LOCUS       NM_008855               8830 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus protein kinase C, beta (Prkcb), transcript variant 1,
            mRNA.
ACCESSION   NM_008855 XM_914168
VERSION     NM_008855.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8830)
  AUTHORS   Shu,Y., Gumma,N., Hassan,F., Branch,D.A., Baer,L.A.,
            Ostrowski,M.C., Stanford,K.I., Baskin,K.K. and Mehta,K.D.
  TITLE     Hepatic protein kinase Cbeta deficiency mitigates late-onset
            obesity
  JOURNAL   J Biol Chem 299 (8), 104917 (2023)
   PUBMED   37315788
  REMARK    GeneRIF: Hepatic protein kinase Cbeta deficiency mitigates
            late-onset obesity.
REFERENCE   2  (bases 1 to 8830)
  AUTHORS   Song,X., Hu,Q., Xu,X. and Pan,W.
  TITLE     Protein kinase C beta relieves autism-like behavior in EN2 knockout
            mice via upregulation of the FTO/PGC-1alpha/UCP1 axis
  JOURNAL   J Biochem Mol Toxicol 37 (1), e23236 (2023)
   PUBMED   36239013
  REMARK    GeneRIF: Protein kinase C beta relieves autism-like behavior in EN2
            knockout mice via upregulation of the FTO/PGC-1alpha/UCP1 axis.
REFERENCE   3  (bases 1 to 8830)
  AUTHORS   Sloth,R.A., Axelsen,T.V., Espejo,M.S., Toft,N.J., Voss,N.C.S.,
            Burton,M., Thomassen,M., Vahl,P. and Boedtkjer,E.
  TITLE     Loss of RPTPgamma primes breast tissue for acid extrusion, promotes
            malignant transformation and results in early tumour recurrence and
            shortened survival
  JOURNAL   Br J Cancer 127 (7), 1226-1238 (2022)
   PUBMED   35821297
  REMARK    GeneRIF: Loss of RPTPgamma primes breast tissue for acid extrusion,
            promotes malignant transformation and results in early tumour
            recurrence and shortened survival.
REFERENCE   4  (bases 1 to 8830)
  AUTHORS   Shu,Y., Hassan,F., Ostrowski,M.C. and Mehta,K.D.
  TITLE     Role of hepatic PKCbeta in nutritional regulation of hepatic
            glycogen synthesis
  JOURNAL   JCI Insight 6 (19), e149023 (2021)
   PUBMED   34622807
  REMARK    GeneRIF: Role of hepatic PKCbeta in nutritional regulation of
            hepatic glycogen synthesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8830)
  AUTHORS   Wang,C.C., Weyrer,C., Fioravante,D., Kaeser,P.S. and Regehr,W.G.
  TITLE     Presynaptic Short-Term Plasticity Persists in the Absence of PKC
            Phosphorylation of Munc18-1
  JOURNAL   J Neurosci 41 (35), 7329-7339 (2021)
   PUBMED   34290081
REFERENCE   6  (bases 1 to 8830)
  AUTHORS   Tracy,S., van der Geer,P. and Hunter,T.
  TITLE     The receptor-like protein-tyrosine phosphatase, RPTP alpha, is
            phosphorylated by protein kinase C on two serines close to the
            inner face of the plasma membrane
  JOURNAL   J Biol Chem 270 (18), 10587-10594 (1995)
   PUBMED   7537734
REFERENCE   7  (bases 1 to 8830)
  AUTHORS   Akimoto,K., Mizuno,K., Osada,S., Hirai,S., Tanuma,S., Suzuki,K. and
            Ohno,S.
  TITLE     A new member of the third class in the protein kinase C family, PKC
            lambda, expressed dominantly in an undifferentiated mouse embryonal
            carcinoma cell line and also in many tissues and cells
  JOURNAL   J Biol Chem 269 (17), 12677-12683 (1994)
   PUBMED   7513693
REFERENCE   8  (bases 1 to 8830)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   9  (bases 1 to 8830)
  AUTHORS   Tang,Y.M. and Ashendel,C.L.
  TITLE     Isolation of cloned mouse protein kinase C beta-II cDNA and its
            sequence
  JOURNAL   Nucleic Acids Res 18 (17), 5310 (1990)
   PUBMED   2402470
REFERENCE   10 (bases 1 to 8830)
  AUTHORS   Wada,H., Ohno,S., Kubo,K., Taya,C., Tsuji,S., Yonehara,S. and
            Suzuki,K.
  TITLE     Cell type-specific expression of the genes for the protein kinase C
            family: down regulation of mRNAs for PKC alpha and nPKC epsilon
            upon in vitro differentiation of a mouse neuroblastoma cell line
            neuro 2a
  JOURNAL   Biochem Biophys Res Commun 165 (1), 533-538 (1989)
   PUBMED   2590242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY729820.1, CJ050078.1, AK051862.1 and AC016522.10.
            
            On Oct 27, 2006 this sequence version replaced NM_008855.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.68452.1,
                                           SRR1660813.82847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               BY729820.1         1-211
            212-653             CJ050078.1         3-444
            654-2304            AK051862.1         647-2297
            2305-8830           AC016522.10        54180-60705         c
FEATURES             Location/Qualifiers
     source          1..8830
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 65.75 cM"
     gene            1..8830
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /note="protein kinase C, beta"
                     /db_xref="GeneID:18751"
                     /db_xref="MGI:MGI:97596"
     exon            1..393
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..2242
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /EC_number="2.7.11.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein kinase C, beta 1; protein kinase C beta-II;
                     protein kinase C beta type"
                     /codon_start=1
                     /product="protein kinase C beta type isoform 1"
                     /protein_id="NP_032881.1"
                     /db_xref="CCDS:CCDS21815.1"
                     /db_xref="GeneID:18751"
                     /db_xref="MGI:MGI:97596"
                     /translation="MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFF
                     KQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKH
                     KFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRG
                     RIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCS
                     LNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFK
                     LLSQEEGEYFNVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNR
                     DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR
                     VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI
                     AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYI
                     APEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSK
                     EAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR
                     NAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPEVKS"
     exon            394..425
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            426..508
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            509..620
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            621..749
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..906
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1041
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1138
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1285
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1459
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1551
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1614
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1753
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1834
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1942
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2083
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..8830
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3427..3432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /note="hexamer: AATACA"
     polyA_site      3446
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
     regulatory      8806..8811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /note="hexamer: ATTAAA"
     polyA_site      8830
                     /gene="Prkcb"
                     /gene_synonym="PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2"
                     /note="major polyA site"
ORIGIN      
        1 aagcacagct ggaccagcgg cagcagctgg gcgagtgaca gcccagctac gcgcgcgcgg
       61 ccgccgccag agccggcgcg aaggggcagc gcggccctgc ggtccccggg cggcagcagc
      121 ggccgcctag tcccgcgcct ttccgggctt gcagccccgc ggtcccgccg ccccggggcc
      181 gccacctctc ggggctcccc ccagtccccg cgcgcgcaag atggctgacc cggctgcggg
      241 gccgccgccg agcgagggcg aggagagcac agtgcgcttc gcccgcaaag gcgccctccg
      301 gcagaagaac gtgcacgagg tgaagaacca caaattcacc gcccgcttct tcaagcagcc
      361 caccttctgc agccactgca ccgacttcat ctggggcttc gggaagcagg gattccagtg
      421 tcaagtctgc tgctttgttg tacacaagcg ctgccatgag ttcgtcacgt tctcctgccc
      481 cggtgcggac aagggcccgg cctctgatga cccccggagc aaacacaagt ttaagatcca
      541 cacgtactcc agtcctacct tctgtgacca ctgtggatcg ctgctgtatg gacttattca
      601 ccaggggatg aaatgcgaca cctgtatgat gaacgtgcac aagcgctgcg tgatgaacgt
      661 ccccagcctc tgcggcactg accacacgga acgccgcggc cgcatctata tccaggccca
      721 catcgacaga gaggttctca ttgttgttgt aagagatgct aaaaatctgg tacctatgga
      781 ccccaatggc ttgtcagatc cctacgttaa actgaaactg atccctgatc ccaaaagtga
      841 gagcaaacag aagaccaaga ccatcaagtg ttccctcaat ccagagtgga atgaaacctt
      901 cagatttcag ctgaaggaat cagacaaaga cagaagactg tctgtagaga tctgggattg
      961 ggacctgacc agcaggaatg acttcatggg atctctgtca tttgggattt cagaactaca
     1021 gaaagccggt gtggatggct ggttcaagtt actaagccag gaagagggtg aatacttcaa
     1081 tgtgcccgtg ccgcccgaag gaagcgaggg caatgaagag ctgcggcaga agtttgagag
     1141 agccaagatt ggccaaggta ccaaggctcc agaagaaaag acagctaaca ctatctccaa
     1201 atttgacaac aatggcaaca gggaccggat gaaactgacc gattttaact tcctgatggt
     1261 gctggggaaa ggcagctttg gcaaggtcat gctctcagag cggaagggta cagatgaact
     1321 ctatgccgtg aagatcctga agaaggacgt ggtgatccaa gatgacgatg tggagtgcac
     1381 catggtggag aagcgggtgc tggccctgcc tgggaagccc ccgttcctga ctcagctcca
     1441 ttcctgcttc cagaccatgg accgcctgta ctttgtgatg gagtatgtga acgggggtga
     1501 cctcatgtac cacatccaac aagttggccg tttcaaggag ccccatgctg tattttacgc
     1561 cgcagagatt gccatcggtc tgttcttctt gcagagcaag ggcattattt accgcgacct
     1621 gaaacttgac aacgtgatgc tggattctga ggggcacatc aaaatcgctg actttggcat
     1681 gtgtaaggag aacatctggg atggggtgac aaccaagaca ttctgtggca ctccggacta
     1741 cattgctcca gagatcattg cttatcagcc ctacgggaag tctgtggact ggtgggcatt
     1801 tggagtcctg ctgtatgaaa tgttggctgg ccaggcaccg tttgaagggg aggatgagga
     1861 tgaactcttc cagtcaatca tggaacacaa tgtggcgtat cccaagtcca tgtccaagga
     1921 agccgtggca atctgcaaag ggctaatgac caaacaccca ggcaagcgcc tgggttgtgg
     1981 gcctgaaggg gaacgagaca ttaaggagca tgcgtttttc cggtatattg actgggagaa
     2041 actcgaacgc aaggagattc agccacctta taaaccaaaa gcttgtgggc gaaacgctga
     2101 aaacttcgac cggtttttca cccgccatcc accagtccta acacctcctg accaggaagt
     2161 catcaggaat attgaccaat cagaattcga aggattttcc tttgttaact ctgaattttt
     2221 aaaacctgaa gtcaagagct aagtagatcc gtagacctcc gtcctccatt tctgtcattc
     2281 aagcgcaaca gctgtcatgg tgacattttt tctttttcat tgccgagtta catccgtgtt
     2341 ttcttttctg atgaggctag agtggccatg tttcagaacc caaatgtctt caagtagttt
     2401 ggagcatctc aaggagatgg aattatgcag gtggcatgta gaaagtgctg cataatcgag
     2461 acacgctcgg agtcctacta tgtgcgtccc tagcatgtcg gctcacagac ccccacggga
     2521 gagaaaatgc ttgcttttct ccctggtcct ctgcactgcc atctttaccc caaccctcca
     2581 ggctacatcc tccctacaaa atggatggat gaaccaaatg ctagcaatat ccttccactt
     2641 tccaggctgg gagcttggct tgaatccaag tatatggctg ctttgcccta gagggaatcc
     2701 ctccacgctg cctgttctgg aagcagttga gctttgaaaa gaacatgcta aaaataaatt
     2761 tttattttta tttttttaac tcagtgttaa gaagattatc taagtcctgg ggaaaaaagt
     2821 ggggggaatg cgcttttaga caagtttcca tctaaaagca cttcagggtc aaaaggcaac
     2881 cagcttgggt gctgtcacct tgccatagtt tctaatactg tatgtctgat agcggtacct
     2941 tcatccccca aactactcaa gaatgacatt tggcactgtt cctggaacca catggtcact
     3001 ctagccaggt cccaaaggac cctgattcta cattacattt caaatgttac ttgcttttta
     3061 tttctgtcat cattgaaatg caaaaagaaa aaagaaaaaa aagaaaacga aagaaaaaga
     3121 aaaaaatact cactttgtta cacatgcttt aagatctgtg tccagatgtt attaaccata
     3181 atggcctgct ttgttcaacc aagaagatgg ctatggaacc cagcagactt gtgcccatgg
     3241 ggaggggatt tgtctagatg tcccactggt attggagagg taattgtgtg ctctgagaaa
     3301 gacgccatct ccccaaacca tgatgggtgc attcttcagt atgatgttat tttgcaagat
     3361 gtttgtggga atgtttattt gcacttcagt atctgttctg atatctttct cctagcatca
     3421 agatacaata caaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga
     3481 aagagagaga gagagagaga aaggaaagga aatcctattt caaagaaaac tgttcccttt
     3541 gaacaatgag gacccatact acagattagg gtctaaagaa ggaactcagg agaaaggaac
     3601 taaagctgga cctttaatag cctcagcgtt aaccagccag agagtagagc ccggagacta
     3661 ttcagagatg cctgatgtcc tgaaatgggg tggggtagac aggctggagc ttcccacagc
     3721 atcagacttc agagaccaca ttcccatcag aatcaagctt aggaacattc ccaaggctct
     3781 taaacttctc atcagaatca ccactcttac aaattttagc atccttgagc aagcaactca
     3841 atgagctccc agaagtccaa gggagccctt ggagcaggag agacttcatt tctccctgaa
     3901 cagatgggca cagcaggtgg ccccttaccc ttgcctacat cttagcaccc tgctcctcac
     3961 acacagtctt gaggcaaatt cttattacag gctaaaaaat gtctgggtcc tccagtgctt
     4021 ctgagagatc acacagaaat gtccaaagga ccagtgtcct tgaagtatac ctcctcatct
     4081 ttaagaagac tatgcctttg ggttcttccg aggcaaagac ccttataggt cattctttcc
     4141 tggcctctta gcaactcagc tttaagctta ggccttgccc tgcttagatc atgtgaagca
     4201 agcttgttgt cctaacaatc ttacgatttt agctgccaaa agagaccaga gcaatcctgc
     4261 tcctcactct gctattaggg cacctgacat ctgaagagta gaagttattt tctgcttggt
     4321 tgatcagtgg tgatgcaaac acaagtcttg tggccaatga cacaggactc tgttctataa
     4381 caaaataaat atctctgagc cacatgtcca ttcccaggca agttatgtag ggtctttcat
     4441 ttggtcaatg ggtcaccagg ccttggacat atgctcagaa taaaaaccac agagaaatct
     4501 tgggccattg gcaagtgatc tgagacgacc ttagaaaaca gtgtaggaag gaaggatggt
     4561 tagatggatg gatggatgaa tagatagatg gatagataga tagatagata gatagataga
     4621 tagatagata atagtatata tgtaaatata tacactacgc tctacatttt caggttctta
     4681 ccattatgtt ttaaggttcg tagttgtcag aaatagatac tcaagccaaa gtgtctgttc
     4741 ccttagctta gcttgatggg ggtgggtcag agaagcttct gtggaaataa tggatcatga
     4801 atcagacctc ccactgcttc ctcggccacc agtgttctag atcagaggaa gccaagaagc
     4861 agtttccatc acgtaagatc cttaggaaat attttaaaat tttatccaaa aaagaaataa
     4921 tttgtttttt tttttcatcc atccatttat acatcttcca tccatttgag tagcatttat
     4981 tgaccaccaa ctgtgtgcca ggctgggtgc caggatcctg gtgaaaacta tgaaagatgc
     5041 agtccatgcc cttctccctc tttctccagc tcaccatctg tggaaagatg gccataaaac
     5101 aagtaattga aagtatgctg ttgtctagag tctctgagct tattaaaaaa tttttctgct
     5161 ggaggtcttc caggcttctt agtctctcta tagaccatag tttgaagcta tcaagccata
     5221 gtatcaagct ccatacttga tcggaccaca gacgctccca caacatgaac ggtgcccgtg
     5281 tcttatggag gaagggaact aactggcttt gtgacttatc tccgagtctt cagtgtcagc
     5341 tgtcattttg catccatcac ttggctatct gcaggccctt ggggaatacc attccagttt
     5401 agagcactgc tgatcaaatc atgtgaccct tgctggtcac atcctgatct ctctagctca
     5461 tctgaaacag gattaaaatt ttcacacaca cacacactca cacacatatt taacttctag
     5521 aagaactgaa ggaaaaaaac aaactaaaag aaatctaact aaagctgctg tgaactgtga
     5581 ccagtcatgt gtctggatcc aagaatccac ttttaaattt catatatttt tggctgattt
     5641 cctcctctaa gaaaggataa ggccatgata gacccaaggc agaccggtag aattaactct
     5701 cttcctagga tgggagtttc tggtctcatg tggcttcaga tgcaaatttc caaaacgatt
     5761 gtcacaacaa aggagcccat tccctcccaa ccttgtatgg taaaatcctg gagttttcct
     5821 gggaaggtcc actcatgaga tgaaacccat gaaaaggaag tcttatttga aacacatggc
     5881 ttactgaagc acggcaaata aaaaaggctt ccaaagttgg agctggtagg aagggaagtc
     5941 ctgccacatg ctccaagtta aggatgcctg ggtagaaaga gacccccaaa agaggagcta
     6001 tcttctgccc ccaggtctgc ccttctcctt tccacacaaa gccttgtagc ttccagaccc
     6061 tgctcataca tcgttcactc catactggct ccatttacat aagtcttagg acctgtaaaa
     6121 ataactgtta tcattttgct tcagtgtgaa gaggaatctg cctcaggaat taggaaaagc
     6181 aaggaagcgc cccagtaagg aagtcttttt tatcaattag atgagtactt atcaacagcc
     6241 tattgtgtgc tcagtagcac tgaaaacaca atagcccagg aacagactag gaccttgccc
     6301 gaaaggagaa aaacaatgca aattccccaa agcaggaaat gcccagaagc tgaaggggct
     6361 gcaaacacat ggcttataga atcaggaaag agaagacagc attaaagaga cagaaggcat
     6421 ctgagcttcc ctcgggaagc agaaagtaac agcatggaca gcctggaacc ctccaccaaa
     6481 actcagtatg gacaggatac cacaagagaa gagccaccat gtaggaaacg gcttcatggg
     6541 tagccttcgc cttgtcttct atacctatcc tctttcagat gacctcctga tgccaatttg
     6601 tctccctcaa ctcagtccca taaccttact catacacccc agtaggaagt acctatcgca
     6661 ggagaccatc cagaaagaag taggttagag cctagcaaca ggaaattcat atcagccagt
     6721 ctccgttagg ggctaaacct actaagattg gccaaagtga atcagccaac aaactcttct
     6781 gtaacacacc atggcctcag ccaggcacct tacctgttgc taggaatccc aggcactgtg
     6841 aaaacagtct tcaggctttc tctccagcca gagtagttgt catgaggcaa gaatcatctg
     6901 ctatgtggtc agatataagt ctccaacccg ctgcacaggc ttggccaagt cccttcactg
     6961 acctgtgccc tggttttctc atatgtccaa cagtgggaga caatcacatc agctttgcct
     7021 tctccagacc cgtgaggtga gattgggaag ggctagtagg cttacaggag ccctggcgag
     7081 gccagcacat caaaaagcca cccacattca cattctctgg cagaacgtgc ctcaaactag
     7141 tcagcaattc ctgtacacat gcaggccagc aggcagaccg gcaggcagga agaaaggaag
     7201 gaagggagag agggaaggag gaaggcaggc aggcaggcag gcaggcaggc aggctggcca
     7261 ggttacctac tacaagagtt gagcagtttt attcttcaag cttgccttca tactttaagc
     7321 tttgtataga agcacaccac cagcatcttt ggagagactc tggctactga agacccagat
     7381 tctacgctag tgttcagctt ttgagcagca tttcagagcc tagctttcac caatttcttt
     7441 tggggggcgg ctgaatctaa aatatgagtt aagtagaccc taacgggctg gccaactctg
     7501 agtcagatcg tctgacacaa ttctggcacc agctaggctg tctgtggtca gcagtgagtc
     7561 tcagacagta tgaggaagag gtagatggtg tttagcttct tgcaatgaac actgcttccc
     7621 tcacatggct atttgccttc tgagagcaat gtgtatatac tctctctctc tctctctctc
     7681 tctctctctc tctctctctc tctctctctc tctctcttct ctctctctct ctcctccccc
     7741 aacaaagtca gctcctggcc acaggggtcg ccattgagtt gttttcttcc aggatactct
     7801 atctaagagc caagtctatg gcattagctg tgagaagtag ttaccactgt aattcacctc
     7861 aaagtcgaag cataggactc ccccccacac aaacacacat ttctttaggg caattcttaa
     7921 aaaaaaaaaa aaaaaaaaaa aagaggatga atcttttctt ctcatagaaa attggcacca
     7981 agtttcctcc cccaagccag catataacat gaactgagag ctgatgtgag gcatgcagct
     8041 gctccacgct gtcagcacag ggctttctga ccactcagga gcttccctcg gccttctggt
     8101 aactggcatg tcctggtcat gtttgctgct gcttctgctt ctgttttaat gtgttcgctt
     8161 tccatttggc agagagacaa gcgagacacc tccaacttcg acaaagagtt caccaggcag
     8221 cctgtggaac tgactcccac tgacaaactc ttcatcatga acttggacca aaatgagttt
     8281 gctggcttct cgtatactaa cccagagttt gtcattaatg tgtaggtgaa tgcagagtcc
     8341 attgccgagc ctgtgtgtaa ggcttcaggc cgaatgtctg ttaccaattc cagtcttcca
     8401 ggattcatgg tgcctctatt ggcatccgtc atgtggagag cttgtcttag agggcttttc
     8461 tttgtatgtt tagcttgcta gtttgttttc tatatttcaa actgtttagt ttagaataag
     8521 agcattgccc accgatagag gtacactttt ccagacttcc agaaactcat ccaatgaacc
     8581 gacagtgtca aaacttaact gtgtccaata ccaaaatgct tcagtatttg taatttttaa
     8641 agtcagatgc tgatgttcct ggtcaaagtt tttacagtta ctctctacta tctcctttga
     8701 atgctaccta agcatgaccg gtatttttaa aagttgtgag taagctttgc agttcctgtg
     8761 aattcgtgtc tcttggagga aactttttgt ttaagaattg gtatgattaa actgaattca
     8821 tatatgcaaa
//
