LOCUS       NM_133364                905 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus proline rich membrane anchor 1 (Prima1), mRNA.
ACCESSION   NM_133364 XM_001052097 XM_001052098 XM_001052099
VERSION     NM_133364.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 905)
  AUTHORS   Mohr,F., Krejci,E., Zimmermann,M. and Klein,J.
  TITLE     Dysfunctional Presynaptic M2 Receptors in the Presence of
            Chronically High Acetylcholine Levels: Data from the PRiMA Knockout
            Mouse
  JOURNAL   PLoS One 10 (10), e0141136 (2015)
   PUBMED   26506622
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 905)
  AUTHORS   Petrov,K.A., Girard,E., Nikitashina,A.D., Colasante,C., Bernard,V.,
            Nurullin,L., Leroy,J., Samigullin,D., Colak,O., Nikolsky,E.,
            Plaud,B. and Krejci,E.
  TITLE     Schwann cells sense and control acetylcholine spillover at the
            neuromuscular junction by alpha7 nicotinic receptors and
            butyrylcholinesterase
  JOURNAL   J Neurosci 34 (36), 11870-11883 (2014)
   PUBMED   25186736
REFERENCE   3  (bases 1 to 905)
  AUTHORS   Garcia-Ayllon,M.S., Campanari,M.L., Montenegro,M.F.,
            Cuchillo-Ibanez,I., Belbin,O., Lleo,A., Tsim,K., Vidal,C.J. and
            Saez-Valero,J.
  TITLE     Presenilin-1 influences processing of the acetylcholinesterase
            membrane anchor PRiMA
  JOURNAL   Neurobiol Aging 35 (7), 1526-1536 (2014)
   PUBMED   24612677
  REMARK    GeneRIF: It interacts with PS1 and undergoes proteolytic
            processing.
REFERENCE   4  (bases 1 to 905)
  AUTHORS   Lamotte d'Incamps,B. and Ascher,P.
  TITLE     Subunit composition and kinetics of the Renshaw cell heteromeric
            nicotinic receptors
  JOURNAL   Biochem Pharmacol 86 (8), 1114-1121 (2013)
   PUBMED   23811311
REFERENCE   5  (bases 1 to 905)
  AUTHORS   Farar,V., Hrabovska,A., Krejci,E. and Myslivecek,J.
  TITLE     Developmental adaptation of central nervous system to extremely
            high acetylcholine levels
  JOURNAL   PLoS One 8 (7), e68265 (2013)
   PUBMED   23861875
  REMARK    GeneRIF: Elevated expression of muscarinic receptors is responsible
            for physiological adaptation of PRiMA-deficient developing mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 905)
  AUTHORS   Silvestri,C., Narimatsu,M., von Both,I., Liu,Y., Tan,N.B., Izzi,L.,
            McCaffery,P., Wrana,J.L. and Attisano,L.
  TITLE     Genome-wide identification of Smad/Foxh1 targets reveals a role for
            Foxh1 in retinoic acid regulation and forebrain development
  JOURNAL   Dev Cell 14 (3), 411-423 (2008)
   PUBMED   18331719
  REMARK    Erratum:[Dev Cell. 2008 Apr;14(4):633]
REFERENCE   7  (bases 1 to 905)
  AUTHORS   Xie,H.Q., Choi,R.C., Leung,K.W., Siow,N.L., Kong,L.W., Lau,F.T.,
            Peng,H.B. and Tsim,K.W.
  TITLE     Regulation of a transcript encoding the proline-rich membrane
            anchor of globular muscle acetylcholinesterase. The suppressive
            roles of myogenesis and innervating nerves
  JOURNAL   J Biol Chem 282 (16), 11765-11775 (2007)
   PUBMED   17324938
  REMARK    GeneRIF: expression of PRiMA, as well as PRiMA-associated G(4)
            AChE, in muscle is suppressed by muscle regulatory factors,
            muscular activity, and nerve-derived trophic factors
REFERENCE   8  (bases 1 to 905)
  AUTHORS   Noureddine,H., Schmitt,C., Liu,W., Garbay,C., Massoulie,J. and
            Bon,S.
  TITLE     Assembly of acetylcholinesterase tetramers by peptidic motifs from
            the proline-rich membrane anchor, PRiMA: competition between
            degradation and secretion pathways of heteromeric complexes
  JOURNAL   J Biol Chem 282 (6), 3487-3497 (2007)
   PUBMED   17158452
  REMARK    GeneRIF: A peptidic motif of PRiMA1 is defined which is nearly as
            efficient as the complete extracellular domain of PRiMA for
            recruitment of acetylcholinesterase subunits into secreted
            heteromeric complexes.
REFERENCE   9  (bases 1 to 905)
  AUTHORS   Perrier,N.A., Kherif,S., Perrier,A.L., Dumas,S., Mallet,J. and
            Massoulie,J.
  TITLE     Expression of PRiMA in the mouse brain: membrane anchoring and
            accumulation of 'tailed' acetylcholinesterase
  JOURNAL   Eur J Neurosci 18 (7), 1837-1847 (2003)
   PUBMED   14622217
  REMARK    GeneRIF: PRiMA expression is predominantly to the cholinergic
            system and that anchoring of cholinesterases to cell membranes by
            PRiMA represents a limiting factor for production of the AChE
            tailed splice variant (AChET)-PRiMA complex.
REFERENCE   10 (bases 1 to 905)
  AUTHORS   Perrier,A.L., Massoulie,J. and Krejci,E.
  TITLE     PRiMA: the membrane anchor of acetylcholinesterase in the brain
  JOURNAL   Neuron 33 (2), 275-285 (2002)
   PUBMED   11804574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140034.1, AY043275.1 and AK039705.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_001052098.1, XM_001052097.1, XM_001052099.1, NM_133364.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY043275.1, SRR17784646.984404.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AK140034.1         2-126
            126-721             AY043275.1         127-722
            722-905             AK039705.1         586-769
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 52.9 cM"
     gene            1..905
                     /gene="Prima1"
                     /gene_synonym="B230212M13Rik; PRiMA"
                     /note="proline rich membrane anchor 1"
                     /db_xref="GeneID:170952"
                     /db_xref="MGI:MGI:1926097"
     exon            1..72
                     /gene="Prima1"
                     /gene_synonym="B230212M13Rik; PRiMA"
                     /inference="alignment:Splign:2.1.0"
     exon            73..195
                     /gene="Prima1"
                     /gene_synonym="B230212M13Rik; PRiMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..564
                     /gene="Prima1"
                     /gene_synonym="B230212M13Rik; PRiMA"
                     /note="acetylcholinesterase membrane anchor"
                     /codon_start=1
                     /product="proline-rich membrane anchor 1 precursor"
                     /protein_id="NP_579942.2"
                     /db_xref="CCDS:CCDS26127.1"
                     /db_xref="GeneID:170952"
                     /db_xref="MGI:MGI:1926097"
                     /translation="MLLRDLVLRHGCCWPSLLLHCALHPLWGLVQVTHAEPQKSCSKV
                     TDSCQHICQCRPPPPLPPPPPPPPPPRLLSAPAPNSTSCPAEDSWWSGLVIIVAVVCA
                     SLVFLTVLVIICYKAIKRKPLRKDENGTSVAEYPMSSSQSHKGVDVNAAVV"
     exon            196..331
                     /gene="Prima1"
                     /gene_synonym="B230212M13Rik; PRiMA"
                     /inference="alignment:Splign:2.1.0"
     exon            332..461
                     /gene="Prima1"
                     /gene_synonym="B230212M13Rik; PRiMA"
                     /inference="alignment:Splign:2.1.0"
     exon            462..905
                     /gene="Prima1"
                     /gene_synonym="B230212M13Rik; PRiMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      885..890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prima1"
                     /gene_synonym="B230212M13Rik; PRiMA"
                     /note="hexamer: AATGAA"
     polyA_site      891
                     /gene="Prima1"
                     /gene_synonym="B230212M13Rik; PRiMA"
                     /note="major polyA site"
     polyA_site      905
                     /gene="Prima1"
                     /gene_synonym="B230212M13Rik; PRiMA"
                     /note="major polyA site"
ORIGIN      
        1 agagctgctg tgggggcaac cctgacctcc cttctccgtg tcgacgatcg gtgggggtcg
       61 ccaccaggca agttagctca ccagtgggcg ccgcaggccg agatgctact ccgggacctg
      121 gtgctgcgcc atggctgctg ctggccctca cttctgctgc actgtgcgct gcacccactc
      181 tggggtttag ttcaggtgac acacgctgag ccccagaagt cttgctctaa ggtgactgac
      241 agctgccaac acatctgcca gtgccggccc ccaccccctc ttccccctcc acccccacct
      301 ccgccacctc ccagactact ctccgcccca gctcccaact ctacctcctg ccctgcagag
      361 gacagctggt ggtctggtct ggtgatcatt gtcgctgtgg tctgtgcctc cctggtgttt
      421 ctgactgtcc tggtcatcat ttgctacaaa gccataaaga ggaaaccact gagaaaggat
      481 gagaatggca ccagtgtcgc tgagtacccc atgagctcct cacagagcca caaaggggtg
      541 gatgtgaacg ctgcagtggt gtgaacctgc aggccctggg acccactggc cagaagggca
      601 ccgtggtgac actggtggac atggatggca ggtggacatg agctgaccgt gggcctgtcc
      661 aggacttcgt gcttcgcggg cttcgagcct cctgaaagag aaagcatcct cttcccaggc
      721 tagccctggt cacccccgag gggtgcaaca ccgacaccag gcttgagcca ggctcccctg
      781 catgtggccc ctgagcagca ccaccaccca gggatctcca tactctcctt gtctcgcatt
      841 gggcgcactg actgtcacca gttgctactg aaagcatgta ttccaatgaa agcagagggt
      901 ctgtc
//
