LOCUS       NM_011174                870 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus proline rich protein HaeIII subfamily 1 (Prh1), mRNA.
ACCESSION   NM_011174
VERSION     NM_011174.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Lopez-Solis,R.O. and Kemmerling,U.
  TITLE     Codominant expression of genes coding for different sets of
            inducible salivary polypeptides associated with parotid hypertrophy
            in two inbred mouse strains
  JOURNAL   J Cell Biochem 95 (1), 99-107 (2005)
   PUBMED   15723342
REFERENCE   2  (bases 1 to 870)
  AUTHORS   Scalzo,A.A., Wheat,R., Dubbelde,C., Stone,L., Clark,P., Du,Y.,
            Dong,N., Stoll,J., Yokoyama,W.M. and Brown,M.G.
  TITLE     Molecular genetic characterization of the distal NKC recombination
            hotspot and putative murine CMV resistance control locus
  JOURNAL   Immunogenetics 55 (6), 370-378 (2003)
   PUBMED   12920489
REFERENCE   3  (bases 1 to 870)
  AUTHORS   Bachmanov,A.A., Li,X., Li,S., Neira,M., Beauchamp,G.K. and
            Azen,E.A.
  TITLE     High-resolution genetic mapping of the sucrose octaacetate taste
            aversion (Soa) locus on mouse Chromosome 6
  JOURNAL   Mamm Genome 12 (9), 695-699 (2001)
   PUBMED   11641717
REFERENCE   4  (bases 1 to 870)
  AUTHORS   Depatie,C., Lee,S.H., Stafford,A., Avner,P., Belouchi,A., Gros,P.
            and Vidal,S.M.
  TITLE     Sequence-ready BAC contig, physical, and transcriptional map of a
            2-Mb region overlapping the mouse chromosome 6 host-resistance
            locus Cmv1
  JOURNAL   Genomics 66 (2), 161-174 (2000)
   PUBMED   10860661
REFERENCE   5  (bases 1 to 870)
  AUTHORS   Azen,E.A., Johnson,E.B. and Sekhon,G.S.
  TITLE     Assignment of the proline-rich protein gene Prp2 (alias D6Mit13) to
            mouse chromosome 6G1 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 14-15 (2000)
   PUBMED   10894928
REFERENCE   6  (bases 1 to 870)
  AUTHORS   Capeless,C.G., Whitney,G. and Azen,E.A.
  TITLE     Chromosome mapping of Soa, a gene influencing gustatory sensitivity
            to sucrose octaacetate in mice
  JOURNAL   Behav Genet 22 (6), 655-663 (1992)
   PUBMED   1290451
REFERENCE   7  (bases 1 to 870)
  AUTHORS   Scalzo,A.A., Fitzgerald,N.A., Wallace,C.R., Gibbons,A.E.,
            Smart,Y.C., Burton,R.C. and Shellam,G.R.
  TITLE     The effect of the Cmv-1 resistance gene, which is linked to the
            natural killer cell gene complex, is mediated by natural killer
            cells
  JOURNAL   J Immunol 149 (2), 581-589 (1992)
   PUBMED   1378069
REFERENCE   8  (bases 1 to 870)
  AUTHORS   Roberts,S.G., Layfield,R., Bannister,A.J. and McDonald,C.J.
  TITLE     Gene sequence of mouse B-type proline-rich protein MP4.
            Transcriptional start point and an upstream phylogenetic footprint
            with ets-like and rel/NFkB-like elements
  JOURNAL   Eur J Biochem 202 (3), 969-974 (1991)
   PUBMED   1765104
REFERENCE   9  (bases 1 to 870)
  AUTHORS   Yokoyama,W.M., Ryan,J.C., Hunter,J.J., Smith,H.R., Stark,M. and
            Seaman,W.E.
  TITLE     cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49.
            Identification of a natural killer cell gene complex on mouse
            chromosome 6
  JOURNAL   J Immunol 147 (9), 3229-3236 (1991)
   PUBMED   1680927
REFERENCE   10 (bases 1 to 870)
  AUTHORS   Ann,D.K. and Carlson,D.M.
  TITLE     The structure and organization of a proline-rich protein gene of a
            mouse multigene family
  JOURNAL   J Biol Chem 260 (29), 15863-15872 (1985)
   PUBMED   2999141
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124523.5.
            
            On Jun 1, 2011 this sequence version replaced NM_011174.3.
            
            Summary: This gene encodes a member of the heterogeneous family of
            proline-rich salivary glycoproteins. The expression of this gene is
            dramatically induced in the parotid and submandibular glands of
            mice by beta-adrenergic stimulation. The encoded protein serves an
            important dental function by protecting mice against toxic dietary
            polyphenols such as tannins and influence the visco-elastic
            properties of the mucus. This gene is located in a cluster of
            closely related salivary proline-rich proteins on chromosome 6.
            [provided by RefSeq, Nov 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC124523.5         46371-46434
            65-870              AC124523.5         48125-48930
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 64.03 cM"
     gene            1..870
                     /gene="Prh1"
                     /gene_synonym="MP2; Prp"
                     /note="proline rich protein HaeIII subfamily 1"
                     /db_xref="GeneID:19131"
                     /db_xref="MGI:MGI:97773"
     CDS             1..870
                     /gene="Prh1"
                     /gene_synonym="MP2; Prp"
                     /note="proline-rich salivary protein; proline-rich protein
                     MP-2"
                     /codon_start=1
                     /product="proline-rich protein HaeIII subfamily 1
                     precursor"
                     /protein_id="NP_035304.4"
                     /db_xref="CCDS:CCDS57460.1"
                     /db_xref="GeneID:19131"
                     /db_xref="MGI:MGI:97773"
                     /translation="MLVVLFTVALLALSSAQEPREENQNQIQIPNQRPPPSGFQPRPP
                     VNGSQQGPPPPGGPQPRPPQGPPPPGGPQPRPPQGPPPPGVPQPRPPQGPPPPGGPQQ
                     RPPQGPPPPGGPQHRPPQGPPPPGGPQQRPPQGPPPPGGPQPRPPQGPPPPGGPQQRP
                     PQGPPPPGGPQLRPPQGPPPPAGPQPRPPQGPPPPAGPQPRPPQGPPTTGPQPRPTQG
                     PPPTGGPQQRPPQGPPPPGGPQPRPPQGPPPPGGPQPSPTQGPPPTGGPQQTPPLAGN
                     TQGPPQGRPQGPR"
     exon            1..64
                     /gene="Prh1"
                     /gene_synonym="MP2; Prp"
                     /inference="alignment:Splign:2.1.0"
     exon            65..870
                     /gene="Prh1"
                     /gene_synonym="MP2; Prp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctggtgg tcctgtttac agtggccctg ctggccctga gctctgctca ggaaccccgt
       61 gaagaaaatc agaatcaaat ccagatccca aatcaaaggc cacctccttc agggttccaa
      121 ccaagaccgc ctgttaatgg gagccagcaa ggcccaccac caccaggagg cccacagccg
      181 agaccccctc aaggcccacc accaccagga ggcccacagc cgagaccccc tcaaggccca
      241 ccaccaccag gagtaccaca gccgagaccc cctcaaggcc caccaccacc aggaggccca
      301 cagcagagac cccctcaagg cccaccacca ccaggaggcc cacagcatag gccccctcaa
      361 ggcccaccac caccaggagg cccacagcag agaccccctc aaggcccacc accaccagga
      421 ggcccacagc ctaggccccc tcaaggccca ccaccaccag gaggcccaca gcagagaccc
      481 cctcaaggcc caccaccacc aggaggccca cagctgagac cccctcaagg gccaccacca
      541 ccagcaggcc cacagccgag accccctcaa ggcccaccac caccagcagg cccacagcct
      601 aggccccctc aaggcccacc cacaacaggc ccacaaccaa gacctactca aggcccaccc
      661 ccaacaggag gcccacagca gcgaccccct caaggcccac caccaccagg aggcccacag
      721 ccgagacccc ctcaaggccc accaccaccc ggaggcccac agccgagtcc cactcaaggc
      781 ccacccccaa caggaggccc acagcaaaca cctcctctgg ctggaaacac acaaggccca
      841 ccacaaggca gaccccaggg acctcggtaa
//
