LOCUS       NP_001277553             624 aa            linear   ROD 05-MAY-2025
DEFINITION  prickle planar cell polarity protein 3 [Mus musculus].
ACCESSION   NP_001277553 XP_006527714
VERSION     NP_001277553.1
DBSOURCE    REFSEQ: accession NM_001290624.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 624)
  AUTHORS   Ru,J., Guo,D., Fan,J., Zhang,J., Ju,R., Ouyang,H., Wei,L., Liu,Y.
            and Liu,C.
  TITLE     Malformation of Tear Ducts Underlies the Epiphora and Precocious
            Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for
            Tear Duct Genesis
  JOURNAL   Invest Ophthalmol Vis Sci 61 (13), 6 (2020)
   PUBMED   33141892
REFERENCE   2  (residues 1 to 624)
  AUTHORS   Yu,J., Liang,X., Ji,Y., Ai,C., Liu,J., Zhu,L., Nie,Z., Jin,X.,
            Wang,C., Zhang,J., Zhao,F., Mei,S., Zhao,X., Zhou,X., Zhang,M.,
            Wang,M., Huang,T., Jiang,P. and Guan,M.X.
  TITLE     PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary
            optic neuropathy
  JOURNAL   J Clin Invest 130 (9), 4935-4946 (2020)
   PUBMED   32516135
  REMARK    GeneRIF: PRICKLE3 linked to ATPase biogenesis manifested Leber's
            hereditary optic neuropathy.
REFERENCE   3  (residues 1 to 624)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 624)
  AUTHORS   Fu,H., Cai,J., Clevers,H., Fast,E., Gray,S., Greenberg,R.,
            Jain,M.K., Ma,Q., Qiu,M., Rowitch,D.H., Taylor,C.M. and Stiles,C.D.
  TITLE     A genome-wide screen for spatially restricted expression patterns
            identifies transcription factors that regulate glial development
  JOURNAL   J Neurosci 29 (36), 11399-11408 (2009)
   PUBMED   19741146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672231.7.
            
            On Mar 15, 2014 this sequence version replaced XP_006527714.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049258.1, AK037217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.45 cM"
     Protein         1..624
                     /product="prickle planar cell polarity protein 3"
                     /note="prickle-like protein 3; LIM domain only protein 6;
                     triple LIM domain protein 6; prickle homolog 3"
                     /calculated_mol_wt=69596
     Region          1..26
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80VL3.1)"
     Region          82..178
                     /region_name="PET_Prickle"
                     /note="The PET domain of Prickle; cd09827"
                     /db_xref="CDD:193602"
     Region          186..244
                     /region_name="LIM1_Prickle"
                     /note="The first LIM domain of Prickle; cd09415"
                     /db_xref="CDD:188799"
     Site            order(186,189,212,215,218,221,239,242)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188799"
     Region          249..304
                     /region_name="LIM2_Prickle"
                     /note="The second LIM domain of Prickle; cd09418"
                     /db_xref="CDD:188802"
     Site            order(251,254,272,275,278,281,299,302)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188802"
     Region          309..367
                     /region_name="LIM3_Prickle"
                     /note="The third LIM domain of Prickle; cd09420"
                     /db_xref="CDD:188804"
     Site            order(311,314,333,338,341,344,362,366)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188804"
     Region          371..617
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80VL3.1)"
     Site            475
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80VL3.1)"
     Site            491
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43900; propagated from
                     UniProtKB/Swiss-Prot (Q80VL3.1)"
     CDS             1..624
                     /gene="Prickle3"
                     /gene_synonym="Lmo6; Pk3; Sfc16"
                     /coded_by="NM_001290624.2:83..1957"
                     /db_xref="CCDS:CCDS72329.1"
                     /db_xref="GeneID:54630"
                     /db_xref="MGI:MGI:1859635"
ORIGIN      
        1 mfargsrrrr sgrappeaed pargqpcnsc reqcpgfllh gwrkicqhck cpreehavrt
       61 vpvdlerimc rlisdfqrhs isdddsgcas eeyawvppgl kpeqvyqffs clpedkvpyv
      121 nspgekyrik qllhqlpphd seaqyctale eeekkelraf sqqrkrenlg ratvrifpvt
      181 itgaiceecg kqigggdiav fasraglgac whpqcfvctt cqellvdliy fyhagkvycg
      241 rhhaeclrpr cqacdeiifs pecteaegrh whmghfccfe ceaslggqry vmrqsrphcc
      301 acyearhaey cdgcgehigl dqgqmayegq hwhasdrcfc csrcsrpllg rpflprrgli
      361 fcsracslgs ettapgpgrr swsagtvttp lttstasfsa tegtsetask gtctkaepaa
      421 gpeepshflr gaphrhsmpe lglrsapepp tespghpaph pddnafgrqs tprvsfrdpl
      481 vseggprrtl sappaqrrrp rsppprtpsc hhhhhhrrrr qrhrrrgshh hhhhpgrhgh
      541 hrcdlgsgsd sgscssspss pssesseddg fflgeriplp phlcrprttq dtstetfnsp
      601 aqplvqeshp vmprqtrdkn civa
//
