LOCUS       NM_011102               3127 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus protein kinase C, gamma (Prkcg), transcript variant 1,
            mRNA.
ACCESSION   NM_011102 XM_891345
VERSION     NM_011102.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3127)
  AUTHORS   Hu,L., Liu,X.Y., Zhao,L., Hu,Z.B., Li,Z.X., Liu,W.T., Song,N.N.,
            Hu,Y.Q., Jiang,L.P., Zhang,L., Tao,Y.C., Zhang,Q., Chen,J.Y.,
            Lang,B., Wang,Y.B., Yue,L. and Ding,Y.Q.
  TITLE     Ventricular Netrin-1 deficiency leads to defective pyramidal
            decussation and mirror movement in mice
  JOURNAL   Cell Death Dis 15 (5), 343 (2024)
   PUBMED   38760361
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3127)
  AUTHORS   Miranda,C.O., Hegedus,K., Kis,G. and Antal,M.
  TITLE     Synaptic Targets of Glycinergic Neurons in Laminae I-III of the
            Spinal Dorsal Horn
  JOURNAL   Int J Mol Sci 24 (8), 6943 (2023)
   PUBMED   37108107
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3127)
  AUTHORS   Wei,H.P., Peng,Z.F., Shao,K.M., Zhang,P.H., Chen,L., Hu,J.A.,
            Chai,H. and Liu,J.M.
  TITLE     cPKCgamma Inhibits Caspase-9-Initiated Neuronal Apoptosis in an
            Ischemia Reperfusion Model In Vitro Through p38 MAPK-p90RSK-Bad
            Pathway
  JOURNAL   Neurochem Res 48 (2), 362-374 (2023)
   PUBMED   36152136
  REMARK    GeneRIF: cPKCgamma Inhibits Caspase-9-Initiated Neuronal Apoptosis
            in an Ischemia Reperfusion Model In Vitro Through p38
            MAPK-p90RSK-Bad Pathway.
REFERENCE   4  (bases 1 to 3127)
  AUTHORS   Chirila,A.M., Rankin,G., Tseng,S.Y., Emanuel,A.J.,
            Chavez-Martinez,C.L., Zhang,D., Harvey,C.D. and Ginty,D.D.
  TITLE     Mechanoreceptor signal convergence and transformation in the dorsal
            horn flexibly shape a diversity of outputs to the brain
  JOURNAL   Cell 185 (24), 4541-4559 (2022)
   PUBMED   36334588
REFERENCE   5  (bases 1 to 3127)
  AUTHORS   Watanave,M., Takahashi,N., Hosoi,N., Konno,A., Yamamoto,H.,
            Yasui,H., Kawachi,M., Horii,T., Matsuzaki,Y., Hatada,I. and
            Hirai,H.
  TITLE     Protein kinase Cgamma in cerebellar Purkinje cells regulates
            Ca2+-activated large-conductance K+ channels and motor coordination
  JOURNAL   Proc Natl Acad Sci U S A 119 (7) (2022)
   PUBMED   35145028
  REMARK    GeneRIF: Protein kinase Cgamma in cerebellar Purkinje cells
            regulates Ca(2+)-activated large-conductance K(+) channels and
            motor coordination.
REFERENCE   6  (bases 1 to 3127)
  AUTHORS   Watson,M.L., Rao,J.K., Gilkeson,G.S., Ruiz,P., Eicher,E.M.,
            Pisetsky,D.S., Matsuzawa,A., Rochelle,J.M. and Seldin,M.F.
  TITLE     Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis
            gene to disease manifestations and renal disease-modifying loci
  JOURNAL   J Exp Med 176 (6), 1645-1656 (1992)
   PUBMED   1460423
REFERENCE   7  (bases 1 to 3127)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   8  (bases 1 to 3127)
  AUTHORS   Rudert,F., Saunders,A.M., Rebstock,S., Thompson,J.A. and
            Zimmermann,W.
  TITLE     Characterization of murine carcinoembryonic antigen gene family
            members
  JOURNAL   Mamm Genome 3 (5), 262-273 (1992)
   PUBMED   1638085
REFERENCE   9  (bases 1 to 3127)
  AUTHORS   Bhatia,K., Huppi,K., McKeithan,T., Siwarski,D., Mushinski,J.F. and
            Magrath,I.
  TITLE     Mouse bcl-3: cDNA structure, mapping and stage-dependent expression
            in B lymphocytes
  JOURNAL   Oncogene 6 (9), 1569-1573 (1991)
   PUBMED   1923524
REFERENCE   10 (bases 1 to 3127)
  AUTHORS   Cavanna,J.S., Greenfield,A.J., Johnson,K.J., Marks,A.R.,
            Nadal-Ginard,B. and Brown,S.D.
  TITLE     Establishment of the mouse chromosome 7 region with homology to the
            myotonic dystrophy region of human chromosome 19q
  JOURNAL   Genomics 7 (1), 12-18 (1990)
   PUBMED   1970795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC245272.2 and AC217111.9.
            
            On Feb 24, 2023 this sequence version replaced NM_011102.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144419.1, X67129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-438               AC245272.2         202340-202777
            439-470             AC245272.2         203124-203155
            471-553             AC245272.2         204162-204244
            554-665             AC245272.2         209382-209493
            666-797             AC245272.2         209654-209785
            798-954             AC245272.2         211207-211363
            955-1089            AC245272.2         212516-212650
            1090-1177           AC245272.2         212951-213038
            1178-1207           AC245272.2         213330-213359
            1208-1360           AC217111.9         16880-17032
            1361-1549           AC217111.9         17551-17739
            1550-1641           AC217111.9         20360-20451
            1642-1704           AC217111.9         20537-20599
            1705-1843           AC217111.9         21476-21614
            1844-1924           AC217111.9         25436-25516
            1925-2032           AC217111.9         27055-27162
            2033-2173           AC217111.9         27848-27988
            2174-3127           AC217111.9         28166-29119
FEATURES             Location/Qualifiers
     source          1..3127
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 1.93 cM"
     gene            1..3127
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /note="protein kinase C, gamma"
                     /db_xref="GeneID:18752"
                     /db_xref="MGI:MGI:97597"
     exon            1..438
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..2362
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /EC_number="2.7.11.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein kinase C gamma type; PKC-gamma"
                     /codon_start=1
                     /product="protein kinase C gamma type isoform 1"
                     /protein_id="NP_035232.1"
                     /db_xref="CCDS:CCDS57470.1"
                     /db_xref="GeneID:18752"
                     /db_xref="MGI:MGI:97597"
                     /translation="MAGLGPGGGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFK
                     QPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHK
                     FRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGR
                     LQLEIRAPTSDEIHITVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTKTVKAT
                     LNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYK
                     LLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDS
                     KRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDD
                     VDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLG
                     KFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFP
                     GSTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQA
                     IMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLER
                     LEIAPPFRPRPCGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVH
                     PDARSPTSPVPVPVM"
     exon            439..470
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            471..553
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            554..665
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            666..797
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            798..954
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1089
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1177
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1207
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1360
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1549
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1641
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1704
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1843
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1924
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2032
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2173
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..3127
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3101..3106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /note="hexamer: AATAAA"
     polyA_site      3127
                     /gene="Prkcg"
                     /gene_synonym="Pkcc; PKCgamma; Prkcc"
                     /note="major polyA site"
ORIGIN      
        1 acatttcagc aggtgctgag agcgaagctc ccgccgccgc ccgtgcctgc ggctccttga
       61 tgccccagcc ttcagctctg accccacccg ctttctcccc ggtcggtgct gcccgtgccg
      121 gggtgttgct ttctgccgtg tgctgtgcac cgttaggtgc cttgcccctg tccttcctat
      181 ctcagagtct gcggagtcct cctaccgccg tccacctgtt tcctcggaaa aagggccagc
      241 tcgtgatccc ttctgcgttc ctggggccat ggcgggtctg ggccctggcg gaggcgactc
      301 agagggggga ccccgacccc tgttttgcag aaagggggcg ctgaggcaga aggtggtcca
      361 cgaggtgaag agccacaagt tcaccgctcg tttcttcaag cagccaacct tctgcagtca
      421 ctgtaccgac ttcatctggg gcattggaaa gcagggcctg caatgtcaag tctgtagctt
      481 tgtggttcac cgccgatgcc acgaatttgt gaccttcgag tgtccaggcg ctggaaaggg
      541 cccccagacg gacgaccctc gcaacaagca caagttccgt ctgcacagct acagcagtcc
      601 caccttctgc gaccactgtg gctccctcct ttacgggctg gtgcaccagg gcatgaaatg
      661 ttcctgttgc gagatgaatg tgcaccggcg ctgtgtgcgc agcgtgccct ccctttgcgg
      721 tgtggaccac acagagcgcc gtggacgtct gcaactggaa atccgggctc ctacgtcgga
      781 tgagatccat attactgttg gcgaggcccg gaacctcatt cctatggacc ccaatggcct
      841 gtctgatccc tacgtgaaac tgaagctgat cccggaccct cggaacctga caaaacagaa
      901 gacaaagacc gtgaaagcca cactgaatcc cgtgtggaac gagaccttcg tgttcaacct
      961 gaagccaggg gatgtagagc gccggctcag tgtggaggtg tgggattggg ataggacatc
     1021 ccgaaatgac ttcatgggtg ccatgtcctt tggtgtctca gagctactca aggcccctgt
     1081 ggatggatgg tacaagttac tgaaccagga ggagggcgaa tattacaatg taccggtggc
     1141 cgatgctgac aactgcagcc tcctccagaa gtttgaggcc tgcaattacc ccttggaatt
     1201 gtatgagaga gtgcggatgg gcccctcttc ctcccccatc ccttctccat cccccagtcc
     1261 tacggactcc aagcgatgct tctttggtgc cagcccagga cgcctgcata tctctgactt
     1321 cagcttcctc atggttctag ggaaaggcag ttttgggaag gtaatgctgg cagagcgcag
     1381 aggctccgac gaactctatg ccatcaagat actgaagaaa gacgtcatcg tccaggatga
     1441 cgatgtagac tgcaccctcg tagagaagcg tgtcctggca ttgggaggcc gaggtcctgg
     1501 aggccggcca cactttctca cgcagcttca ctccaccttt cagactccgg accgcctgta
     1561 ttttgtgatg gagtatgtca ctgggggcga tttaatgtac cacatccagc aactgggcaa
     1621 gtttaaggag cctcatgcag cattctacgc tgcggaaatc gccataggcc tcttcttcct
     1681 tcacaaccag ggcatcatct acagggacct caagttggat aatgtgatgc tggatgctga
     1741 aggacacatc aagatcacag actttggcat gtgtaaagag aatgtcttcc ctgggtccac
     1801 aacccgcacc ttctgtggca ccccagacta catagcacct gagatcattg cctatcagcc
     1861 ctacgggaag tctgtcgact ggtggtcttt tggggtcctg ctgtatgaga tgttggcagg
     1921 acagccaccc tttgatgggg aagatgagga agagttgttt caagccatca tggaacaaac
     1981 tgtcacctat cccaagtcac tttcccggga agctgtggcc atctgcaaag ggttcctgac
     2041 caagcaccca ggaaaacgcc tgggctcagg gccagatggg gaacccacca tccgggctca
     2101 tggctttttc cgttggatcg attgggagag gttggagaga ctggaaattg cacctccttt
     2161 cagaccacgt ccgtgtggcc gcagtggcga aaactttgac aagttcttca cgcgggcagc
     2221 gccagcactg accccgccag accgcttggt tctagccagc atcgaccaag ctgatttcca
     2281 gggctttact tatgtgaacc cggacttcgt gcacccagat gcccgcagcc ccacaagccc
     2341 tgtgcccgtg cctgtcatgt aatctcatct gctgccgcta ggtgtcccca gtgctccctc
     2401 cgccaagccg gctgtaacac ccatctaccc tctctagtcc gaattctagg tctcttaacc
     2461 cacctagcct tctggcctct ttcacgcacc ccaacgagtt ctagacgctg tttcccagca
     2521 ttgctggcat tttaaactca aagagtctct agagcctttc tgtgttctag attccgttgt
     2581 gctgagccct gattttcccc acccccaaca tctggatact gttccaactc ttcccagaaa
     2641 ccccacttgg tagtttatgc cttctctctc cctagaccat tctggggaaa atagtctcat
     2701 gagattgcct gctccagact aagactccag atctgctccc cgcatccttc aaggctcctc
     2761 ctacctccac ttcagttgta gagttaagtg ggagtctggg ctcagcgttc cagaccacct
     2821 cccttccacg ctctggggat tcctggcatg caccaagaat tctttccccc tacttttctc
     2881 agtcagcttt tgttctagac ttgttccaga atccctcaat gctcacctgc cccgtgcatg
     2941 gctccagcct tggtcggaat cacacacaca cacacacaca cacacacaca cacacacaca
     3001 cacacagccc ttgtcctccg cagtgcctgc aactttctgg gactttctca ttccccaccc
     3061 ccttccttta tcctctccca cccagacaca gctgctggag aataaatttg ggatgctgat
     3121 gctaaaa
//
