LOCUS       NM_008858               3804 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus protein kinase D1 (Prkd1), transcript variant 1, mRNA.
ACCESSION   NM_008858
VERSION     NM_008858.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3804)
  AUTHORS   Snyder,J.D., Yoon,T.W., Lee,S., Halder,P., Fitzpatrick,E.A. and
            Yi,A.K.
  TITLE     Protein kinase D1 in myeloid lineage cells contributes to the
            accumulation of CXCR3+CCR6+ nonconventional Th1 cells in the lungs
            and potentiates hypersensitivity pneumonitis caused by S.
            rectivirgula
  JOURNAL   Front Immunol 15, 1403155 (2024)
   PUBMED   39464896
  REMARK    Erratum:[Front Immunol. 2024 Nov 05;15:1513635. doi:
            10.3389/fimmu.2024.1513635. PMID: 39564134]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3804)
  AUTHORS   Tuladhar,A., Shaver,J.C., McGee,W.A., Yu,K., Dorn,J., Horne,J.L.,
            Alhamad,D.W., Hagan,M.L., Cooley,M.A., Zhong,R., Bollag,W.,
            Johnson,M., Hamrick,M.W. and McGee-Lawrence,M.E.
  TITLE     Prkd1 regulates the formation and repair of plasma membrane
            disruptions (PMD) in osteocytes
  JOURNAL   Bone 186, 117147 (2024)
   PUBMED   38866124
  REMARK    GeneRIF: Prkd1 regulates the formation and repair of plasma
            membrane disruptions (PMD) in osteocytes.
REFERENCE   3  (bases 1 to 3804)
  AUTHORS   Waheed-Ullah,Q., Wilsdon,A., Abbad,A., Rochette,S., Bu'Lock,F.,
            Hitz,M.P., Dombrowsky,G., Cuello,F., Brook,J.D. and Loughna,S.
  TITLE     Effect of deletion of the protein kinase PRKD1 on development of
            the mouse embryonic heart
  JOURNAL   J Anat 245 (1), 70-83 (2024)
   PUBMED   38419169
  REMARK    GeneRIF: Effect of deletion of the protein kinase PRKD1 on
            development of the mouse embryonic heart.
REFERENCE   4  (bases 1 to 3804)
  AUTHORS   Godoy-Corchuelo,J.M., Ali,Z., Brito Armas,J.M., Martins-Bach,A.B.,
            Garcia-Toledo,I., Fernandez-Beltran,L.C., Lopez-Carbonero,J.I.,
            Bascunana,P., Spring,S., Jimenez-Coca,I., Munoz de Bustillo
            Alfaro,R.A., Sanchez-Barrena,M.J., Nair,R.R., Nieman,B.J.,
            Lerch,J.P., Miller,K.L., Ozdinler,H.P., Fisher,E.M.C.,
            Cunningham,T.J., Acevedo-Arozena,A. and Corrochano,S.
  TITLE     TDP-43-M323K causes abnormal brain development and progressive
            cognitive and motor deficits associated with mislocalised and
            increased levels of TDP-43
  JOURNAL   Neurobiol Dis 193, 106437 (2024)
   PUBMED   38367882
  REMARK    Erratum:[Neurobiol Dis. 2024 Nov;202:106708. doi:
            10.1016/j.nbd.2024.106708. PMID: 39462744]
REFERENCE   5  (bases 1 to 3804)
  AUTHORS   Herwig,M., Begovic,M., Budde,H., Delalat,S., Zhazykbayeva,S.,
            Sieme,M., Schneider,L., Jaquet,K., Mugge,A., Akin,I.,
            El-Battrawy,I., Fielitz,J. and Hamdani,N.
  TITLE     Protein Kinase D Plays a Crucial Role in Maintaining Cardiac
            Homeostasis by Regulating Post-Translational Modifications of
            Myofilament Proteins
  JOURNAL   Int J Mol Sci 25 (5), 2790 (2024)
   PUBMED   38474037
  REMARK    GeneRIF: Protein Kinase D Plays a Crucial Role in Maintaining
            Cardiac Homeostasis by Regulating Post-Translational Modifications
            of Myofilament Proteins.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3804)
  AUTHORS   Matthews,S.A., Rozengurt,E. and Cantrell,D.
  TITLE     Characterization of serine 916 as an in vivo autophosphorylation
            site for protein kinase D/Protein kinase Cmu
  JOURNAL   J Biol Chem 274 (37), 26543-26549 (1999)
   PUBMED   10473617
REFERENCE   7  (bases 1 to 3804)
  AUTHORS   Passalacqua,M., Patrone,M., Sparatore,B., Melloni,E. and
            Pontremoli,S.
  TITLE     Protein kinase C-theta is specifically localized on centrosomes and
            kinetochores in mitotic cells
  JOURNAL   Biochem J 337 (Pt 1) (Pt 1), 113-118 (1999)
   PUBMED   9854032
REFERENCE   8  (bases 1 to 3804)
  AUTHORS   Van Lint,J.V., Sinnett-Smith,J. and Rozengurt,E.
  TITLE     Expression and characterization of PKD, a phorbol ester and
            diacylglycerol-stimulated serine protein kinase
  JOURNAL   J Biol Chem 270 (3), 1455-1461 (1995)
   PUBMED   7836415
REFERENCE   9  (bases 1 to 3804)
  AUTHORS   Valverde,A.M., Sinnett-Smith,J., Van Lint,J. and Rozengurt,E.
  TITLE     Molecular cloning and characterization of protein kinase D: a
            target for diacylglycerol and phorbol esters with a distinctive
            catalytic domain
  JOURNAL   Proc Natl Acad Sci U S A 91 (18), 8572-8576 (1994)
   PUBMED   8078925
REFERENCE   10 (bases 1 to 3804)
  AUTHORS   Osada,S., Mizuno,K., Saido,T.C., Akita,Y., Suzuki,K., Kuroki,T. and
            Ohno,S.
  TITLE     A phorbol ester receptor/protein kinase, nPKC eta, a new member of
            the protein kinase C family predominantly expressed in lung and
            skin
  JOURNAL   J Biol Chem 265 (36), 22434-22440 (1990)
   PUBMED   2266135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154543.2, CT010578.16, AC099603.15 and CT009740.17.
            
            On May 22, 2020 this sequence version replaced NM_008858.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z34524.1, SRR7345562.4857799.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-534               AC154543.2         189098-189631       c
            535-673             CT010578.16        36451-36589         c
            674-805             AC099603.15        27219-27350
            806-966             AC099603.15        29854-30014
            967-990             AC099603.15        35577-35600
            991-1201            AC099603.15        60413-60623
            1202-1279           AC099603.15        60777-60854
            1280-1484           AC099603.15        62414-62618
            1485-1608           AC099603.15        64004-64127
            1609-1686           AC099603.15        65466-65543
            1687-1966           AC099603.15        66921-67200
            1967-2019           AC099603.15        68185-68237
            2020-2092           AC099603.15        70238-70310
            2093-2199           AC099603.15        71947-72053
            2200-2361           CT009740.17        130760-130921       c
            2362-2460           CT009740.17        130072-130170       c
            2461-2728           CT009740.17        128970-129237       c
            2729-2814           CT009740.17        107512-107597       c
            2815-3804           CT009740.17        105689-106678       c
FEATURES             Location/Qualifiers
     source          1..3804
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 21.78 cM"
     gene            1..3804
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /note="protein kinase D1"
                     /db_xref="GeneID:18760"
                     /db_xref="MGI:MGI:99879"
     exon            1..534
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            535..673
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            674..805
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            806..966
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            967..990
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1201
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1279
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1484
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1608
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1686
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1966
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2019
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2092
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2199
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2361
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2460
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2728
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2814
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..3804
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3786..3791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /note="hexamer: AATAAA"
     polyA_site      3804
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; PKD; PKD1; Prkcm"
                     /note="major polyA site"
ORIGIN      
        1 ggtcgcgcgg acccgccgtg gtccccggag cggagcgcgc cgcggccgca gtagctgggc
       61 gcctcccccg cgctgccgcg cgcccgcctg ctcgcctgcc cgcccgccgg ccccggctcc
      121 gctcggccat cttcgcggct cccgccctca ccagctccgg tcgcgcgccc tgtccccgcg
      181 cgcggacttt cccggaaagt ttggtggttc ttctccgccg ccgcaggcag cggcgccgcg
      241 ccccacgtcc gccaaacttt ggggctcact ggcgcgatga gcgtccctcc gctgctgcga
      301 ccgcctagcc cgctcctgcc cgccgcggcc gccgtggctg ctgccgccgc tgcgctggtc
      361 ccaggctccg ggcccgcgcc cttcccggcg cctggggccg ccccggcggg gggcatctcg
      421 ttccatctgc agatcggcct gagccgcgag ccggtgctgc tcctgcagga ctcctctggc
      481 gactacagcc tggcgcatgt ccgggagatg gcttgttcca tcgtggacca gaagttcccc
      541 gaatgtggtt tctatggact ctatgataag atcctgcttt ttcggcacga tcctgcctcc
      601 gacaacatcc ttcagctggt gaaaatcgca agtgatatcc aggagggtga tctcattgaa
      661 gtggtcctgt cagcttcagc caccttcgaa gacttccaga tccggcccca tgctctcttc
      721 gttcattcat acagagcccc agctttctgt gatcactgtg gagaaatgct gtgggggctg
      781 gtgcgtcaag gccttaaatg tgaaggatgt ggtctgaatt accataagag atgtgcattt
      841 aaaatcccca acaattgcag tggagttaga aggagaagac tctccaatgt gtccctcact
      901 ggactcggta ctgtccgcac agcatcggct gagttctcca ccagtgtccc tgatgagcct
      961 ttactgtctc ctgtgagccc tggctttgag caaaagtctc catctgagtc atttatcggc
     1021 cgtgagaaga ggtcaaattc gcagtcatac atcggacggc cgattcagct cgacaagctc
     1081 ctgatgtcta aggtgaaggt gccacacacc tttgtcatcc actcctacac acggcccacg
     1141 gtctgccagt tctgtaagaa gctcctcaag ggcctcttcc ggcagggctt gcagtgcaaa
     1201 gattgcagat tcaactgtca caaacgctgc gcaccaaaag taccaaacaa ctgcttgggt
     1261 gaagtgacca tcaatggaga attacttagc cctggtgcag aatctgatgt tgttatggaa
     1321 gaagggagtg atgacaatga cagtgagcgg aacagtgggc tcatggatga catggacgag
     1381 gccatggtcc aagatactga gatggctttg gcagagggcc agagtggagg tgcagagatg
     1441 caagatccag atgcagacca ggaggactcc aacagaacca tcagcccttc aacgagcaac
     1501 aacatcccgc tcatgagggt agtgcagtct gtgaagcaca cgaagcggag gagcagcact
     1561 gtgatgaagg aagggtggat ggtccactac accagcaagg acacactgcg gaaaaggcac
     1621 tactggagat tggacagcaa atgcataaca ctcttccaaa atgacacagg gagccggtac
     1681 tacaaggaaa ttcctttatc agaaatatta tgtctggaac cagcaaaacc ttcagcttta
     1741 actcccgttg gagcgactcc tcattgtttt gaaatcacta cagcgaatgt agtgtattat
     1801 gtgggagaaa acgtggttaa cccatcaagt tccccaccaa acaacagtgt tctccccagt
     1861 ggcatcggtc cggatgtggc caggatgtgg gaggtggcca tccagcatgc tcttatgccc
     1921 gtcatcccca agggctcctc tgttggctcc ggatccaact cacacaaaga tatttctgtg
     1981 agcatttccg tttcaaattg ccagattcag gaaaatgtgg atatcagcac agtctatcaa
     2041 atatttcctg atgaagttct gggttccgga cagtttggaa ttgtttatgg aggtaaacat
     2101 cgtaaaacag gaagagatgt agctattaag attattgaca aattaagatt tcctacaaaa
     2161 caagaaagtc agcttcgtaa tgaggttgca attttacaga accttcatca ccctggtgtt
     2221 gtaaatttgg agtgtatgtt tgagacgcct gaaagagtgt ttgttgttat ggaaaaactc
     2281 catggagaca tgctggagat gatcttgtca agtgaaaagg gcaggttgcc agaacacata
     2341 acgaagtttt taattactca gatactagtg gctttgcgac atcttcattt taaaaacatc
     2401 gttcactgtg acctcaagcc agaaaatgtg ttgctggcat cagccgaccc tttccctcag
     2461 gtgaagctct gtgattttgg ttttgcccgg atcattggag agaagtcttt taggaggtca
     2521 gtggtgggta ccccagcata cctggcacct gaagttctga ggaacaaggg ctataaccgc
     2581 tctctggaca tgtggtctgt tggggtcatc atctatgtga gcctgagtgg taccttccct
     2641 tttaatgaag atgaagatat ccatgatcag atccagaatg cagccttcat gtatccaccc
     2701 aacccgtgga aggagatttc tcatgaagcc attgatctta tcaataactt gctacaagtg
     2761 aaaatgagaa aacgctacag tgtggataaa accttgagtc acccttggct acaggactat
     2821 cagacctggt tagatttacg agagctggaa tgcagaattg gagaacgcta tattacccac
     2881 gaaagcgatg actccaggtg ggaacagtac gcaggcgagc aggggctgca gtacccggcg
     2941 cacctgatca gtctgagtgc tagccacagc gacagtcctg aggctgaaga gagagagatg
     3001 aaagccctca gtgagcgtgt cagcatcctc tgattccatc ccctctaatc tgtcaaaaca
     3061 ctgtggaatt aataaataca tacggtcagg tttaacattt gccttgcaga actgccatta
     3121 ttttctgtca gatgagaaca aagctgttaa actgttagca ctgttgatgt atctgagttg
     3181 ccaagacaaa tcaacagaag catttgtatt ttgtgtgacc aactgtgttg tattaacaaa
     3241 agttcccgga aacactaaac ttgttattgt gaatgattta tgttatattt aatacattaa
     3301 acctgtctcc actgtgcctt tgcaaatcag tgtttttcct accagagcct cattttggtg
     3361 agagccagga cctatccagg acaccattgt gtttggtgtg ctcccattga tagtggtgtt
     3421 gtaagcaaac tcttgaggag tagataatct gccggtgttc tatgaacaac tcaaaatgca
     3481 cagtaggtgg gggcagggag aatgaaagat gaggagaggg cgtaaatgtc ctcagattga
     3541 ctcgcatgga aacagttcta ctgtgtggtt tcaactgttc tgcctgtctg ttgtgcctca
     3601 gtgtatttaa actctagtaa gtgcacctca atatgtggag ctactgctct aagcctaaat
     3661 gccttagaat gtaaactgct atccatacca gatgcatttc ttcctttctt acaataccaa
     3721 ctgtatccac ggaaaaccag caactcagca aatgttggcc ttttgtgtat ttttcaataa
     3781 taagaaataa atcttctttt caaa
//
