LOCUS       NM_016781               1604 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus protein kinase, AMP-activated, gamma 1 non-catalytic
            subunit (Prkag1), transcript variant 1, mRNA.
ACCESSION   NM_016781
VERSION     NM_016781.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1604)
  AUTHORS   Bai,W., Guo,T., Wang,H., Li,B., Sun,Q., Wu,W., Zhang,J., Zhou,J.,
            Luo,J., Zhu,M., Lu,J., Li,P., Dong,B., Han,S., Pang,X., Zhang,G.,
            Bai,Y. and Wang,S.
  TITLE     S-nitrosylation of AMPKgamma impairs coronary collateral
            circulation and disrupts VSMC reprogramming
  JOURNAL   EMBO Rep 25 (1), 128-143 (2024)
   PUBMED   38177907
  REMARK    GeneRIF: S-nitrosylation of AMPKgamma impairs coronary collateral
            circulation and disrupts VSMC reprogramming.
REFERENCE   2  (bases 1 to 1604)
  AUTHORS   An,H., Wang,Y., Qin,C., Li,M., Maheshwari,A. and He,L.
  TITLE     The importance of the AMPK gamma 1 subunit in metformin suppression
            of liver glucose production
  JOURNAL   Sci Rep 10 (1), 10482 (2020)
   PUBMED   32591547
  REMARK    GeneRIF: The importance of the AMPK gamma 1 subunit in metformin
            suppression of liver glucose production.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1604)
  AUTHORS   Ngoei,K.R.W., Langendorf,C.G., Ling,N.X.Y., Hoque,A., Varghese,S.,
            Camerino,M.A., Walker,S.R., Bozikis,Y.E., Dite,T.A., Ovens,A.J.,
            Smiles,W.J., Jacobs,R., Huang,H., Parker,M.W., Scott,J.W.,
            Rider,M.H., Foitzik,R.C., Kemp,B.E., Baell,J.B. and Oakhill,J.S.
  TITLE     Structural Determinants for Small-Molecule Activation of Skeletal
            Muscle AMPK alpha2beta2gamma1 by the Glucose Importagog SC4
  JOURNAL   Cell Chem Biol 25 (6), 728-737 (2018)
   PUBMED   29657085
REFERENCE   4  (bases 1 to 1604)
  AUTHORS   Boudaba,N., Marion,A., Huet,C., Pierre,R., Viollet,B. and Foretz,M.
  TITLE     AMPK Re-Activation Suppresses Hepatic Steatosis but its
            Downregulation Does Not Promote Fatty Liver Development
  JOURNAL   EBioMedicine 28, 194-209 (2018)
   PUBMED   29343420
REFERENCE   5  (bases 1 to 1604)
  AUTHORS   Woods,A., Williams,J.R., Muckett,P.J., Mayer,F.V., Liljevald,M.,
            Bohlooly-Y,M. and Carling,D.
  TITLE     Liver-Specific Activation of AMPK Prevents Steatosis on a
            High-Fructose Diet
  JOURNAL   Cell Rep 18 (13), 3043-3051 (2017)
   PUBMED   28355557
  REMARK    GeneRIF: These results emphasize the clinical relevance of
            activating AMPK in the liver to combat non-alcoholic fatty liver
            disease.
REFERENCE   6  (bases 1 to 1604)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 1604)
  AUTHORS   Shamsadin,R., Jantsan,K., Adham,I. and Engel,W.
  TITLE     Cloning, organisation, chromosomal localization and expression
            analysis of the mouse Prkag1 gene
  JOURNAL   Cytogenet Cell Genet 92 (1-2), 134-138 (2001)
   PUBMED   11306812
REFERENCE   8  (bases 1 to 1604)
  AUTHORS   Turnley,A.M., Stapleton,D., Mann,R.J., Witters,L.A., Kemp,B.E. and
            Bartlett,P.F.
  TITLE     Cellular distribution and developmental expression of AMP-activated
            protein kinase isoforms in mouse central nervous system
  JOURNAL   J Neurochem 72 (4), 1707-1716 (1999)
   PUBMED   10098881
REFERENCE   9  (bases 1 to 1604)
  AUTHORS   Salt,I., Celler,J.W., Hawley,S.A., Prescott,A., Woods,A.,
            Carling,D. and Hardie,D.G.
  TITLE     AMP-activated protein kinase: greater AMP dependence, and
            preferential nuclear localization, of complexes containing the
            alpha2 isoform
  JOURNAL   Biochem J 334 (Pt 1) (Pt 1), 177-187 (1998)
   PUBMED   9693118
REFERENCE   10 (bases 1 to 1604)
  AUTHORS   Piosik,P.A., van Groenigen,M., Ponne,N.J., Valentijn,L.J.,
            Bolhuis,P.A. and Baas,F.
  TITLE     Caprine homologue of rodent 5'-AMP-activated protein kinase subunit
            and yeast SNF4/CAT3 is down-regulated by thyroid hormone
  JOURNAL   Brain Res Mol Brain Res 40 (2), 240-253 (1996)
   PUBMED   8872308
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161165.5.
            
            On Aug 26, 2022 this sequence version replaced NM_016781.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086660.1, AF036535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC161165.5         40779-40822         c
            45-90               AC161165.5         35037-35082         c
            91-200              AC161165.5         25225-25334         c
            201-282             AC161165.5         25008-25089         c
            283-341             AC161165.5         24846-24904         c
            342-387             AC161165.5         24663-24708         c
            388-442             AC161165.5         24532-24586         c
            443-569             AC161165.5         23858-23984         c
            570-735             AC161165.5         23537-23702         c
            736-773             AC161165.5         23355-23392         c
            774-920             AC161165.5         22946-23092         c
            921-1604            AC161165.5         22146-22829         c
FEATURES             Location/Qualifiers
     source          1..1604
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.73 cM"
     gene            1..1604
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /note="protein kinase, AMP-activated, gamma 1
                     non-catalytic subunit"
                     /db_xref="GeneID:19082"
                     /db_xref="MGI:MGI:108411"
     exon            1..44
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /inference="alignment:Splign:2.1.0"
     exon            45..90
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /inference="alignment:Splign:2.1.0"
     exon            91..200
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /inference="alignment:Splign:2.1.0"
     exon            201..282
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /inference="alignment:Splign:2.1.0"
     exon            283..341
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /inference="alignment:Splign:2.1.0"
     exon            342..387
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /inference="alignment:Splign:2.1.0"
     exon            388..442
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /inference="alignment:Splign:2.1.0"
     exon            443..569
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /inference="alignment:Splign:2.1.0"
     exon            570..735
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /inference="alignment:Splign:2.1.0"
     exon            736..773
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /inference="alignment:Splign:2.1.0"
     exon            774..920
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1604
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1578..1583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /note="hexamer: ATTAAA"
     polyA_site      1604
                     /gene="Prkag1"
                     /gene_synonym="Prkaac"
                     /note="major polyA site"
ORIGIN      
        1 agctttccaa gctgaggaac tggcgggcgc tagcaatgga gtcggttgct gcagagagct
       61 cgccagctct agagaatgaa cactttcaag agaccccgga atcaaacaat agtgtgtata
      121 cttccttcat gaagtctcat cgctgctatg acctaattcc cacaagttcc aagttggtgg
      181 tatttgacac ttcgctacag gtaaagaaag ccttttttgc cctggtgacc aatggtgttc
      241 gtgccgcccc tttgtgggac agtaagaagc agagttttgt gggcatgctg accatcaccg
      301 acttcatcaa cattttgcac cgatactata agtcagccct ggtgcagatc tacgaactgg
      361 aggagcacaa gatagagacg tggagagagg tgtacctgca ggactccttt aagccacttg
      421 tctgcatctc tccaaatgcc agcttgtttg atgctgtctc ttcattaatt cgaaataaga
      481 tccacaggct cccagttatc gacccagagt caggcaacac cttgtacatc cttactcaca
      541 agcggatcct caagttcctc aagttgttta tcaccgagtt ccccaagccg gaattcatgt
      601 ctaagtctct ccaagagctg cagattggca cctatgccaa tattgccatg gtccgtacta
      661 ccacgcctgt ctacgtggct ctgggcatct ttgtacagca ccgagtctcc gccttacctg
      721 tagtggatga gaaagggcgt gtggtggaca tctactccaa gtttgatgtg atcaatttgg
      781 cagccgaaaa gacctacaac aacctagatg tgtctgtgac aaaagccctg cagcatcggt
      841 cccactactt tgagggtgtt ctcaaatgct acctgcatga gactctggaa accatcatca
      901 ataggctggt ggaggcagag gttcaccgtc tggtggtggt ggatgaacac gacgtggtca
      961 agggcatcgt ttcgctgtct gacatcttac aggctctggt gctcacgggt ggagagaaga
     1021 agccctgagc atggggaaga acaggcggtg cctggggagg tggccccctc actgcctgcc
     1081 tgctggaagc tctgggaatc agatggaatc ctgggagaac tgagtcttct ctcaggagct
     1141 ccacgcccac tgtctagagc tagagaaggg gaaaggagga ggactgtcag cctccctgac
     1201 cgtcctgtta cactggagag aacgtcagcc cagccagtcc aggcccgcgc ctgccgcagc
     1261 ccccttctgg gtgagccacg ggctttgtgc tcctcgggta gattctgatc tctacgagat
     1321 ccctagacct caccacaccc tgctctgccc ctgcccttac tccacctaag ataatagctc
     1381 tgcacaagtc tcggtaaaat atttttattc gtcttgtttc actgtgtgga ggaggctggg
     1441 cccatttgct gtcagtcctt cccatgagtc tagggaggcg cgtccgggtt cttgtgctgt
     1501 gcagacgaag gcagatggct atgtggagga gggcggtggg taggtagcca agattaatgc
     1561 tttttgtggc gaatctaatt aaatgacaag gtttcatcat ggta
//
