LOCUS       NM_008922               1990 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus DNA primase, p58 subunit (Prim2), mRNA.
ACCESSION   NM_008922
VERSION     NM_008922.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1990)
  AUTHORS   Chung H, Kim HJ, Jang KS, Kim M, Yang J, Kang KS, Kim HL, Yoon BI,
            Lee MO, Lee BH, Kim JH, Lee YS and Kong G.
  TITLE     Comprehensive analysis of differential gene expression profiles on
            D-galactosamine-induced acute mouse liver injury and regeneration
  JOURNAL   Toxicology 227 (1-2), 136-144 (2006)
   PUBMED   16962228
REFERENCE   2  (bases 1 to 1990)
  AUTHORS   Yatsula,B., Galvao,C., McCrann,M. and Perkins,A.S.
  TITLE     Assessment of F-MuLV-induced tumorigenesis reveals new candidate
            tumor genes including Pecam1, St7, and Prim2
  JOURNAL   Leukemia 20 (1), 162-165 (2006)
   PUBMED   16307020
REFERENCE   3  (bases 1 to 1990)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 1990)
  AUTHORS   Loebel DA, O'Rourke MP, Steiner KA, Banyer J and Tam PP.
  TITLE     Isolation of differentially expressed genes from wild-type and
            Twist mutant mouse limb buds
  JOURNAL   Genesis 33 (3), 103-113 (2002)
   PUBMED   12124942
REFERENCE   5  (bases 1 to 1990)
  AUTHORS   Eggenschwiler JT, Espinoza E and Anderson KV.
  TITLE     Rab23 is an essential negative regulator of the mouse Sonic
            hedgehog signalling pathway
  JOURNAL   Nature 412 (6843), 194-198 (2001)
   PUBMED   11449277
REFERENCE   6  (bases 1 to 1990)
  AUTHORS   Mizuno T, Okamoto T, Yokoi M, Izumi M, Kobayashi A, Hachiya T,
            Tamai K, Inoue T and Hanaoka F.
  TITLE     Identification of the nuclear localization signal of mouse DNA
            primase: nuclear transport of p46 subunit is facilitated by
            interaction with p54 subunit
  JOURNAL   J Cell Sci 109 (Pt 11), 2627-2636 (1996)
   PUBMED   8937981
REFERENCE   7  (bases 1 to 1990)
  AUTHORS   Stadlbauer F, Brueckner A, Rehfuess C, Eckerskorn C, Lottspeich F,
            Forster V, Tseng BY and Nasheuer HP.
  TITLE     DNA replication in vitro by recombinant
            DNA-polymerase-alpha-primase
  JOURNAL   Eur J Biochem 222 (3), 781-793 (1994)
   PUBMED   8026492
REFERENCE   8  (bases 1 to 1990)
  AUTHORS   Miyazawa H, Izumi M, Tada S, Takada R, Masutani M, Ui M and Hanaoka
            F.
  TITLE     Molecular cloning of the cDNAs for the four subunits of mouse DNA
            polymerase alpha-primase complex and their gene expression during
            cell proliferation and the cell cycle
  JOURNAL   J Biol Chem 268 (11), 8111-8122 (1993)
   PUBMED   8463324
REFERENCE   9  (bases 1 to 1990)
  AUTHORS   Adler DA, Tseng BY, Wang TS and Disteche CM.
  TITLE     Physical mapping of the genes for three components of the mouse DNA
            replication complex: polymerase alpha to the X chromosome, primase
            p49 subunit to chromosome 10, and primase p58 subunit to chromosome
            1
  JOURNAL   Genomics 9 (4), 642-646 (1991)
   PUBMED   2037291
REFERENCE   10 (bases 1 to 1990)
  AUTHORS   Prussak CE, Almazan MT and Tseng BY.
  TITLE     Mouse primase p49 subunit molecular cloning indicates conserved and
            divergent regions
  JOURNAL   J Biol Chem 264 (9), 4957-4963 (1989)
   PUBMED   2925677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY131806.1, AK077760.1 and BE983705.1.
            
            [WARNING] On May 2, 2023 this sequence was replaced by NM_008922.3.
            
            On Aug 7, 2013 this sequence version replaced NM_008922.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168246.1, AK077760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BY131806.1         2-15
            15-1969             AK077760.1         2-1956
            1970-1990           BE983705.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..1990
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 12.7 cM"
     gene            1..1990
                     /gene="Prim2"
                     /note="DNA primase, p58 subunit"
                     /db_xref="GeneID:19076"
                     /db_xref="MGI:MGI:97758"
     exon            1..171
                     /gene="Prim2"
                     /inference="alignment:Splign:2.1.0"
     exon            172..334
                     /gene="Prim2"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1698
                     /gene="Prim2"
                     /note="DNA primase 58 kDa subunit"
                     /codon_start=1
                     /product="DNA primase large subunit"
                     /protein_id="NP_032948.1"
                     /db_xref="CCDS:CCDS14862.1"
                     /db_xref="GeneID:19076"
                     /db_xref="MGI:MGI:97758"
                     /translation="MQFSGRIRKKLRLAGDQRNASYPHSLQFYLQPPTENISLTEFEN
                     LAFDRVKLLKAIENLGVSYVKGTEQYQSKLEAEIRKLKFSYRENLEDEYEPRRRDHIS
                     HFILRLAYCQSEDLRRWFIQQEMDLLRFRFSILPKDKVQSFLKDSHLHFEAISDEEKT
                     LREQDIMASSPSLSGIKLESESVYKVPFADALDLFRGRKVYLEDGFAYVPLKDIVAII
                     LNEFRATLSKALALTARSLPAVQSDERLQPLLNHLSHSYTGQDYSTQKNTGKISLDQI
                     DSLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTLEQALQFWKQEFIRG
                     KMDPDKFDKGYSYNIRHSFGKEGKRTDYTPFSCMKIILTNPPGQGDYHGCPFRHSDAE
                     LLKQKMQSYKIPASGISQILDLVKGNHYQVACQKYFEMTHNVDDCGFSLNHPNQFFFE
                     SQRILTGGKDIKKEISQPETPQHKPSTQKTRDAASALASLDSSLEMDLEGLEEYF"
     exon            335..438
                     /gene="Prim2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..518
                     /gene="Prim2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..639
                     /gene="Prim2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..735
                     /gene="Prim2"
                     /inference="alignment:Splign:2.1.0"
     exon            736..873
                     /gene="Prim2"
                     /inference="alignment:Splign:2.1.0"
     exon            874..941
                     /gene="Prim2"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1014
                     /gene="Prim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1200
                     /gene="Prim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1327
                     /gene="Prim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1410
                     /gene="Prim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1479
                     /gene="Prim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1976
                     /gene="Prim2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcccgttcc aaatgaactc tcccgccact gggagagagc ggctgtcagc gcgggtgttt
       61 ctttcagcct ggctgctggc tggttaaaca atctactgcg gctttatttg ggacggagag
      121 aagccgtgga gttggaagct tgtgagctga cctggtggga ccgagtgaca ggtggtcaag
      181 atgcagttct caggaaggat ccggaagaag ctgcgattgg cgggtgacca gagaaatgct
      241 agttaccctc acagccttca gttttacctg cagccgccta ctgaaaacat atcgttgacg
      301 gagtttgaaa acttggcttt tgacagagtt aaattgctta aagcaattga gaacctcggt
      361 gtgagctatg tgaaaggaac cgaacaatac cagagtaaat tggaggccga gattcgaaag
      421 ctcaagtttt cctacagaga gaacctggag gatgagtatg agccacggcg aagggaccac
      481 atctcccact ttatcctacg cctcgcgtac tgccagtcgg aagatcttag acgatggttt
      541 attcaacaag aaatggatct gcttcggttt cgattcagta ttttaccaaa ggataaagtc
      601 cagagtttct tgaaggatag tcatttgcat tttgaggcta tcagtgacga ggagaagacc
      661 cttcgggaac aggatatcat ggcgtcctct ccaagcctaa gtgggatcaa gttggagtca
      721 gagtcagttt ataaggtccc ctttgctgat gctctggacc tgttcagagg aaggaaagtc
      781 tacttggaag atggctttgc ttatgtgcca cttaaggaca tcgtggccat tatcttgaac
      841 gagtttagag ccacgctgtc taaggctttg gcactaacgg ccaggtcgct gcctgctgtg
      901 cagtccgatg aacgacttca gcctctgctc aaccacctca gtcattctta cactggtcaa
      961 gattatagta cccagaagaa caccggcaag atttccttag atcagattga ttcgctgtct
     1021 acaaaatcct tcccaccttg catgcgtcag ctgcacaagg cgctgaggga gaaccaccat
     1081 ctccgtcacg gaggccggat gcagtacggc ctgttcctca agggcattgg gctaacgctg
     1141 gagcaggcat tgcagttctg gaagcaggag tttatcagag gaaagatgga cccagacaag
     1201 tttgataaag gttactctta caatatccgg catagcttcg gaaaggaagg caagaggaca
     1261 gactatacgc ctttcagttg catgaagatt atcctgacca acccaccagg ccaaggggat
     1321 tatcatgggt gccccttccg tcacagtgat gcagagctgc tgaagcagaa gatgcagtcc
     1381 tacaagatcc ctgcctcggg gatcagccag attttggatt tggtaaaggg gaatcattac
     1441 caagtagcct gtcagaagta cttcgagatg acacataatg tggacgattg tggcttttct
     1501 ttgaatcatc caaatcagtt cttttttgag agccagcgca tcctaactgg tggcaaagat
     1561 atcaagaagg aaatcagtca gccagaaaca cctcagcaca aacctagcac ccagaagacc
     1621 agggatgctg catctgcgct ggcctcccta gactcctccc tggaaatgga cctggagggg
     1681 ctggaagagt acttttagta aatgatgtgg ccactgtagt atctcctttc ccccagcgaa
     1741 tacattcctg tttgaaaggt ttacaaaggc acacccatgc acacacacac atttactggg
     1801 aagcaggctt gcttccacct tacttttgac agaatgggaa aggaagcatt cctattgaaa
     1861 ctgttaaaat cctcaagcag caagacaatt aaaactaact tttaaagttt tgtataatgt
     1921 tggccaagtc ctcttttgga ttgtttttgc taataaacaa catgtatatg actataaaaa
     1981 aaaaaaaaaa
//
