LOCUS       NM_001310682            2639 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus protein kinase C, delta (Prkcd), transcript variant 1,
            mRNA.
ACCESSION   NM_001310682 XM_006518696
VERSION     NM_001310682.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2639)
  AUTHORS   Lajiness,J.D., Bloodworth,J.C., Blankenship,R.L., Kosins,A.E. and
            Cook-Mills,J.M.
  TITLE     Dendritic cell-specific deletion of PKCdelta in offspring of
            allergic mothers prevents the predisposition for development of
            allergic lung inflammation in offspring
  JOURNAL   J Leukoc Biol 116 (6), 1432-1445 (2024)
   PUBMED   39312649
REFERENCE   2  (bases 1 to 2639)
  AUTHORS   Ghoshal,K., Luther,J.M., Pakala,S.B., Chetyrkin,S., Falck,J.R.,
            Zent,R., Wasserman,D.H. and Pozzi,A.
  TITLE     Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin
            Signaling by Controlling FATP2 Localization and Activation of the
            DAG/PKCdelta Axis
  JOURNAL   Diabetes 73 (8), 1229-1243 (2024)
   PUBMED   38743615
  REMARK    GeneRIF: Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and
            Insulin Signaling by Controlling FATP2 Localization and Activation
            of the DAG/PKCdelta Axis.
REFERENCE   3  (bases 1 to 2639)
  AUTHORS   Singh,G., O-Sullivan,I., Natarajan Anbazhagan,A., Ranjan,K. C,
            Farooqui,Z., Ma,K., Wang,J., Mwale,F., Votta-Velis,G., Bruce,B.,
            Ronald Kahn,C., van Wijnen,A.J. and Im,H.J.
  TITLE     Loss of PKCdelta/Prkcd prevents cartilage degeneration in joints
            but exacerbates hyperalgesia in an experimental osteoarthritis
            mouse model
  JOURNAL   Gene 893, 147920 (2024)
   PUBMED   37890601
  REMARK    GeneRIF: Loss of PKCdelta/Prkcd prevents cartilage degeneration in
            joints but exacerbates hyperalgesia in an experimental
            osteoarthritis mouse model.
REFERENCE   4  (bases 1 to 2639)
  AUTHORS   Chaib,M., Holt,J.R., Fisher,E.L., Sipe,L.M., Bohm,M.S.,
            Joseph,S.C., Simmons,B.W., Eugin Simon,S., Yarbro,J.R., Tanveer,U.,
            Halle,J.L., Carson,J.A., Hollingsworth,T.J., Wei,Q., Rathmell,J.C.,
            Thomas,P.G., Hayes,D.N. and Makowski,L.
  TITLE     Protein kinase C delta regulates mononuclear phagocytes and hinders
            response to immunotherapy in cancer
  JOURNAL   Sci Adv 9 (51), eadd3231 (2023)
   PUBMED   38134280
  REMARK    GeneRIF: Protein kinase C delta regulates mononuclear phagocytes
            and hinders response to immunotherapy in cancer.
REFERENCE   5  (bases 1 to 2639)
  AUTHORS   Colgan,L.A., Parra-Bueno,P., Holman,H.L., Tu,X., Jain,A.,
            Calubag,M.F., Misler,J.A., Gary,C., Oz,G., Suponitsky-Kroyter,I.,
            Okaz,E. and Yasuda,R.
  TITLE     Dual Regulation of Spine-Specific and Synapse-to-Nucleus Signaling
            by PKCdelta during Plasticity
  JOURNAL   J Neurosci 43 (30), 5432-5447 (2023)
   PUBMED   37277178
REFERENCE   6  (bases 1 to 2639)
  AUTHORS   Motwani,M., White,R.A., Guo,N., Dowler,L.L., Tauber,A.I. and
            Sastry,K.N.
  TITLE     Mouse surfactant protein-D. cDNA cloning, characterization, and
            gene localization to chromosome 14
  JOURNAL   J Immunol 155 (12), 5671-5677 (1995)
   PUBMED   7499852
REFERENCE   7  (bases 1 to 2639)
  AUTHORS   Kim,H.M., Hirota,S., Onoue,H., Hirata,T., Suzuki,K., Ohno,S.,
            Kuroki,T., Kitamura,Y. and Nomura,S.
  TITLE     Localization and developmental expression of a novel protein kinase
            C delta gene
  JOURNAL   Brain Res Dev Brain Res 70 (2), 239-244 (1992)
   PUBMED   1477958
REFERENCE   8  (bases 1 to 2639)
  AUTHORS   Osada,S., Mizuno,K., Saido,T.C., Suzuki,K., Kuroki,T. and Ohno,S.
  TITLE     A new member of the protein kinase C family, nPKC theta,
            predominantly expressed in skeletal muscle
  JOURNAL   Mol Cell Biol 12 (9), 3930-3938 (1992)
   PUBMED   1508194
REFERENCE   9  (bases 1 to 2639)
  AUTHORS   Mizuno,K., Kubo,K., Saido,T.C., Akita,Y., Osada,S., Kuroki,T.,
            Ohno,S. and Suzuki,K.
  TITLE     Structure and properties of a ubiquitously expressed protein kinase
            C, nPKC delta
  JOURNAL   Eur J Biochem 202 (3), 931-940 (1991)
   PUBMED   1765103
REFERENCE   10 (bases 1 to 2639)
  AUTHORS   Mischak,H., Bodenteich,A., Kolch,W., Goodnight,J., Hofer,F. and
            Mushinski,J.F.
  TITLE     Mouse protein kinase C-delta, the major isoform expressed in mouse
            hemopoietic cells: sequence of the cDNA, expression patterns, and
            characterization of the protein
  JOURNAL   Biochemistry 30 (32), 7925-7931 (1991)
   PUBMED   1868068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY750197.1, CF170573.1, AK168768.1, AC154646.2, AA616214.1,
            AI385711.1 and AW122017.1.
            
            On Jul 17, 2015 this sequence version replaced XM_006518696.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011812.1, SRR13422597.745638.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               BY750197.1         228-516
            290-855             CF170573.1         1-566
            856-987             AK168768.1         1080-1211
            988-1065            AC154646.2         78327-78404
            1066-1692           AK168768.1         1212-1838
            1693-2241           AA616214.1         95-643
            2242-2601           AI385711.1         27-386              c
            2602-2639           AW122017.1         1-38                c
FEATURES             Location/Qualifiers
     source          1..2639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 18.82 cM"
     gene            1..2639
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /note="protein kinase C, delta"
                     /db_xref="GeneID:18753"
                     /db_xref="MGI:MGI:97598"
     exon            1..123
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            124..323
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            324..384
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            385..547
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            548..579
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            580..665
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            666..795
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            796..896
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1065
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1166
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1340
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1432
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1495
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1634
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1823
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1952
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2624
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2603..2608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /note="hexamer: AATAAA"
     polyA_site      2624
                     /gene="Prkcd"
                     /gene_synonym="D14Ertd420e; Pkcd; PKCdelta; PKC[d]"
                     /note="major polyA site"
ORIGIN      
        1 gctccatcat ggcacccttc ctgcgcatct ccttcaattc ctatgagctg ggctccctgc
       61 aagttgagga cgaagcaagc cagcctttct gtgctgtgaa gatgaaggag gcactcagca
      121 cagagcgagg gaagacactg gtacagaaga agcccaccat gtatcctgag tggaagacaa
      181 cgttcgacgc ccacatctat gaaggccgtg ttatccagat tgtgctgatg cgggcagctg
      241 aagaccccgt gtctgaggtc acggtgggcg tgtcagtact ggctgagcgc tgcaagaaga
      301 acaacggcaa ggctgagttc tggctggatc tgcagcctca ggccaaggtg ctgatgtgtg
      361 tgcagtattt cctggaggat ggggattgca aacagtctat gcgtagtgag gaggaggcaa
      421 agtttccaac catgaaccgt cgtggagcca ttaaacaggc caagatccac tacatcaaga
      481 accacgagtt tatcgccacc ttcttcgggc agcccacctt ctgttctgtg tgcaaagagt
      541 ttgtctgggg cctcaacaag caaggctaca aatgcaggca atgcaacgct gccatccaca
      601 agaaatgcat tgacaagatt atcggccgct gcactggcac tgccaccaat agccgggaca
      661 ccatcttcca gaaagaacgc ttcaacatcg acatgcctca ccgattcaag gtttataact
      721 acatgagccc caccttctgt gaccactgtg gcagtttgct ctggggactg gtgaagcagg
      781 gattaaagtg tgaagattgt ggcatgaatg tgcaccacaa atgccgggag aaggtggcca
      841 acctgtgtgg tatcaaccaa aagctcttgg ctgaggcctt gaaccaagtg acccagagat
      901 cttcccggaa gctggacaca acagagtctg tcggaatata ccagggattt gagaagaagc
      961 cagaagtctc tgggagtgac atcctaggtg aagctgggtc acatatctct ttaaagctat
     1021 cattccccag cagggcaaag gaaaaggaca gtagtgagac ctgcgacaac aacgggacct
     1081 atggcaagat ctgggagggg agcacccggt gcacccttga gaacttcacc ttccaaaaag
     1141 tacttggcaa aggcagcttt ggcaaggtgc tgctggcaga gctgaagggc aaagacaagt
     1201 actttgcaat caagtgtctg aagaaggacg tggtgttgat tgacgatgat gtagagtgta
     1261 ccatggtgga gaagcgggtg ctggcgctcg cctgggagag tcccttcctc acccacctca
     1321 tctgtacctt ccagaccaag gaccacctgt tcttcgtgat ggagtttctc aatgggggtg
     1381 acctgatgtt ccacattcag gacaaaggcc gcttcgaact ctaccgggct acgttttatg
     1441 cagctgagat catctgcgga ctgcagtttc tacacagcaa aggcattatt tacagggacc
     1501 tcaagctgga caatgtgatg ctagacaggg acggccacat caagatcgct gactttggga
     1561 tgtgcaaaga gaatatattt ggggagggcc gggccagcac attctgcggc actcctgact
     1621 acatcgcccc tgagatcctg cagggcctga agtactcctt ctcggtggac tggtggtctt
     1681 tcggggtcct cctgtacgaa atgctcatcg gccagtcccc cttccacggc gacgatgagg
     1741 acgagctctt cgagtccatc cgggtggaca caccacacta tccccgttgg atcaccaagg
     1801 aatccaagga catcatggag aagctattcg agagggaccc tgacaagagg ctgggagtaa
     1861 caggaaacat caggattcac ccctttttca agactatcaa ctggtccctc ctggagaagc
     1921 ggaaggtgga gccgcccttt aagcccaaag tgaaatcccc ttcagactac agcaactttg
     1981 acccagagtt cctgaatgag aaacctcagc tttccttcag tgacaagaac ctcatcgact
     2041 ctatggacca ggaagccttc catggcttct cctttgtgaa tcccaagttt gagcaattcc
     2101 tggacattta attaagctcc cagacctgct ttaaacgccc tggcagagta ggcccgtctg
     2161 ccctggtttg caccgcattg cccgtggaga acagtgggtg actggctgat ttctgctgcc
     2221 accccctcct ccttggagag tccggctcct gctggctggg ctcacagtac ttcctctgtg
     2281 aactgtttgt gaatttgcct tccctttgcc atcagaggga aactgtaaat cctgtgtttc
     2341 attacttgaa tgtagttatt gaaatatata ttatatatat gcacatatat ataataggct
     2401 gtatatattg ctcagtatag aaagcatgta ggagactggt gatgtgttga cctttttaaa
     2461 aaaaaacata tgtatatgtg tgtatatata tatacacaca tatacatata tatgtgtatg
     2521 tatgtacgta tgtatatata tatgaccaaa agaaaagaag agcacaagct gtctgaacca
     2581 caggttcttt tatgtgtgtc taaataaaca ctgaatggta ccaaaaaaaa aaaaaaaaa
//
