LOCUS       NM_008923               2632 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus protein kinase, cAMP dependent regulatory, type I beta
            (Prkar1b), transcript variant 1, mRNA.
ACCESSION   NM_008923
VERSION     NM_008923.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2632)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2632)
  AUTHORS   Mathieu,M., Drelon,C., Rodriguez,S., Tabbal,H., Septier,A.,
            Damon-Soubeyrand,C., Dumontet,T., Berthon,A., Sahut-Barnola,I.,
            Djari,C., Batisse-Lignier,M., Pointud,J.C., Richard,D.,
            Kerdivel,G., Calmejane,M.A., Boeva,V., Tauveron,I.,
            Lefrancois-Martinez,A.M., Martinez,A. and Val,P.
  TITLE     Steroidogenic differentiation and PKA signaling are programmed by
            histone methyltransferase EZH2 in the adrenal cortex
  JOURNAL   Proc Natl Acad Sci U S A 115 (52), E12265-E12274 (2018)
   PUBMED   30541888
  REMARK    GeneRIF: EZH2 ensures normal cortical differentiation by repression
            of phosphodiesterases PDE1B, 3A, and 7A and of PRKAR1B.
REFERENCE   3  (bases 1 to 2632)
  AUTHORS   Berthon,A., Faucz,F.R., Espiard,S., Drougat,L., Bertherat,J. and
            Stratakis,C.A.
  TITLE     Age-dependent effects of Armc5 haploinsufficiency on adrenocortical
            function
  JOURNAL   Hum Mol Genet 26 (18), 3495-3507 (2017)
   PUBMED   28911199
REFERENCE   4  (bases 1 to 2632)
  AUTHORS   Zhou,T., Li,J., Zhao,P., Liu,H., Jia,D., Jia,H., He,L., Cang,Y.,
            Boast,S., Chen,Y.H., Thibault,H., Scherrer-Crosbie,M., Goff,S.P.
            and Li,B.
  TITLE     Palmitoyl acyltransferase Aph2 in cardiac function and the
            development of cardiomyopathy
  JOURNAL   Proc Natl Acad Sci U S A 112 (51), 15666-15671 (2015)
   PUBMED   26644582
REFERENCE   5  (bases 1 to 2632)
  AUTHORS   Neidhardt,L.M., Kispert,A. and Herrmann,B.G.
  TITLE     A mouse gene of the paired-related homeobox class expressed in the
            caudal somite compartment and in the developing vertebral column,
            kidney and nervous system
  JOURNAL   Dev Genes Evol 207 (5), 330-339 (1997)
   PUBMED   27747430
REFERENCE   6  (bases 1 to 2632)
  AUTHORS   Brandon,E.P., Zhuo,M., Huang,Y.Y., Qi,M., Gerhold,K.A.,
            Burton,K.A., Kandel,E.R., McKnight,G.S. and Idzerda,R.L.
  TITLE     Hippocampal long-term depression and depotentiation are defective
            in mice carrying a targeted disruption of the gene encoding the RI
            beta subunit of cAMP-dependent protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8851-8855 (1995)
   PUBMED   7568030
REFERENCE   7  (bases 1 to 2632)
  AUTHORS   Rogers,K.V., Boring,L.F., McKnight,G.S. and Clegg,C.H.
  TITLE     Promoter for the regulatory type I beta subunit of the 3',5'-cyclic
            adenosine monophosphate-dependent protein kinase directs transgene
            expression in the central nervous system
  JOURNAL   Mol Endocrinol 6 (10), 1756-1765 (1992)
   PUBMED   1448119
REFERENCE   8  (bases 1 to 2632)
  AUTHORS   Solberg,R., Tasken,K., Keiserud,A. and Jahnsen,T.
  TITLE     Molecular cloning, cDNA structure and tissue-specific expression of
            the human regulatory subunit RI beta of cAMP-dependent protein
            kinases
  JOURNAL   Biochem Biophys Res Commun 176 (1), 166-172 (1991)
   PUBMED   1708242
REFERENCE   9  (bases 1 to 2632)
  AUTHORS   Cadd,G. and McKnight,G.S.
  TITLE     Distinct patterns of cAMP-dependent protein kinase gene expression
            in mouse brain
  JOURNAL   Neuron 3 (1), 71-79 (1989)
   PUBMED   2619996
REFERENCE   10 (bases 1 to 2632)
  AUTHORS   Clegg,C.H., Cadd,G.G. and McKnight,G.S.
  TITLE     Genetic characterization of a brain-specific form of the type I
            regulatory subunit of cAMP-dependent protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 85 (11), 3703-3707 (1988)
   PUBMED   3375237
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY237508.1, AK161621.1, CO425808.1, AK158994.1, CD775616.1 and
            BB429442.1.
            
            On Jul 24, 2009 this sequence version replaced NM_008923.2.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. Variants 1-6 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011424.1, AK161621.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                BY237508.1         2-71
            71-642              AK161621.1         2-573
            643-1331            CO425808.1         56-744
            1332-1960           AK158994.1         1331-1959
            1961-2616           CD775616.1         17-672              c
            2617-2632           BB429442.1         204-219
FEATURES             Location/Qualifiers
     source          1..2632
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 77.74 cM"
     gene            1..2632
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /note="protein kinase, cAMP dependent regulatory, type I
                     beta"
                     /db_xref="GeneID:19085"
                     /db_xref="MGI:MGI:97759"
     exon            1..109
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            110..308
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1277
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1;
                     cAMP-dependent protein kinase type I-beta regulatory
                     subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase type I-beta
                     regulatory subunit isoform a"
                     /protein_id="NP_032949.3"
                     /db_xref="CCDS:CCDS19803.1"
                     /db_xref="GeneID:19085"
                     /db_xref="MGI:MGI:97759"
                     /translation="MASPSCFHSEDEDSLKGCEMYVQKHGIQQVLKECIVHLCVAKPD
                     RPLRFLREHFEKLEKEENRQILARQKSNSQCDSHDEEISPTPPNPVVKARRRRGGVSA
                     EVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFSHLDDNERSDIFDAMFPVTHIG
                     GETVIQQGNEGDNFYVIDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAK
                     TDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQF
                     EDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRP
                     RAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNSFISLTV"
     exon            309..479
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            480..571
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            572..633
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            634..680
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            681..839
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            840..900
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1022
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1104
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..2632
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2600..2605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /note="hexamer: ATTAAA"
     regulatory      2611..2616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /note="hexamer: AATGAA"
     polyA_site      2619
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /note="major polyA site"
     polyA_site      2630
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
ORIGIN      
        1 gggggcgggc ggagggcggc gccgctgcag tgcggggacc cgctcgccgt ccccgcgtcc
       61 ccgcgtcctc gcgcagcctc ctccggcctc gggcaccgcg catctacagg agcatagaag
      121 acattctgac catggcctcc ccatcatgct tccactcgga ggatgaggac tctctgaaag
      181 gatgcgagat gtacgtgcag aaacatggca tccagcaggt gctcaaagaa tgcattgtgc
      241 acctctgtgt cgccaagccg gaccggccac tgcgattcct ccgggagcac tttgagaagt
      301 tggagaagga ggaaaacagg cagatcctgg ctcggcagaa gtcaaactcc cagtgtgatt
      361 cccacgatga ggagatctcc ccaacacctc caaaccccgt ggtcaaggcg cgtcgccggc
      421 ggggcggtgt gagtgctgaa gtctacactg aagaagatgc tgtctcctac gtgaggaagg
      481 tcattcccaa ggactataag accatgaccg cgctggccaa ggccatttct aagaacgtgc
      541 tcttttctca cctggacgac aacgagagaa gtgacatatt tgacgccatg tttcctgtca
      601 ctcacatcgg tggggaaaca gtcatacagc aagggaatga aggagataat ttctatgtga
      661 ttgaccaagg agaagtagat gtatatgtga acggggaatg ggtgaccaac atcagtgagg
      721 ggggaagctt cggggagctg gctctcatct acggcacccc cagagcggct accgtgaagg
      781 ccaagacgga cctcaagctc tggggtatcg accgtgacag ctacaggcgc atcctcatgg
      841 gaagcacact gaggaaacgc aagatgtatg aggagttcct cagcaaagtc tccatcctag
      901 aatccctgga gaagtgggaa cgcctgactg tagctgatgc cctggagcct gtgcagtttg
      961 aagatggaga gaaaattgtt gtgcaggggg agcctggaga tgacttctac atcatcacag
     1021 agggcactgc ttcagtcctc cagcgacgat cccccaatga ggagtacgtg gaagtggggc
     1081 gccttggacc ctctgactac tttggggaga ttgccctgct gctgaatcgg ccccgtgcag
     1141 ccactgtggt ggcccggggt cccctcaagt gtgtgaagtt agaccggcct cgttttgagc
     1201 gtgtcctggg cccctgctct gagatcctga agaggaacat ccagcgttac aacagcttca
     1261 tctccctaac tgtctgagct tgtgttgcgc ctgcacccct gggggcctcc ccatgtggcc
     1321 ctgtgaccca tttcctatgc cagaggcctg ggagctgctg gttagtagct gagtgcggct
     1381 ggtgcccggc ccggagccta ccctttctct ggactcactt ttggaataaa taaccatctt
     1441 gtgcttcttc aaaaacaaag ggcaagaggc aactgagtcc ccagaccagg gcagtgacag
     1501 ctggctcccc ctgcagcctt atcttggggc caccttatcc cctctccaag tcttctggga
     1561 attcttgtct gatccccata cttgaactgg ccctgtgtcc tgccaggtct caagagtggg
     1621 gctgtggcca cccttgtagc tttcccccag agctgggagt taatcagaac actgtccctg
     1681 gttcttgtaa gattctctgg tctaggccca agtgtaaaac agattgtgac aaatggagat
     1741 gtcctcaaat gagcactcaa gctgagagaa gaaacagagg ttgaaaggca ttcttggtcc
     1801 ctgcgcactg tccccaactc tcagaaggac ccctgaagga cccaaattga tcctagcctc
     1861 ctatccagag actaagctat ggccccagaa agtcaggagg tggtggctga gccctctcta
     1921 ctctcacagc gcttgggaag tccatttccg ggtaggccag gcaccctgac ctcatgtcag
     1981 gacagttggc caagcccgtg accccttact ggctggacgc ccagattggg caggaagtgt
     2041 ggctgacggc ggggctttcc aaacgtggtg agtctgggct gagtccccat ctcctggaga
     2101 ccaggagcca tgactctgtc aacctgccta ttggagaccc caaggaacag caagcaactc
     2161 caacttgcta gttaaagttg tagttttgag ccttcccaga ctctctctgt aaagcccgaa
     2221 tccctgtccc ttgacttcca aacacctctc acccgagtct ctctgttccc ttacaagagg
     2281 ggataatgta ctgaaaccag gcttgacccc acatccctaa accatccacc gtggagtgtg
     2341 atatgagcca gccagaccca agggccacat gagtgtccac aactgcttag tgtcccctgg
     2401 gtgaccggca tgtcatgaga cagtgtgatc aaccttttct tgccccgctg tgcacgtcta
     2461 ggtgaccctt ccagctgacc atcagctccc cgctgtgtgg ccctggccat gtgtgtcgtg
     2521 cctgcactgt ggactatctg tggattctgt ggccctgctt ctccatcccc tatttatgtc
     2581 accaagcgct gcatgaacta ttaaatgtgc aatgaagaac cctttcccaa cc
//
