LOCUS       NM_016914                949 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus proteoglycan 3 (Prg3), mRNA.
ACCESSION   NM_016914
VERSION     NM_016914.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 949)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 949)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   3  (bases 1 to 949)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 949)
  AUTHORS   Bettigole,S.E., Lis,R., Adoro,S., Lee,A.H., Spencer,L.A.,
            Weller,P.F. and Glimcher,L.H.
  TITLE     The transcription factor XBP1 is selectively required for
            eosinophil differentiation
  JOURNAL   Nat Immunol 16 (8), 829-837 (2015)
   PUBMED   26147683
REFERENCE   5  (bases 1 to 949)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 949)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   7  (bases 1 to 949)
  AUTHORS   Macias,M.P., Welch,K.C., Denzler,K.L., Larson,K.A., Lee,N.A. and
            Lee,J.J.
  TITLE     Identification of a new murine eosinophil major basic protein
            (mMBP) gene: cloning and characterization of mMBP-2
  JOURNAL   J Leukoc Biol 67 (4), 567-576 (2000)
   PUBMED   10770291
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL935159.11.
            
            On Nov 17, 2006 this sequence version replaced NM_016914.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF202533.1, AK158110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AL935159.11        72695-72781
            88-221              AL935159.11        73139-73272
            222-529             AL935159.11        73705-74012
            530-661             AL935159.11        75882-76013
            662-770             AL935159.11        77464-77572
            771-949             AL935159.11        78188-78366
FEATURES             Location/Qualifiers
     source          1..949
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     gene            1..949
                     /gene="Prg3"
                     /gene_synonym="MBP2; MBPH"
                     /note="proteoglycan 3"
                     /db_xref="GeneID:53856"
                     /db_xref="MGI:MGI:1858200"
     exon            1..87
                     /gene="Prg3"
                     /gene_synonym="MBP2; MBPH"
                     /inference="alignment:Splign:2.1.0"
     exon            88..221
                     /gene="Prg3"
                     /gene_synonym="MBP2; MBPH"
                     /inference="alignment:Splign:2.1.0"
     exon            222..529
                     /gene="Prg3"
                     /gene_synonym="MBP2; MBPH"
                     /inference="alignment:Splign:2.1.0"
     exon            530..661
                     /gene="Prg3"
                     /gene_synonym="MBP2; MBPH"
                     /inference="alignment:Splign:2.1.0"
     exon            662..770
                     /gene="Prg3"
                     /gene_synonym="MBP2; MBPH"
                     /inference="alignment:Splign:2.1.0"
     exon            771..949
                     /gene="Prg3"
                     /gene_synonym="MBP2; MBPH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacagaccct tgggtagtga gtgctgtgct cacacatagc acagaccagg atcccaactg
       61 gagggcctgt ttttaggatc agcatagaag ctgcgttgga cacaaaagga cagctgtgag
      121 gacgaaggtg gaattgtctc tactacagga tcaagtagac atgaaacagc ccctgatcct
      181 gtcctttctc ctgctgggga tggtttctgc ttttcatctg gagactgctc atctggagaa
      241 tcccaagaga gaggaaagcc tgaagcagga agcagatggt tcgagggagc aagggagaga
      301 gttggctctg actcaagaga caaagcagac agagggagag gaggttgagg gttcccaaca
      361 ccaagacatt tttgaggatg aggaggcaat ggagtcagat ccagatgcct taaataagga
      421 ctctgcttgc cccaaggaag aggacacaac tcattttcag ggaactcctg ggtgcaagag
      481 ctgcaactat gtgctggtga ggactcccga gacatttgat aaggctcaga gagtctgcag
      541 gagatgctac cgaggcaacc ttgcttccgt ccacagttat agtttcaact accaaattca
      601 gaacttggcc aggaagatca atcagtccat cgtctggatt ggaggcatcc tcaggggatg
      661 gttctggaag aagttttgct ggatggatgg gagctgctgg gattttggat actgggcccc
      721 agggcagcct gggagtgggg gaggacactg tgtgactctg tgtaccaaag ggggccattg
      781 gcgaagagct tcatgcaaaa gtcacctgcc tttcatctgc tccttctaag atggagctag
      841 atcctacttg gaatctcctg ccttcacagc cctggctgct tatccccatc ctttggcatt
      901 caattctgtc cccagtccct cctggtcata aagtcaggct ttccacagc
//
