LOCUS       NM_001164200            4294 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein kinase, cAMP dependent, catalytic, beta
            (Prkacb), transcript variant 4, mRNA.
ACCESSION   NM_001164200
VERSION     NM_001164200.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4294)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4294)
  AUTHORS   Li,D., Li,F., Meng,L., Wei,H., Zhang,Q., Jiang,F., Chen,D.N.,
            Li,W., Tan,Y.Q. and Li,J.D.
  TITLE     RNF216 regulates meiosis and PKA stability in the testes
  JOURNAL   FASEB J 35 (4), e21460 (2021)
   PUBMED   33724554
REFERENCE   3  (bases 1 to 4294)
  AUTHORS   Balta,E.A., Schaffner,I., Wittmann,M.T., Sock,E., von Zweydorf,F.,
            von Wittgenstein,J., Steib,K., Heim,B., Kremmer,E., Haberle,B.M.,
            Ueffing,M., Lie,D.C. and Gloeckner,C.J.
  TITLE     Phosphorylation of the neurogenic transcription factor SOX11 on
            serine 133 modulates neuronal morphogenesis
  JOURNAL   Sci Rep 8 (1), 16196 (2018)
   PUBMED   30385877
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4294)
  AUTHORS   Isobe,K., Jung,H.J., Yang,C.R., Claxton,J., Sandoval,P., Burg,M.B.,
            Raghuram,V. and Knepper,M.A.
  TITLE     Systems-level identification of PKA-dependent signaling in
            epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 114 (42), E8875-E8884 (2017)
   PUBMED   28973931
  REMARK    GeneRIF: Protein kinase A signaling explains vasopressin-mediated
            regulation of membrane trafficking and gene transcription.
REFERENCE   5  (bases 1 to 4294)
  AUTHORS   Berthon,A., Faucz,F.R., Espiard,S., Drougat,L., Bertherat,J. and
            Stratakis,C.A.
  TITLE     Age-dependent effects of Armc5 haploinsufficiency on adrenocortical
            function
  JOURNAL   Hum Mol Genet 26 (18), 3495-3507 (2017)
   PUBMED   28911199
REFERENCE   6  (bases 1 to 4294)
  AUTHORS   Brandon,E.P., Zhuo,M., Huang,Y.Y., Qi,M., Gerhold,K.A.,
            Burton,K.A., Kandel,E.R., McKnight,G.S. and Idzerda,R.L.
  TITLE     Hippocampal long-term depression and depotentiation are defective
            in mice carrying a targeted disruption of the gene encoding the RI
            beta subunit of cAMP-dependent protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8851-8855 (1995)
   PUBMED   7568030
REFERENCE   7  (bases 1 to 4294)
  AUTHORS   Beebe,S.J., Oyen,O., Sandberg,M., Froysa,A., Hansson,V. and
            Jahnsen,T.
  TITLE     Molecular cloning of a tissue-specific protein kinase (C gamma)
            from human testis--representing a third isoform for the catalytic
            subunit of cAMP-dependent protein kinase
  JOURNAL   Mol Endocrinol 4 (3), 465-475 (1990)
   PUBMED   2342480
REFERENCE   8  (bases 1 to 4294)
  AUTHORS   Cadd,G. and McKnight,G.S.
  TITLE     Distinct patterns of cAMP-dependent protein kinase gene expression
            in mouse brain
  JOURNAL   Neuron 3 (1), 71-79 (1989)
   PUBMED   2619996
REFERENCE   9  (bases 1 to 4294)
  AUTHORS   Chrivia,J.C., Uhler,M.D. and McKnight,G.S.
  TITLE     Characterization of genomic clones coding for the C alpha and C
            beta subunits of mouse cAMP-dependent protein kinase
  JOURNAL   J Biol Chem 263 (12), 5739-5744 (1988)
   PUBMED   2833513
REFERENCE   10 (bases 1 to 4294)
  AUTHORS   Uhler,M.D., Chrivia,J.C. and McKnight,G.S.
  TITLE     Evidence for a second isoform of the catalytic subunit of
            cAMP-dependent protein kinase
  JOURNAL   J Biol Chem 261 (33), 15360-15363 (1986)
   PUBMED   3023318
  REMARK    Erratum:[J Biol Chem 1987 Apr 15;262(11):5431]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114618.9.
            
            On Aug 8, 2022 this sequence version replaced NM_001164200.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150134.1, AK150122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               AC114618.9         19079-19353
            276-337             AC114618.9         42732-42793
            338-466             AC114618.9         44740-44868
            467-565             AC114618.9         48955-49053
            566-648             AC114618.9         49935-50017
            649-775             AC114618.9         52453-52579
            776-871             AC114618.9         53805-53900
            872-994             AC114618.9         55118-55240
            995-1159            AC114618.9         62402-62566
            1160-4294           AC114618.9         67787-70921
FEATURES             Location/Qualifiers
     source          1..4294
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 72.28 cM"
     gene            1..4294
                     /gene="Prkacb"
                     /gene_synonym="CbPKA; PKA C-beta; Pkacb"
                     /note="protein kinase, cAMP dependent, catalytic, beta"
                     /db_xref="GeneID:18749"
                     /db_xref="MGI:MGI:97594"
     exon            1..275
                     /gene="Prkacb"
                     /gene_synonym="CbPKA; PKA C-beta; Pkacb"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1285
                     /gene="Prkacb"
                     /gene_synonym="CbPKA; PKA C-beta; Pkacb"
                     /EC_number="2.7.11.11"
                     /note="isoform 4 is encoded by transcript variant 4;
                     cAMP-dependent protein kinase catalytic subunit beta;
                     cAMP-dependent protein kinase C beta; Cbeta2 PKA"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     beta isoform 4"
                     /protein_id="NP_001157672.1"
                     /db_xref="CCDS:CCDS51092.1"
                     /db_xref="GeneID:18749"
                     /db_xref="MGI:MGI:97594"
                     /translation="MAAHKELSSGQHSGTPTALQKLEGFASRLFHRHSRGTAQEHRAA
                     LEDDGLRASEHTASWDKSMKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSF
                     GRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKD
                     NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPE
                     NLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLI
                     YEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKN
                     GVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEEIRVSITEKCG
                     KEFCEF"
     exon            276..337
                     /gene="Prkacb"
                     /gene_synonym="CbPKA; PKA C-beta; Pkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            338..466
                     /gene="Prkacb"
                     /gene_synonym="CbPKA; PKA C-beta; Pkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            467..565
                     /gene="Prkacb"
                     /gene_synonym="CbPKA; PKA C-beta; Pkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            566..648
                     /gene="Prkacb"
                     /gene_synonym="CbPKA; PKA C-beta; Pkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            649..775
                     /gene="Prkacb"
                     /gene_synonym="CbPKA; PKA C-beta; Pkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            776..871
                     /gene="Prkacb"
                     /gene_synonym="CbPKA; PKA C-beta; Pkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            872..994
                     /gene="Prkacb"
                     /gene_synonym="CbPKA; PKA C-beta; Pkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1159
                     /gene="Prkacb"
                     /gene_synonym="CbPKA; PKA C-beta; Pkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..4294
                     /gene="Prkacb"
                     /gene_synonym="CbPKA; PKA C-beta; Pkacb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4275..4280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkacb"
                     /gene_synonym="CbPKA; PKA C-beta; Pkacb"
                     /note="hexamer: ATTAAA"
     polyA_site      4294
                     /gene="Prkacb"
                     /gene_synonym="CbPKA; PKA C-beta; Pkacb"
                     /note="major polyA site"
ORIGIN      
        1 agcacatgca tagctcttag cgtcttggta ggaagttgag ctccttctga aaacacttgc
       61 agttacttta aagtgtaaat gcacgcgaat ggcagctcac aaagaactgt ccagtggcca
      121 gcacagtggc acgcccaccg ccctccagaa gctggagggg ttcgctagcc gcctgtttca
      181 caggcactcc agaggcaccg cacaagagca cagggcagct ctggaagatg acggccttcg
      241 ggcctctgag cacactgcct catgggacaa atcaatgaaa gagtttctag ccaaagccaa
      301 agaagacttt ctgaggaaat gggagaaccc tcccccgagt aatgctgggc ttgaggattt
      361 tgagaggaag aaaaccctcg ggacgggttc ctttggaaga gtcatgttgg tgaagcataa
      421 agccactgag cagtactacg ccatgaagat cttagacaag cagaaggttg ttaagctgaa
      481 gcaaatagag cacactctga atgagaagag aatcctgcag gccgtggagt tcccgttcct
      541 tgtgcggctg gagtactctt ttaaggataa ttctaattta tacatggtta tggaatacgt
      601 ccctggggga gagatgttct cacatctgag aagaattgga aggttcagtg agccccacgc
      661 ccgtttctat gcagcccaga ttgtgctaac atttgagtac cttcattccc tcgacctcat
      721 ctacagagat ctcaagccgg aaaacctctt aattgaccac cagggttaca tccaggtcac
      781 agatttcggg ttcgccaaaa gagtcaaggg caggacatgg acattgtgtg gcaccccaga
      841 gtacctggcc ccggagatca tcctcagcaa gggttacaat aaggcggtgg actggtgggc
      901 actgggcgtg ctgatctatg agatggctgc tggctaccct ccattctttg ctgaccagcc
      961 aattcagatc tatgagaaga ttgtctctgg aaaggtccgg ttcccatcac acttcagctc
     1021 cgatctcaag gaccttctgc ggaacctgct gcaggtggat ctgacaaagc gattcgggaa
     1081 cctgaagaac ggcgtgagtg acataaagac ccacaagtgg tttgccacaa ctgactggat
     1141 tgctatttat cagagaaagg ttgaggctcc attcatacca aagttcagag gctctggcga
     1201 taccagcaac ttcgatgact atgaagaaga agaaatccgt gtgtctataa cagaaaaatg
     1261 tggaaaggaa ttttgtgaat tttagggagg agaaagatag cctggagctc acactcagcc
     1321 cttgcacgct gtggaggtgg aaggtggagc cgagacctgc ttgttggagc gggttccaat
     1381 cccttcattc cagcaactgc gtgaggtctt tcctgcgtca tcagtgtgcg ctcgctctgc
     1441 aaccacctgt gtccccaggc acggctccgc agcatcgtct gccataacac ggtgtgcacc
     1501 acgtcctcct ggtttggttt ttctccaccc tcctatatcc ttctcattca cttctctgac
     1561 cagtgctccc tttattttcc tggtgtttca gatgggcagt gttatggctg tgtgatattt
     1621 aaaaggaaag ctacatgttg ctttttgtag ttttgagcaa tatttttgct gaccagtggc
     1681 ttgaagataa actctctaat gattattttt attttgagta gcttgaattc agttttgcca
     1741 aaactcttag taattttgaa gatggaatgt cttgtcagca tgggaatttg cataagtaaa
     1801 gataactttt caggggtcac tgatgcagca gtgagtcaga gcgcctagag agcagtgagg
     1861 actcctggac gagaggctac gttcccctgg gccttctagt gctcttcact ccgtgagata
     1921 gtaagtgacc agacagataa gtgaggggca tggctcctcg ccgcagctgt ctcccttggt
     1981 accgacctct ctgtgggctg gagagaggcc taaggtttct gagccttggc tcttccatgg
     2041 gggcttcagc cagtatttga ggaaagtgtg actgagaaat gacactttgg gaggtttctc
     2101 cgtcctcatc ggtgggctct taagggaaaa gagcaaacgt gcatttggat aaatgctaag
     2161 tcagcagaag ccttgatacc tgcttgcagc ttagaggttc tctcctttaa gggaacttgt
     2221 ctgtttgctt tggttcgtac caggtaagaa aacaagcaaa gcagtagctt attgcgtcct
     2281 cttctgaggg aagaagacgg caggcgggca ctgccgcagc tctgccgtgt ccctgcctgg
     2341 ctagtgacag gagaacgcaa agcttgagac actgccacat ttgtatttca tgctgagctg
     2401 tgatatcttt aagtacgtca gaattgctaa cctcttcctt ctctttcata gacagagtat
     2461 atgatcatgc ggatacagtt ttcatatttg cttttcctta atttttctat acattttgcc
     2521 aattgactta acaatgttgc catcgtgagg acatttcaag cactcttgca catttagttc
     2581 agtgttcctt tgtgaataaa tggcttcact ttttttttac tatactttca ttacttttaa
     2641 ttttctcacc tcattttatc tctgtatcag tgacctacct taaatagtcc acttacccaa
     2701 atagtttaaa atatttcatt tcatgatgaa tctccaagga tataagattg ttttaagtca
     2761 gacaaaccct gttgtatata gagcctctct atctgcctcc ttactggtgc aggtaggtca
     2821 ttgacagcag tcctagtcat atgcacacac accctcacca aacccttgaa gacattgaaa
     2881 atcctatctg agaccttctc tccacctatc tgcatgtgtt ttggttgtca agtgtttctg
     2941 catggcaatg tcccacagta acaaataatg atttcagttg gtccacctgt atttaaaatg
     3001 tgcaagaaaa actgaaatac tctgctgtag caagttctgt gtaacaaaga tatatcatcg
     3061 tgttaataaa ctgaaagcat catttgtata aaatacttta tttactttta tgtatttcat
     3121 ttaaatccaa gaacatgcta atcatgtgtt ctatgtatgc tacaaattct ctggtagcgt
     3181 tgttgtatat taatgtaaaa ttacttcaat aaattgtggg gatgacaatt tgattattat
     3241 aatttagttt tcaaaaattg atgaacagat ttctatgaat cctaaaaata tttttttcta
     3301 taaaattatt agtgcccagc tagaatctac ccaggtagat gacacctagg tttctggggc
     3361 ttctcagcca ttccatttta ttgtctctgt tggaagtaca cgagcaaacc atcagctggg
     3421 tcaaggggtc tctttctgac taaccaagta cactaaattg gagtattttt aacatgccta
     3481 aaattcccat ttttagccac agctgaaaag actttcttta aaaacttgaa atagtaagtc
     3541 agtggcaaaa accagtattt tattcaaagt atattacgta agacagaaga aatggtgttt
     3601 tgcccattaa atcaagagat ggcattgtat aggacagagc cctggactga gggagacttg
     3661 ttggagtggc gttgtgcaga cagagggcag aagcaggcac gttgtgggac ccccgactcc
     3721 ctgaggtagg tcaggattcc ctcctcagct aatattctca agggtatccc gctgtgaagt
     3781 aagctttgat agcaacacgt ttctgtttgt cctccctctt acctccacag tgtgctgaaa
     3841 accctttgac tatcagaaag gccttgtctg ttccattcct tccttcctcc ctcactgatg
     3901 ctaaatagac acttgatatc aaactgtcag cctaccaaaa agaagccgtg gcttatgggt
     3961 attgctgtct tgttcttggt gtgtacctgt actgattgcc ccttggtctg aaaaaaaaaa
     4021 aaaacaatgc tcattgtaag cctaaaaata catgattatc ttttcccact gactgttgtt
     4081 ctttccttct gcttgttgta agaatcaaat gaaataatgt atgtaaaggc accttgtaaa
     4141 ctgtacgctt tcaatgtaag acgtaaggtg tgttatttca ttaattagtt ctttgtttag
     4201 agtgcaattt cctatgcgct actatagcta ggaaatgctg aaaatgtgtt ttttaattca
     4261 tcaataaccg caaaattaaa gtatcttcaa agga
//
