LOCUS       NM_008924               4973 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus protein kinase, cAMP dependent regulatory, type II
            alpha (Prkar2a), mRNA.
ACCESSION   NM_008924
VERSION     NM_008924.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4973)
  AUTHORS   Wei,L., Zhang,R., Zhang,J., Li,J., Kong,D., Wang,Q., Fang,J. and
            Wang,L.
  TITLE     PRKAR2A deficiency protects mice from experimental colitis by
            increasing IFN-stimulated gene expression and modulating the
            intestinal microbiota
  JOURNAL   Mucosal Immunol 14 (6), 1282-1294 (2021)
   PUBMED   34349238
  REMARK    GeneRIF: PRKAR2A deficiency protects mice from experimental colitis
            by increasing IFN-stimulated gene expression and modulating the
            intestinal microbiota.
REFERENCE   2  (bases 1 to 4973)
  AUTHORS   London,E., Wester,J.C., Bloyd,M., Bettencourt,S., McBain,C.J. and
            Stratakis,C.A.
  TITLE     Loss of habenular Prkar2a reduces hedonic eating and increases
            exercise motivation
  JOURNAL   JCI Insight 5 (23), 141670 (2020)
   PUBMED   33141766
  REMARK    GeneRIF: Loss of habenular Prkar2a reduces hedonic eating and
            increases exercise motivation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4973)
  AUTHORS   Isensee,J., Kaufholz,M., Knape,M.J., Hasenauer,J., Hammerich,H.,
            Gonczarowska-Jorge,H., Zahedi,R.P., Schwede,F., Herberg,F.W. and
            Hucho,T.
  TITLE     PKA-RII subunit phosphorylation precedes activation by cAMP and
            regulates activity termination
  JOURNAL   J Cell Biol 217 (6), 2167-2184 (2018)
   PUBMED   29615473
  REMARK    GeneRIF: RII phosphorylation precedes cAMP binding and controls the
            inactivation by modulating the reassociation involving the
            coordinated action of phosphodiesterases and phosphatases.
REFERENCE   4  (bases 1 to 4973)
  AUTHORS   Kong,D., Shen,Y., Liu,G., Zuo,S., Ji,Y., Lu,A., Nakamura,M.,
            Lazarus,M., Stratakis,C.A., Breyer,R.M. and Yu,Y.
  TITLE     PKA regulatory IIalpha subunit is essential for PGD2-mediated
            resolution of inflammation
  JOURNAL   J Exp Med 213 (10), 2209-2226 (2016)
   PUBMED   27621415
  REMARK    GeneRIF: PGD2-DP1 axis-induced M2 polarization facilitates
            resolution of inflammation through the PRKAR2A-mediated suppression
            of JAK2/STAT1 signaling.
REFERENCE   5  (bases 1 to 4973)
  AUTHORS   Zhou,T., Li,J., Zhao,P., Liu,H., Jia,D., Jia,H., He,L., Cang,Y.,
            Boast,S., Chen,Y.H., Thibault,H., Scherrer-Crosbie,M., Goff,S.P.
            and Li,B.
  TITLE     Palmitoyl acyltransferase Aph2 in cardiac function and the
            development of cardiomyopathy
  JOURNAL   Proc Natl Acad Sci U S A 112 (51), 15666-15671 (2015)
   PUBMED   26644582
REFERENCE   6  (bases 1 to 4973)
  AUTHORS   Imaizumi-Scherrer,T., Faust,D.M., Benichou,J.C., Hellio,R. and
            Weiss,M.C.
  TITLE     Accumulation in fetal muscle and localization to the neuromuscular
            junction of cAMP-dependent protein kinase A regulatory and
            catalytic subunits RI alpha and C alpha
  JOURNAL   J Cell Biol 134 (5), 1241-1254 (1996)
   PUBMED   8794865
REFERENCE   7  (bases 1 to 4973)
  AUTHORS   Greene,R.M., Lloyd,M.R., Uberti,M., Nugent,P. and Pisano,M.M.
  TITLE     Patterns of cyclic AMP-dependent protein kinase gene expression
            during ontogeny of the murine palate
  JOURNAL   J Cell Physiol 163 (3), 431-440 (1995)
   PUBMED   7775586
REFERENCE   8  (bases 1 to 4973)
  AUTHORS   Cadd,G. and McKnight,G.S.
  TITLE     Distinct patterns of cAMP-dependent protein kinase gene expression
            in mouse brain
  JOURNAL   Neuron 3 (1), 71-79 (1989)
   PUBMED   2619996
REFERENCE   9  (bases 1 to 4973)
  AUTHORS   Oyen,O., Myklebust,F., Scott,J.D., Hansson,V. and Jahnsen,T.
  TITLE     Human testis cDNA for the regulatory subunit RII alpha of
            cAMP-dependent protein kinase encodes an alternate amino-terminal
            region
  JOURNAL   FEBS Lett 246 (1-2), 57-64 (1989)
   PUBMED   2540040
REFERENCE   10 (bases 1 to 4973)
  AUTHORS   Scott,J.D., Glaccum,M.B., Zoller,M.J., Uhler,M.D., Helfman,D.M.,
            McKnight,G.S. and Krebs,E.G.
  TITLE     The molecular cloning of a type II regulatory subunit of the
            cAMP-dependent protein kinase from rat skeletal muscle and mouse
            brain
  JOURNAL   Proc Natl Acad Sci U S A 84 (15), 5192-5196 (1987)
   PUBMED   3037538
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT571271.12 and AC173341.1.
            
            On Feb 20, 2019 this sequence version replaced NM_008924.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF533977.1, BC080276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-570               CT571271.12        120359-120928
            571-606             CT571271.12        142489-142524
            607-659             CT571271.12        145079-145131
            660-743             CT571271.12        147419-147502
            744-850             CT571271.12        156390-156496
            851-1004            CT571271.12        161326-161479
            1005-1106           CT571271.12        168651-168752
            1107-1181           CT571271.12        168904-168978
            1182-1247           CT571271.12        172446-172511
            1248-1389           CT571271.12        173698-173839
            1390-2616           CT571271.12        175077-176303
            2617-4973           AC173341.1         112521-114877
FEATURES             Location/Qualifiers
     source          1..4973
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.63 cM"
     gene            1..4973
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /note="protein kinase, cAMP dependent regulatory, type II
                     alpha"
                     /db_xref="GeneID:19087"
                     /db_xref="MGI:MGI:108025"
     exon            1..570
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..1523
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase type II-alpha
                     regulatory subunit"
                     /protein_id="NP_032950.1"
                     /db_xref="CCDS:CCDS23536.1"
                     /db_xref="GeneID:19087"
                     /db_xref="MGI:MGI:108025"
                     /translation="MSHIQIPAGLTELLQGYTVEVLRQQPPDLVDFAVEYFTRLREAR
                     RQESDTFIVSPTTFHTQESSAVPVIEEDGESDSDSEDADLEVPVPSKFTRRVSVCAET
                     FNPDEEEEDNDPRVVHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFEKIVKT
                     DEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAAT
                     IIATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLFKSLEMSERMKIVDVIG
                     EKIYKDGERIIAQGEKADSFYIIESGEVSILIRSKTKSNKNGGNQEVEIAHCHKGQYF
                     GELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFG
                     SNLDLMDPGQ"
     exon            571..606
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /inference="alignment:Splign:2.1.0"
     exon            607..659
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /inference="alignment:Splign:2.1.0"
     exon            660..743
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /inference="alignment:Splign:2.1.0"
     exon            744..850
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1004
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1106
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1181
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1247
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1389
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..4973
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4941..4946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /note="hexamer: AATAAA"
     polyA_site      4971
                     /gene="Prkar2a"
                     /gene_synonym="1110061A24Rik; RII(alpha)"
                     /note="major polyA site"
ORIGIN      
        1 acaacccggg cgcctgccgc gcccgtccag cttgcctgcc cggcggtccc cgcggcggcg
       61 gcggcgcggc ggcggcagcg gcggcggctg cggccgggtg acaacagcag cggcgccagg
      121 ctggcttgct agcggaaggg tcgcgcggcc cgcacaacaa actcagaccc ggccagaata
      181 aggcgcgacg cgaggaaggc cgagacgggc cgcgcgggag accgcgggcg cggagtgaca
      241 ggccggcgtg agggagcgcg caggttgcag ccgccggccg cccggacccg ccgggcccct
      301 cggacgtcgc aggcatgagc cacatccaga tccccgcggg gctcacggag ctgctgcagg
      361 gctacaccgt ggaggtgctt cggcagcagc cgcccgacct cgtcgacttc gcggtggagt
      421 acttcacacg cctgcgcgag gcccgccgcc aggaatcaga cacgttcatc gtctccccga
      481 cgacctttca cacgcaggag tccagcgcag tccccgtcat cgaggaggac ggggagagtg
      541 actcggactc ggaagatgcc gatctggaag ttccggttcc tagcaaattt actagacgag
      601 tatcagtctg tgcagaaacg tttaaccctg atgaagaaga ggaggataac gatccaaggg
      661 tggttcatcc caaaactgat gagcagagat gccggcttca ggaagcttgt aaagatattc
      721 ttcttttcaa aaaccttgat caggaacagc tttctcaagt tctggatgcc atgtttgaaa
      781 agattgtcaa aactgacgag catgtcattg accaaggcga cgacggggac aacttttatg
      841 tcatagaacg gggaacctat gacattttag taacgaaaga taatcaaaca cgttctgttg
      901 gtcagtatga caaccgtggc agttttggag aactagctct gatgtacaat accccgagag
      961 ctgctaccat catcgccacc tcagaaggct ccctttgggg attggaccgg gtgactttta
     1021 gaagaatcat agtgaaaaac aatgcaaaga agaggaagat gtttgaatca tttattgagt
     1081 ctgttccact ctttaagtca ctagagatgt cagaacgaat gaagattgtg gatgtgatcg
     1141 gggaaaagat ctataaggac ggagagcgaa taatcgcaca gggtgaaaag gccgacagct
     1201 tctatatcat agagtctggg gaagtgagca tcttgattag aagcaagacc aagtcaaaca
     1261 agaatggagg gaaccaggag gtcgagattg cccattgcca taaggggcag tacttcggag
     1321 aacttgccct ggtcaccaac aaacccagag ctgcttccgc ttacgcggtt ggagatgtca
     1381 aatgcttagt tatggatgtt caagcatttg agaggcttct gggcccctgc atggacatca
     1441 tgaagaggaa catctcacat tacgaagaac agctggtgaa gatgtttggc tccaacttgg
     1501 atctgatgga ccccgggcag tagatgtgat gaatcttgga gccttctcag tgtgatacca
     1561 aaaccttcca gtcagccaca agaacacaca cagaaaacag acacgacaga accgctcctg
     1621 ctgctgtctc cgccgctgcc attgctgtgg ttaagggcat ttagaaatct tgaaagtcag
     1681 cactgaaaga tggatggagg ttccacccac acccaccctc cactttgctt ctgaacgccg
     1741 tcattagacc acttatgtca tgagtactcc aacccaggtt tcacatttgg ttcagaatgt
     1801 ctctccagca atttaagtgc ctgattcaaa gtccaaagcg taacaccctc ctttcctctc
     1861 ttgctgctaa cgttgcttct gaaagttcta aggtctgcag acacctgttg agtagctgta
     1921 gacagcacct ccgcagtcct tctcgaggga gaaaatggta gagccttccg tctcgtttgt
     1981 cttttagaaa gtccacagtg tgttcacaat gctgctttac tctcacagtg gaaggtggta
     2041 gcagttatac tggaggtctc tgccccagag gctctgtacc atttgctggc agctacacac
     2101 tttacagctg tgtctaaact cagaaagagg cccagcagat ccgtatgggc agattgagta
     2161 ctaagactca cgttagcagg aaacttggat tcaacactct ttccagtagt agccaggaaa
     2221 ggttatctgg gttagggttt ttgttgtttg tatttagtag gtttttgttt tgttttgttt
     2281 tgtttaacct ctgtgctgtt tacataaaca aattgctatc cttttctaag gagccagggg
     2341 tggctggtta gctcagctgg tcagggcatg gtgctgatat gaggagccag ggtctggagg
     2401 tgttgtcact ttatctgacc tgagtacttc cctgagtgag ccctgcctgt ccctttcact
     2461 ggctgatagc gggaagccag caggaggctg tgctgcacag agaactcctt cccttctagc
     2521 gttactgcat agcgtgccta gaaatcatca gtttttaaac tcttaacaaa gaagctattt
     2581 ttttttaagg aaattatttc tctatttaga gaattcacct tggatgtatt catatacatg
     2641 gagtttgtcc actgactcag gcatttgtcc taaatatccg ttttcaaaac taggtatcat
     2701 tgggggtagg ggctgggtgc agctcggtga caaagcacac ggggcacgtg caaggctctg
     2761 ggtttggtct ccagcactgt aacagccaca ggaagacaag ttatcatgta gaaatgtgga
     2821 attactgtga aggcctttct aagtaacagt ctcgactttt gccatggtca ccatagccaa
     2881 gaaatgtcca aagcaggtga gttgccacaa ttttggtaat tagtcacttt ttcttgtgtt
     2941 ccatgaggta aaagcaggac tctccaggct gatctgagta gcctacgtta cagatctggg
     3001 aattgtacag tcgtaactac tactatgaag caggcagcta gcactggaaa accctcaaag
     3061 tgatcccgaa ttttcctaag gtccttttct atggtattgc tttattaaat aaatcaggcc
     3121 ttgtactttg acagaataac acctgatttc ttgcaaaggt aagaggtgca ttgggctcca
     3181 ggagtagccc agaagtccaa ccccagacct tataaagact ctgaaccctc ccccaccctc
     3241 catgccagcg ttggataagg ctggctgtga ctctcctgcc agagttattc ctgtaggctg
     3301 ctagggtagg ccttcgcctg ccctcgccct tcccgggcta ggcttcagag tcctccttgt
     3361 cacccttcct gcctcactga cagctgctct tttacagaga aggcatcaag tccaagttct
     3421 gctgtagcca ctgattgagt cttcgctgca gtgtggccct gtgttggggc acgtgtgacg
     3481 gggtcatggg agaggtacac ggagtctgcg ggagctccgg tggtggtgaa agatggctgt
     3541 caccacagtg ccaggccctg acagtattcc aggtctctct gcagcttaga gaatcagagg
     3601 tgacagacca ggtttttctc acggttgcag ggtccccatt gtggcaggca actcccacag
     3661 cagatggctg ggccctagga ggagtatcag aaagattcct taggtagctc ctctcttctg
     3721 agggtgcgcc tttccctccc tcctccctgg ctttgctatt gatttgaaat gacagagaat
     3781 gttcctcaga gccgtgaggt ccagctgcag tatttctctt cctttctgcc ccagcttagc
     3841 ccactcactg tcttctcttg gttgaattct ctgcaggaca ggctcttttg ttctcatcct
     3901 caggctcata gtcttcttaa agaattatat gttcctggta tagagtctca gaaatcagca
     3961 ttgagctttt ctttgagcag tttagtaagc aaattcagca gcaaagtggc aaaagaaaaa
     4021 agaaaaaaag aaagaaagaa agaaagaaaa agaaagccct gcactccagc cggaggggcc
     4081 tcatgcaccc tgactgccca gattctctgc ttgtggtggc ggagccgcta tgtgctgctg
     4141 ctggtgtccc agcgccctgt gcacacagca ttttatggcg tgtcacagtc ttcattttaa
     4201 aaagatgaaa gcattttgca cagagaaaga aaagacccat gaatgtcatc ttttatcttt
     4261 ctcaaatcag ttgataatgg aatttttgtt tttgataatg cacttgtaag ccagtctccc
     4321 cacgatctgg gtagttttta tctctcacta cagttacctc ttgtctctcc tgtcttgact
     4381 gctgacgttc tccgtgattc tgatgtctgt gctatgggga gcagccttcc cgtgggattc
     4441 ctagtacact ctgcagggct atctttataa aaaaaaaaaa cattaaaaaa aaaaaaagag
     4501 tgaaaattgt cgctcacctc atgggggatt tgcagaaaac catttagccc accttgaaca
     4561 aagattagat tccttgtttt tttgttgctt tgtttttaac tcattgtaat aatttaaaaa
     4621 aaaacccaat taagaattat tgtgctacct caaaggtaaa atgattctaa ggtcctgagt
     4681 tatattcatg gtgtttgaaa tgtctctcaa ttggaattat gttttaaatc attggggtaa
     4741 atcttatttt aacctgtttt acacttgtat tttaatctca aaagaatata tgattggaaa
     4801 gcaaacaatt cttgatctgt agccttgaac atataattaa aagtcactag aagttaatca
     4861 tagtttgctg taaacaaggt tgggttgttt ttttgtttgt tttttaaagg aaactctagg
     4921 gcccggcttc actcttgact aataaaggct gacaaatcat gtctgacttt cct
//
