LOCUS       NM_008860               4311 bp    mRNA    linear   ROD 04-JUL-2023
DEFINITION  Mus musculus protein kinase C, zeta (Prkcz), transcript variant 1,
            mRNA.
ACCESSION   NM_008860
VERSION     NM_008860.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4311)
  AUTHORS   Yang X, Liang M, Tang Y, Ma D, Li M, Yuan C, Hou Y, Sun C, Liu J,
            Wei Q, Chang Y, Wang C and Zhang J.
  TITLE     KLF7 promotes adipocyte inflammation and glucose metabolism
            disorder by activating the PKCzeta/NF-kappaB pathway
  JOURNAL   FASEB J 37 (7), e23033 (2023)
   PUBMED   37342904
  REMARK    GeneRIF: KLF7 promotes adipocyte inflammation and glucose
            metabolism disorder by activating the PKCzeta/NF-kappaB pathway.
REFERENCE   2  (bases 1 to 4311)
  AUTHORS   Barlow HR, Ahuja N, Bierschenk T, Htike Y, Fassetta L, Azizoglu DB,
            Flores J, Gao N, De la O S, Sneddon JB, Marciano DK and Cleaver O.
  TITLE     Rab11 is essential to pancreas morphogenesis, lumen formation and
            endocrine mass
  JOURNAL   Dev Biol 499, 59-74 (2023)
   PUBMED   37172642
REFERENCE   3  (bases 1 to 4311)
  AUTHORS   Sterling NA, Park JY, Park R, Cho SH and Kim S.
  TITLE     An entosis-like process induces mitotic disruption in Pals1
            microcephaly pathogenesis
  JOURNAL   Nat Commun 14 (1), 82 (2023)
   PUBMED   36604424
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4311)
  AUTHORS   Zhang K, Yao E, Chuang E, Chen B, Chuang EY and Chuang PT.
  TITLE     mTORC1 signaling facilitates differential stem cell differentiation
            to shape the developing murine lung and is associated with
            mitochondrial capacity
  JOURNAL   Nat Commun 13 (1), 7252 (2022)
   PUBMED   36433959
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4311)
  AUTHORS   Akturk A, Day M and Tarchini B.
  TITLE     RGS12 polarizes the GPSM2-GNAI complex to organize and elongate
            stereocilia in sensory hair cells
  JOURNAL   Sci Adv 8 (42), eabq2826 (2022)
   PUBMED   36260679
REFERENCE   6  (bases 1 to 4311)
  AUTHORS   Crespo P, Mischak H and Gutkind JS.
  TITLE     Overexpression of mammalian protein kinase C-zeta does not affect
            the growth characteristics of NIH 3T3 cells
  JOURNAL   Biochem Biophys Res Commun 213 (1), 266-272 (1995)
   PUBMED   7639744
REFERENCE   7  (bases 1 to 4311)
  AUTHORS   Bareggi R, Grill V, Zweyer M, Narducci P and Martelli AM.
  TITLE     Distribution of the extended family of protein kinase C isoenzymes
            in fetal organs of mice: an immunohistochemical study
  JOURNAL   Cell Tissue Res 280 (3), 617-625 (1995)
   PUBMED   7606770
REFERENCE   8  (bases 1 to 4311)
  AUTHORS   Bareggi R, Neri LM, Grill V, Cocco L and Martelli AM.
  TITLE     An immunohistochemical study of protein kinase C distribution in
            fetal mouse vertebral column
  JOURNAL   Anat Embryol (Berl) 190 (1), 47-54 (1994)
   PUBMED   7985811
REFERENCE   9  (bases 1 to 4311)
  AUTHORS   Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF and Mischak H.
  TITLE     The cDNA sequence, expression pattern and protein characteristics
            of mouse protein kinase C-zeta
  JOURNAL   Gene 122 (2), 305-311 (1992)
   PUBMED   1487145
REFERENCE   10 (bases 1 to 4311)
  AUTHORS   Wada H, Ohno S, Kubo K, Taya C, Tsuji S, Yonehara S and Suzuki K.
  TITLE     Cell type-specific expression of the genes for the protein kinase C
            family: down regulation of mRNAs for PKC alpha and nPKC epsilon
            upon in vitro differentiation of a mouse neuroblastoma cell line
            neuro 2a
  JOURNAL   Biochem Biophys Res Commun 165 (1), 533-538 (1989)
   PUBMED   2590242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670227.7, BY073558.1, AK165750.1, CK339309.1, AK049959.1,
            BC033047.1 and AV343761.1.
            
            [WARNING] On Oct 11, 2023 this sequence was replaced by
            NM_008860.4.
            
            On Sep 26, 2013 this sequence version replaced NM_008860.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M94632.1, BC139761.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AL670227.7         78252-78288         c
            38-86               BY073558.1         2-50
            87-173              AK165750.1         2-88
            174-373             BY073558.1         138-337
            374-780             CK339309.1         123-529
            781-4255            AK049959.1         565-4039
            4256-4309           BC033047.1         482-535
            4310-4311           AV343761.1         270-271
FEATURES             Location/Qualifiers
     source          1..4311
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 86.17 cM"
     gene            1..4311
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /note="protein kinase C, zeta"
                     /db_xref="GeneID:18762"
                     /db_xref="MGI:MGI:97602"
     exon            1..277
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1985
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /EC_number="2.7.11.13"
                     /note="isoform a is encoded by transcript variant 1;
                     protein kinase C zeta type; protein kinase C zeta
                     subspecies; atypical protein kinase C"
                     /codon_start=1
                     /product="protein kinase C zeta type isoform a"
                     /protein_id="NP_032886.2"
                     /db_xref="CCDS:CCDS19026.1"
                     /db_xref="GeneID:18762"
                     /db_xref="MGI:MGI:97602"
                     /translation="MPSRTDPKMDRSGGRVRLKAHYGGDILITSVDAMTTFKDLCEEV
                     RDMCGLHQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLVCQGRDEVLIIHVFPSIPEQ
                     PGMPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRGAYCGQCSERIWGLSRQGYR
                     CINCKLLVHKRCHVLVPLTCRRHMDSVMPSQEPPVDDKNDGVDLPSEETDGIAYISSS
                     RKHDNIKDDSEDLKPVIDGVDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQ
                     IYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVN
                     GGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKL
                     TDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSP
                     FDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTG
                     FSDIKSHAFFRSIDWDLLEKKQTLPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDV
                     IKRIDQSEFEGFEYINPLLLSAEESV"
     exon            278..399
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            400..489
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            490..540
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            541..626
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            627..758
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            759..840
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            841..893
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1082
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1180
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1267
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1403
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1491
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1611
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1691
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1781
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1897
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..4311
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtgcccc cagctccgcg caccgcccaa gttccgcgga gttggcgagg cgggtgccgt
       61 ctgtcccgtg ctgcgcgctc ccttccgcgc gctcccttcc gcgttccgcc gtctgccccg
      121 cctggcaacc cggcccttct ccggggccgc tagccatggc cggagcgccc tggaagcagc
      181 gctgacggcg gctggctgag tgcgccatgc ccagcaggac ggaccccaag atggaccgga
      241 gcggcggccg cgtccgtctg aaggcgcact acggcgggga catcctgatt accagcgtgg
      301 atgccatgac aacattcaag gacctctgtg aggaagtgcg agacatgtgt ggcctgcacc
      361 agcagcaccc actcaccctc aagtgggtgg acagtgaagg tgacccttgt actgtgtcct
      421 cacagatgga gctggaggag gccttccgcc tggtctgtca gggcagggac gaagtgctca
      481 tcattcatgt tttcccaagc atcccagagc agccgggcat gccttgtcct ggagaagaca
      541 agtccatcta ccgccgtgga gccagaagat ggaggaagct gtaccgagcc aacggccacc
      601 tcttccaagc caagcgcttt aacaggggag cgtactgcgg ccagtgcagc gaaaggatat
      661 ggggtctctc gaggcagggc tacaggtgca tcaactgcaa gctgctggtc cataaacgct
      721 gccacgtcct cgtcccgctg acctgcagga ggcatatgga ttctgtcatg ccttcccaag
      781 agcctccagt agatgacaag aacgatggtg tagaccttcc ttcagaagaa actgatggaa
      841 ttgcttatat ttcttcatct cggaaacatg ataatatcaa agatgattct gaggacctta
      901 agcctgtcat cgatggggtg gatgggatca aaatctctca ggggctgggg ctgcaagact
      961 tcgacctcat cagagtcatc gggcgtggaa gctatgccaa ggtcctcctg gtgcggttga
     1021 agaaaaacga ccagatttac gccatgaagg tggtaaagaa ggagcttgtc cacgacgacg
     1081 aggatatcga ctgggtgcag acagagaaac atgtgtttga gcaggcgtcc agcaacccct
     1141 tcctggttgg cttacactcc tgcttccaga caacgagccg gttgttcctg gtcatcgagt
     1201 atgtcaatgg cggggacctc atgttccaca tgcagaggca gagaaaactt ccagaggagc
     1261 atgccaggtt ctatgctgct gagatctgta tcgctctcaa cttcttgcat gagaggggga
     1321 tcatctaccg ggacctaaaa ctggacaacg tcctccttga tgccgacgga cacattaagc
     1381 tgacggacta cggcatgtgc aaggaaggtc taggccccgg tgatacaaca agcacttttt
     1441 gtggaacccc gaactatatc gcccccgaaa tcctgcgagg agaagagtac gggttcagcg
     1501 tggactggtg ggcactgggt gtccttatgt ttgagatgat ggctgggcgc tccccctttg
     1561 acatcatcac ggacaaccct gacatgaaca ctgaagacta ccttttccaa gttatcctgg
     1621 aaaagccaat ccggattccc cgtttcctgt ctgtcaaggc ctcacacgtc ttaaaaggat
     1681 ttttaaataa ggatcccaaa gagaggcttg gctgccggcc acagactggg ttttccgaca
     1741 tcaagtctca tgctttcttc cgcagcatag actgggacct gctggaaaag aagcagaccc
     1801 tgcctccctt ccagccccag atcacagatg actatggcct ggacaacttt gacacgcagt
     1861 tcaccagcga gcctgtgcag ctgaccccag atgatgagga cgtcataaag aggatcgacc
     1921 agtccgaatt tgaaggcttt gagtacatca acccacttct gctgtctgct gaggagtccg
     1981 tgtgaggcca tgagcatctc tgttgtggac acgcctgtga atgaccctgt cactttaccc
     2041 ttaactacag catatgcatg ccaggccggg caccgaggct ccaagcagcc agggagggat
     2101 gctggccacc aagaccgaag aggggcgtcc aacaggcact tctagacaga gcaatctctt
     2161 gtgtccaggc cccagaggct ggctttgtgc tggaggaacc gcttcctgtg cacagaggcc
     2221 ctaccggagg gtgagacagc cagccacgcc gtttggaaag gtgcacatct tccacagaaa
     2281 cagaactcga tgcactgacc cgctccagga aaagttagcg tgtaatgccc tgaggaataa
     2341 agtgtaccga tgatgtcgaa gcttcctctg atgccttttt tctgtggcac ccgcctgatg
     2401 tccccagcgc agcccccaca tgaggaggag ctgcgctttc tgagcagtca ggacgtaggc
     2461 aggggacagg cacccaagtg cctgcaggga tgcgctgcaa caagaattgt tacagattcg
     2521 gaacgttttc taaatcccgg taagttctgt tgttaatatt taacaagtat tttcatacct
     2581 agcacagcta gccatggtag gccaaggccg aagggacacc cttaccaggt tggtggcact
     2641 gttcccacca actgtttgga ctctgatggg gaaaattgga tcatagagat tctaaaacat
     2701 tgctcaccaa agcatcagta aaccaaataa ataggtaaat aaataaaaag ggaaaataat
     2761 tgaaaactaa atccgcacaa aatatatttc tgaaaacact agccagtgcc tccaagacat
     2821 cttgtgttat acattagatt ttttggaaaa tatttttatc attaatactc cagattagga
     2881 aatttaaaga caacgtgtgt gatggaccct agccttaaag tgacagacta cccataatct
     2941 cacactcttc ctgaggaagc acgcctgctt ccataactgc tgtgctcagc catcctcctc
     3001 tccagcttag ttccaaaggc cagcccaagg ctttctggga agaggtcagc taacgttacc
     3061 cttagcaggt cgggtgtggc catggcttac ccacctttgt cgtgggcagg agatggagaa
     3121 ggcacaccgc agtgactgag caccccagac ccacccaagc caggctggcc catatggcaa
     3181 acatgctaca caccccccca accctgccag gttgagaccc tcagtctcca cgtcagggca
     3241 gagtggagtc taggctccgg tcatatttgc ttcatgcctt ggggttggtg gtcctgacaa
     3301 agatcagagt tggagaaaat gaaaatctta gaggcgctgt tacggtgctg ccctgcttct
     3361 ccgtgacgcc cagtggccac ccacagccct caccccaaaa cactcaggtt tctcaggcca
     3421 tcgccatgtc tggcactgaa acgtgtcaga gccacaccca gatccatggt gctgggacag
     3481 aacaggcagc ccaggtttct gacaccatat cccaagtcca ggcttctggg tggctctgtg
     3541 tctcctattg atcatggaca cattttagcc agcactccct gtgtccattg gtaagatatg
     3601 tccccaacta gtcaaaaaat gcaaatagag cctaagagcc gatttttggg cctcccagga
     3661 gtacccagcc cagcctgggg gccttccagg ggtacttagc ctagtctggg ggtccaagtg
     3721 gctggagccc cagtctgagg cctgtgtagt cacagctgcc catgagttga gctgctaaga
     3781 taaagagccc gcagatgatc caaatgcaaa cgggctcctg cgagcctcct ttcctcccag
     3841 tgtgctgcct agggacagca acaactgctt tgcccaagca gcactggaac cctggattgt
     3901 tagacatggg ggcttatttg gatactgccc tattgccaaa tgacttgctg gttactggtt
     3961 cggctgctca tgtacaaatg tgtgaataat attgtgccca ccagaggggg agatttttat
     4021 atatagcaat ttgttttata aattaaagaa agtgaaggat gtattgaaat gtgactactg
     4081 gggggggggt gggaaacacc ctaaagtttg caaatggctc tgggcaagaa agcgtgtgtt
     4141 ctcagacact ggtgacttca tgattgtaac tcggtaacca tgtggttttg tacaattgat
     4201 cagtggagcc catcgccggc cggcattcct tctgtgggcg atatcttcgc cctccacggc
     4261 caaggtcgtt cttactcttg cacatccatt aaagactttg atgaaaatgc c
//
