LOCUS       NM_001252458            3340 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus protein kinase D2 (Prkd2), transcript variant 2, mRNA.
ACCESSION   NM_001252458
VERSION     NM_001252458.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3340)
  AUTHORS   Waheed-Ullah,Q., Wilsdon,A., Abbad,A., Rochette,S., Bu'Lock,F.,
            Hitz,M.P., Dombrowsky,G., Cuello,F., Brook,J.D. and Loughna,S.
  TITLE     Effect of deletion of the protein kinase PRKD1 on development of
            the mouse embryonic heart
  JOURNAL   J Anat 245 (1), 70-83 (2024)
   PUBMED   38419169
REFERENCE   2  (bases 1 to 3340)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3340)
  AUTHORS   Connelly,J.A., Zhang,X., Chen,Y., Chao,Y., Shi,Y., Jacob,T.C. and
            Wang,Q.J.
  TITLE     Protein kinase D2 confers neuroprotection by promoting AKT and CREB
            activation in ischemic stroke
  JOURNAL   Neurobiol Dis 187, 106305 (2023)
   PUBMED   37730136
  REMARK    GeneRIF: Protein kinase D2 confers neuroprotection by promoting AKT
            and CREB activation in ischemic stroke.
REFERENCE   4  (bases 1 to 3340)
  AUTHORS   Burciaga,S.D., Saavedra,F., Fischer,L., Johnstone,K. and
            Jensen,E.D.
  TITLE     Protein kinase D3 conditional knockout impairs osteoclast formation
            and increases trabecular bone volume in male mice
  JOURNAL   Bone 172, 116759 (2023)
   PUBMED   37044359
REFERENCE   5  (bases 1 to 3340)
  AUTHORS   Chen,L., Zhao,J., Chao,Y., Roy,A., Guo,W., Qian,J., Xu,W.,
            Domsic,R.T., Lafyatis,R., Lu,B., Deng,F. and Wang,Q.J.
  TITLE     Loss of Protein Kinase D2 Activity Protects Against
            Bleomycin-Induced Dermal Fibrosis in Mice
  JOURNAL   Lab Invest 103 (2), 100018 (2023)
   PUBMED   37039152
  REMARK    GeneRIF: Loss of Protein Kinase D2 Activity Protects Against
            Bleomycin-Induced Dermal Fibrosis in Mice.
REFERENCE   6  (bases 1 to 3340)
  AUTHORS   Matthews,S.A., Navarro,M.N., Sinclair,L.V., Emslie,E.,
            Feijoo-Carnero,C. and Cantrell,D.A.
  TITLE     Unique functions for protein kinase D1 and protein kinase D2 in
            mammalian cells
  JOURNAL   Biochem J 432 (1), 153-163 (2010)
   PUBMED   20819079
  REMARK    GeneRIF: Data demonstrate that, unlike PKD1, PKD2 catalytic
            activity is dispensable for normal embryogenesis.
REFERENCE   7  (bases 1 to 3340)
  AUTHORS   Yin,D.M., Huang,Y.H., Zhu,Y.B. and Wang,Y.
  TITLE     Both the establishment and maintenance of neuronal polarity require
            the activity of protein kinase D in the Golgi apparatus
  JOURNAL   J Neurosci 28 (35), 8832-8843 (2008)
   PUBMED   18753385
REFERENCE   8  (bases 1 to 3340)
  AUTHORS   Sinnett-Smith,J., Zhukova,E., Rey,O. and Rozengurt,E.
  TITLE     Protein kinase D2 potentiates MEK/ERK/RSK signaling, c-Fos
            accumulation and DNA synthesis induced by bombesin in Swiss 3T3
            cells
  JOURNAL   J Cell Physiol 211 (3), 781-790 (2007)
   PUBMED   17226786
  REMARK    GeneRIF: PKD2, like PKD, facilitates mitogenesis in 3T3 cells
REFERENCE   9  (bases 1 to 3340)
  AUTHORS   Oster,H., Abraham,D. and Leitges,M.
  TITLE     Expression of the protein kinase D (PKD) family during mouse
            embryogenesis
  JOURNAL   Gene Expr Patterns 6 (4), 400-408 (2006)
   PUBMED   16377259
REFERENCE   10 (bases 1 to 3340)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY202739.1, AK037030.1 and BF146730.1.
            
            Transcript Variant: This variant (2) has a different 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096444.1, SRR7345562.3766484.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               BY202739.1         2-349
            349-1827            AK037030.1         635-2113
            1828-1979           BF146730.1         254-405
            1980-3340           AK037030.1         2266-3626
FEATURES             Location/Qualifiers
     source          1..3340
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.15 cM"
     gene            1..3340
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /note="protein kinase D2"
                     /db_xref="GeneID:101540"
                     /db_xref="MGI:MGI:2141917"
     exon            1..132
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            133..514
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..2902
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /EC_number="2.7.11.13"
                     /note="nPKC-D2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase D2"
                     /protein_id="NP_001239387.1"
                     /db_xref="CCDS:CCDS20855.1"
                     /db_xref="GeneID:101540"
                     /db_xref="MGI:MGI:2141917"
                     /translation="MAAAPSHPAGLPGSPGPGSPPPPGGLDLQSPPPLLPQIPAPGSG
                     VSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTS
                     ANLLQLVRSAADIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLF
                     GLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGSSESLPCT
                     AEELSRSTTDLLPRRPPSSSSSSSSSSFYTGRPIELDKMLMSKVKVPHTFLIHSYTRP
                     TVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEAADYS
                     EADKSSISDELEDSGVIPGSHSESALHASEEEEGEGHKAQSSLGYIPLMRVVQSVRHT
                     TRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILAV
                     EPAQNFSLVPPGTNPHCFEIITANVTYFVGETPGGAPGGPSGQGTEAVRGWETAIRQA
                     LMPVILQDAPSAPGHTPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVV
                     YGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKV
                     FVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVL
                     LASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGV
                     IMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISSGAIDLINNLLQVKMRKRYS
                     VDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWDQFVAERHGTPAEGDLGG
                     ACLPQDHEMQGLAERISIL"
     exon            515..653
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..785
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..940
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1166
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1244
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1398
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1516
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1594
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1853
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1906
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..1979
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2086
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2248
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2347
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2615
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2701
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..3340
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3214..3219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /note="hexamer: AATAAA"
     polyA_site      3244
                     /gene="Prkd2"
                     /gene_synonym="PKD2"
                     /note="major polyA site"
ORIGIN      
        1 gattggccag ctgtgccatc gctcctgaga cttccttctg ggccgccgct gccgacttaa
       61 actttgaagg gggaaaaata gagctacccg cgctgtgcga ccctcccttg tccccgaccc
      121 gccccgcctt cggatcccgc catcctcgcg tctctcaacc tgacagattt ctctctcaaa
      181 tgcctgcgtt cttaccacca ccgcaagaga gctctcggat ctaggtccca gggtccttgg
      241 tgagctttgg gcggcagatc tggatctggc ccccatggcc gccgccccct cccatcccgc
      301 aggactcccc ggctctccgg ggcccgggtc tcctccgccc cccggtggct tggatctcca
      361 gtcgccgcca cctctgctgc ctcagatccc ggctccgggt tcgggggtct ccttccatat
      421 ccagatcgga ttgacccgag agttcgtgct gttgccggct gcctcagagt tggctcatgt
      481 gaagcaacta gcctgttcta tcgtggacca gaagttccca gagtgtggct tctacggcct
      541 gtacgacaag atcctgctct tcaaacatga cccaacatca gccaacctcc tgcagctggt
      601 gcgatcagct gcagatatcc aggagggtga cctggtggag gtggttctgt cggcctcggc
      661 caccttcgag gatttccaga tccgaccgca tgctctcact gtgcactcgt accgcgctcc
      721 cgccttctgt gaccactgcg gggagatgct cttcggcctc gtgcgccagg gcctcaagtg
      781 cgatggctgc gggctgaatt accacaaacg ctgcgccttc agcatcccga acaactgcag
      841 tggtgctcga aagcgccgcc tgtcatccac gtctctggcc agtggccatt ctgtgcgcct
      901 tggcagctcc gagtccttac cctgcaccgc cgaagagctg agccgtagca ccaccgacct
      961 ccttcctcgc cgaccaccct cgtcgtcgtc ctcctcctct tcctcttcct tctacacagg
     1021 ccgacccatt gagttggaca agatgctgat gtccaaggtc aaggtgccac acaccttcct
     1081 tatacatagc tacacacggc ccaccgtttg ccaggcttgc aagaaactgc tcaagggtct
     1141 attccgccag ggcctgcagt gcaaagactg caagtttaac tgtcacaaac gctgtgctac
     1201 ccgcgtccct aacgactgcc tgggggaggc gctcatcaat ggagacgtgc cgatggagga
     1261 agccgctgat tacagtgagg ctgataagag ctccatctca gatgagttgg aggattctgg
     1321 tgtcatcccc ggctcccact cagagagtgc tctccatgcc agtgaggaag aggaaggcga
     1381 gggacacaag gcccagagct cgctgggata catccccctg atgcgcgtgg tacagtctgt
     1441 gcgacacacg acccggaaat ccagcaccac cctgcgggag ggctgggtgg tccattacag
     1501 caacaaggac acactgagga aacggcacta ctggcgtcta gactgtaaat gcattaccct
     1561 cttccagaac aacacgacca acagatacta caaggaaatc ccgctgtctg aaatccttgc
     1621 ggtggaaccg gctcagaact tcagcctcgt acccccgggc accaacccac actgcttcga
     1681 gatcatcacg gccaatgtca cctactttgt gggcgaaacc cctggcgggg ccccgggagg
     1741 gccaagtgga cagggaacag aggccgttcg gggttgggag acagccatcc gccaggcact
     1801 gatgcccgtt atcctccaag atgcgcccag tgccccgggg cacacaccgc acagacaagc
     1861 gtctctgagt atctccgtgt ccaacagtca gatccaagag aatgtggata tcgccactgt
     1921 ctaccagatc ttcccagatg aggtgctggg ctctgggcag tttggagtgg tttatggagg
     1981 aaaacacagg aagactggca gagacgttgc agtaaaggtc attgacaaac tgcgcttccc
     2041 caccaagcag gagagccagc tcaggaatga agtggccatt ctccagagtc tacggcaccc
     2101 cgggattgtg aacctcgagt gcatgtttga gactcctgag aaggtattcg tggtgatgga
     2161 gaaactgcac ggggacatgt tggagatgat cctctccagt gagaagggcc ggcttcctga
     2221 gcgtctcacc aagttcctta tcacgcagat cctggtggcg ctgagacacc tgcacttcaa
     2281 gaacatcgtc cactgtgact tgaaaccaga gaatgtgtta ctggcatcag ccgatccgtt
     2341 tcctcaggtg aagctctgtg actttggctt cgctcgcatc atcggcgaga agtccttccg
     2401 gcgctcagtg gtgggcacgc ctgcctacct ggcacccgag gtactgctca accagggtta
     2461 caaccgctcg ctggacatgt ggtccgtggg tgtgatcatg tacgtgagcc ttagtggcac
     2521 gttccccttc aatgaggacg aggacatcaa tgaccagata cagaacgcgg cctttatgta
     2581 cccggccagc ccctggagcc acatctcatc tggagccatc gacctcatca acaacctgtt
     2641 gcaggtgaag atgcgcaagc gctacagcgt ggacaagtct ctcagccacc catggttaca
     2701 ggagtaccag acgtggcttg acctccgaga gctagaggga aagatgggcg agcgatatat
     2761 cacgcacgag agcgacgacg cacgctggga tcagtttgtg gcagagcgcc atgggactcc
     2821 tgcagaaggg gacctgggtg gcgcctgtct gccgcaggac cacgagatgc aggggctggc
     2881 tgagcgcatc agcatcctct gaggccagtg ttccccctgg gcagcttgct ttctttggag
     2941 tcctgcacat catcccagaa atgaactctt gtagaggaag cagcttcctg cgcagactgg
     3001 aggggccagg gaaatagact cttcccaggg ccatgatctt agtccctgat gcctcaacct
     3061 tggagcgata aggctggaga gttgactctg ggggtaaagg cgcttgccac caagcctaac
     3121 aacttgagtt tgattcctgg gatgaaccgg tttggagaat tgactccttc cgtttgtccc
     3181 ctgaccacca taagtgccca cataaacaca ggcaataaaa tgtatttttt ctttttataa
     3241 caaatgaagc acccactggc catggtgata atataatccc agcacttgga gaggctgagg
     3301 aaggagggtc tctttaagtt caaggccagc caaggatgct
//
