LOCUS       NM_011158               3364 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus protein kinase, cAMP dependent regulatory, type II
            beta (Prkar2b), transcript variant 1, mRNA.
ACCESSION   NM_011158 XM_126885
VERSION     NM_011158.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3364)
  AUTHORS   Wang,B., Zhao,M., Su,Z., Jin,B., Yang,X., Zhang,C., Guo,B., Li,J.,
            Hong,W., Liu,J., Zhao,Y., Hou,Y., Lai,F., Zhang,W., Qin,L.,
            Zhang,W., Luo,J. and Zheng,R.
  TITLE     RIIbeta-PKA in GABAergic Neurons of Dorsal Median Hypothalamus
            Governs White Adipose Browning
  JOURNAL   Adv Sci (Weinh) 10 (5), e2205173 (2023)
   PUBMED   36529950
  REMARK    GeneRIF: RIIbeta-PKA in GABAergic Neurons of Dorsal Median
            Hypothalamus Governs White Adipose Browning.
REFERENCE   2  (bases 1 to 3364)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3364)
  AUTHORS   Zhang,J., Zhang,C., Chen,X., Wang,B., Ma,W., Yang,Y., Zheng,R. and
            Huang,Z.
  TITLE     PKA-RIIbeta autophosphorylation modulates PKA activity and seizure
            phenotypes in mice
  JOURNAL   Commun Biol 4 (1), 263 (2021)
   PUBMED   33649504
  REMARK    GeneRIF: PKA-RIIbeta autophosphorylation modulates PKA activity and
            seizure phenotypes in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3364)
  AUTHORS   Yoon,H., Jang,H., Kim,E.Y., Moon,S., Lee,S., Cho,M., Cho,H.J.,
            Ko,J.J., Chang,E.M., Lee,K.A. and Choi,Y.
  TITLE     Knockdown of PRKAR2B Results in the Failure of Oocyte Maturation
  JOURNAL   Cell Physiol Biochem 45 (5), 2009-2020 (2018)
   PUBMED   29518769
  REMARK    GeneRIF: RNAi-mediated Prkar2b suppression resulted in MI-stage
            arrest during oocyte development, and these oocytes exhibited
            abnormal spindle formation and chromosome aggregation.
REFERENCE   5  (bases 1 to 3364)
  AUTHORS   Berthon,A., Faucz,F.R., Espiard,S., Drougat,L., Bertherat,J. and
            Stratakis,C.A.
  TITLE     Age-dependent effects of Armc5 haploinsufficiency on adrenocortical
            function
  JOURNAL   Hum Mol Genet 26 (18), 3495-3507 (2017)
   PUBMED   28911199
REFERENCE   6  (bases 1 to 3364)
  AUTHORS   Greene,R.M., Lloyd,M.R., Uberti,M., Nugent,P. and Pisano,M.M.
  TITLE     Patterns of cyclic AMP-dependent protein kinase gene expression
            during ontogeny of the murine palate
  JOURNAL   J Cell Physiol 163 (3), 431-440 (1995)
   PUBMED   7775586
REFERENCE   7  (bases 1 to 3364)
  AUTHORS   Brandon,E.P., Gerhold,K.A., Qi,M., McKnight,G.S. and Idzerda,R.L.
  TITLE     Derivation of novel embryonic stem cell lines and targeting of
            cyclic AMP-dependent protein kinase genes
  JOURNAL   Recent Prog Horm Res 50, 403-408 (1995)
   PUBMED   7740174
REFERENCE   8  (bases 1 to 3364)
  AUTHORS   Luo,Z., Singh,I.S., Fujihira,T. and Erlichman,J.
  TITLE     Characterization of a minimal promoter element required for
            transcription of the mouse type II beta regulatory subunit (RII
            beta) of cAMP-dependent protein kinase
  JOURNAL   J Biol Chem 267 (34), 24738-24747 (1992)
   PUBMED   1332964
REFERENCE   9  (bases 1 to 3364)
  AUTHORS   Singh,I.S., Luo,Z.J., Eng,A. and Erlichman,J.
  TITLE     Molecular cloning and characterization of the promoter region of
            the mouse regulatory subunit RII beta of type II cAMP-dependent
            protein kinase
  JOURNAL   Biochem Biophys Res Commun 178 (1), 221-226 (1991)
   PUBMED   2069562
REFERENCE   10 (bases 1 to 3364)
  AUTHORS   Cadd,G. and McKnight,G.S.
  TITLE     Distinct patterns of cAMP-dependent protein kinase gene expression
            in mouse brain
  JOURNAL   Neuron 3 (1), 71-79 (1989)
   PUBMED   2619996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135621.1, AK138963.1, CJ238090.1 and CT010463.9.
            
            On Jun 15, 2018 this sequence version replaced NM_011158.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138963.1, AK041013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AK135621.1         5-38
            35-3157             AK138963.1         3-3125
            3158-3356           CJ238090.1         500-698
            3357-3364           CT010463.9         91623-91630         c
FEATURES             Location/Qualifiers
     source          1..3364
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.74 cM"
     gene            1..3364
                     /gene="Prkar2b"
                     /gene_synonym="Pkarb2; PKARIIbeta; RII(beta)"
                     /note="protein kinase, cAMP dependent regulatory, type II
                     beta"
                     /db_xref="GeneID:19088"
                     /db_xref="MGI:MGI:97760"
     exon            1..496
                     /gene="Prkar2b"
                     /gene_synonym="Pkarb2; PKARIIbeta; RII(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            497..532
                     /gene="Prkar2b"
                     /gene_synonym="Pkarb2; PKARIIbeta; RII(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            533..585
                     /gene="Prkar2b"
                     /gene_synonym="Pkarb2; PKARIIbeta; RII(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            586..669
                     /gene="Prkar2b"
                     /gene_synonym="Pkarb2; PKARIIbeta; RII(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            670..776
                     /gene="Prkar2b"
                     /gene_synonym="Pkarb2; PKARIIbeta; RII(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            777..930
                     /gene="Prkar2b"
                     /gene_synonym="Pkarb2; PKARIIbeta; RII(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1032
                     /gene="Prkar2b"
                     /gene_synonym="Pkarb2; PKARIIbeta; RII(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1107
                     /gene="Prkar2b"
                     /gene_synonym="Pkarb2; PKARIIbeta; RII(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1173
                     /gene="Prkar2b"
                     /gene_synonym="Pkarb2; PKARIIbeta; RII(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1312
                     /gene="Prkar2b"
                     /gene_synonym="Pkarb2; PKARIIbeta; RII(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..3364
                     /gene="Prkar2b"
                     /gene_synonym="Pkarb2; PKARIIbeta; RII(beta)"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3354..3359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkar2b"
                     /gene_synonym="Pkarb2; PKARIIbeta; RII(beta)"
                     /note="hexamer: AATAAA"
     polyA_site      3359
                     /gene="Prkar2b"
                     /gene_synonym="Pkarb2; PKARIIbeta; RII(beta)"
                     /note="major polyA site"
ORIGIN      
        1 agatgctgcc aaccctcccc gggctgtgct cgctctgctg ctgccgccgc acggagcagc
       61 ctcgccgggg gcccagtgcg ccgcgctcgc agccggtagc gcccggggcg ctcgctcggg
      121 agccgcgcag cccgagaccg gaccgcggat agggggcgag ggcggcgtcc aggcgcctcg
      181 gcgtgcacgg gcaggatgag catcgagatc cccgcggggc tcacggagct gctgcagggc
      241 ttcacggtgg aggtgctgag gcaccagccc gccgacctgc tggagttcgc gctgcagcac
      301 ttcacgcggc tgcagcagga gaacgagcgc aagggcgccg cgcgcttcgg ccatgagggc
      361 aggacctggg gggacgcggg cgcagccgcc gggggcggca tccccagtaa gggtgtcaac
      421 ttcgccgagg agcccatgcg ctccgactcc gagaacggcg aggaggagga ggccgcggaa
      481 gcaggggcgt tcaacgctcc agttataaac cggttcacaa ggcgtgcctc ggtctgtgca
      541 gaagcttata atcctgatga agaggaagac gatgcagagt ccaggataat acatcccaaa
      601 accgatgatc agagaaacag attgcaagag gcttgcaaag acatcctgct gtttaagaac
      661 ctggatccag agcagatgtc ccaagtttta gatgccatgt ttgaaaaatt ggtcaaagaa
      721 ggggaacacg taattgacca aggtgatgac ggtgacaact tttacgtcat tgacagagga
      781 acatttgata tttatgtaaa atgtgatggc gttggaagat gcgtcggtaa ctatgataac
      841 cgtgggagtt ttggagaact ggccttaatg tacaatacac ccagagcagc tacaatcact
      901 gctacctctc ctggtgctct gtggggtttg gacagggtga ccttcaggag aataattgta
      961 aaaaacaatg ccaaaaagag gaagatgtac gagagcttta tcgagtccct gccgttcctc
     1021 aagtctctag aggtttctga acgcctgaag gtggtggatg tgattggcac caaagtttac
     1081 aatgatggag agcagatcat tgctcaggga gatttggcag actctttctt cattgtagaa
     1141 tctggagaag tgaaaattac tatgaaaaga aagggtaaat cagaagttga agagaacgga
     1201 gctgtggaaa tcgctcggtg ctttcggggc cagtactttg gagagcttgc cctggtcact
     1261 aacaaaccaa gagcagcgtc tgcacacgcc atcgggactg tcaaatgctt agccatggat
     1321 gtgcaagcat ttgaaaggct tttgggacct tgcatggaaa ttatgaagag gaacatcgcc
     1381 acctatgaag aacaattagt tgcgctgttt ggaacaaaca tggatattgt tgagcccact
     1441 gcatgaagca aaagtatggg gaagaagacc attagtgaaa cagttccgta gtagtggtta
     1501 gtccactgag aatgtgtttg tggagatgcc aagcagtttc tgtgattcca ggtttttcct
     1561 tttttaaaca aacaaaaaaa ccatttacaa tatatcagta aacagtagtg atttaatagt
     1621 caataggctt taacatcact ttctaatggg tagttcataa attaacataa tcataaaaat
     1681 gactttctat ttcataaaac tgactgaagg tttattcaaa tggttataat atattgaaag
     1741 catacatgtt taagaagata attaaaagat gtactcatag gccaatctgt atgtttggat
     1801 tattcaagta tcgtattagt gactatgctc ctttaggggg gaagctggca gtggctcatg
     1861 cgctctaacg tggtattcca ttctttttat aattcatcag atggtaaagt gtcaatcatt
     1921 tcattttcta ccttttctgg cttgataact tgtgtgttag ccttggccta ttggtaaaat
     1981 ggtgtgaaaa tcatatgcaa ttttgaaatt ttttatattt ttgcaataaa gtacatttca
     2041 acttctttga caaatgtcag tcagcagcct gtgtaatcga gtggctttgg aggccgggta
     2101 agttagtcat tatggtgatt gggcaaagag tcttttaaga tgaaagatca tcactggcat
     2161 ctttcactat caactctatc ttctcactgc ttaccatttt ttatttagca acctgctgta
     2221 ttctttataa aatgcatttt gacatttaat gtcacaaagg ttgtaatttt tttcaaggca
     2281 atttaatctt aatctgacat ttttttgtcc tctgaaagtc ctgaatctta tatttagaaa
     2341 aaggaaatgt ttcctgtcag tatcaagagg catttgggat tcttaaccac atgcccacaa
     2401 gatatggctt tgctctgtaa ggcccgaggg ccgcagccct gtgcgtgtct gtgcccacag
     2461 tcctctgttc ttccttgtcc tgaacgtcaa ccagcaagct cattgattga tcagtagcca
     2521 atcaagtgtg gttttgtttt ccaaactctc ctacagtggt ggaaataggt ttgtgtataa
     2581 gcaaagccat atatagtgat taatgtaatt tctgtctata ttgcatatca ttcgacctta
     2641 tccctagctt taaagtaaac tcacagtcaa aagtacacta agtacaacag ttcctttggt
     2701 caacagatgc ttatttttat ggcaaatatg atgaattgtt atatacaacc aattgtaaaa
     2761 gcaatatact tttacgattt tcaggcccca tgaccaaatg tttagagaca ttaactctcg
     2821 ccagttattc acgtttaaat gggtaatttc actttgggaa acatgtttgt aaggaacaga
     2881 ggtatctatg tatgttaaat tcatctatgg ctgacatgat cttataagag aatgttcata
     2941 gtcctctttg tacatgaaat cgtggctaga atgttaaatg gataatgtat aaacaagaag
     3001 tatgttatac tgctcactat acctttagct gtgttttgaa atatagtttt gcaaaatctt
     3061 tctgtaggaa aaggagcact ctctacatga aggtcacatg ttttctattt cagagttcag
     3121 aagctctgtg ttaaaggagg aacaattccc aaaacagaaa aacaagaaaa aaagccactc
     3181 agattcctgg ctccccctgt cttctttcct cagtttccca ggttgcattg cagaggctga
     3241 acgttggcgt tcacggaaca ggaaatgaat gcctcggcta tgaatgccag ctctgttctg
     3301 ttcagtattg ttggttatat ttaaattttc cttataataa agcacacttt tataataaac
     3361 gttc
//
