LOCUS       NM_008854               2300 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus protein kinase, cAMP dependent, catalytic, alpha
            (Prkaca), transcript variant 1, mRNA.
ACCESSION   NM_008854
VERSION     NM_008854.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2300)
  AUTHORS   Karatsai,O., Lehka,L., Wojton,D., Grabowska,A.I., Duda,M.K.,
            Lenartowski,R. and Redowicz,M.J.
  TITLE     Unconventional myosin VI in the heart: Involvement in cardiac
            dysfunction progressing with age
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (6), 166748 (2023)
   PUBMED   37169038
REFERENCE   2  (bases 1 to 2300)
  AUTHORS   Park,E.J., Kim,H.S., Lee,D.H., Kim,S.M., Yoon,J.S., Lee,J.M.,
            Im,S.J., Lee,H., Lee,M.W. and Lee,C.W.
  TITLE     Ssu72 phosphatase is essential for thermogenic adaptation by
            regulating cytosolic translation
  JOURNAL   Nat Commun 14 (1), 1097 (2023)
   PUBMED   36841836
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2300)
  AUTHORS   Quevillon Huberdeau,M., Shah,V.N., Nahar,S., Neumeier,J., Houle,F.,
            Bruckmann,A., Gypas,F., Nakanishi,K., Grosshans,H., Meister,G. and
            Simard,M.J.
  TITLE     A specific type of Argonaute phosphorylation regulates binding to
            microRNAs during C. elegans development
  JOURNAL   Cell Rep 41 (11), 111822 (2022)
   PUBMED   36516777
REFERENCE   4  (bases 1 to 2300)
  AUTHORS   Nolan,M.A., Babcock,D.F., Wennemuth,G., Brown,W., Burton,K.A. and
            McKnight,G.S.
  TITLE     Sperm-specific protein kinase A catalytic subunit Calpha2
            orchestrates cAMP signaling for male fertility
  JOURNAL   Proc Natl Acad Sci U S A 101 (37), 13483-13488 (2004)
   PUBMED   15340140
  REMARK    GeneRIF: Calpha(2) null males are infertile despite normal mating
            behavior
REFERENCE   5  (bases 1 to 2300)
  AUTHORS   Taylor,S.S., Yang,J., Wu,J., Haste,N.M., Radzio-Andzelm,E. and
            Anand,G.
  TITLE     PKA: a portrait of protein kinase dynamics
  JOURNAL   Biochim Biophys Acta 1697 (1-2), 259-269 (2004)
   PUBMED   15023366
  REMARK    Review article
REFERENCE   6  (bases 1 to 2300)
  AUTHORS   Agustin,J.T., Wilkerson,C.G. and Witman,G.B.
  TITLE     The unique catalytic subunit of sperm cAMP-dependent protein kinase
            is the product of an alternative Calpha mRNA expressed specifically
            in spermatogenic cells
  JOURNAL   Mol Biol Cell 11 (9), 3031-3044 (2000)
   PUBMED   10982398
REFERENCE   7  (bases 1 to 2300)
  AUTHORS   Orellana,S.A. and McKnight,G.S.
  TITLE     Mutations in the catalytic subunit of cAMP-dependent protein kinase
            result in unregulated biological activity
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4726-4730 (1992)
   PUBMED   1584809
REFERENCE   8  (bases 1 to 2300)
  AUTHORS   Knighton,D.R., Zheng,J.H., Ten Eyck,L.F., Ashford,V.A., Xuong,N.H.,
            Taylor,S.S. and Sowadski,J.M.
  TITLE     Crystal structure of the catalytic subunit of cyclic adenosine
            monophosphate-dependent protein kinase
  JOURNAL   Science 253 (5018), 407-414 (1991)
   PUBMED   1862342
REFERENCE   9  (bases 1 to 2300)
  AUTHORS   Beebe,S.J., Oyen,O., Sandberg,M., Froysa,A., Hansson,V. and
            Jahnsen,T.
  TITLE     Molecular cloning of a tissue-specific protein kinase (C gamma)
            from human testis--representing a third isoform for the catalytic
            subunit of cAMP-dependent protein kinase
  JOURNAL   Mol Endocrinol 4 (3), 465-475 (1990)
   PUBMED   2342480
REFERENCE   10 (bases 1 to 2300)
  AUTHORS   Chrivia,J.C., Uhler,M.D. and McKnight,G.S.
  TITLE     Characterization of genomic clones coding for the C alpha and C
            beta subunits of mouse cAMP-dependent protein kinase
  JOURNAL   J Biol Chem 263 (12), 5739-5744 (1988)
   PUBMED   2833513
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC156028.2, BU059097.1,
            CD807077.1, CB248596.1 and BQ031203.1.
            
            On Apr 27, 2013 this sequence version replaced NM_008854.4.
            
            Summary: This gene encodes a member of the serine/threonine protein
            kinase family. The holoenzyme, protein kinase A (also known as
            cyclic-AMP dependent protein kinase), mediates cellular response to
            changes in cyclic-AMP levels. This gene encodes the alpha catalytic
            subunit of protein kinase A. Protein kinase A-mediated signaling is
            transduced via phosphorylation of target proteins, and is important
            for many cellular functions, including mammalian sperm maturation
            and motility. Alternative splicing results in multiple transcript
            variants. A pseudogene of this gene has been defined on the X
            chromosome. [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (1, also known as Calpha1)
            represents the longer transcript and encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054834.1, SRR7652917.882340.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC156028.2         139689-139738
            51-815              BU059097.1         1-765
            816-1277            CD807077.1         220-681
            1278-1740           CB248596.1         175-637
            1741-2300           BQ031203.1         1-560               c
FEATURES             Location/Qualifiers
     source          1..2300
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.22 cM"
     gene            1..2300
                     /gene="Prkaca"
                     /gene_synonym="Pkaca; PKCD"
                     /note="protein kinase, cAMP dependent, catalytic, alpha"
                     /db_xref="GeneID:18747"
                     /db_xref="MGI:MGI:97592"
     exon            1..255
                     /gene="Prkaca"
                     /gene_synonym="Pkaca; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            256..317
                     /gene="Prkaca"
                     /gene_synonym="Pkaca; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            318..446
                     /gene="Prkaca"
                     /gene_synonym="Pkaca; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            447..545
                     /gene="Prkaca"
                     /gene_synonym="Pkaca; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            546..628
                     /gene="Prkaca"
                     /gene_synonym="Pkaca; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            629..755
                     /gene="Prkaca"
                     /gene_synonym="Pkaca; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            756..851
                     /gene="Prkaca"
                     /gene_synonym="Pkaca; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            852..974
                     /gene="Prkaca"
                     /gene_synonym="Pkaca; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1139
                     /gene="Prkaca"
                     /gene_synonym="Pkaca; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..2292
                     /gene="Prkaca"
                     /gene_synonym="Pkaca; PKCD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2268..2273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkaca"
                     /gene_synonym="Pkaca; PKCD"
                     /note="hexamer: AATAAA"
     polyA_site      2292
                     /gene="Prkaca"
                     /gene_synonym="Pkaca; PKCD"
                     /note="major polyA site"
ORIGIN      
        1 ggacagagga cttgggctga ggctcccccg cgggcgggcg cagagagacg cgggaagcag
       61 gggctgggcg ggggtcgtgg cgccgcagcc agcgcagcca gccccagggg ccgccgcctc
      121 cgctgcccag cgcgctccgg ggccgccggc caccttagca cccgccgcgt cgcagctccg
      181 ggactggccc cggccgcgac gccgccgcga tgggcaacgc cgccgccgcc aagaagggca
      241 gcgagcagga gagcgtgaaa gagttcctag ccaaagccaa ggaagatttc ctgaaaaaat
      301 gggagacccc ttctcagaat acagcccagt tggatcagtt tgatagaatc aagacccttg
      361 gcaccggctc ctttgggcga gtgatgctgg tgaagcacaa ggagagtggg aaccactacg
      421 ccatgaagat cttagacaag cagaaggtgg tgaagctaaa gcagatcgag cacactctga
      481 atgagaagcg catcctgcag gccgtcaact tcccgttcct ggtcaaactt gaattctcct
      541 tcaaggacaa ctcaaacctg tacatggtca tggagtatgt agctggtggc gagatgttct
      601 cccacctacg gcggattgga aggttcagcg agccccatgc ccgtttctac gcggcgcaga
      661 tcgtcctgac ctttgagtat ctgcactccc tggacctcat ctaccgggac ctgaagcccg
      721 agaatcttct catcgaccag cagggctata ttcaggtgac agacttcggt tttgccaagc
      781 gtgtgaaagg ccgtacttgg accttgtgtg ggacccctga gtacttggcc cccgagatta
      841 tcctgagcaa aggctacaac aaggctgtgg actggtgggc tctcggagtc ctcatctacg
      901 agatggctgc tggttaccca cccttcttcg ctgaccagcc tatccagatc tatgagaaaa
      961 tcgtctctgg gaaggtgcgg ttcccatccc acttcagctc tgacttgaag gacctgctgc
     1021 ggaaccttct gcaggtggat ctcaccaagc gctttgggaa cctcaagaac ggggtcaatg
     1081 acatcaagaa ccacaagtgg tttgccacga ctgactggat tgccatctat cagagaaagg
     1141 tggaagctcc cttcatacca aagtttaaag gccctgggga cacgagtaac tttgacgact
     1201 atgaggagga agagatccgg gtctccatca atgagaagtg tggcaaggag tttactgagt
     1261 tttaggggtg tgcttgtgcc ccttgggttc tctttcattt tttctttttc tttctatttt
     1321 ttttccggtt gggggtggga gggttggatc gaacagccag agggccctag agttccatgc
     1381 atctaattta acatccactc cacaccccca gggttaagga gagcaggaaa gcgctccaga
     1441 tactggggaa ggggcaacat cagctgctcc ccctctccct tcttctccac ccttccctgc
     1501 ctgttttcaa tgaatttctt agctccagcc atacccaatc ttgctggtgt atccaggggc
     1561 agggtacgga aagagggccc caaattcagc ctccttcccg accctagcac tggatactaa
     1621 ggatgaacga acagtaacgc caaccttccc ttccatgcag ccctacctgg aaagggagat
     1681 tttatgacct gtacagaggg ctgcttgcca gtggggtttt tttttttttt catttaaatt
     1741 aagttccacc agtgcctccc accctccaaa ctgtcccacc ctccccaaac accctcctca
     1801 ctccctaaat ccattctgat gagacccggg tagccaactg accctgtcaa ggaaggaact
     1861 gggcttggaa tctcgccctg agctgctagc ctcccggccc ccctttccag tggtctcatg
     1921 ccaattgtcc tgtgcatcag cccccttaag aagcctcccc catcctgggc gcctcgcttc
     1981 tagcttagct gtcagctgtc catcacctct tgccgtgcgt ccccactcac tgcaacccca
     2041 agtctgattg tgctttttct ctcaatagaa aggtggggag ctgctgggga aattacccca
     2101 tttatccctg tgtttatccc tctcgtaact tctcccaaaa aggaggagct ctcaggcctg
     2161 ggtgggggcc ccgggtggac gagggggtcg ttcaacctgt gtgcttcgaa ggatgagact
     2221 tcctcttgaa cagtgtgctg ttgtaaacat atttgaaaac tattaccaat aaagttttgt
     2281 tttaaaataa aaaaaaaaaa
//
