LOCUS       NP_032886                592 aa            linear   ROD 14-FEB-2025
DEFINITION  protein kinase C zeta type isoform a [Mus musculus].
ACCESSION   NP_032886
VERSION     NP_032886.2
DBSOURCE    REFSEQ: accession NM_008860.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 592)
  AUTHORS   Arriagada,C., Lin,E., Schonning,M. and Astrof,S.
  TITLE     Mesodermal fibronectin controls cell shape, polarity, and
            mechanotransduction in the second heart field during cardiac
            outflow tract development
  JOURNAL   Dev Cell 60 (1), 62-84 (2025)
   PUBMED   39413783
REFERENCE   2  (residues 1 to 592)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 592)
  AUTHORS   Kinoshita,H., Martinez-Ordonez,A., Cid-Diaz,T., Han,Q., Duran,A.,
            Muta,Y., Zhang,X., Linares,J.F., Nakanishi,Y., Kasashima,H.,
            Yashiro,M., Maeda,K., Albaladejo-Gonzalez,A., Torres-Moreno,D.,
            Garcia-Solano,J., Conesa-Zamora,P., Inghirami,G., Diaz-Meco,M.T.
            and Moscat,J.
  TITLE     Epithelial aPKC deficiency leads to stem cell loss preceding
            metaplasia in colorectal cancer initiation
  JOURNAL   Dev Cell 59 (15), 1972-1987 (2024)
   PUBMED   38815584
REFERENCE   4  (residues 1 to 592)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 592)
  AUTHORS   Bernheim,S., Borgel,A., Le Garrec,J.F., Perthame,E., Desgrange,A.,
            Michel,C., Guillemot,L., Sart,S., Baroud,C.N., Krezel,W.,
            Raimondi,F., Bonnet,D., Zaffran,S., Houyel,L. and Meilhac,S.M.
  TITLE     Identification of Greb1l as a genetic determinant of crisscross
            heart in mice showing torsion of the heart tube by shortage of
            progenitor cells
  JOURNAL   Dev Cell 58 (21), 2217-2234 (2023)
   PUBMED   37852253
REFERENCE   6  (residues 1 to 592)
  AUTHORS   Crespo,P., Mischak,H. and Gutkind,J.S.
  TITLE     Overexpression of mammalian protein kinase C-zeta does not affect
            the growth characteristics of NIH 3T3 cells
  JOURNAL   Biochem Biophys Res Commun 213 (1), 266-272 (1995)
   PUBMED   7639744
REFERENCE   7  (residues 1 to 592)
  AUTHORS   Bareggi,R., Grill,V., Zweyer,M., Narducci,P. and Martelli,A.M.
  TITLE     Distribution of the extended family of protein kinase C isoenzymes
            in fetal organs of mice: an immunohistochemical study
  JOURNAL   Cell Tissue Res 280 (3), 617-625 (1995)
   PUBMED   7606770
REFERENCE   8  (residues 1 to 592)
  AUTHORS   Bareggi,R., Neri,L.M., Grill,V., Cocco,L. and Martelli,A.M.
  TITLE     An immunohistochemical study of protein kinase C distribution in
            fetal mouse vertebral column
  JOURNAL   Anat Embryol (Berl) 190 (1), 47-54 (1994)
   PUBMED   7985811
REFERENCE   9  (residues 1 to 592)
  AUTHORS   Goodnight,J., Kazanietz,M.G., Blumberg,P.M., Mushinski,J.F. and
            Mischak,H.
  TITLE     The cDNA sequence, expression pattern and protein characteristics
            of mouse protein kinase C-zeta
  JOURNAL   Gene 122 (2), 305-311 (1992)
   PUBMED   1487145
REFERENCE   10 (residues 1 to 592)
  AUTHORS   Wada,H., Ohno,S., Kubo,K., Taya,C., Tsuji,S., Yonehara,S. and
            Suzuki,K.
  TITLE     Cell type-specific expression of the genes for the protein kinase C
            family: down regulation of mRNAs for PKC alpha and nPKC epsilon
            upon in vitro differentiation of a mouse neuroblastoma cell line
            neuro 2a
  JOURNAL   Biochem Biophys Res Commun 165 (1), 533-538 (1989)
   PUBMED   2590242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670227.7 and AL670413.19.
            
            On Jan 13, 2006 this sequence version replaced NP_032886.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784650.811881.1, M94632.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..592
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 86.17 cM"
     Protein         1..592
                     /product="protein kinase C zeta type isoform a"
                     /EC_number="2.7.11.13"
                     /note="protein kinase C zeta type; protein kinase C zeta
                     subspecies; atypical protein kinase C"
                     /calculated_mol_wt=67551
     Region          16..98
                     /region_name="PB1_aPKC"
                     /note="PB1 domain is an essential modular domain of the
                     atypical protein kinase C (aPKC) which in complex with
                     Par6 and Par3 proteins is crucial for establishment of
                     apical-basal polarity of animal cells. PB1 domain is a
                     modular domain mediating specific...; cd06404"
                     /db_xref="CDD:99725"
     Site            order(62,64,66,75)
                     /site_type="other"
                     /note="PB1 interaction surface [polypeptide binding]"
                     /db_xref="CDD:99725"
     Region          79..145
                     /region_name="Interaction with SQSTM1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02956.2)"
     Region          129..183
                     /region_name="C1"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     superfamily; cl00040"
                     /db_xref="CDD:412127"
     Region          236..592
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(258..261,264,266,279,281,314,330..333,376,380..381,
                     383,393..394)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Site            410
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PDPK1 and PI3K.
                     /evidence=ECO:0000250|UniProtKB:Q05513; propagated from
                     UniProtKB/Swiss-Prot (Q02956.2)"
     Site            560
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q02956.2)"
     Site            591
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09217; propagated from
                     UniProtKB/Swiss-Prot (Q02956.2)"
     CDS             1..592
                     /gene="Prkcz"
                     /gene_synonym="aPKCzeta; nPKC-zeta; Pkcz; zetaPKC"
                     /coded_by="NM_008860.4:178..1956"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19026.1"
                     /db_xref="GeneID:18762"
                     /db_xref="MGI:MGI:97602"
ORIGIN      
        1 mpsrtdpkmd rsggrvrlka hyggdilits vdamttfkdl ceevrdmcgl hqqhpltlkw
       61 vdsegdpctv ssqmeleeaf rlvcqgrdev liihvfpsip eqpgmpcpge dksiyrrgar
      121 rwrklyrang hlfqakrfnr gaycgqcser iwglsrqgyr cinckllvhk rchvlvpltc
      181 rrhmdsvmps qeppvddknd gvdlpseetd giayisssrk hdnikddsed lkpvidgvdg
      241 ikisqglglq dfdlirvigr gsyakvllvr lkkndqiyam kvvkkelvhd dedidwvqte
      301 khvfeqassn pflvglhscf qttsrlflvi eyvnggdlmf hmqrqrklpe eharfyaaei
      361 cialnflher giiyrdlkld nvlldadghi kltdygmcke glgpgdttst fcgtpnyiap
      421 eilrgeeygf svdwwalgvl mfemmagrsp fdiitdnpdm ntedylfqvi lekpiriprf
      481 lsvkashvlk gflnkdpker lgcrpqtgfs dikshaffrs idwdllekkq tlppfqpqit
      541 ddygldnfdt qftsepvqlt pddedvikri dqsefegfey inplllsaee sv
//
