LOCUS       NM_001253890            2633 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus protein kinase, cAMP dependent regulatory, type I beta
            (Prkar1b), transcript variant 2, mRNA.
ACCESSION   NM_001253890
VERSION     NM_001253890.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2633)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2633)
  AUTHORS   Mathieu,M., Drelon,C., Rodriguez,S., Tabbal,H., Septier,A.,
            Damon-Soubeyrand,C., Dumontet,T., Berthon,A., Sahut-Barnola,I.,
            Djari,C., Batisse-Lignier,M., Pointud,J.C., Richard,D.,
            Kerdivel,G., Calmejane,M.A., Boeva,V., Tauveron,I.,
            Lefrancois-Martinez,A.M., Martinez,A. and Val,P.
  TITLE     Steroidogenic differentiation and PKA signaling are programmed by
            histone methyltransferase EZH2 in the adrenal cortex
  JOURNAL   Proc Natl Acad Sci U S A 115 (52), E12265-E12274 (2018)
   PUBMED   30541888
  REMARK    GeneRIF: EZH2 ensures normal cortical differentiation by repression
            of phosphodiesterases PDE1B, 3A, and 7A and of PRKAR1B.
REFERENCE   3  (bases 1 to 2633)
  AUTHORS   Berthon,A., Faucz,F.R., Espiard,S., Drougat,L., Bertherat,J. and
            Stratakis,C.A.
  TITLE     Age-dependent effects of Armc5 haploinsufficiency on adrenocortical
            function
  JOURNAL   Hum Mol Genet 26 (18), 3495-3507 (2017)
   PUBMED   28911199
REFERENCE   4  (bases 1 to 2633)
  AUTHORS   Zhou,T., Li,J., Zhao,P., Liu,H., Jia,D., Jia,H., He,L., Cang,Y.,
            Boast,S., Chen,Y.H., Thibault,H., Scherrer-Crosbie,M., Goff,S.P.
            and Li,B.
  TITLE     Palmitoyl acyltransferase Aph2 in cardiac function and the
            development of cardiomyopathy
  JOURNAL   Proc Natl Acad Sci U S A 112 (51), 15666-15671 (2015)
   PUBMED   26644582
REFERENCE   5  (bases 1 to 2633)
  AUTHORS   Neidhardt,L.M., Kispert,A. and Herrmann,B.G.
  TITLE     A mouse gene of the paired-related homeobox class expressed in the
            caudal somite compartment and in the developing vertebral column,
            kidney and nervous system
  JOURNAL   Dev Genes Evol 207 (5), 330-339 (1997)
   PUBMED   27747430
REFERENCE   6  (bases 1 to 2633)
  AUTHORS   Brandon,E.P., Zhuo,M., Huang,Y.Y., Qi,M., Gerhold,K.A.,
            Burton,K.A., Kandel,E.R., McKnight,G.S. and Idzerda,R.L.
  TITLE     Hippocampal long-term depression and depotentiation are defective
            in mice carrying a targeted disruption of the gene encoding the RI
            beta subunit of cAMP-dependent protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8851-8855 (1995)
   PUBMED   7568030
REFERENCE   7  (bases 1 to 2633)
  AUTHORS   Rogers,K.V., Boring,L.F., McKnight,G.S. and Clegg,C.H.
  TITLE     Promoter for the regulatory type I beta subunit of the 3',5'-cyclic
            adenosine monophosphate-dependent protein kinase directs transgene
            expression in the central nervous system
  JOURNAL   Mol Endocrinol 6 (10), 1756-1765 (1992)
   PUBMED   1448119
REFERENCE   8  (bases 1 to 2633)
  AUTHORS   Solberg,R., Tasken,K., Keiserud,A. and Jahnsen,T.
  TITLE     Molecular cloning, cDNA structure and tissue-specific expression of
            the human regulatory subunit RI beta of cAMP-dependent protein
            kinases
  JOURNAL   Biochem Biophys Res Commun 176 (1), 166-172 (1991)
   PUBMED   1708242
REFERENCE   9  (bases 1 to 2633)
  AUTHORS   Cadd,G. and McKnight,G.S.
  TITLE     Distinct patterns of cAMP-dependent protein kinase gene expression
            in mouse brain
  JOURNAL   Neuron 3 (1), 71-79 (1989)
   PUBMED   2619996
REFERENCE   10 (bases 1 to 2633)
  AUTHORS   Clegg,C.H., Cadd,G.G. and McKnight,G.S.
  TITLE     Genetic characterization of a brain-specific form of the type I
            regulatory subunit of cAMP-dependent protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 85 (11), 3703-3707 (1988)
   PUBMED   3375237
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158994.1, AK161621.1, CK332907.1, BU560122.1, BU844021.1 and
            CJ290554.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 3. Variants 1-6 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-839               AK158994.1         2-840
            840-1033            AK161621.1         773-966
            1034-1286           AK158994.1         1035-1287
            1287-1637           CK332907.1         185-535
            1638-2140           BU560122.1         122-624
            2141-2614           BU844021.1         70-543
            2615-2633           CJ290554.1         400-418
FEATURES             Location/Qualifiers
     source          1..2633
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 77.74 cM"
     gene            1..2633
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /note="protein kinase, cAMP dependent regulatory, type I
                     beta"
                     /db_xref="GeneID:19085"
                     /db_xref="MGI:MGI:97759"
     exon            1..107
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            108..306
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1275
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 2;
                     cAMP-dependent protein kinase type I-beta regulatory
                     subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase type I-beta
                     regulatory subunit isoform a"
                     /protein_id="NP_001240819.1"
                     /db_xref="CCDS:CCDS19803.1"
                     /db_xref="GeneID:19085"
                     /db_xref="MGI:MGI:97759"
                     /translation="MASPSCFHSEDEDSLKGCEMYVQKHGIQQVLKECIVHLCVAKPD
                     RPLRFLREHFEKLEKEENRQILARQKSNSQCDSHDEEISPTPPNPVVKARRRRGGVSA
                     EVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFSHLDDNERSDIFDAMFPVTHIG
                     GETVIQQGNEGDNFYVIDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAK
                     TDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQF
                     EDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRP
                     RAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNSFISLTV"
     exon            307..477
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            478..569
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            570..631
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            632..678
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            679..837
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            838..898
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1020
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1102
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..2630
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2598..2603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /note="hexamer: ATTAAA"
     regulatory      2609..2614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /note="hexamer: AATGAA"
     polyA_site      2617
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
                     /note="major polyA site"
     polyA_site      2628
                     /gene="Prkar1b"
                     /gene_synonym="RIbeta"
ORIGIN      
        1 ggaggaacaa attcagggag ctggtcagtg tagatagacg agtggggagc tggtgaatgg
       61 aagaacagat tggggaacag ggtgtgagca caggtgagtc aggacaggag catagaagac
      121 attctgacca tggcctcccc atcatgcttc cactcggagg atgaggactc tctgaaagga
      181 tgcgagatgt acgtgcagaa acatggcatc cagcaggtgc tcaaagaatg cattgtgcac
      241 ctctgtgtcg ccaagccgga ccggccactg cgattcctcc gggagcactt tgagaagttg
      301 gagaaggagg aaaacaggca gatcctggct cggcagaagt caaactccca gtgtgattcc
      361 cacgatgagg agatctcccc aacacctcca aaccccgtgg tcaaggcgcg tcgccggcgg
      421 ggcggtgtga gtgctgaagt ctacactgaa gaagatgctg tctcctacgt gaggaaggtc
      481 attcccaagg actataagac catgaccgcg ctggccaagg ccatttctaa gaacgtgctc
      541 ttttctcacc tggacgacaa cgagagaagt gacatatttg acgccatgtt tcctgtcact
      601 cacatcggtg gggaaacagt catacagcaa gggaatgaag gagataattt ctatgtgatt
      661 gaccaaggag aagtagatgt atatgtgaac ggggaatggg tgaccaacat cagtgagggg
      721 ggaagcttcg gggagctggc tctcatctac ggcaccccca gagcggctac cgtgaaggcc
      781 aagacggacc tcaagctctg gggtatcgac cgtgacagct acaggcgcat cctcatggga
      841 agcacactga ggaaacgcaa gatgtatgag gagttcctca gcaaagtctc catcctagaa
      901 tccctggaga agtgggaacg cctgactgta gctgatgccc tggagcctgt gcagtttgaa
      961 gatggagaga aaattgttgt gcagggggag cctggagatg acttctacat catcacagag
     1021 ggcactgctt cagtcctcca gcgacgatcc cccaatgagg agtacgtgga agtggggcgc
     1081 cttggaccct ctgactactt tggggagatt gccctgctgc tgaatcggcc ccgtgcagcc
     1141 actgtggtgg cccggggtcc cctcaagtgt gtgaagttag accggcctcg ttttgagcgt
     1201 gtcctgggcc cctgctctga gatcctgaag aggaacatcc agcgttacaa cagcttcatc
     1261 tccctaactg tctgagcttg tgttgcgcct gcacccctgg gggcctcccc atgtggccct
     1321 gtgacccatt tcctatgcca gaggcctggg agctgctggt tagtagctga gtgcggctgg
     1381 tgcccggccc ggagcctacc ctttctctgg actcactttt ggaataaata accatcttgt
     1441 gcttcttcaa aaacaaaggg caagaggcaa ctgagtcccc agaccagggc agtgacagct
     1501 ggctccccct gcagccttat cttggggcca ccttatcccc tctccaagtc ttctgggaat
     1561 tcttgtctga tccccatact tgaactggcc ctgtgtcctg ccaggtctca agagtggggc
     1621 tgtggccacc cttgtagctt tcccccagag ctgggagtta atcagaacac tgtccctggt
     1681 tcttgtaaga ttctctggtc taggcccaag tgtaaaacag attgtgacaa atggagatgt
     1741 cctcaaatga gcactcaagc tgagagaaga aacagaggtt gaaaggcatt cttggtccct
     1801 gcgcactgtc cccaactctc agaaggaccc ctgaaggacc caaattgatc ctagcctcct
     1861 atccagagac taagctatgg ccccagaaag tcaggaggtg gtggctgagc cctctctact
     1921 ctcacagcgc ttgggaagtc catttccggg taggccaggc accctgacct catgtcagga
     1981 cagttggcca agcccgtgac cccttactgg ctggacgccc agattgggca ggaagtgtgg
     2041 ctgacggcgg ggctttccaa acgtggtgag tctgggctga gtccccatct cctggagacc
     2101 aggagccatg actctgtcaa cctgcctatt ggagacccca aggaacagca agcaactcca
     2161 acttgctagt taaagttgta gttttgagcc ttcccagact ctctctgtaa agcccgaatc
     2221 cctgtccctt gacttccaaa cacctctcac ccgagtctct ctgttccctt acaagagggg
     2281 ataatgtact gaaaccaggc ttgaccccac atccctaaac catccaccgt ggagtgtgat
     2341 atgagccagc cagacccaag ggccacatga gtgtccacaa ctgcttagtg tcccctgggt
     2401 gaccggcatg tcatgagaca gtgtgatcaa ccttttcttg ccccgctgtg cacgtctagg
     2461 tgacccttcc agctgaccat cagctccccg ctgtgtggcc ctggccatgt gtgtcgtgcc
     2521 tgcactgtgg actatctgtg gattctgtgg ccctgcttct ccatccccta tttatgtcac
     2581 caagcgctgc atgaactatt aaatgtgcaa tgaagaaccc tttcccaacc aaa
//
