LOCUS       NM_031869               2008 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus protein kinase, AMP-activated, beta 1 non-catalytic
            subunit (Prkab1), transcript variant 1, mRNA.
ACCESSION   NM_031869
VERSION     NM_031869.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2008)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2008)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2008)
  AUTHORS   Day,E.A., Townsend,L.K., Rehal,S., Batchuluun,B., Wang,D.,
            Morrow,M.R., Lu,R., Lundenberg,L., Lu,J.H., Desjardins,E.M.,
            Smith,T.K.T., Raphenya,A.R., McArthur,A.G., Fullerton,M.D. and
            Steinberg,G.R.
  TITLE     Macrophage AMPK beta1 activation by PF-06409577 reduces the
            inflammatory response, cholesterol synthesis, and atherosclerosis
            in mice
  JOURNAL   iScience 26 (11), 108269 (2023)
   PUBMED   38026185
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2008)
  AUTHORS   Wu,Y., Xu,X., Liu,F., Jing,Z., Shen,D., He,P., Chen,T., Wu,T.,
            Jia,H., Mo,D., Li,Y., Zhang,H. and Yang,S.
  TITLE     Three-Dimensional Matrix Stiffness Activates the
            Piezo1-AMPK-Autophagy Axis to Regulate the Cellular Osteogenic
            Differentiation
  JOURNAL   ACS Biomater Sci Eng 9 (8), 4735-4746 (2023)
   PUBMED   37428711
  REMARK    GeneRIF: Three-Dimensional Matrix Stiffness Activates the
            Piezo1-AMPK-Autophagy Axis to Regulate the Cellular Osteogenic
            Differentiation.
REFERENCE   5  (bases 1 to 2008)
  AUTHORS   Banskota,S., Wang,H., Kwon,Y.H., Gautam,J., Haq,S., Grondin,J.,
            Steinberg,G.R. and Khan,W.I.
  TITLE     Inhibition of NADPH Oxidase (NOX) 2 Mitigates Colitis in Mice with
            Impaired Macrophage AMPK Function
  JOURNAL   Biomedicines 11 (5), 1443 (2023)
   PUBMED   37239114
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2008)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 2008)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2008)
  AUTHORS   Chen,Z., Heierhorst,J., Mann,R.J., Mitchelhill,K.I., Michell,B.J.,
            Witters,L.A., Lynch,G.S., Kemp,B.E. and Stapleton,D.
  TITLE     Expression of the AMP-activated protein kinase beta1 and beta2
            subunits in skeletal muscle
  JOURNAL   FEBS Lett 460 (2), 343-348 (1999)
   PUBMED   10544261
REFERENCE   9  (bases 1 to 2008)
  AUTHORS   Turnley,A.M., Stapleton,D., Mann,R.J., Witters,L.A., Kemp,B.E. and
            Bartlett,P.F.
  TITLE     Cellular distribution and developmental expression of AMP-activated
            protein kinase isoforms in mouse central nervous system
  JOURNAL   J Neurochem 72 (4), 1707-1716 (1999)
   PUBMED   10098881
REFERENCE   10 (bases 1 to 2008)
  AUTHORS   Salt,I., Celler,J.W., Hawley,S.A., Prescott,A., Woods,A.,
            Carling,D. and Hardie,D.G.
  TITLE     AMP-activated protein kinase: greater AMP dependence, and
            preferential nuclear localization, of complexes containing the
            alpha2 isoform
  JOURNAL   Biochem J 334 (Pt 1) (Pt 1), 177-187 (1998)
   PUBMED   9693118
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115795.11.
            
            On Mar 6, 2023 this sequence version replaced NM_031869.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088250.1, AK153552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               AC115795.11        103237-103536       c
            301-464             AC115795.11        100629-100792       c
            465-558             AC115795.11        99520-99613         c
            559-673             AC115795.11        99150-99264         c
            674-807             AC115795.11        97094-97227         c
            808-876             AC115795.11        94060-94128         c
            877-2008            AC115795.11        92741-93872         c
FEATURES             Location/Qualifiers
     source          1..2008
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.1 cM"
     gene            1..2008
                     /gene="Prkab1"
                     /gene_synonym="1300015D22Rik; E430008F22"
                     /note="protein kinase, AMP-activated, beta 1 non-catalytic
                     subunit"
                     /db_xref="GeneID:19079"
                     /db_xref="MGI:MGI:1336167"
     exon            1..300
                     /gene="Prkab1"
                     /gene_synonym="1300015D22Rik; E430008F22"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..954
                     /gene="Prkab1"
                     /gene_synonym="1300015D22Rik; E430008F22"
                     /note="AMPKb; AMPK subunit beta-1"
                     /codon_start=1
                     /product="5'-AMP-activated protein kinase subunit beta-1"
                     /protein_id="NP_114075.1"
                     /db_xref="CCDS:CCDS19598.1"
                     /db_xref="GeneID:19079"
                     /db_xref="MGI:MGI:1336167"
                     /translation="MGNTSSERAALERQAGHKTPRRDSSGGAKDGDRPKILMDSPEDA
                     DIFHSEEIKAPEKEEFLAWQHDLEANDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSK
                     LPLTRSQNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDF
                     EVFDALMVDSQKCSDVSELSSSPPGPYHQEPYMSKPEERFKAPPILPPHLLQVILNKD
                     TGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI"
     exon            301..464
                     /gene="Prkab1"
                     /gene_synonym="1300015D22Rik; E430008F22"
                     /inference="alignment:Splign:2.1.0"
     exon            465..558
                     /gene="Prkab1"
                     /gene_synonym="1300015D22Rik; E430008F22"
                     /inference="alignment:Splign:2.1.0"
     exon            559..673
                     /gene="Prkab1"
                     /gene_synonym="1300015D22Rik; E430008F22"
                     /inference="alignment:Splign:2.1.0"
     exon            674..807
                     /gene="Prkab1"
                     /gene_synonym="1300015D22Rik; E430008F22"
                     /inference="alignment:Splign:2.1.0"
     exon            808..876
                     /gene="Prkab1"
                     /gene_synonym="1300015D22Rik; E430008F22"
                     /inference="alignment:Splign:2.1.0"
     exon            877..2008
                     /gene="Prkab1"
                     /gene_synonym="1300015D22Rik; E430008F22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1988..1993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkab1"
                     /gene_synonym="1300015D22Rik; E430008F22"
                     /note="hexamer: AATAAA"
     polyA_site      2008
                     /gene="Prkab1"
                     /gene_synonym="1300015D22Rik; E430008F22"
                     /note="major polyA site"
ORIGIN      
        1 gttccagtcg cggtcgcccg agccaggtaa agcggagctc ggcgggcgag cgagcgcgcg
       61 atccgagagg gcgtgactcg cgatccccgg gggtccgacc cggcctttcc ggcttccttg
      121 tgtccctgca gattcccagc catgggcaac acgagcagcg agcgcgccgc gctggagcgg
      181 caggcgggcc acaagacgcc gcggagggac agctccgggg gcgccaagga tggggacagg
      241 cccaagatcc tcatggacag ccctgaagac gccgacatct tccactccga agagatcaag
      301 gctccagaga aagaggaatt cctggcctgg cagcacgacc tggaagcgaa tgataaagcc
      361 cccgcccagg cccggcccac cgtgtttcga tggacagggg gtggaaagga agtctacttg
      421 tctgggtcct tcaacaactg gagcaagctt cccctcacga gaagccagaa taactttgta
      481 gccatcctgg acctgcctga aggagagcat cagtacaagt tcttcgtgga tggacagtgg
      541 acccatgatc cttctgagcc aatagtaacc agccagcttg gcacagttaa caacatcatt
      601 caagtgaaga aaactgactt tgaagtattt gatgctttaa tggtggattc ccaaaagtgc
      661 tccgatgtgt ctgagctgtc cagctcgccc ccaggaccct accaccagga gccttacatg
      721 tctaaaccag aagagaggtt caaagccccg cccatcctcc cgccacacct gctgcaggtc
      781 atcttgaaca aggacacggg catctcttgt gacccagcac tgcttccgga gcccaaccac
      841 gtcatgctga accacctcta tgcactctcc atcaaggatg gagtgatggt gctcagtgca
      901 acacaccggt acaagaaaaa gtatgtcacc accctcctct acaagccgat atgagggaat
      961 gagaggcagc catggaccac agggatggca ggcggtgctg ggctctccgt gtgcatgcac
     1021 atcctcactc actctgggac atctcaccca ccctagtcct ccttgaaggt ctgtccaggc
     1081 atagccaaaa atagggatgg cacggccgcc tgcagcccca gcatcgcagt gcacgaggct
     1141 ttgtgctcta cgcatcatcc cctctgctgg ccagagatgt ctacagccag acccgaacct
     1201 ggggagcagg gacagaagcc acacagaagt cctcatcatc gtttgcctcc gtgaggccgc
     1261 tggcctgtcc ctggtgaggc ctggctgggg aggaaagcag tgttgggtct tgcctgtcct
     1321 tctgaatcaa agcagtagat tgtagatcct atggaaattc agtgtctgat ttccggatgc
     1381 agctttgcaa tcgtttcccg acactgtgtg cactaagacc tctttaacca gagtggctgg
     1441 ctggccactc ctacgtaagg caataagtca ccaggatgag actagagatc atgtgactac
     1501 actcagcaat aatcactctc aagacagact tcaaacccca ctgccatttc tccattaagc
     1561 cagatgatcc tgaggaccga ccactgcaga aagtcggcta caccttattt cagttgcaat
     1621 gttggccaca ttaccatggc aacctggtcg aagcacccac cctcctttta gttccagcat
     1681 gtgctcctca gctggggacc tgcatctcta gtgagcagag agtatcacgg tggttgctgt
     1741 tgcttgttcc aaaagaagag ctcggaaccc tacagcagac tgctgggttt ccagcagggg
     1801 agcaggaatg aacctatctt atactccatc tggtttccat ggtgacatca cagctgtgcc
     1861 cattgggaca aggtcctgtc acctgtcagc agaggcaggc acagtatttg gttaagcctg
     1921 agttttgggt accttttgtt actgttttca aaaccctgac ttgctcttat cttgatgtac
     1981 aagtttcaat aaagctttgt aaaaatta
//
