LOCUS       NM_011104               6254 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus protein kinase C, epsilon (Prkce), mRNA.
ACCESSION   NM_011104 XM_989478 XM_989507 XM_989534
VERSION     NM_011104.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6254)
  AUTHORS   Li,X., Wang,J., Liao,C., Yang,X., Zhao,Z., Liu,Y., Xue,Q., Luo,Y.,
            Liu,X. and Liu,Z.
  TITLE     The binding of PKCepsilon and MEG2 to STAT3 regulates IL-6-mediated
            microglial hyperalgesia during inflammatory pain
  JOURNAL   FASEB J 38 (8), e23590 (2024)
   PUBMED   38656553
  REMARK    GeneRIF: The binding of PKCepsilon and MEG2 to STAT3 regulates
            IL-6-mediated microglial hyperalgesia during inflammatory pain.
REFERENCE   2  (bases 1 to 6254)
  AUTHORS   Dugan,M.P., Maiya,R., Fleischer,C., Bajo,M., Snyder,A.E.,
            Koduri,A., Srinivasan,S., Roberto,M. and Messing,R.O.
  TITLE     Brain-specific serine/threonine-protein kinase 1 is a substrate of
            protein kinase C epsilon involved in sex-specific ethanol and
            anxiety phenotypes
  JOURNAL   Addict Biol 29 (3), e13388 (2024)
   PUBMED   38497285
  REMARK    GeneRIF: Brain-specific serine/threonine-protein kinase 1 is a
            substrate of protein kinase C epsilon involved in sex-specific
            ethanol and anxiety phenotypes.
REFERENCE   3  (bases 1 to 6254)
  AUTHORS   Colgan,L.A., Parra-Bueno,P., Holman,H.L., Tu,X., Jain,A.,
            Calubag,M.F., Misler,J.A., Gary,C., Oz,G., Suponitsky-Kroyter,I.,
            Okaz,E. and Yasuda,R.
  TITLE     Dual Regulation of Spine-Specific and Synapse-to-Nucleus Signaling
            by PKCdelta during Plasticity
  JOURNAL   J Neurosci 43 (30), 5432-5447 (2023)
   PUBMED   37277178
REFERENCE   4  (bases 1 to 6254)
  AUTHORS   Qin,W. and Weng,J.
  TITLE     Hepatocyte NLRP3 interacts with PKCepsilon to drive hepatic insulin
            resistance and steatosis
  JOURNAL   Sci Bull (Beijing) 68 (13), 1413-1429 (2023)
   PUBMED   37336688
  REMARK    GeneRIF: Hepatocyte NLRP3 interacts with PKCepsilon to drive
            hepatic insulin resistance and steatosis.
REFERENCE   5  (bases 1 to 6254)
  AUTHORS   Wang,X.T., Zhou,L., Dong,B.B., Xu,F.X., Wang,D.J., Shen,E.W.,
            Cai,X.Y., Wang,Y., Wang,N., Ji,S.J., Chen,W., Schonewille,M.,
            Zhu,J.J., De Zeeuw,C.I. and Shen,Y.
  TITLE     cAMP-EPAC-PKCepsilon-RIM1alpha signaling regulates presynaptic
            long-term potentiation and motor learning
  JOURNAL   Elife 12, e80875 (2023)
   PUBMED   37159499
  REMARK    GeneRIF: cAMP-EPAC-PKCepsilon-RIM1alpha signaling regulates
            presynaptic long-term potentiation and motor learning.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6254)
  AUTHORS   Morrish,B.C. and Rumsby,M.G.
  TITLE     The 5' UTR of protein kinase C epsilon confers translational
            regulation in vitro and in vivo
  JOURNAL   Biochem Biophys Res Commun 283 (5), 1091-1098 (2001)
   PUBMED   11355884
REFERENCE   7  (bases 1 to 6254)
  AUTHORS   Akimoto,K., Mizuno,K., Osada,S., Hirai,S., Tanuma,S., Suzuki,K. and
            Ohno,S.
  TITLE     A new member of the third class in the protein kinase C family, PKC
            lambda, expressed dominantly in an undifferentiated mouse embryonal
            carcinoma cell line and also in many tissues and cells
  JOURNAL   J Biol Chem 269 (17), 12677-12683 (1994)
   PUBMED   7513693
REFERENCE   8  (bases 1 to 6254)
  AUTHORS   Osada,S., Mizuno,K., Saido,T.C., Akita,Y., Suzuki,K., Kuroki,T. and
            Ohno,S.
  TITLE     A phorbol ester receptor/protein kinase, nPKC eta, a new member of
            the protein kinase C family predominantly expressed in lung and
            skin
  JOURNAL   J Biol Chem 265 (36), 22434-22440 (1990)
   PUBMED   2266135
REFERENCE   9  (bases 1 to 6254)
  AUTHORS   Wada,H., Ohno,S., Kubo,K., Taya,C., Tsuji,S., Yonehara,S. and
            Suzuki,K.
  TITLE     Cell type-specific expression of the genes for the protein kinase C
            family: down regulation of mRNAs for PKC alpha and nPKC epsilon
            upon in vitro differentiation of a mouse neuroblastoma cell line
            neuro 2a
  JOURNAL   Biochem Biophys Res Commun 165 (1), 533-538 (1989)
   PUBMED   2590242
REFERENCE   10 (bases 1 to 6254)
  AUTHORS   Schaap,D., Parker,P.J., Bristol,A., Kriz,R. and Knopf,J.
  TITLE     Unique substrate specificity and regulatory properties of
            PKC-epsilon: a rationale for diversity
  JOURNAL   FEBS Lett 243 (2), 351-357 (1989)
   PUBMED   2917656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154542.2, CT030001.16, AC154351.2, AC154236.2 and AC096777.1.
            
            On Apr 6, 2010 this sequence version replaced NM_011104.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082438.1, SRR7652917.683364.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 11355884
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1156              AC154542.2         119788-120943       c
            1157-1220           CT030001.16        83053-83116
            1221-1380           AC154351.2         14561-14720         c
            1381-1415           AC154351.2         13488-13522         c
            1416-1501           AC154351.2         12146-12231         c
            1502-1631           AC154351.2         6788-6917           c
            1632-1774           AC154351.2         735-877             c
            1775-1871           AC154236.2         18238-18334
            1872-2071           AC154236.2         20708-20907
            2072-2245           AC154236.2         23425-23598
            2246-2400           AC154236.2         86638-86792
            2401-2539           AC154236.2         147379-147517
            2540-2728           AC154236.2         152812-153000
            2729-2875           AC154236.2         157548-157694
            2876-6254           AC096777.1         26250-29628
FEATURES             Location/Qualifiers
     source          1..6254
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 56.74 cM"
     gene            1..6254
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /note="protein kinase C, epsilon"
                     /db_xref="GeneID:18754"
                     /db_xref="MGI:MGI:97599"
     exon            1..1156
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     regulatory      644..694
                     /regulatory_class="uORF"
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:11355884]"
                     /note="this uORF is predicted to encode a 16 aa peptide
                     (PMID:11355884)"
     CDS             809..3022
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /EC_number="2.7.11.13"
                     /note="nPKC-epsilon; PCK epsilon"
                     /codon_start=1
                     /product="protein kinase C epsilon type"
                     /protein_id="NP_035234.1"
                     /db_xref="CCDS:CCDS29008.1"
                     /db_xref="GeneID:18754"
                     /db_xref="MGI:MGI:97599"
                     /translation="MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIAL
                     NVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQF
                     EELLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAV
                     RRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIIT
                     KCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVC
                     KMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLAAGAESPQPAS
                     GNSPSEDDRSKSAPTSPCDQELKELENNIRKALSFDNRGEEHRASSATDGQLASPGEN
                     GEVRPGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDV
                     DCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPR
                     SRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIMNGVTTTT
                     FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDV
                     LYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIK
                     PPFKPRIKTKRDVNNFDQDFTREEPILTLVDEAIIKQINQEEFKGFSYFGEDLMP"
     exon            1157..1220
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1380
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1415
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1501
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1631
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1774
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1871
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2071
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2245
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2400
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2539
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2728
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2875
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..6254
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6229..6234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /note="hexamer: AATAAA"
     polyA_site      6254
                     /gene="Prkce"
                     /gene_synonym="5830406C15Rik; Pkce; PKCepsilon; PKC[e]"
                     /note="major polyA site"
ORIGIN      
        1 agtccctgcc cggccgccgc gctgcgcacc gccgggtgcc ggcctgcgcc ccgaacccaa
       61 gtggcggcca cctctacctc ccaagcccgc gcggatgtga gatcccaggc accgggcgcc
      121 tcgcgatcgc cggctacggc gcgactctgc ttaacccggg aggtgacggc ggggctgatc
      181 gtgcggcttg tggatttttt aaaaatttgg ctccggggag gaccatttcc tctcgacatg
      241 catccctccg gatagactgc acatccctca gtccaccctc cgccccgcgc cgtccgaggc
      301 aggcgctggg tgggcgaaga ggatccgggt tgaaatctgt gcccccggtt ctcgtccccg
      361 ccccgtcccg ccgccccctc cccctccggg agtcgaaatt gcccggggat tatgtttcgg
      421 aaaggtaggt gagcgccggg cgcggcgcct gcttctccgc acacggaccc gaagaaccag
      481 cgaggcggcg aggcagcccc cgcggcttgc agcggaggcg acagctcgtc tcctgccgtg
      541 gaggtgtcgc cggtggtggg ggggagagac ttgctccaaa aaaacggacg tctccagctc
      601 tcccccctcc ctgttttccg ttaggaatcc ggcgaggaaa tacatgcact cgctgagaat
      661 cggcggcgcc aggaggcagc gccacaaggt gtagcgagtg agtggggtgg ggcaagaggg
      721 gacccaggag tcccccaggc tcccggcgcg cctgctcctg ctcttcaatc ctgccctcgg
      781 ggcggacgga gtgacccccg ccccgaccat ggtagtgttc aatggccttc ttaagatcaa
      841 aatctgcgag gcggtgagct tgaagcccac agcctggtcg ctgcgccatg cggtgggacc
      901 ccggccacag acgttccttt tggaccccta cattgccctt aacgtggacg actcgcgcat
      961 cggccaaaca gccaccaagc aaaagaccaa cagcccggcc tggcacgatg agttcgtcac
     1021 cgatgtgtgc aatgggcgca agatcgagct ggctgtcttt cacgacgctc ctatcggcta
     1081 cgacgacttc gtggccaact gcaccatcca gttcgaggag ctgctgcaga atgggagccg
     1141 tcacttcgag gactggattg acctggagcc agaaggaaaa gtgtacgtga tcatcgatct
     1201 ctcgggatca tcgggtgaag cccctaaaga caatgaagaa cgagtgttca gggagcgtat
     1261 gcggccaagg aagcggcaag gggctgtcag gcgcagggtc caccaggtca atggccacaa
     1321 gttcatggcc acctacttgc ggcaacccac ctactgctcc cactgcagag atttcatctg
     1381 gggtgtcata ggaaaacagg gatatcaatg tcaagtttgc acttgcgttg tccacaagcg
     1441 atgtcatgag ctcattatta caaagtgcgc tgggctgaag aaacaggaaa cccctgacga
     1501 ggtgggctcc caacggttca gcgtcaacat gccccacaag ttcgggatcc acaactacaa
     1561 ggtccccacg ttctgtgacc actgtgggtc cctgctctgg ggcctcttgc ggcagggctt
     1621 gcagtgtaaa gtctgcaaaa tgaatgttca ccggcgatgt gagaccaatg tggctcccaa
     1681 ctgtggggta gacgccagag gaattgccaa agtgctggct gaccttggtg ttactccaga
     1741 caaaatcacc aacagtggcc aaaggaggaa aaagctcgct gctggtgctg agtccccaca
     1801 gccggcttct ggaaactccc catctgaaga cgaccgatcc aagtcagcgc ccacctcccc
     1861 ttgtgaccag gaactaaaag aacttgaaaa caacattcgg aaggccttgt catttgacaa
     1921 ccgaggagag gagcaccgag cgtcgtcggc caccgatggc cagctggcaa gccccggaga
     1981 gaacggggaa gtccggccag gccaggccaa gcgcttgggg ctggatgagt tcaacttcat
     2041 caaggtgttg ggcaaaggca gctttggcaa ggtcatgttg gcggaactca aaggcaaaga
     2101 tgaagtctac gctgtgaagg tcttgaagaa ggacgttatc ctacaagacg atgatgtgga
     2161 ctgcacaatg acagagaaga ggattttggc tctggctcgg aaacaccctt atctaaccca
     2221 actctattgc tgcttccaga ccaaggaccg cctcttcttc gtcatggaat atgtaaatgg
     2281 tggagacctc atgttccaga ttcagcggtc ccgaaaattt gatgagcctc gttctcggtt
     2341 ctatgccgca gaggtcacat cagccctcat gtttctccac cagcacggag tgatctacag
     2401 ggatttgaaa ctggacaaca tccttctaga tgcagaaggc cactgcaagc tggctgactt
     2461 tgggatgtgc aaggaaggga ttatgaatgg tgtgacaact accaccttct gtgggactcc
     2521 tgactacata gctccagaga tcctacagga gttggagtac ggcccctcag tggactggtg
     2581 ggccctgggg gtgctgatgt acgagatgat ggctgggcag cccccctttg aagctgacaa
     2641 cgaggacgac ttgttcgaat ccatccttca tgatgatgtt ctctatcctg tctggcttag
     2701 caaggaagct gtcagcatcc tgaaagcttt catgaccaag aacccgcaca agcgcctggg
     2761 ctgtgtggca gcgcagaacg gggaggacgc catcaagcaa catccattct tcaaggagat
     2821 tgactgggta ctgctggagc agaagaaaat caagcccccc ttcaagccga gaattaaaac
     2881 caaaagagat gtcaataact ttgaccaaga ctttacgcgg gaagagccaa tacttacact
     2941 tgtggatgaa gcaatcatta agcagatcaa ccaggaagaa ttcaaaggct tctcctactt
     3001 tggtgaagac ctgatgccct gagaggctgc ttcggatgga gggagctcat gctgcaagga
     3061 cggtgttgag atactcccaa gctgcagagg ctccgaaggt ctcaactcct cctcctcctc
     3121 cccctcccca gagccccagt cccatgtcca ctctcttatt tattgcattc ccccacccca
     3181 ggccacgtcc ctccccaccc tcccagtgat cagaaggcac tcttggtcta gactcaccaa
     3241 gatcacagat ttgaattgca tcagctacct gtgggtagct gtgcgcagtg ttgggtttga
     3301 tgtatccatc caaccgcaag ccagaagcag cttcagttct tttactacaa agaaaaaaaa
     3361 aaaaaaacaa ctcgaagact ctggctctgc cactggacgt ggactcctga tttctccctc
     3421 ctcccattcc tcctcgtctc cagcctgcca tccctgccca gctacctaag agaagagagc
     3481 agagtttctt ccacgggagg gcgggtgccc caaggcttgc ccttgatgga aggagcctga
     3541 gttgctcagg tggtccagct gtggccgtgt gctctggaat cgcacattcc tgcttgcttt
     3601 ggttttagct ttttttgagc atgccaaagt tgtatgcgtt tgtatctcat ggaagaaatc
     3661 attttgattt tgaactctaa acattacaaa aaaaaaaagc agaaagaaag gaagagagaa
     3721 aggaaggaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa
     3781 agaaagaaag aaagaaaact attactacgt tcactttcta attggccaaa agatagacat
     3841 cccaacgtga acacgggtag atattaaagg gctaatacac ggtgagaatc cagtcatccg
     3901 acgtttgtta ttgatgcttt agtgacacat gaggtctatg caaagagagc aaagaaaact
     3961 ctggcttctc atcatgagaa ttttccctga gcacaaagac caccagagca acagccaaga
     4021 tcccagggtt ccagaaaaac ttaattccca aattctctct ccagtcttgg tcccatgttc
     4081 ccagcataaa cccttatttt ctctgtgctt ctacaagatg gccgtaccac tctgttgtgg
     4141 tttgaaacgt tcgctatgta ggataaactc tgaagtatct gttttgggaa tgcagggaac
     4201 gaaacacagc cggggtcagg cagaaggtct caggagacta aggagcaact gatctgaggg
     4261 ccgtcgaggt gctgggatgt agccagagtt ttggtgacat gcgatggtaa ctcacgtgga
     4321 ctgatattac ctcctgtagc tatgctgaca gtgttacagt tttgattcct aagggttccc
     4381 tgtggctttg tgtatatgtt ccctgaaggt catttgatta cctattttat tgaactgact
     4441 tagcagggag tggaatccat tccaaccatt gcacgtggat ttcccaacca cccctaagta
     4501 gatatacctg tgagtggcaa actgacacta acgaagcttt ttgccttttg tacatttgag
     4561 attttttttg tatatagtgt tcgctgcaag gcctgtggag ttaaatcatt gactatagag
     4621 gtatcaactg ctgcatgttc aggcatatta tagaacttta gtctatgaaa gaataactat
     4681 aataatgtcc aggtgcaatc tccttatcac ctattggttc aagttgctga gagagaggta
     4741 tgtttctttc cagggagggc tggggtcctt catattgttt atttcctttt gggttaaaag
     4801 tgtaagcaca tagtgaactc tgttaaagtc acgctcggtt ctcctgtgta gtgtcatgcc
     4861 ctgagagaga tggcagacgg gaaagaatgt tctcgatagt ggtttccaag cttggacagt
     4921 gactattttg agcccatact aaatgtgtcc ctatttgcat ctggctggtc acagcctttg
     4981 tctctaatga cgaccttcag ttttcctctt tgttttgctt ttttttttta agaaaaactc
     5041 aggtgtaact gtgatctgtt cttatgatga ttgcaaatat taaatgctat gctgtatcaa
     5101 tctgtatgtt tggcatacca gggaagtgat gaagaacatt agattaattt aatttatctt
     5161 cagtaacttg acatactggg ggaagactat cttttggagt ggaaaacaag cacagaaaca
     5221 tcttcatggt ggtatcatct caatgtttag aaaaaacata ataatcccat tatactcaga
     5281 tataatctct ctttctctct ctctctcttt ctctttccct ctccctctcc ctcttcctcc
     5341 ctccctccct cccttccttc tgctttcttt accattgtga acattggaca gccaaggcca
     5401 atatcaagtg tttttccccc agggtttggt agtgttaatg ttacagtgaa ggctacaccc
     5461 ttcctcatgg ccagttggca ctgttgctgg gaagtcaaac aacacattcc accagcaact
     5521 ctaagaagtc aggcccctga tacccttttg gtgcccatag ccctgctggc taggaggctt
     5581 ccagccaacg ctttgaatct agtggagacc tacacacgag tgtgttcttt ggatgtatac
     5641 tgagtcctgt cagcaagaac ttagccacag ggaatgtggc ttggtggcag aactcttgcc
     5701 tggctggtgt gaagccttgt acatgggtcc cagcatcaca aaaacagcag tggtggggat
     5761 ggccaagctg gcaccagggt atctggggaa tggccacact ggcaccaggg gatctgccag
     5821 gtctatattt ttccaactct cactttcttt atcttaaagg aaaaaagtgg gggggaaaaa
     5881 gccaaaaaat actacatgaa ggatagtaat tcctccctgc ctctcattat ggacttcttg
     5941 aagtagaaac attttttttc ctccaaaggt gaaaacacca ttcattcttg ctttaaaaat
     6001 aaaagaaggc ttaaaaaaat tacctctttt taaattatgt gcaaagtaat tctggttaat
     6061 agaaatgtat tcaattttag gggttttatt ttgtattgtg aagctttctt ttcctttccg
     6121 gatgtgattt taatcccttg ccatctatca gtgtgatttc attgtaaaca ttattgtgcc
     6181 aaatgtactg tactcaaaag gatgtgaatg tgtattgttc cagaacgtaa taaatatgat
     6241 gatgttaaat ctta
//
