LOCUS       NM_182997               4278 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protein kinase, AMP-activated, beta 2 non-catalytic
            subunit (Prkab2), mRNA.
ACCESSION   NM_182997
VERSION     NM_182997.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4278)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4278)
  AUTHORS   Neopane,K., Kozlov,N., Negoita,F., Murray-Segal,L., Brink,R.,
            Hoque,A., Ovens,A.J., Tjin,G., McAloon,L.M., Yu,D., Ling,N.X.Y.,
            Sanders,M.J., Oakhill,J.S., Scott,J.W., Steinberg,G.R., Loh,K.,
            Kemp,B.E., Sakamoto,K. and Galic,S.
  TITLE     Blocking AMPK beta1 myristoylation enhances AMPK activity and
            protects mice from high-fat diet-induced obesity and hepatic
            steatosis
  JOURNAL   Cell Rep 41 (12), 111862 (2022)
   PUBMED   36543129
REFERENCE   3  (bases 1 to 4278)
  AUTHORS   Muraleedharan,R., Gawali,M.V., Tiwari,D., Sukumaran,A., Oatman,N.,
            Anderson,J., Nardini,D., Bhuiyan,M.A.N., Tkac,I., Ward,A.L.,
            Kundu,M., Waclaw,R., Chow,L.M., Gross,C., Rao,R., Schirmeier,S. and
            Dasgupta,B.
  TITLE     AMPK-Regulated Astrocytic Lactate Shuttle Plays a
            Non-Cell-Autonomous Role in Neuronal Survival
  JOURNAL   Cell Rep 32 (9), 108092 (2020)
   PUBMED   32877674
REFERENCE   4  (bases 1 to 4278)
  AUTHORS   Katwan,O.J., Alghamdi,F., Almabrouk,T.A., Mancini,S.J., Kennedy,S.,
            Oakhill,J.S., Scott,J.W. and Salt,I.P.
  TITLE     AMP-activated protein kinase complexes containing the beta2
            regulatory subunit are up-regulated during and contribute to
            adipogenesis
  JOURNAL   Biochem J 476 (12), 1725-1740 (2019)
   PUBMED   31189568
  REMARK    GeneRIF: these data indicate that increased expression of AMPKbeta2
            is an important feature of efficient adipogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4278)
  AUTHORS   Yeganeh,B., Lee,J., Ermini,L., Lok,I., Ackerley,C. and Post,M.
  TITLE     Autophagy is required for lung development and morphogenesis
  JOURNAL   J Clin Invest 129 (7), 2904-2919 (2019)
   PUBMED   31162135
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4278)
  AUTHORS   Ho,R.C., Fujii,N., Witters,L.A., Hirshman,M.F. and Goodyear,L.J.
  TITLE     Dissociation of AMP-activated protein kinase and p38
            mitogen-activated protein kinase signaling in skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 362 (2), 354-359 (2007)
   PUBMED   17709097
  REMARK    GeneRIF: Results suggest that p38 MAPK is not a downstream
            component of AMPK-mediated signaling in skeletal muscle.
REFERENCE   7  (bases 1 to 4278)
  AUTHORS   Yang,S.N., Wenna,N.D., Yu,J., Yang,G., Qiu,H., Yu,L.,
            Juntti-Berggren,L., Kohler,M. and Berggren,P.O.
  TITLE     Glucose recruits K(ATP) channels via non-insulin-containing
            dense-core granules
  JOURNAL   Cell Metab 6 (3), 217-228 (2007)
   PUBMED   17767908
REFERENCE   8  (bases 1 to 4278)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   9  (bases 1 to 4278)
  AUTHORS   Chen,Z., Heierhorst,J., Mann,R.J., Mitchelhill,K.I., Michell,B.J.,
            Witters,L.A., Lynch,G.S., Kemp,B.E. and Stapleton,D.
  TITLE     Expression of the AMP-activated protein kinase beta1 and beta2
            subunits in skeletal muscle
  JOURNAL   FEBS Lett 460 (2), 343-348 (1999)
   PUBMED   10544261
REFERENCE   10 (bases 1 to 4278)
  AUTHORS   Turnley,A.M., Stapleton,D., Mann,R.J., Witters,L.A., Kemp,B.E. and
            Bartlett,P.F.
  TITLE     Cellular distribution and developmental expression of AMP-activated
            protein kinase isoforms in mouse central nervous system
  JOURNAL   J Neurochem 72 (4), 1707-1716 (1999)
   PUBMED   10098881
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC060228.1.
            
            On Aug 12, 2005 this sequence version replaced NM_182997.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060228.1, SRR1660821.177518.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4278
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.25 cM"
     gene            1..4278
                     /gene="Prkab2"
                     /gene_synonym="5730553K21Rik"
                     /note="protein kinase, AMP-activated, beta 2 non-catalytic
                     subunit"
                     /db_xref="GeneID:108097"
                     /db_xref="MGI:MGI:1336185"
     exon            1..158
                     /gene="Prkab2"
                     /gene_synonym="5730553K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            159..336
                     /gene="Prkab2"
                     /gene_synonym="5730553K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            337..503
                     /gene="Prkab2"
                     /gene_synonym="5730553K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            504..597
                     /gene="Prkab2"
                     /gene_synonym="5730553K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            598..718
                     /gene="Prkab2"
                     /gene_synonym="5730553K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            719..852
                     /gene="Prkab2"
                     /gene_synonym="5730553K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            853..921
                     /gene="Prkab2"
                     /gene_synonym="5730553K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            922..4277
                     /gene="Prkab2"
                     /gene_synonym="5730553K21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3241..3246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkab2"
                     /gene_synonym="5730553K21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3271
                     /gene="Prkab2"
                     /gene_synonym="5730553K21Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaggcggtac ctcgtcgcgg gccttgtagc cattttagga ggaaacccgg ttcgctggtt
       61 tggggcgcgg cttcaatttc aataacttta ttggtctcct tgtacgccga acagccggcg
      121 tgcgtgtagc cacgcgagcc cggagcgcat cgcccgaggt tgcccccgac tcgagctgca
      181 gccatgggaa acactaccag cgagcgggtg tccggggagc gccacggagc caaagctgct
      241 cgagctgagg gcggcggcca tggcccggga aaggagcaca agatcatggt ggggagcacg
      301 gacgacccca gcgtcttcag cctgcccgac tccaagctcc ccggggacaa agagtttgta
      361 ccctggcagc aggatttgga tgattctgtg aagcccgccc agcaggcccg gcccaccgtt
      421 atccgctggt ctgaaggagg caaggaggtc ttcatctctg ggtccttcaa caattggagc
      481 accaagatcc ctctgataaa gagtcataat gacttcgttg ccatcctgga tcttccagag
      541 ggagagcatc agtacaagtt ctttgtggac ggacagtggg ttcatgatcc gtcagagcct
      601 gtggttacca gtcagcttgg aacaattaat aacttgatcc acgtcaagaa atctgatttt
      661 gaagtatttg acgctttaaa gttagactct atggaaagct cggagacgtc atgtcgagac
      721 ctgtccagct caccccctgg gccttacggt caagaaatgt atgtgtttcg atctgaggag
      781 agattcaaat ccccacccat cctgccccct cacctactcc aagttattct taacaaggac
      841 acgaatattt catgtgaccc agccttactt cctgagccca atcatgttat gctgaaccat
      901 ctctatgcac tgtccattaa ggacagtgtg atggtcctta gcgcaaccca tcgctacaag
      961 aagaagtatg tcaccacgct gctgtataag cccatctgag gaaggcgtca cgccttgccc
     1021 ccaaggattc tggagaagca tctcccttgc ctttgaactg agctggcctc ctctgaggct
     1081 ggcaggctgg tttgttttga ggctgctgtg tgtgtcagag cctctgatag gatgctctgc
     1141 tttgcatttg attgcagatg agagctttat gagttcacgg agtttatttt aagaaacaca
     1201 aaaccatata tatgcatatg agagaaaggt taccggaagt ctcctggccc cgctgtacag
     1261 gttctctctg cctgtgggtg gtcgccaggg cctgactggg aagcagtggc cacaggaatg
     1321 ggcatcccag aagcttcttt ttctaaagtg agagaatagc aaactcttag gatctttgtt
     1381 gggcagaggt tctggaccac tggtgtccag gggtgagatg tgtgccaggc tgctgccctc
     1441 cttagagctg cctcagtgca gggtggcttt ccttgcatgg actgattctg tattcccaca
     1501 ctatgtgaca caatctcctg tgtgtttata tgacactaga tgccccacaa gaaccctctt
     1561 cattttatgt acccaattta ataagtcccc tcagatctca tacatggccc agtaatgcaa
     1621 aactcactgg gcaagggacc cttctgaaaa gtctgtgtga ttagactctc ctgagagact
     1681 agaggtgcca gggtctcctt tttagctcag cgaaggccta acccagtgtg ttacaattta
     1741 ttttaacatc taggggaaaa tgaagctctt tttgtttcag tttggtcctg tatattggct
     1801 gtgtgagcct gtttacggtt tttctttatc agagcattca gtttgtagat aggtttggaa
     1861 ttagggaaaa cttccgtatc tttcatccct gaaagatttt ttttttatgt gcctacattt
     1921 ttctttaatt aaaaaaaaaa agcttatcca tccatgttaa caggctgtta aaggacctca
     1981 ggcttttgac aaatggttct taagcttttc ttctctagtc taggcaattc tacagtcttg
     2041 ggttaatatg gccagccatg tgtacctcgc tacccaagca cagctctaga cacaagttca
     2101 tgcagactca ctggatgctc atgcaggctc actgggtgct catgcgaggt ttccctacca
     2161 ttaaagatgt gtgaggcaag gaactaccct cggtgttcat aaccgtgcac agtattgctc
     2221 tttgcaccaa atattaacaa agtatttttt tctttcgcct cttcccttta aatgtgtttg
     2281 atgatggaat ggggtcactg ataaccactg actgagaagt attccaacct actcaggatt
     2341 gaaaggaaat attttttcca gtatcttgac acttccattt tacagataaa tgtaagtcaa
     2401 tcattaggca ctgtttctgg ttgagagcct tcctgtctcc tgagatgagc cagccacatt
     2461 gaaagggacc tgctggtcag ttcacctacc tcctggctct cccacatgag ggtggcacag
     2521 caagtcctct gcacacctct gaggcctctt atcacaaggg tgaataggaa gatggggagg
     2581 tttctgtcct gcagggagta cagatcgctc aatgccttgg tacatgagtc ctgggagatg
     2641 ccgcttcagc catcccaagc cacctccctc agctgagact ctgtggagaa ccctcgtggt
     2701 ccagtcagct ttctgaatag tgttccattt tgaaagccaa ggcctcatct tggtttttca
     2761 tcaactctaa ggcccttcag ttatgtcgaa aggttttatt tattttttct gtttttcctc
     2821 agtgctgatt tagaagtggg ccacccagga ggattcaaaa gccttgcttg tttcccagta
     2881 ggattgttgt atctacactt cctgttaaca gtctaagctg ggatcatctg tgtttgtgca
     2941 ttaagttttg acccctcaaa gttgtagcta tggaagggtg gggaaagctg tcttcagtct
     3001 ctcactcagg ctgatgcttc tctgacgggt gaggctgtgg tgatagaggg gtgggtgctg
     3061 atggcctcat ctggaaatgc aggagagagt tagaagggct ggctgatagc tcaccagcac
     3121 tgtccctgtc ctggcccctg accctgggga atgctgcccc tgtcaccagg aaacacttgt
     3181 aaagagacag agtgagtacc gcttttcttt agttacttta aggggcagtg tgttttctac
     3241 aataaaaagt cggacagaat taagaaacaa atcaaggcaa aactatttct ttttctttcc
     3301 cacctatggg aattttgcag ggtcagttgg tagtaaaacg gcccttaagg aggctaacac
     3361 aacacctgta gtgtagatca gtgcctgtga ggccagggaa gcagcgaagg agcccaaggg
     3421 agatagcagg aactgaaggc tcagggagct tggcactgaa aatgtcccct taaagagttc
     3481 aagcagacat cacctggtac aaaccactta gcagcccaga aactgtcttc ttaccctgtt
     3541 ctcacccttt cctctgcgtt ctgtctgact tcacttatca gtaagacagg ttcaccagag
     3601 tctcaaggaa aaagacctag acagtgtgaa gagctttcac tcgagccatg gttattagcc
     3661 tcctgtcaac ctagacctga gtaggattca cacctctgaa gggctcagct agcttcttca
     3721 agagccctgg cctcttgggc cggaagtaca aaggaagaaa acccgtttct gagagaaacc
     3781 ttcgcccagc cgtccctgct ggttttggtt ttttgtagat ctaatggatc tttcataaac
     3841 cttttgaaaa gtgtcactat tgcatgcatg ctgttaaagt gatgtgacgt ggaagtggga
     3901 acagggcctt taaatgtttg acctcaaaac aatatgcaat agtccctgtg ggtgtgtgtg
     3961 tgtgtgcaca tatgtgtatg tggtattcct tctgttctca gagatactta gtcctcatat
     4021 tcttgtgacc tggggcttaa gagcagataa atattttgtt ggtgtgttat gactaatcct
     4081 caaagccaag ttcttgctgt cttctgtcag cggcagactc cagttactca tgaatatgag
     4141 accaggaaga aataagggtc tttcaggact ctggatctag gcatttgtct gtccttaagt
     4201 gacaatcaca actggagatt gaaagactga tttctgcagt gaacaaacat gtttggagta
     4261 aaaaaaaaaa aaaaaaaa
//
