LOCUS       NM_001013367            4655 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus protein kinase, AMP-activated, alpha 1 catalytic
            subunit (Prkaa1), transcript variant 1, mRNA.
ACCESSION   NM_001013367 XM_139298
VERSION     NM_001013367.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4655)
  AUTHORS   Huang,Z., Luo,L., Xiao,Z., Xiong,M. and Wen,Z.
  TITLE     Omentin-1 mitigates non-alcoholic fatty liver disease by preserving
            autophagy through AMPKalpha/mTOR signaling pathway
  JOURNAL   Sci Rep 14 (1), 31464 (2024)
   PUBMED   39732921
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4655)
  AUTHORS   Singh,S., Singh,P.K., Ahmad,Z., Das,S., Foretz,M., Viollet,B.,
            Giri,S. and Kumar,A.
  TITLE     Myeloid Cell-Specific Deletion of AMPKalpha1 Worsens Ocular
            Bacterial Infection by Skewing Macrophage Phenotypes
  JOURNAL   J Immunol 213 (11), 1656-1665 (2024)
   PUBMED   39413004
REFERENCE   3  (bases 1 to 4655)
  AUTHORS   Hossain,M.N., Gao,Y., Li,X., Zhao,L., Liu,X., Marie de Avila,J.,
            Zhu,M.J. and Du,M.
  TITLE     Single-cell RNA transcriptomics in mice reveals embryonic origin of
            fibrosis due to maternal obesity
  JOURNAL   EBioMedicine 109, 105421 (2024)
   PUBMED   39476533
  REMARK    Erratum:[EBioMedicine. 2025 Jan 27;112:105573. doi:
            10.1016/j.ebiom.2025.105573.. PMID: 39874704]
REFERENCE   4  (bases 1 to 4655)
  AUTHORS   Yang,J.H., Gao,J., E,Y.Q., Jiao,L.J., Wu,R., Yan,Q.Y., Wei,Z.Y.,
            Yan,G.L., Liang,J.L. and Li,H.Z.
  TITLE     Hydrogen sulfide inhibits skeletal muscle ageing by up-regulating
            autophagy through promoting deubiquitination of adenosine
            5'-monophosphate (AMP)-activated protein kinase alpha1 via
            ubiquitin specific peptidase 5
  JOURNAL   J Cachexia Sarcopenia Muscle 15 (5), 2118-2133 (2024)
   PUBMED   39189428
  REMARK    GeneRIF: Hydrogen sulfide inhibits skeletal muscle ageing by
            up-regulating autophagy through promoting deubiquitination of
            adenosine 5'-monophosphate (AMP)-activated protein kinase alpha1
            via ubiquitin specific peptidase 5.
REFERENCE   5  (bases 1 to 4655)
  AUTHORS   Ma,H., Jia,H., Zou,W., Ji,F., Wang,W., Zhao,J., Yuan,C. and Jiao,J.
  TITLE     Gasdermin D Mediated Mitochondrial Metabolism Orchestrate
            Neurogenesis Through LDHA During Embryonic Development
  JOURNAL   Adv Sci (Weinh) 11 (35), e2402285 (2024)
   PUBMED   39033542
REFERENCE   6  (bases 1 to 4655)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4655)
  AUTHORS   Sato,T., Sato-Harada,R., Takano,M., Kato,S., Saburi,S. and
            Harada,A.
  TITLE     Localization of cAMP-dependent protein kinase in the actin and
            microtubule cytoskeletons in mouse hippocampal neurons
  JOURNAL   Neurosci Lett 325 (2), 83-86 (2002)
   PUBMED   12044627
REFERENCE   8  (bases 1 to 4655)
  AUTHORS   Fryer,L.G., Foufelle,F., Barnes,K., Baldwin,S.A., Woods,A. and
            Carling,D.
  TITLE     Characterization of the role of the AMP-activated protein kinase in
            the stimulation of glucose transport in skeletal muscle cells
  JOURNAL   Biochem J 363 (Pt 1), 167-174 (2002)
   PUBMED   11903059
REFERENCE   9  (bases 1 to 4655)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 4655)
  AUTHORS   Turnley,A.M., Stapleton,D., Mann,R.J., Witters,L.A., Kemp,B.E. and
            Bartlett,P.F.
  TITLE     Cellular distribution and developmental expression of AMP-activated
            protein kinase isoforms in mouse central nervous system
  JOURNAL   J Neurochem 72 (4), 1707-1716 (1999)
   PUBMED   10098881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY134921.1, AK160612.1, CB245934.1, AK081874.1 and AC135079.9.
            
            On May 5, 2006 this sequence version replaced NM_001013367.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086695.1, SRR1660813.253715.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               BY134921.1         1-252
            253-721             AK160612.1         234-702
            722-1377            CB245934.1         18-673
            1378-2750           AK081874.1         233-1605
            2751-4655           AC135079.9         88492-90396         c
FEATURES             Location/Qualifiers
     source          1..4655
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 1.99 cM"
     gene            1..4655
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /note="protein kinase, AMP-activated, alpha 1 catalytic
                     subunit"
                     /db_xref="GeneID:105787"
                     /db_xref="MGI:MGI:2145955"
     exon            1..135
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1688
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /EC_number="2.7.11.31"
                     /note="isoform 1 is encoded by transcript variant 1;
                     5'-AMP-activated protein kinase catalytic subunit alpha-1;
                     AMP-activated protein kinase, alpha 1 catalytic subunit;
                     AMPK subunit alpha-1; ACACA kinase; HMGCR kinase;
                     acetyl-CoA carboxylase kinase; hydroxymethylglutaryl-CoA
                     reductase kinase; tau-protein kinase PRKAA1"
                     /codon_start=1
                     /product="5'-AMP-activated protein kinase catalytic
                     subunit alpha-1 isoform 1"
                     /protein_id="NP_001013385.3"
                     /db_xref="CCDS:CCDS49574.1"
                     /db_xref="GeneID:105787"
                     /db_xref="MGI:MGI:2145955"
                     /translation="MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVG
                     KHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFM
                     VMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDA
                     HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYAL
                     LCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRAAIKDIREH
                     EWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVA
                     YHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDEL
                     NPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNP
                     VTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDS
                     DAEAQGKPSDVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ"
     exon            136..277
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            278..371
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            372..516
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            517..604
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            605..829
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1316
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1443
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..4655
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4261..4266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4280
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /note="major polyA site"
     regulatory      4624..4629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4648
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
ORIGIN      
        1 gcggcgccat gcgcagactc agttcctgga gaaagatggc gacggccgag aagcagaagc
       61 acgacgggcg ggtgaagatc ggccactaca tcctggggga cacgcttggt gtcggcacct
      121 tcgggaaagt gaaggtgggc aagcacgagt tgaccggaca taaagtggct gtgaagatac
      181 tcaaccggca gaagattcgg agccttgacg tggtgggaaa aatccgccgg gagattcaga
      241 acctgaagct gttcaggcac cctcacatca tcaaactgta ccaggtcatc agtacaccat
      301 ctgatatttt catggtgatg gaatatgtct ctggaggaga gctatttgat tatatctgta
      361 aaaatggaag gttggacgaa aaggaaagcc gccgtctgtt ccagcagatc ctttccggtg
      421 tggattattg tcacaggcat atggtggtcc acagagattt gaaacctgag aacgtcctgc
      481 ttgatgcaca catgaatgca aagatagccg actttggtct ttcaaacatg atgtcagatg
      541 gtgaattttt aagaacaagc tgtggctcac ccaattatgc cgcaccagaa gtcatttcag
      601 gaagattgta cgcaggcccc gaggtggaca tctggagcag cggggtcatt ctctatgctt
      661 tgctgtgtgg aaccctccct tttgatgatg accatgtgcc aactcttttt aagaagatat
      721 gtgatgggat cttttatacc cctcagtact taaacccttc agtaatcagc cttttgaaac
      781 atatgctgca ggtggatccc atgaagaggg ccgcaataaa agatatcagg gaacacgagt
      841 ggtttaaaca ggaccttccg aagtatctct ttcctgagga cccatcttat agttcaacca
      901 tgatcgatga cgaagccttg aaagaagtgt gtgagaagtt cgagtgttcg gaggaggagg
      961 tcctcagctg cctgtacaac agaaaccacc aggacccact agccgtcgcc taccacctca
     1021 tcatagacaa caggagaata atgaatgaag ccaaagattt ctacctagca accagcccac
     1081 ctgactcttt cctggacgac caccatttaa ctcggcctca ccctgaaaga gtaccgttct
     1141 tggttgccga aacaccacgg gcccggcaca ccctggatga attaaaccca cagaaatcca
     1201 aacaccaagg tgtacggaag gcaaaatggc atttgggaat tcgaagtcaa agccgaccca
     1261 atgatatcat ggcagaagtt tgtagagcaa tcaagcagtt ggattatgaa tggaaggttg
     1321 taaaccccta ttatttgcgt gtacgaagga agaatcctgt gacaagcaca ttttccaaaa
     1381 tgagtctaca gctataccaa gtggatagta ggacttactt gttggatttc cgtagtattg
     1441 atgatgagat tacagaagcc aaatcaggga ctgctactcc acagagatcg ggatccatca
     1501 gcaactatcg atcttgccaa aggagtgact ctgatgccga agctcaagga aagccctcag
     1561 acgtctccct tacctcatct gtcacctccc tcgactcctc ccctgtcgac gtagctccaa
     1621 gaccaggaag tcatacaata gaattttttg aaatgtgtgc aaatctaatt aaaattcttg
     1681 cacagtaaac ctaaaatttt gcttatttct ttgatgcaat aagcatgcat aataaataat
     1741 agccaaatac ttccacttac caagttatat atatgtgtgt atataactga ggattggcct
     1801 tttggaatgc agtttgcaca gggactggaa aacgattgat cgttaaaagc ctgatgtgca
     1861 gaattgaatg aggatcactc tgttatcccg tattcagtag gtacacacag cgtaacacac
     1921 acacaatgga ctgtaggtct caagcttact tgacttttgg ccatttgaat ttgctgtaac
     1981 aggtctcagt cgaccataaa tttaccataa agccttcaca tattagtaca tgttgatgta
     2041 ttttatatta gcttcatgaa tttattgagt tgcctggaat cctcatagac cttattagat
     2101 aatgctgttt tctgggctcc ttaacttcca aaatagctac tagtttccat ttttggttac
     2161 attgtgaact atttccatat tcctcttaac atgctatttt tgtgtagtaa gtcatttcag
     2221 agagcagtct ggatttaaca tttttctttg gcttgtgagc ccccaaagcc ccagaattta
     2281 tatgttcaga ccctccaagc cctgaattta ctttttcagg tttgcccttt tatatatgaa
     2341 gtgctgcttt ggatccaaga gccgagttgc tcacactgta gtgaatcgtg ttgcttctgt
     2401 cagtgcacag agacgctatc atgtcagcca gtgttgaatg tctttggtat tttctaagcc
     2461 aatccagtgc atagaaagga cagtgtttat acgctctgaa tgctaggatt ggggttttag
     2521 cccctgattt tattctggac aatttttaaa gaaagaaaag ttgcaagaat ttagtgactg
     2581 catgtgtatt tactacttag ctcctacaac tactgtttgg ccatatttgc tctctagatc
     2641 cacacatgta taatatacag atatgcacat atattcgagt atatgtttgc ttttattctg
     2701 aaccactgag atgttaaggt atatatatat atatatatat accagccctg aatacttcag
     2761 cacttcctaa aaataataat aatgtccttt agaaaccttc tgaaaccatt ataaaatcaa
     2821 taatttccag atagtgcctg gttttccaga ttagctgtaa ctgcccagaa ttccatttaa
     2881 gttacagcct gattttattt gcagttcttt aatcaggtta ataacactat tttgaaaaga
     2941 tgtagaagaa atcctttctt caaactggcc aagtttattt caggttttaa ttcaaaataa
     3001 tgagtggcta aagaagtgtg atttttcttc aatctctgat ttatatgcct ctctcctttt
     3061 agtggtagca tagcataatg ggtgtaagtg aagatttaag tcacgctaga caaagccggt
     3121 attgtgtgag ctaataatta atgtcatatt ggccatattt ggtttccttt aagtttagga
     3181 aattggtcag aggctctagc ccagtggtga ggctgggtca tctccagcaa cgtgaaacaa
     3241 aatgcatttt ctttaaacat taaccatccc ccctttgtaa gagagacttt tccccccact
     3301 gcattcattt aaaaatattt tgccccatcc ccaaacctgt ccagcactta tgtaagaacg
     3361 catttggagg acatgatagc ttgcataaaa gatgacgcta tagtttatgc actgatttcc
     3421 ggacaaaaat gatgcttctt tttgttcggg gcttgtttta ttcaactccg aattgaatgc
     3481 tgtataaagt aatggagact ccatttacct gagttcctga ctgtatttat acctgtgtgt
     3541 ttgtgccctc tgtgtggggc tccctgatgt cacgtatgct gtctgaatgc agcgctgtat
     3601 tcccgctgtg tagaacagaa ggctgcattt gtaaagttat agatttgtaa ataaaactga
     3661 ggaatatctc tataaactgt tggggggacg gggcacaaaa ggaggagcca actaaatagg
     3721 accttctaaa atttgttaat tttgtaatct ttgcttcttt tataagttat tctgtgattc
     3781 cttttagtta ccgagtttta ttttgaagac attaaaatat tgcacttgta taaatagtat
     3841 gataaatgca gactattgca gtcaaatttt ttaaaagcta ggatatctga aatgacaact
     3901 ttcagttaag tatgtcaagc ccaggacagg attttcacaa atgtattgta gtttgcaaat
     3961 tcttacactg aaaatgtaaa gggagtcaat gcaaatgatt tttaatcttt tttttattat
     4021 cttttcagca atttatattt tcttgtgatt ttatgcaacc atatttttac tttgtcttga
     4081 caactgaaag ctgtgtgatg tttttgacag aaaagtactg tatacatagt tttaaatata
     4141 acagattttg ctgatatgta aaaattttgc cattaaagtt gatttctcat gaaaggaact
     4201 tttctaccaa gtcgggagac gcaagagctt aatatatcta atttaaaata atttcactga
     4261 aataaacacc attgctttta ctttgattct atttttttct taagatgctt ttatagtgtt
     4321 tgggagtttt agataatttt atatgaattc tctccctacc ttgccccatc ctttggatct
     4381 ttgataccat tcacaaataa actcatgtgg ctgggtgtgt aaagatatgt accccaaggg
     4441 gcatcttggg aaagaaaacc ataaattctt ctccttaact cctccctctg cctgttcatt
     4501 gtgggctctg acatgatgaa tggaatgcca cacacagcct gactgtaagc cgttgttggg
     4561 aggagtccac cattgtggct tatgtatgtt tgcccagagt aacctgattt agaaagatgg
     4621 cataataaag aaaaaagttc gtttttcatt tgtta
//
