LOCUS       NM_001373913            3338 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus protein kinase, cAMP dependent regulatory, type I,
            alpha (Prkar1a), transcript variant 8, mRNA.
ACCESSION   NM_001373913
VERSION     NM_001373913.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3338)
  AUTHORS   Malawsky,D.S., Dismuke,T., Liu,H., Castellino,E., Brenman,J.,
            Dasgupta,B., Tikunov,A. and Gershon,T.R.
  TITLE     Chronic AMPK inactivation slows SHH medulloblastoma progression by
            inhibiting mTORC1 signaling and depleting tumor stem cells
  JOURNAL   iScience 26 (12), 108443 (2023)
   PUBMED   38094249
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3338)
  AUTHORS   Sahut-Barnola,I., Lefrancois-Martinez,A.M., Dufour,D., Botto,J.M.,
            Kamilaris,C., Faucz,F.R., Stratakis,C.A., Val,P. and Martinez,A.
  TITLE     Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney
            Complex Syndrome
  JOURNAL   J Invest Dermatol 142 (11), 2949-2957 (2022)
   PUBMED   35568059
REFERENCE   3  (bases 1 to 3338)
  AUTHORS   Djari,C., Sahut-Barnola,I., Septier,A., Plotton,I., Montanier,N.,
            Dufour,D., Levasseur,A., Wilmouth,J. Jr., Pointud,J.C., Faucz,F.R.,
            Kamilaris,C., Lopez,A.G., Guillou,F., Swain,A., Vainio,S.J.,
            Tauveron,I., Val,P., Lefebvre,H., Stratakis,C.A., Martinez,A. and
            Lefrancois-Martinez,A.M.
  TITLE     Protein kinase A drives paracrine crisis and WNT4-dependent testis
            tumor in Carney complex
  JOURNAL   J Clin Invest 131 (23) (2021)
   PUBMED   34850745
  REMARK    GeneRIF: Protein kinase A drives paracrine crisis and
            WNT4-dependent testis tumor in Carney complex.
REFERENCE   4  (bases 1 to 3338)
  AUTHORS   Liu,Y., Chen,J., Xia,P., Stratakis,C.A. and Cheng,Z.
  TITLE     Loss of PKA regulatory subunit 1alpha aggravates cardiomyocyte
            necrosis and myocardial ischemia/reperfusion injury
  JOURNAL   J Biol Chem 297 (1), 100850 (2021)
   PUBMED   34087234
  REMARK    GeneRIF: Loss of PKA regulatory subunit 1alpha aggravates
            cardiomyocyte necrosis and myocardial ischemia/reperfusion injury.
REFERENCE   5  (bases 1 to 3338)
  AUTHORS   Leal,L.F., Szarek,E., Berthon,A., Nesterova,M., Faucz,F.R.,
            London,E., Mercier,C., Abu-Asab,M., Starost,M.F., Dye,L.,
            Bilinska,B., Kotula-Balak,M., Antonini,S.R. and Stratakis,C.A.
  TITLE     Pde8b haploinsufficiency in mice is associated with modest adrenal
            defects, impaired steroidogenesis, and male infertility, unaltered
            by concurrent PKA or Wnt activation
  JOURNAL   Mol Cell Endocrinol 522, 111117 (2021)
   PUBMED   33338547
REFERENCE   6  (bases 1 to 3338)
  AUTHORS   Rogers,K.V., Boring,L.F., McKnight,G.S. and Clegg,C.H.
  TITLE     Promoter for the regulatory type I beta subunit of the 3',5'-cyclic
            adenosine monophosphate-dependent protein kinase directs transgene
            expression in the central nervous system
  JOURNAL   Mol Endocrinol 6 (10), 1756-1765 (1992)
   PUBMED   1448119
REFERENCE   7  (bases 1 to 3338)
  AUTHORS   Cadd,G. and McKnight,G.S.
  TITLE     Distinct patterns of cAMP-dependent protein kinase gene expression
            in mouse brain
  JOURNAL   Neuron 3 (1), 71-79 (1989)
   PUBMED   2619996
REFERENCE   8  (bases 1 to 3338)
  AUTHORS   Lem,J., Chin,A.C., Thayer,M.J., Leach,R.J. and Fournier,R.E.
  TITLE     Coordinate regulation of two genes encoding gluconeogenic enzymes
            by the trans-dominant locus Tse-1
  JOURNAL   Proc Natl Acad Sci U S A 85 (19), 7302-7306 (1988)
   PUBMED   2902627
REFERENCE   9  (bases 1 to 3338)
  AUTHORS   Munke,M. and Francke,U.
  TITLE     The physical map of Mus musculus chromosome 11 reveals evolutionary
            relationships with different syntenic groups of genes in Homo
            sapiens
  JOURNAL   J Mol Evol 25 (2), 134-140 (1987)
   PUBMED   3116273
REFERENCE   10 (bases 1 to 3338)
  AUTHORS   Peterson,T.C., Killary,A.M. and Fournier,R.E.
  TITLE     Chromosomal assignment and trans regulation of the tyrosine
            aminotransferase structural gene in hepatoma hybrid cells
  JOURNAL   Mol Cell Biol 5 (9), 2491-2494 (1985)
   PUBMED   2874483
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK005039.1 and AL732387.10.
            
            Summary: The encoded protein is a regulatory subunit of the
            cAMP-dependent protein kinase (PKA) complex, which is responsible
            for transducing most of the cAMP signals in eukaryotic cells. The
            inactive PKA complex contains two regulatory and two catalytic
            subunits. Binding of cAMP dissociates the complex, allowing
            monomeric catalytic subunits to phosphorylate cytosolic proteins or
            induce gene expression in the nucleus. Several transcript variants
            encoding the same protein have been found for this gene. [provided
            by RefSeq, Sep 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051068.1, AK145797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2786              AK005039.1         3-2788
            2787-3338           AL732387.10        8736-9287           c
FEATURES             Location/Qualifiers
     source          1..3338
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 72.33 cM"
     gene            1..3338
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /note="protein kinase, cAMP dependent regulatory, type I,
                     alpha"
                     /db_xref="GeneID:19084"
                     /db_xref="MGI:MGI:104878"
     exon            1..125
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /inference="alignment:Splign:2.1.0"
     exon            126..308
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1277
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /EC_number="2.7.11.1"
                     /note="protein kinase, cAMP dependent regulatory, type 1,
                     alpha"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase type I-alpha
                     regulatory subunit"
                     /protein_id="NP_001360842.1"
                     /db_xref="GeneID:19084"
                     /db_xref="MGI:MGI:104878"
                     /translation="MASGSMATSEEERSLRECELYVQKHNIQALLKDSIVQLCTTRPE
                     RPMAFLREYFERLEKEEARQIQCLQKTGIRTDSREDEISPPPPNPVVKGRRRRGAISA
                     EVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIA
                     GETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAK
                     TNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQF
                     EDGQKIVVQGEPGDEFFIILEGTAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRP
                     RAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV"
     exon            309..479
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..571
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..633
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..680
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..839
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..900
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1022
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1104
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..3338
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1449..1454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /note="hexamer: AATAAA"
     polyA_site      1470
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /note="major polyA site"
     regulatory      2827..2832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /note="hexamer: AATAAA"
     polyA_site      2852
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
     regulatory      3302..3307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /note="hexamer: AATAAA"
     regulatory      3316..3321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
                     /note="hexamer: AATAAT"
     polyA_site      3317
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
     polyA_site      3326
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
     polyA_site      3338
                     /gene="Prkar1a"
                     /gene_synonym="1300018C22Rik; RIalpha; Tse-1; Tse1"
ORIGIN      
        1 ggagccgtcg ccgagccgct atcgcagagt ggtagtgagg ctgcgagctg agcccgctgg
       61 acgctcggtc accccggccg cctcgccctg cgttagcccc tgctcgtgcc gccgcccgcc
      121 ctcagagaac catggcgtct ggcagtatgg caaccagtga ggaagagcgg agtctccggg
      181 aatgcgagct ctatgtgcag aagcacaata tccaggccct gctgaaggac tccatcgtgc
      241 agctgtgcac tacgcggccc gagaggccca tggcattcct tcgggaatac tttgagaggt
      301 tggagaagga ggaggcaaga cagattcagt gtctacagaa aaccggcatc cgtactgact
      361 cgagggagga cgagatctct cctccacccc ccaatccagt ggtgaagggc cgacggcgcc
      421 gaggtgctat cagtgctgaa gtttacactg aggaggatgc tgcctcctac gttagaaagg
      481 ttattccaaa agattataag acaatggctg ctttagccaa ggccatcgaa aagaatgtgc
      541 tgttttcaca ccttgatgat aacgagagaa gtgacatttt tgatgctatg tttccagtct
      601 cctttattgc tggagagacg gttattcagc aaggtgatga aggggataac ttctatgtga
      661 ttgatcaagg agaaatggat gtctatgtca ataatgaatg ggcaaccagt gttggggaag
      721 gagggagctt tggagagctg gctttgattt atggaacacc cagagcagcc actgtcaaag
      781 caaagacaaa cgtgaaactg tggggcatcg accgagacag ctaccgaaga atcctcatgg
      841 gaagcactct gcgaaagagg aagatgtatg aagaattcct tagtaaagtg tctattttag
      901 agtctctgga caagtgggag cgtctcacag tagccgatgc attggagcct gtccagtttg
      961 aagatggaca gaagatcgtg gtgcaaggag agccggggga tgagttcttc atcattttag
     1021 agggcacagc tgctgtgctg cagcgtcggt cagaaaacga agaatttgtt gaagtgggac
     1081 gactggggcc ttctgattat tttggtgaaa ttgccctgct gatgaatcgt cctcgggctg
     1141 ccactgtggt tgcccggggc cctttgaagt gcgttaagtt ggaccggcct cggtttgaac
     1201 gcgtccttgg cccgtgctca gacatcctca agcggaacat ccagcagtac aacagcttcg
     1261 tgtccctgtc cgtctgaccc gcgcctcctg tgcctcctcc ccagtccatg cttcactcac
     1321 gcagactgct ttctctccct agccgcagcg cccagtggcc actgcttcac agcttcttgt
     1381 ctctttatac taaaagttgc tttattgcac catttttcat tgggagcgtt attaaatgct
     1441 cattcacaaa taaatagaga gttgtatgga cttggctgtc accgcttctc tgtgcagtgc
     1501 tcgtgttcaa cctgggcagc aagtgccgcg ctttttgctg agggcggtcc ctgcaccact
     1561 gaattaccgt aatgatgtaa tagctgtgca gggcttttaa gtgacacagg tttccatttc
     1621 catatgacac aagtgacata cttagactgt ggccatgttt gctgtatttc tttatagagt
     1681 aaatgatttt aacctttaag gattagaaga atgaatatag aaaactccta gcacagtaga
     1741 aagacatctg cctgtaatta agctagttta agtgtgggag tgcccatgtt ttgctaatca
     1801 ccaggcactg cagctagttc agccctctca gcctggtttg gtgtgtctgt tgctagtgtt
     1861 tcttctccaa ccctgaaatg ttttggtgtg gctggccgtc tatccctgcc tttaagtttg
     1921 aaatcatttg tagatggcaa gtactggttg tgacttcact gcacctgtct gagctcacag
     1981 acgctgataa ctttatttat ccagctggtg ccaaatcctg aggatgagac acagaaatgt
     2041 gagaatttga ggtcttcact ctggggagtt aaccgtggtt aactcgtgtg atctgccctc
     2101 agttacagac tagggcgttg gaattactga gaatagacaa atagagcaag ctccagagag
     2161 aaggggatgg aggcagtgct gctgaaggtg gatggcggtc aggtgtccag aagcaggaag
     2221 ctgggtctgt cccctgggtt tctgttagga acagtggtgg ggtgtgaccg tgttgtggtc
     2281 tgaaaggcca ccccgctgag tcctgccttt tcctgtctaa ccttgaattt ctctggtaaa
     2341 ctttctttat tgttttttgt ttgtgtgtgt gtgtttaaag taaacttgtg ttcttgactg
     2401 tatttcagta ttttccagcc ttatgtgtta cattattcca gtgataaccc aacagtttat
     2461 ttttattact gttatttttt aaacaaaatt cacagttcgt aacgaggcac acttatcttg
     2521 tgatttctgt ataatgtcgg gttctatttg ggagtgactg cgttttcatg tgtgtgcaag
     2581 tggttctgat taataattcc ctccctccct ttcccagtta acttaaattg ttggttatgg
     2641 tagatttttt tcttggtaga ttgaaaagct tctagattgt tactaatttg ggaaaaagtt
     2701 tcatttaggt tttagcatgg gatagaaagc taccttgttg ccatatctaa aacttccata
     2761 atctatatta aatgagggtt ttctgtactt actttgtggt tggctatctt tttttatatt
     2821 taaaaaaata aaaattatgt tactagctta aagcttaatt tgatatttgt ttaaatgcca
     2881 aaaatgtatg tatgtgaatg atgtagaacg ccataaaatg catttcatgt gtatataccc
     2941 ccttggtctg tacggagata aacacctgct ttctaagagt tccatgctag cttacaagtt
     3001 acgccctttt gtcgttttac tcttagactt ttcaagataa gtctaaattt aaaaattacc
     3061 acatttaaag ctttatcttt gtgcaattta aatatcagtc agaagtcgtg gttggcatac
     3121 tgtgtctttg tggactcttg gcaccattgt ctctggatgg gtgggcgaat ttaagcaatc
     3181 tgctgagaaa gcagagctgg ccaaagggac agttgctgtt tcctggacac tagtctgata
     3241 tactctgtgc taatctaatc gctgttcttt tgttacagac tgtctcaatg gtaggtcaca
     3301 gaataaaaaa gatgaaataa tttaaattct taaacgaa
//
