LOCUS       NM_008857               4465 bp    mRNA    linear   ROD 03-FEB-2024
DEFINITION  Mus musculus protein kinase C, iota (Prkci), mRNA.
ACCESSION   NM_008857
VERSION     NM_008857.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4465)
  AUTHORS   Muta,Y., Linares,J.F., Martinez-Ordonez,A., Duran,A., Cid-Diaz,T.,
            Kinoshita,H., Zhang,X., Han,Q., Nakanishi,Y., Nakanishi,N.,
            Cordes,T., Arora,G.K., Ruiz-Martinez,M., Reina-Campos,M.,
            Kasashima,H., Yashiro,M., Maeda,K., Albaladejo-Gonzalez,A.,
            Torres-Moreno,D., Garcia-Solano,J., Conesa-Zamora,P., Inghirami,G.,
            Metallo,C.M., Osborne,T.F., Diaz-Meco,M.T. and Moscat,J.
  TITLE     Enhanced SREBP2-driven cholesterol biosynthesis by PKClambda/iota
            deficiency in intestinal epithelial cells promotes aggressive
            serrated tumorigenesis
  JOURNAL   Nat Commun 14 (1), 8075 (2023)
   PUBMED   38092754
  REMARK    GeneRIF: Enhanced SREBP2-driven cholesterol biosynthesis by
            PKClambda/iota deficiency in intestinal epithelial cells promotes
            aggressive serrated tumorigenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4465)
  AUTHORS   Barlow,H.R., Ahuja,N., Bierschenk,T., Htike,Y., Fassetta,L.,
            Azizoglu,D.B., Flores,J., Gao,N., De la,O. S, Sneddon,J.B.,
            Marciano,D.K. and Cleaver,O.
  TITLE     Rab11 is essential to pancreas morphogenesis, lumen formation and
            endocrine mass
  JOURNAL   Dev Biol 499, 59-74 (2023)
   PUBMED   37172642
REFERENCE   3  (bases 1 to 4465)
  AUTHORS   Sterling,N.A., Park,J.Y., Park,R., Cho,S.H. and Kim,S.
  TITLE     An entosis-like process induces mitotic disruption in Pals1
            microcephaly pathogenesis
  JOURNAL   Nat Commun 14 (1), 82 (2023)
   PUBMED   36604424
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4465)
  AUTHORS   Hirose,T., Sugitani,Y., Kurihara,H., Kazama,H., Kusaka,C., Noda,T.,
            Takahashi,H. and Ohno,S.
  TITLE     PAR3 restricts the expansion of neural precursor cells by
            regulating hedgehog signaling
  JOURNAL   Development 149 (21) (2022)
   PUBMED   36218069
REFERENCE   5  (bases 1 to 4465)
  AUTHORS   Weatherly,S.M., Collin,G.B., Charette,J.R., Stone,L., Damkham,N.,
            Hyde,L.F., Peterson,J.G., Hicks,W., Carter,G.W., Naggert,J.K.,
            Krebs,M.P. and Nishina,P.M.
  TITLE     Identification of Arhgef12 and Prkci as genetic modifiers of
            retinal dysplasia in the Crb1rd8 mouse model
  JOURNAL   PLoS Genet 18 (6), e1009798 (2022)
   PUBMED   35675330
  REMARK    GeneRIF: Identification of Arhgef12 and Prkci as genetic modifiers
            of retinal dysplasia in the Crb1rd8 mouse model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4465)
  AUTHORS   Pauken,C.M. and Capco,D.G.
  TITLE     The expression and stage-specific localization of protein kinase C
            isotypes during mouse preimplantation development
  JOURNAL   Dev Biol 223 (2), 411-421 (2000)
   PUBMED   10882525
REFERENCE   7  (bases 1 to 4465)
  AUTHORS   Kotani,K., Ogawa,W., Matsumoto,M., Kitamura,T., Sakaue,H., Hino,Y.,
            Miyake,K., Sano,W., Akimoto,K., Ohno,S. and Kasuga,M.
  TITLE     Requirement of atypical protein kinase clambda for insulin
            stimulation of glucose uptake but not for Akt activation in 3T3-L1
            adipocytes
  JOURNAL   Mol Cell Biol 18 (12), 6971-6982 (1998)
   PUBMED   9819385
REFERENCE   8  (bases 1 to 4465)
  AUTHORS   Diaz-Meco,M.T., Municio,M.M., Frutos,S., Sanchez,P., Lozano,J.,
            Sanz,L. and Moscat,J.
  TITLE     The product of par-4, a gene induced during apoptosis, interacts
            selectively with the atypical isoforms of protein kinase C
  JOURNAL   Cell 86 (5), 777-786 (1996)
   PUBMED   8797824
REFERENCE   9  (bases 1 to 4465)
  AUTHORS   Quaderi,N.A., Gianfrancesco,F., Brown,S.D., D'Urso,M. and
            D'Esposito,M.
  TITLE     Genetic mapping of a gene encoding an atypical protein kinase C,
            protein kinase C lambda, to the proximal region of mouse chromosome
            3
  JOURNAL   Genomics 29 (3), 815-816 (1995)
   PUBMED   8575788
REFERENCE   10 (bases 1 to 4465)
  AUTHORS   Akimoto,K., Mizuno,K., Osada,S., Hirai,S., Tanuma,S., Suzuki,K. and
            Ohno,S.
  TITLE     A new member of the third class in the protein kinase C family, PKC
            lambda, expressed dominantly in an undifferentiated mouse embryonal
            carcinoma cell line and also in many tissues and cells
  JOURNAL   J Biol Chem 269 (17), 12677-12683 (1994)
   PUBMED   7513693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK220517.1 and AK009442.1.
            
            [WARNING] On Mar 19, 2024 this sequence was replaced by
            NM_008857.4.
            
            On Mar 20, 2007 this sequence version replaced NM_008857.2.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus based on the presence of an upstream translation start
            codon, which is supported by available transcript and conservation
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144979.1, AK220517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4462              AK220517.1         25-4486
            4463-4465           AK009442.1         2166-2168
FEATURES             Location/Qualifiers
     source          1..4465
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 14.65 cM"
     gene            1..4465
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /note="protein kinase C, iota"
                     /db_xref="GeneID:18759"
                     /db_xref="MGI:MGI:99260"
     exon            1..315
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2002
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /EC_number="2.7.11.13"
                     /note="protein kinase C, lambda; nPKC-iota;
                     aPKC-lambda/iota; atypical protein kinase C-lambda/iota"
                     /codon_start=1
                     /product="protein kinase C iota type"
                     /protein_id="NP_032883.2"
                     /db_xref="CCDS:CCDS17289.2"
                     /db_xref="GeneID:18759"
                     /db_xref="MGI:MGI:99260"
                     /translation="MPTQRDSSTMSHTVACGGGGDHSHQVRVKAYYRGDIMITHFEPS
                     ISFEGLCSEVRDMCSFDNEQPFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELL
                     IHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDR
                     IWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPPEPMMPMDQTMHPDHTQTVIPY
                     NPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTD
                     RIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYV
                     NGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIK
                     LTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRS
                     PFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHP
                     QTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD
                     DDIVRKIDQSEFEGFEYINPLLMSAEECV"
     exon            316..437
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            438..527
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            528..578
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            579..664
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            665..805
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            806..857
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            858..916
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1093
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1191
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1278
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1414
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1502
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1628
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1708
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1798
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1914
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..4465
                     /gene="Prkci"
                     /gene_synonym="2310021H13Rik; aPKClambda; mKIAA4165; Pkci;
                     Pkcl; PKClambda; Prkcl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggcgtgt tgtgccgggc ggagggagga gcgctggggc tcgggcttgg cggcgaagcg
       61 accccttgct cgctccgcgc cgcgggctag gcgtgttggt cggcgaggcg ggcggccacg
      121 gcttcccgac aggctcggga ggccgagacc ctcgcggcgc ccggcgctgc cccggccccc
      181 tcggcctcct gcggcgaggc gggggagtga ggagatgccg acccagaggg acagcagcac
      241 catgtcccac acggtcgcgt gcggcggcgg cggggaccat tcccaccagg tccgggtgaa
      301 agcctactac cgcggggata ttatgataac acactttgag ccttccatct cctttgaggg
      361 actttgcagt gaggttcgag atatgtgttc ttttgacaat gagcagccgt tcaccatgaa
      421 atggatagat gaggaaggag acccatgtac agtgtcttct cagttggagt tagaagaggc
      481 tttcaggctg tacgagctga acaaggattc tgaactcttg attcatgtat ttccatgtgt
      541 accagagcgt cctggaatgc cttgcccagg ggaagacaag tccatttacc ggagaggggc
      601 acgccggtgg agaaagctgt attgtgcaaa tggccacact tttcaagcca aacgtttcaa
      661 taggcgcgcc cactgtgcca tctgcacaga cagaatctgg ggcctcggac gacaaggata
      721 caagtgcatc aactgcaaac tgctggttca taagaagtgc cacaagctgg tcacaattga
      781 gtgtgggcgg cactctttgc caccggaacc catgatgcca atggaccaga ccatgcatcc
      841 agaccacaca cagacagtaa ttccatataa tccttcaagt catgagagtt tggaccaagt
      901 tggtgaagaa aaggaggcaa tgaacaccag ggagagtggt aaagcgtcgt ccagtctagg
      961 tctgcaggat ttcgatttgc ttcgagttat agggagggga agttacgcca aagtactgtt
     1021 ggttcggtta aagaaaacag atcgcattta tgcaatgaaa gttgtgaaga aagagctcgt
     1081 caatgacgat gaggatatcg attgggtgca gacagagaag catgtgtttg agcaggcgtc
     1141 caatcaccct tttcttgtcg ggctgcattc ttgcttccag acagaaagca ggttgttttt
     1201 tgtcatagaa tatgtaaatg gaggggacct catgtttcat atgcagcgac agagaaaact
     1261 tcctgaagag catgccaggt tttactctgc agaaatcagt ctagcactga attatcttca
     1321 tgagcgaggg ataatttata gagatttgaa gttggacaat gtactgctag actctgaagg
     1381 acacattaaa ctcactgact acggcatgtg taaggaagga ttgcggcctg gagacacaac
     1441 cagcactttc tgcggcactc ccaattacat tgctccagag atcttaagag gagaagatta
     1501 tggcttcagc gttgactggt gggctcttgg agtgcttatg tttgagatga tggcgggaag
     1561 gtctccgttt gatatcgttg ggagctctga caatcctgac caaaacacag aggattatct
     1621 attccaagtc attttggaaa agcagatccg catcccgcgt tctctgtctg taaaagcagc
     1681 aagtgtactg aagagttttc tcaacaagga cccaaaggaa cgattgggtt gtcaccctca
     1741 aactggattt gctgacattc aaggacatcc attcttcaga aatgtggact gggacatgat
     1801 ggagcaaaag caggtggttc caccctttaa accaaacatt tctggagaat ttggtttgga
     1861 taatttcgat tctcagttta ctaatgaacc agtccagctc actccagatg atgatgacat
     1921 tgtgaggaag attgatcagt ctgaatttga aggttttgag tatatcaacc ccctcttgat
     1981 gtctgcagaa gagtgtgtct gattctgctt gccgccattc agtgcatgga tatccacccg
     2041 tcagcctgct cacagttagc attttatgtt gcccctgcag aagtcgctct cggtatcctg
     2101 ttggagacta ggaatcatac agataaatag aactaagaaa cagaagctag cttcctgaca
     2161 atcatgtcga ccctgcttat gcttgctctc cagacactcc taatgaggaa ggacggtctt
     2221 tgtgtaaagg aaacaacaca gcttgtcaaa gaaagcctct gctgcgttgt gacactcgac
     2281 gggatgacat catcagtctc ccacagttgt tgtcactttg tgttaagtca ttgaaggctt
     2341 aattgcgcag tggagggcca tgcagagtag tgcatctgct agtgttactg gttgccgagg
     2401 tccctcagtt taagatttcc tcctataaat aaatcttctc attactttgg gtaattaata
     2461 attatgaatt gggttctaaa ttattagctg tgtttcaaaa actggcacag tgatttattt
     2521 atttgttttt aattttttaa aattattttt acactaaggg gttagcttct gagcttgcct
     2581 tttcagtgaa aactagcatg ctgatgtgtg ttcagaggca ggattcgaga gtggcagctg
     2641 ctcacataca ggaaaaagta gacgtctaaa gtagctacag aaagaacgat tgtagcattt
     2701 tctttcttac tgtagagtaa atcctacagt tggtgtttaa gatttgatgt aaataatgag
     2761 gaggctctca cttcttagcc agcttagaaa agcattccgt ttattcaggg gaagcggagt
     2821 gaatatattt ttattattat ttagtatatg ggaaaataaa ttatcttctg agtagaatgt
     2881 cttaactact tttggttcct tctccagagt acattatctg tactttgacc tttcgtggag
     2941 tctgcggtga aattcaagac caatgatgat gaccacggat aactatgtaa cacacacaca
     3001 cacacacagt tccagctctt cctgagctcc tatgtcatag ctaacatgtg atacagagtg
     3061 aaatccattt cagggcaggg ttcctcagtt ctctacacta tttttattaa cagtaagtag
     3121 tatttagcaa tctcttattt aaagaagtac cgttttaagc accattctgc tgtttatttt
     3181 aaatattttt atataaagga ctttaaaatg atcgtctaaa taagctacag ttgtcaaatc
     3241 agtaaattta actttaggaa cgccgcgcag tgctgagctt gtgatgattt aaaacctgta
     3301 ggcatttgaa aatcacttgg agaatgctac gtttcattag aagtgtgagt tgtgtcaagt
     3361 ttgtgtcatg cattttcaag taatgtaaga cagagagcag tgagaacccc cattgataaa
     3421 gccaacaagg ggccatcgag gccacttgcc aaaacctgaa gacctgatga tgcctgcagc
     3481 ccacgggctg gtggccatgg cgcgcgcagc cctcccctgc aggacataaa tgcgagggag
     3541 cagaccaata agtgcagtgc gtgcgctgac acatttcatg ttgaagtgtg tgtttcccct
     3601 aagacctgga acagctgtct taatctaaag gcagcattca cgccctaagc tgctaggagc
     3661 tcgggggtgt gtatgctgtg acctaagtgg tgctctccct tggggcattt tagactgaga
     3721 gctgttgaag tgcacagtgt ccagcctgcc tgggactctt tggggctttg tattccattt
     3781 tgagaaactt tttcttcagg ttattctttt tcttgtggcc atatttctta ttggagtgtg
     3841 agtctgtgtt tttttgtgaa aaacatttta agaaaggata accagtgaat tatcatgcat
     3901 ttgtcaacaa acttagatga gtaaattcaa gttgtatgtc ttccctaccc tcacccacaa
     3961 caaaacctgt acattttctg ccaataacat ttaaatgatg aacagttttc tgtgataagg
     4021 ttttaaccat aattaatggt ggtctttgtt tttaaatctt ttttttttct tattgttgtt
     4081 aactaataag acttactatg tgtgttttat acagaattat tacagatgat tttaattcag
     4141 ttctagtttt cagtccttaa gtgccatgca aactctctgt atgtggtgga agcctccttc
     4201 tctcagagtc tccggggaga caggcagagg gatgggcgct tggtgtctta gacaccactt
     4261 atgttgcata agcttgtgat cagatcggtt tatcacatgc agctggatgg gtgtctagtt
     4321 atctgtgtcc ctgttgccag tacttattta gaaaattgtt ttaattttta tcatgtagaa
     4381 cactgccttg ttcactataa tgtaatctgt atttgtataa ttttttttac attaaaatct
     4441 ttaaataaaa tgtttaatac ctatg
//
