LOCUS       NP_714966                489 aa            linear   ROD 15-OCT-2024
DEFINITION  5'-AMP-activated protein kinase subunit gamma-3 [Mus musculus].
ACCESSION   NP_714966
VERSION     NP_714966.1
DBSOURCE    REFSEQ: accession NM_153744.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 489)
  AUTHORS   Eskesen,N.O., Kjobsted,R., Birk,J.B., Henriksen,N.S.,
            Andersen,N.R., Ringholm,S., Pilegaard,H. and Wojtaszewski,J.F.P.
  TITLE     The human AMPKgamma3 R225W mutation negatively impacts site-1
            nucleotide binding and does not enhance basal AMPKgamma3-associated
            activity nor glycogen production in human or mouse skeletal muscle
  JOURNAL   Acta Physiol (Oxf) 240 (10), e14213 (2024)
   PUBMED   39171449
  REMARK    GeneRIF: The human AMPKgamma3 R225W mutation negatively impacts
            site-1 nucleotide binding and does not enhance basal
            AMPKgamma3-associated activity nor glycogen production in human or
            mouse skeletal muscle.
REFERENCE   2  (residues 1 to 489)
  AUTHORS   Kido,K., Eskesen,N.O., Henriksen,N.S., Onslev,J., Kristensen,J.M.,
            Larsen,M.R., Hingst,J.R., Knudsen,J.R., Birk,J.B., Andersen,N.R.,
            Jensen,T.E., Pehmoller,C., Wojtaszewski,J.F.P. and Kjobsted,R.
  TITLE     AMPKgamma3 Controls Muscle Glucose Uptake in Recovery From Exercise
            to Recapture Energy Stores
  JOURNAL   Diabetes 72 (10), 1397-1408 (2023)
   PUBMED   37506328
  REMARK    GeneRIF: AMPKgamma3 Controls Muscle Glucose Uptake in Recovery From
            Exercise to Recapture Energy Stores.
REFERENCE   3  (residues 1 to 489)
  AUTHORS   Aoi,W., Inoue,R., Mizushima,K., Honda,A., Bjornholm,M., Takagi,T.
            and Naito,Y.
  TITLE     Exercise-acclimated microbiota improves skeletal muscle metabolism
            via circulating bile acid deconjugation
  JOURNAL   iScience 26 (3), 106251 (2023)
   PUBMED   36915683
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 489)
  AUTHORS   Rhein,P., Desjardins,E.M., Rong,P., Ahwazi,D., Bonhoure,N.,
            Stolte,J., Santos,M.D., Ovens,A.J., Ehrlich,A.M., Sanchez
            Garcia,J.L., Ouyang,Q., Yabut,J.M., Kjolby,M., Membrez,M.,
            Jessen,N., Oakhill,J.S., Treebak,J.T., Maire,P., Scott,J.W.,
            Sanders,M.J., Descombes,P., Chen,S., Steinberg,G.R. and Sakamoto,K.
  TITLE     Compound- and fiber type-selective requirement of AMPKgamma3 for
            insulin-independent glucose uptake in skeletal muscle
  JOURNAL   Mol Metab 51, 101228 (2021)
   PUBMED   33798773
  REMARK    GeneRIF: Compound- and fiber type-selective requirement of
            AMPKgamma3 for insulin-independent glucose uptake in skeletal
            muscle.
REFERENCE   5  (residues 1 to 489)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   6  (residues 1 to 489)
  AUTHORS   Barnes,B.R., Marklund,S., Steiler,T.L., Walter,M., Hjalm,G.,
            Amarger,V., Mahlapuu,M., Leng,Y., Johansson,C., Galuska,D.,
            Lindgren,K., Abrink,M., Stapleton,D., Zierath,J.R. and Andersson,L.
  TITLE     The 5'-AMP-activated protein kinase gamma3 isoform has a key role
            in carbohydrate and lipid metabolism in glycolytic skeletal muscle
  JOURNAL   J Biol Chem 279 (37), 38441-38447 (2004)
   PUBMED   15247217
REFERENCE   7  (residues 1 to 489)
  AUTHORS   Mahlapuu,M., Johansson,C., Lindgren,K., Hjalm,G., Barnes,B.R.,
            Krook,A., Zierath,J.R., Andersson,L. and Marklund,S.
  TITLE     Expression profiling of the gamma-subunit isoforms of AMP-activated
            protein kinase suggests a major role for gamma3 in white skeletal
            muscle
  JOURNAL   Am J Physiol Endocrinol Metab 286 (2), E194-E200 (2004)
   PUBMED   14559719
  REMARK    GeneRIF: the observation that the AMPKgamma3 isoform is expressed
            primarily in white skeletal muscle, in which it is the predominant
            gamma-isoform, strongly suggests that gamma3 has a key role in this
            tissue
REFERENCE   8  (residues 1 to 489)
  AUTHORS   Yu,H., Fujii,N., Hirshman,M.F., Pomerleau,J.M. and Goodyear,L.J.
  TITLE     Cloning and characterization of mouse 5'-AMP-activated protein
            kinase gamma3 subunit
  JOURNAL   Am J Physiol Cell Physiol 286 (2), C283-C292 (2004)
   PUBMED   14512293
  REMARK    GeneRIF: Gamma3 subunit of AMPK is highly expressed in fast-twitch
            glycolytic skeletal muscle, and wild-type gamma3 functions in the
            regulation of alpha1 catalytic activity, but it is not associated
            with changes in muscle glycogen concentrations
REFERENCE   9  (residues 1 to 489)
  AUTHORS   Amarger,V., Erlandsson,R., Pielberg,G., Jeon,J.T. and Andersson,L.
  TITLE     Comparative sequence analysis of the PRKAG3 region between human
            and pig: evolution of repetitive sequences and potential new exons
  JOURNAL   Cytogenet Genome Res 102 (1-4), 163-172 (2003)
   PUBMED   14970697
REFERENCE   10 (residues 1 to 489)
  AUTHORS   Milan,D., Jeon,J.T., Looft,C., Amarger,V., Robic,A., Thelander,M.,
            Rogel-Gaillard,C., Paul,S., Iannuccelli,N., Rask,L., Ronne,H.,
            Lundstrom,K., Reinsch,N., Gellin,J., Kalm,E., Roy,P.L., Chardon,P.
            and Andersson,L.
  TITLE     A mutation in PRKAG3 associated with excess glycogen content in pig
            skeletal muscle
  JOURNAL   Science 288 (5469), 1248-1251 (2000)
   PUBMED   10818001
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152409.8.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036585.1, SRR13948564.147039.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: PMID: 14512293, 14559719, 15247217
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.54 cM"
     Protein         1..489
                     /product="5'-AMP-activated protein kinase subunit gamma-3"
                     /note="AMP-activated protein kinase gamma subunit; AMPK
                     gamma3; AMPK subunit gamma-3; protein kinase,
                     AMP-activated, gamma 3 non-catatlytic subunit"
                     /calculated_mol_wt=53718
     Region          1..95
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGM7.1)"
     Region          192..329
                     /region_name="CBS_euAMPK_gamma-like_repeat1"
                     /note="Two tandem repeats of the cystathionine
                     beta-synthase (CBS pair) domains found in AMP-activated
                     protein kinase gamma-like proteins, repeat 1; cd04618"
                     /db_xref="CDD:341388"
     Site            order(200,202..204,226..228,307,321,323,325..326,329)
                     /site_type="other"
                     /note="ligand binding site II [chemical binding]"
                     /db_xref="CDD:341388"
     Region          200..273
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341388"
     Site            order(226,240,244..245,248,285,307..309,325)
                     /site_type="other"
                     /note="ligand binding site I [chemical binding]"
                     /db_xref="CDD:341388"
     Region          285..329
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341388"
     Region          293..314
                     /region_name="AMPK pseudosubstrate"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGM7.1)"
     Region          355..478
                     /region_name="CBS_euAMPK_gamma-like_repeat2"
                     /note="CBS pair domain found in 5'-AMP (adenosine
                     monophosphate)-activated protein kinase; cd04641"
                     /db_xref="CDD:341399"
     Site            order(356,358..360,382..384,454,467,469,471..472,475)
                     /site_type="other"
                     /note="ligand binding site II [chemical binding]"
                     /db_xref="CDD:341399"
     Region          356..421
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341399"
     Site            order(382,395,399..400,403,432,454..456,471)
                     /site_type="other"
                     /note="ligand binding site I [chemical binding]"
                     /db_xref="CDD:341399"
     Region          432..475
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341399"
     CDS             1..489
                     /gene="Prkag3"
                     /gene_synonym="Amkg3; Ampkg3; AMPKg3L; AMPKg3S"
                     /coded_by="NM_153744.4:32..1501"
                     /db_xref="CCDS:CCDS15055.1"
                     /db_xref="GeneID:241113"
                     /db_xref="MGI:MGI:1891343"
ORIGIN      
        1 mepelehtlp gtltwshsgg pesqemdfle qgenswpspa vatssertca irgvkasrwt
       61 rqeaveeaep pglgegaqsr paaestrqea tfpkatplaq avplaeaets ptgwdlllpd
      121 caasaggsst gdleltiefp apeawdcele glgkdrprpg pspqapllgl swddelqkpg
      181 aqvymhfmqe htcydamats sklvifdttl eikkaffamv angvraaplw dskkqsfvgm
      241 ltitdfilvl hryyrsplvq iyeieehkie twreiylqgc fkplvsispn dslfeavyal
      301 iknrihrlpv ldpvsgtvly ilthkrllkf lhifgallpr psflcrtiqd lgigtfrdla
      361 vvletapvlt aldifvdrrv salpvvnesg qvvglysrfd vihlaaqqty nhldmsvgea
      421 lrqrtlcleg vlscqphesl gevidriare qvhrlvlvde tqhllgvvsl sdilqalvls
      481 pagidalsa
//
