LOCUS       NM_001033217            4099 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus prickle planar cell polarity protein 1 (Prickle1),
            transcript variant 1, mRNA.
ACCESSION   NM_001033217 XM_128308 XM_894980 XM_902274 XM_902276 XM_902279
VERSION     NM_001033217.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4099)
  AUTHORS   Ahmad,S., Christova,T., Pye,M., Narimatsu,M., Song,S., Wrana,J.L.
            and Attisano,L.
  TITLE     Small Extracellular Vesicles Promote Axon Outgrowth by Engaging the
            Wnt-Planar Cell Polarity Pathway
  JOURNAL   Cells 14 (1), 56 (2025)
   PUBMED   39791757
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4099)
  AUTHORS   Yan,F., Suzuki,A., Iwaya,C., Pei,G., Chen,X., Yoshioka,H., Yu,M.,
            Simon,L.M., Iwata,J. and Zhao,Z.
  TITLE     Single-cell multiomics decodes regulatory programs for mouse
            secondary palate development
  JOURNAL   Nat Commun 15 (1), 821 (2024)
   PUBMED   38280850
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4099)
  AUTHORS   Kunimoto,K., Weiner,A.T., Axelrod,J.D. and Vladar,E.K.
  TITLE     Distinct overlapping functions for Prickle1 and Prickle2 in the
            polarization of the airway epithelium
  JOURNAL   Front Cell Dev Biol 10, 976182 (2022)
   PUBMED   36176272
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4099)
  AUTHORS   Sai,X., Ikawa,Y., Nishimura,H., Mizuno,K., Kajikawa,E., Katoh,T.A.,
            Kimura,T., Shiratori,H., Takaoka,K., Hamada,H. and Minegishi,K.
  TITLE     Planar cell polarity-dependent asymmetric organization of
            microtubules for polarized positioning of the basal body in node
            cells
  JOURNAL   Development 149 (9) (2022)
   PUBMED   35420656
REFERENCE   5  (bases 1 to 4099)
  AUTHORS   Kimura-Yoshida,C., Mochida,K., Kanno,S.I. and Matsuo,I.
  TITLE     USP39 is essential for mammalian epithelial morphogenesis through
            upregulation of planar cell polarity components
  JOURNAL   Commun Biol 5 (1), 378 (2022)
   PUBMED   35440748
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4099)
  AUTHORS   Deans,M.R., Antic,D., Suyama,K., Scott,M.P., Axelrod,J.D. and
            Goodrich,L.V.
  TITLE     Asymmetric distribution of prickle-like 2 reveals an early
            underlying polarization of vestibular sensory epithelia in the
            inner ear
  JOURNAL   J Neurosci 27 (12), 3139-3147 (2007)
   PUBMED   17376975
REFERENCE   7  (bases 1 to 4099)
  AUTHORS   Song,M.R., Shirasaki,R., Cai,C.L., Ruiz,E.C., Evans,S.M., Lee,S.K.
            and Pfaff,S.L.
  TITLE     T-Box transcription factor Tbx20 regulates a genetic program for
            cranial motor neuron cell body migration
  JOURNAL   Development 133 (24), 4945-4955 (2006)
   PUBMED   17119020
REFERENCE   8  (bases 1 to 4099)
  AUTHORS   Tissir,F. and Goffinet,A.M.
  TITLE     Expression of planar cell polarity genes during development of the
            mouse CNS
  JOURNAL   Eur J Neurosci 23 (3), 597-607 (2006)
   PUBMED   16487141
REFERENCE   9  (bases 1 to 4099)
  AUTHORS   Bekman,E. and Henrique,D.
  TITLE     Embryonic expression of three mouse genes with homology to the
            Drosophila melanogaster prickle gene
  JOURNAL   Mech Dev 119 Suppl 1, S77-S81 (2002)
   PUBMED   14516664
REFERENCE   10 (bases 1 to 4099)
  AUTHORS   Robert,F. and Hardy,J.
  TITLE     Cushing's disease: a correlation of radiological, surgical and
            pathological findings with therapeutic results
  JOURNAL   Pathol Res Pract 187 (5), 617-621 (1991)
   PUBMED   1923957
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124592.6 and AC126556.4.
            
            On Jul 12, 2018 this sequence version replaced NM_001033217.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153711.1, SRR17784644.60237.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC124592.6         85716-85924
            210-396             AC126556.4         154986-155172       c
            397-510             AC126556.4         153207-153320       c
            511-648             AC126556.4         151764-151901       c
            649-852             AC126556.4         151089-151292       c
            853-1039            AC126556.4         147565-147751       c
            1040-1906           AC126556.4         145496-146362       c
            1907-4099           AC126556.4         141647-143839       c
FEATURES             Location/Qualifiers
     source          1..4099
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 47.69 cM"
     gene            1..4099
                     /gene="Prickle1"
                     /gene_synonym="1110058P22Rik; b2b019Clo; mpk1; Pk1;
                     Prickle"
                     /note="prickle planar cell polarity protein 1"
                     /db_xref="GeneID:106042"
                     /db_xref="MGI:MGI:1916034"
     exon            1..209
                     /gene="Prickle1"
                     /gene_synonym="1110058P22Rik; b2b019Clo; mpk1; Pk1;
                     Prickle"
                     /inference="alignment:Splign:2.1.0"
     exon            210..396
                     /gene="Prickle1"
                     /gene_synonym="1110058P22Rik; b2b019Clo; mpk1; Pk1;
                     Prickle"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..2763
                     /gene="Prickle1"
                     /gene_synonym="1110058P22Rik; b2b019Clo; mpk1; Pk1;
                     Prickle"
                     /note="prickle homolog 1"
                     /codon_start=1
                     /product="prickle-like protein 1"
                     /protein_id="NP_001028389.1"
                     /db_xref="CCDS:CCDS27769.1"
                     /db_xref="GeneID:106042"
                     /db_xref="MGI:MGI:1916034"
                     /translation="MPLEMEPKMSKLVFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQ
                     IQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSA
                     QRKKEALGRGTIKLLSRAVMHAVCEQCGLQMNGGEVAVFASRAGPGVCWHPSCFVCFT
                     CNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCC
                     LECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATE
                     ACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDIHASDSSDSAFQSARSRDSRRSV
                     RMGRSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDVSLASRQGAGFANEE
                     FWKARVEQEASEDPEEWAEHEDYMTQLLLKFGDKNLFQQQSSEVDPRASEHWIPDNMV
                     TNKPEVKPNHQGLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHGAA
                     GYTHDQSQWYEDSLECLSDLKPEQSIRDSMDSLALSNITGASVDGESKPRPSLYSLQN
                     FEEIEAEDCEKMSNMGTLNSSMLHRSAESLQSLNSGLCPEKILPEEKPAHLPVLRRSK
                     SQSRPQQVKFSDDVIDNGSYDIEIRQPPMSERTRRRAYHFEERGSRPHHHRHRRSRKS
                     RSDNALNLVTERKYSAKDRLRLYTPDNYEKFIQNKSARELQAYMQNANLYSQYAHATS
                     DYALQNPGMNRFLGLCGEDDDSWCSSSTSSSDSEEEGYFLGQPIPQPRPQRFTYYTDD
                     LSSPASALPTPQFTQRTTKSKKKKGHKGKNCIIS"
     exon            397..510
                     /gene="Prickle1"
                     /gene_synonym="1110058P22Rik; b2b019Clo; mpk1; Pk1;
                     Prickle"
                     /inference="alignment:Splign:2.1.0"
     exon            511..648
                     /gene="Prickle1"
                     /gene_synonym="1110058P22Rik; b2b019Clo; mpk1; Pk1;
                     Prickle"
                     /inference="alignment:Splign:2.1.0"
     exon            649..852
                     /gene="Prickle1"
                     /gene_synonym="1110058P22Rik; b2b019Clo; mpk1; Pk1;
                     Prickle"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1039
                     /gene="Prickle1"
                     /gene_synonym="1110058P22Rik; b2b019Clo; mpk1; Pk1;
                     Prickle"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1906
                     /gene="Prickle1"
                     /gene_synonym="1110058P22Rik; b2b019Clo; mpk1; Pk1;
                     Prickle"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..4099
                     /gene="Prickle1"
                     /gene_synonym="1110058P22Rik; b2b019Clo; mpk1; Pk1;
                     Prickle"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4078..4083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prickle1"
                     /gene_synonym="1110058P22Rik; b2b019Clo; mpk1; Pk1;
                     Prickle"
                     /note="hexamer: AATAAA"
     polyA_site      4097
                     /gene="Prickle1"
                     /gene_synonym="1110058P22Rik; b2b019Clo; mpk1; Pk1;
                     Prickle"
                     /note="major polyA site"
ORIGIN      
        1 actccgcctg cagccgagca gcggcccggg agccgccacc accttgcaag ccccgcgccg
       61 cctgcgctga cctggaccgc gcggccgcag cgctacgggc ccggctgcgg acgctcccgg
      121 ggctgcgcac gcgggagcgc gcctgacgcg gaggaccgca gctctcaacg ccaccgccga
      181 ggaccgcgcg gccgcctctc gcgcgtgggc agctgtctct tggatgtcct gtgactaagc
      241 agccagcttt aaaacttcat tattatgcct ttggagatgg aaccgaaaat gagcaaactg
      301 gtcttcgggt gccagagaag ctccacatca gatgatgatt ccggctgtgc acttgaagag
      361 tatgcatggg tcccaccggg cctcaggccc gagcagatcc agctctattt cgcatgcttg
      421 ccagaggaaa aggttcctta tgttaacagc cctggggaga aacacaggat taaacagctc
      481 ctgtaccagt tgcctccaca cgataacgag gtgcggtact gccagtcttt gagcgaagaa
      541 gagaagaagg agctgcaggt gttcagtgct cagaggaaga aagaagctct ggggagagga
      601 accatcaaac tcttgtccag agctgtgatg cacgccgtgt gtgagcagtg tgggctgcag
      661 atgaatggag gggaggtggc cgtgttcgcc tcccgtgcag gacctggagt atgctggcac
      721 ccgtcctgct ttgtctgctt cacgtgtaat gaactactgg tcgacctcat ctatttctat
      781 caggatggaa aaatccactg tggcaggcac cacgctgaac tgctcaagcc tcggtgctca
      841 gcctgtgatg agatcatttt tgctgacgag tgcacggaag ccgagggtcg ccactggcac
      901 atgaagcatt tctgctgtct ggaatgtgag acagtcctgg gagggcagag atatatcatg
      961 aaggacggcc gccccttctg ctgtggctgc ttcgagtctc tctacgctga gtactgcgaa
     1021 acctgtgggg agcatattgg tgtggaccac gcacagatga cctacgacgg gcagcactgg
     1081 cacgccacag aggcctgctt ttcctgtgcg cagtgtaagg cctcgttgct gggatgcccc
     1141 ttcctcccga aacaaggtca gatttactgc tccaagacct gcagccttgg ggaagacatc
     1201 cacgcctctg actcctcgga ctccgccttc cagtcagcca gatccagaga ctctcgcagg
     1261 agcgtgagga tgggcagaag cagccgctcc gccgaccagt gccgacagtc tcttctcttg
     1321 tctcccgccc tgaactacaa gttcccgggt ctctccggca acgctgacga caccctttcc
     1381 cggaagctgg atgacgtgag cctcgccagc aggcagggag caggtttcgc taacgaggaa
     1441 ttctggaaag ccagagtgga gcaggaagcc tccgaagacc ccgaagaatg ggctgagcat
     1501 gaagattata tgacgcagct cctcctcaag ttcggcgaca aaaacctctt ccagcagcag
     1561 agcagcgagg tggatccgag agccagcgag cactggatac ccgacaacat ggttacgaat
     1621 aagcccgagg taaagccgaa tcaccagggc ctcgcgagta aaaagtatca gtctgatatg
     1681 tactgggccc agtcccaaga cgggctgggt gactctgcct acggcagcca tccaggcccc
     1741 gccagcagcc gcaggctgca agagctagat ctggaccacg gtgctgcggg atatactcat
     1801 gaccaaagcc agtggtatga agactccctg gagtgtctat ctgacttgaa accagaacag
     1861 agtatccggg attctatgga ttctttggcg ttgtccaaca tcacaggggc atcagtggat
     1921 ggagaaagca agccaagacc gtcattatat tctctccaaa actttgagga gatagaggca
     1981 gaagattgtg agaaaatgag caatatggga actctgaact cttccatgct gcacaggagt
     2041 gcagaatcct tacaaagtct gaactcaggg ctgtgcccag aaaaaattct acctgaggaa
     2101 aaaccagcac acctgccggt gctcaggaga tccaagtccc agtcccgacc acagcaggtc
     2161 aaattttcag atgacgtcat tgacaacgga agctacgaca tcgaaatccg gcagcctccc
     2221 atgagcgaac ggactcggag acgggcgtat cactttgaag agaggggatc caggcctcac
     2281 caccatcgcc accggagaag cagaaagtct cggtccgaca acgccctgaa cctggtcacg
     2341 gaaaggaagt actccgccaa ggacagactt cggctgtaca cccccgataa ctatgagaaa
     2401 ttcatacaga ataaaagcgc ccgggagctc caagcctaca tgcagaacgc caacctctat
     2461 agccagtatg cccatgccac gtctgattac gccctgcaga acccagggat gaaccggttt
     2521 ctggggctct gcggcgagga cgacgactcg tggtgttcgt cctccacgtc ctcctccgac
     2581 tcagaagaag aaggctattt ccttggccag ccgatccctc agccacggcc acagagattc
     2641 acctactata cagatgacct ttctagcccg gcttccgcac tgcccacccc acagtttact
     2701 cagaggacaa ctaaatccaa gaagaaaaaa ggacacaagg gcaaaaactg tatcatttct
     2761 taaccaagta gacatggaga gtctttgttt aaaacttagt catttagcct ggacttcgac
     2821 cttgtattca tcctaggaaa gtcgctaaaa tagtgtaaaa tgctttctgt ggccccactg
     2881 tgtttacagt cagattaaca catgaaagag gtggcttctc cagtcttggt gccatattaa
     2941 cagagtctta tgcccgtggc aagtaaatta cagccgcttt ggtgtctagt ccacaagaga
     3001 acactccaga aactgccggc aggtgattgg acagagtgca ttttagagga tggatagcca
     3061 cctttgtaag caatagtgct tgccgtcaac acagtcgggt tggctcaggt cctgactggt
     3121 gtcttgtgag gcatgcgtgt cgccatgacg acctagctaa cactgtgtgt tccattgtgt
     3181 aaggccaact tgttctcctt cagcccccat tagccaggta aacatattgt gtcactccca
     3241 gccacaggtt gaaaggactt gctatttata tgtagtattt catagaccta agtgtattcc
     3301 taatttaacg gtgcaaatat taatgtatat actgtacagt tgagatttta aagctgatat
     3361 ttttatatcc ctgaattgca agatgtttgt tacactgcca tgctagattt gttaggaact
     3421 cagaaaacag catccatgga tgaggtgact gcttgtactt tagtcagggc ttctaagttt
     3481 agacagtcaa atttatattg cctagtgatg gaaagttggt tttttttttt tttccttttc
     3541 ttcaatatta aaagaggctc tgtatgcatg gtggggctgt gtacatactt ggtactaggc
     3601 cctgttaatc tcacaagtgt tatttatggg tcaagcttcg taaactgtat aaatgtaaaa
     3661 accaaccaag ccccacacat acctctggag tatctggtga aaccaaggag aagctatctg
     3721 ggcgctcttc ccgggcaggg ggagtctcag caggtgagaa tgtccacgcg atgagctctt
     3781 tctgtgtaga cttactatgt acagaaagct tatttcttct gcccttttcc ttccaacttg
     3841 ctgttggcct ttaaaagcaa ttttgaaaac tgggtttcca gttgcagttt tcttttaaga
     3901 ttcttcagga agactgagcc agacgactcc caagttcatg gggctctggg ttcagccgga
     3961 gagtcatgct ggatttgaac taatgagcgg gtagtttggt ctgtgctgtc cttgcattta
     4021 catcttggtc ctaactaaag gtcccggtgt caccctgggc ttttcaggga ggtgtttaat
     4081 aaaggcttaa taaaccacc
//
