Johnstone,K. and
            Jensen,E.D.
  TITLE     Protein kinase D3 conditional knockout impairs osteoclast formation
            and increases trabecular bone volume in male mice
  JOURNAL   Bone 172, 116759 (2023)
   PUBMED   37044359
  REMARK    GeneRIF: Protein kinase D3 conditional knockout impairs osteoclast
            formation and increases trabecular bone volume in male mice.
REFERENCE   4  (bases 1 to 5887)
  AUTHORS   Veazey,J.M., Wong,G.S., Eliseeva,S.I., Smyth,T.R., Chapman,T.J.,
            Lim,K., Kim,M. and Georas,S.N.
  TITLE     Protein kinase D3 promotes neutrophil migration during viral
            infection
  JOURNAL   Immunol Cell Biol 101 (2), 130-141 (2023)
   PUBMED   36318273
  REMARK    GeneRIF: Protein kinase D3 promotes neutrophil migration during
            viral infection.
REFERENCE   5  (bases 1 to 5887)
  AUTHORS   Koutnik,J., Leitges,M. and Siegmund,K.
  TITLE     T cell-intrinsic protein kinase D3 is dispensable for the cells'
            activation
  JOURNAL   Front Immunol 13, 1049033 (2022)
   PUBMED   36466811
  REMARK    GeneRIF: T cell-intrinsic protein kinase D3 is dispensable for the
            cells' activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5887)
  AUTHORS   Ellwanger,K., Pfizenmaier,K., Lutz,S. and Hausser,A.
  TITLE     Expression patterns of protein kinase D 3 during mouse development
  JOURNAL   BMC Dev Biol 8, 47 (2008)
   PUBMED   18439271
  REMARK    GeneRIF: PKD3 is increasingly expressed in neuronal as well as in
            the supporting connective tissue and in skeletal muscles
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5887)
  AUTHORS   Oster,H., Abraham,D. and Leitges,M.
  TITLE     Expression of the protein kinase D (PKD) family during mouse
            embryogenesis
  JOURNAL   Gene Expr Patterns 6 (4), 400-408 (2006)
   PUBMED   16377259
REFERENCE   8  (bases 1 to 5887)
  AUTHORS   Rey,O., Papazyan,R., Waldron,R.T., Young,S.H.,
            Lippincott-Schwartz,J., Jacamo,R. and Rozengurt,E.
  TITLE     The nuclear import of protein kinase D3 requires its catalytic
            activity
  JOURNAL   J Biol Chem 281 (8), 5149-5157 (2006)
   PUBMED   16380377
  REMARK    GeneRIF: the catalytic activity of PKD3 may regulate its nuclear
            import through autophosphorylation and/or interaction with another
            protein
REFERENCE   9  (bases 1 to 5887)
  AUTHORS   Matthews,S.A., Dayalu,R., Thompson,L.J. and Scharenberg,A.M.
  TITLE     Regulation of protein kinase Cnu by the B-cell antigen receptor
  JOURNAL   J Biol Chem 278 (11), 9086-9091 (2003)
   PUBMED   12506120
  REMARK    GeneRIF: PKCnu is an important component of signaling pathways
            downstream from novel PKC enzymes after B-cell receptor engagement
REFERENCE   10 (bases 1 to 5887)
  AUTHORS   Morrow,T.A., Muljo,S.A., Zhang,J., Hardwick,J.M. and Schlissel,M.S.
  TITLE     Pro-B-cell-specific transcription and proapoptotic function of
            protein kinase Ceta
  JOURNAL   Mol Cell Biol 19 (8), 5608-5618 (1999)
   PUBMED   10409750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151293.2, BC089164.1 and AC154274.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089164.1, SRR9219381.351152.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC151293.2         119262-119362
            102-4743            BC089164.1         1-4642
            4744-5887           AC154274.1         129902-131045       c
FEATURES             Location/Qualifiers
     source          1..5887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 49.69 cM"
     gene            1..5887
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /note="protein kinase D3"
                     /db_xref="GeneID:75292"
                     /db_xref="MGI:MGI:1922542"
     exon            1..132
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            133..1050
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1189
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1321
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1479
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1672
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1750
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1934
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2058
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2136
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2413
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2466
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2539
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2646
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2808
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2907
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3175
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3261
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..5887
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5861..5866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /note="hexamer: AATAAA"
     polyA_site      5882
                     /gene="Prkd3"
                     /gene_synonym="4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3;
                     Prkcn"
                     /note="major polyA site"
ORIGIN      
        1 gggagggagg gcaggaggaa ggggcgcggg cgggcgggtt cgtgcgaggc gcgtgaagcc
       61 tcgctggctc ctgctccggg acgcggacgc tggcgcgcgc cgactttctc cagaacagcc
      121 gagcccgcct ctgttgacag catttcagaa ggcaccagct tttctctctg gatccattca
      181 tccaaagaaa tatgtttgta ctatttttac aagcttttta tttttacttc atcacaggga
      241 agttcagtcc caagatggaa atgagttcct atgagagggt aaactaaggt gtgaccattt
      301 gtggtgtccc gtcaatccct gaaggcatag attatctgaa actactttta atcaggaaga
      361 tttcatatct tgatacagat caactattct gtttgttttt ctgaaatgaa aagcaaaaga
      421 caagagcaga tttagaagaa gtgaagatgt cttgtaaata ttcagcatga actctgttct
      481 tccgacgatg atggtgatgt gaagtggggg acagatctgg gtgtggtcct aaagacaaga
      541 ttcttgatgg gactgatacc gacagcaata ggatcttttg agtattcaac tcggagtaac
      601 agaatttgtc atcaacggca tgaatggctc agccgaggaa atagagcagc tttcatctaa
      661 atccaagcgt gtcgtcattt tttcactgct attattttga aaacttcttc aaaaccattt
      721 aaaaagcatt gacaactaat tttatagatc aaagaaaggc agatgtctgc aaataattcc
      781 cctccatcag cccagaaatc tgtgttccct gcaactgttt ctgctgtgct tccagctcct
      841 tctccgtgtt caagtcccaa aacaggactc tcagctcggc tctctaatgg cagcttcagt
      901 gccccgtcac tcacaaactc tagaggctca gtgcacacag tttcatttct acttcagatt
      961 ggcctcacac gagagagtgt taccatcgag gcccaggaac tgtctctctc tgctgtcaaa
     1021 gacctcgtgt gctccattgt ttatcagaag tttccagagt gtggattctt tggcatgtat
     1081 gataaaattc ttctctttcg ccacgacatg aactcagaaa acattttgca gctgattacc
     1141 tcagcagatg aaatacatga aggggacctg gtagaagttg tcctgtcagc tttggccaca
     1201 gtggaagact tccagatccg ccctcacgct ctctatgtac attcttacaa agcacctact
     1261 ttttgtgatt actgtggtga aatgctctgg ggactggtac gtcaaggatt aaaatgtgaa
     1321 ggctgtggat taaattatca taaacgatgt gccttcaaga ttccaaataa ctgcagtgga
     1381 gtaagaaaga gacgtctgtc aaatgtatct ctgccaggac ctggcctctc agttccaaga
     1441 cccctgcagc ctgagtgtgt gccccttctc agtgaagagt cacatactca ccaagagccc
     1501 agtaagagaa tcccgtcgtg gagtggtcgt ccgatctgga tggaaaagat ggtaatgtgc
     1561 agggtcaaag tccctcacac atttgctgtc cactcttatg gccgcccgac catatgccag
     1621 tactgcaagc gcctgctgaa aggcctcttc cgccaaggga tgcagtgtaa agattgcaaa
     1681 ttcaactgcc ataaacgctg tgcatccaaa gtaccaagag actgccttgg cgaagttact
     1741 ttcaatggag agccgtgcag cgtggggact gatgcagaca tgcccatgga tattgacagt
     1801 agtgatgtga acagtgatgg cagtaggggc ttggatgact cagaggagcc gtccccgccc
     1861 gaagacaaga tgttcttcct cgacccgact gatctcgacg tggagcgaga tgaggagact
     1921 gttaagacaa tcagtccatc caccagcaat aatatcccgc tgatgagggt ggtgcagtcc
     1981 atcaagcaca caaagaggag gagcagcaca gttgtgaagg aagggtggat ggtccactac
     2041 accagcaggg acaacctgag aaagagacat tattggagac ttgacagtaa atgtctaaca
     2101 ttgtttcaaa atgaatctgg atcaaagtat tataaggaaa ttccactttc agaaattctc
     2161 cgtgtatctt caccgcaaga tttcaccagc atttcacaag gcagtaaccc acactgtttt
     2221 gaaatcatca ccgataccgt ggtatacttt gttggtgaga acaatgggag cagctctcat
     2281 aatcctgttc tcgctgccac tggagtggga ctagatgtgg cgcagagctg ggaaaaagca
     2341 attcgccagg ccctcatgcc tgtcactcct caagcaagtg tttgcacttc tccggggcaa
     2401 gggaaggacc acaaagatct ggctaccagt atctccgtgt ctaactgtca ggttcaggag
     2461 aatgtcgaca tcagcagcgt ttaccagatc tttgcggacg aggtgcttgg ttctggccag
     2521 tttggcattg tttatggagg aaaacacaga aagacgggaa gggatgtggc tattaaagtg
     2581 attgataaaa tgaggttccc cacaaagcaa gagagtcagc tccggaacga agtggccatt
     2641 ttacagaatc tgcaccatcc tgggattgta aacctggagt gtatgtttga aaccccagaa
     2701 cgagtcttcg tggtgatgga aaagctccat ggagatatgt tggaaatgat tctgtccagt
     2761 gaaaagagtc gacttccaga acggattacc aaattcatgg tcacacagat acttgttgcc
     2821 ttgaggaatt tacatttcaa gaatattgtg cactgtgatt taaagcccga aaatgtgctg
     2881 cttgcatccg cagagccatt tcctcaggtg aagctgtgtg actttgggtt tgcccgcatc
     2941 attggtgaga agtcgttccg gaggtcagtg gtaggaactc cagcctactt agcccctgag
     3001 gttctcagga gcaaaggcta caaccgttct ctagacatgt ggtcggtggg cgtcatcgtt
     3061 tatgtgagcc tcagtggcac attcccattc aatgaagatg aagatataaa tgaccaaatc
     3121 caaaacgctg cgtttatgta cccaccaaat ccatggcgag aaatttccag tgaagcaatt
     3181 gacttgataa acaacttgct tcaagtgaag atgagaaaac gatacagtgt tgacaaatct
     3241 ctcagtcatc cttggctaca ggattatcag acttggcttg acctcagaga atttgaaact
     3301 cgcattggag aacgttacat tacacacgaa agtgatgatg ctcgctggga aatacacgca
     3361 tacacgcaca atctggaata cccaaagcat ttcattatgg cccccaaccc agacgacatg
     3421 gaggaggatc cttagttgtc agtgcgccga cctcaataag gaaggatttc acttcaagag
     3481 cggatacttt gctgcatggc tggtggcctc tgcaggctac cattgcaagg cggcagcacc
     3541 gtgaggaagt agaaggactt gtggcatcag ttctgtagct cataacgagt aggtacatga
     3601 agggaaactg agtaataaag tcaaaatgga acttctataa atttttatag cataagcaat
     3661 aactggttct gtaatttttc ctaatccttc acattagcac aatgtgagtt agcacttaat
     3721 ttatctcttt tacctctcct tttctgttat tacatcattt gttttaaagg cctatgactg
     3781 tctagttatt gcttataagg ttgattactc aacaggtttg cagttaagca gtaaccatga
     3841 ggctaacagc atacagcttg ctgtaaggac ctttagtgtt tgtccactgt cggaggcatt
     3901 gcttcctcct tcctggaccc gataagcaga ccattgtact gctggccttc cggtggatgc
     3961 gtctttccat atggcctgta tgacagaaga gttgtcacat tttccatgtt ataacagtca
     4021 ctaggataat cgaacaattg gtgttacaaa tgaatagaaa tagctggtca tcactcagct
     4081 ctgcctctga acacgtatgt tctcaattgg caccatcatg ttacagtatg ccacagtcgg
     4141 tgggcacaac gctgcattta actaatttat cctcacctgg agttgaataa tgtatagaca
     4201 aaatcacata ctagagaggg aagctaacac aggtcagtag atgtcactgt tatctgtttc
     4261 ctcttccctt ggcctttgga tggggtttcc aatacctagt gtttttaaat tagcattgtc
     4321 gtttgagcag tttggaggag tgactgaagt caaacatgaa aacttagttt attgaggtgg
     4381 gacctaatta ccagtagagc ggatggagaa ggagtaagaa cgtcttacac ttcagctcca
     4441 acagccagct gttttgtagt agttattaat acaaggtcag tatccctatc tgagctgctc
     4501 tacaccagga aggtttcact gccagatact gaaatgtttg cacactctac tagttgagca
     4561 tccctgacct acaaatccga aatcctccaa attcaagaaa ctttggagtc cttcagattt
     4621 ccacattagt gatattccca cctgtgcttt acccaaagag aaaaagatcc aggaccatcc
     4681 tctcacaaga aatatagtag ctgtttgttt cttcattcct cactagtcac aaaaaaaaaa
     4741 aaacaaaaca aaaacaaaac aggtttttct tgttgttttt ccttttctgt gctgagagca
     4801 agaatttgga atgagaaagc ctgggtttaa gcctaagtgt ctttactctg tggatctgtg
     4861 gggctgagca gataacattg tctgagcatt tgtttgactt agtttctcag tctgtagagt
     4921 agacaccata aattcttcct tctgccttcc tccatgtggc tgtgaagatt gggctatgtg
     4981 accacttgtg acaatctgga atgccagggt tgtcgcttac cacgggctct gagatagcaa
     5041 aggaaaaact gtgtgtgtga gcagaccaaa actaagtgcc atcccagatg agaatgcagc
     5101 tgcagtgatc tgtctaaaat taaaaatgtt cttgaggtga cagaaacagc aggggtgccc
     5161 ggttgtaaat gtttatgctt tgaactgtcc tcacaatagt cacatgacta agcacactta
     5221 aagttgaggc acagggttag ttgtcaaagt gcattgagtt taaatatgga tttaaaccca
     5281 ggcctatatc cccaatccct ttacccgtcc cagccattga caatgtactg tacatctgta
     5341 agaatttcca gaagactttc caaactgtct ctgtaattgt tttcatacag tagttgtgaa
     5401 gagtaatttt aagaaacttc taagaatgga tttttccatt tctgctaagt ctgcttgacc
     5461 agtatgtaca aggtggaact cgtgtgtgtc actaggcagc ccacggtggt tttaccatgg
     5521 gaggtgagaa ctaactgaaa tgactgctgg tttgctgtac ttctgtaatc agactttaca
     5581 agccatgaca ttaattgcac tctgtttttg tcaaagccct gtgctgttta aagagagact
     5641 gtaaaggcgc tgtcacggtg cggagttgag taaccactcc actgtttaac ctgcataact
     5701 ttttgtcatt gtcttaaagc caagctgtgt ttgcatatat gaaagtaatt gtttcttaga
     5761 aacatgtgac aattttcaaa gtagtgtata atgacactgt ttagtacatt ttatattttt
     5821 tgttacatcc cactttttgt aaatattctc aaaacttgat aataaaatgt atttctctat
     5881 caccata
//
