LOCUS       NM_008920                838 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus proteoglycan 2, bone marrow (Prg2), mRNA.
ACCESSION   NM_008920
VERSION     NM_008920.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 838)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 838)
  AUTHORS   First,N.J., Parrish,K.M., Martinez-Perez,A., Gonzalez-Fernandez,A.,
            Bharrhan,S., Woolard,M., McLachlan,J.B., Scott,R.S., Wang,J. and
            Gestal,M.C.
  TITLE     Bordetella spp. block eosinophil recruitment to suppress the
            generation of early mucosal protection
  JOURNAL   Cell Rep 42 (11), 113294 (2023)
   PUBMED   37883230
REFERENCE   3  (bases 1 to 838)
  AUTHORS   Lu,Y., Huang,Y., Li,J., Huang,J., Zhang,L., Feng,J., Li,J., Xia,Q.,
            Zhao,Q., Huang,L., Jiang,S. and Su,S.
  TITLE     Eosinophil extracellular traps drive asthma progression through
            neuro-immune signals
  JOURNAL   Nat Cell Biol 23 (10), 1060-1072 (2021)
   PUBMED   34616019
REFERENCE   4  (bases 1 to 838)
  AUTHORS   Marx,C., Novotny,J., Salbeck,D., Zellner,K.R., Nicolai,L.,
            Pekayvaz,K., Kilani,B., Stockhausen,S., Burgener,N., Kupka,D.,
            Stocker,T.J., Weckbach,L.T., Pircher,J., Moser,M., Joner,M.,
            Desmet,W., Adriaenssens,T., Neumann,F.J., Gerschlick,A.H., Ten
            Berg,J.M., Lorenz,M. and Stark,K.
  TITLE     Eosinophil-platelet interactions promote atherosclerosis and
            stabilize thrombosis with eosinophil extracellular traps
  JOURNAL   Blood 134 (21), 1859-1872 (2019)
   PUBMED   31481482
REFERENCE   5  (bases 1 to 838)
  AUTHORS   Brosig,A., Fuchs,J., Ipek,F., Kroon,C., Schrotter,S., Vadhvani,M.,
            Polyzou,A., Ledderose,J., van Diepen,M., Holzhutter,H.G.,
            Trimbuch,T., Gimber,N., Schmoranzer,J., Lieberam,I., Rosenmund,C.,
            Spahn,C., Scheerer,P., Szczepek,M., Leondaritis,G. and
            Eickholt,B.J.
  TITLE     The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth
            to Branches
  JOURNAL   Cell Rep 29 (7), 2028-2040 (2019)
   PUBMED   31722215
  REMARK    GeneRIF: The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs
            Growth to Branches.
REFERENCE   6  (bases 1 to 838)
  AUTHORS   Plager,D.A., Weiler,D.A., Loegering,D.A., Johnson,W.B., Haley,L.,
            Eddy,R.L., Shows,T.B. and Gleich,G.J.
  TITLE     Comparative structure, proximal promoter elements, and chromosome
            location of the human eosinophil major basic protein genes
  JOURNAL   Genomics 71 (3), 271-281 (2001)
   PUBMED   11170744
REFERENCE   7  (bases 1 to 838)
  AUTHORS   Denzler,K.L., Farmer,S.C., Crosby,J.R., Borchers,M., Cieslewicz,G.,
            Larson,K.A., Cormier-Regard,S., Lee,N.A. and Lee,J.J.
  TITLE     Eosinophil major basic protein-1 does not contribute to
            allergen-induced airway pathologies in mouse models of asthma
  JOURNAL   J Immunol 165 (10), 5509-5517 (2000)
   PUBMED   11067904
REFERENCE   8  (bases 1 to 838)
  AUTHORS   Macias,M.P., Welch,K.C., Denzler,K.L., Larson,K.A., Lee,N.A. and
            Lee,J.J.
  TITLE     Identification of a new murine eosinophil major basic protein
            (mMBP) gene: cloning and characterization of mMBP-2
  JOURNAL   J Leukoc Biol 67 (4), 567-576 (2000)
   PUBMED   10770291
REFERENCE   9  (bases 1 to 838)
  AUTHORS   Denzler,K.L., Levin,W.J., Quiram,P.A., Lee,N.A. and Lee,J.J.
  TITLE     The murine eosinophil major basic protein gene (Prg2) maps to
            chromosome 2
  JOURNAL   Mamm Genome 8 (5), 382-383 (1997)
   PUBMED   9107694
REFERENCE   10 (bases 1 to 838)
  AUTHORS   Larson,K.A., Horton,M.A., Madden,B.J., Gleich,G.J., Lee,N.A. and
            Lee,J.J.
  TITLE     The identification and cloning of a murine major basic protein gene
            expressed in eosinophils
  JOURNAL   J Immunol 155 (6), 3002-3012 (1995)
   PUBMED   7673718
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL935159.11.
            
            On Apr 27, 2007 this sequence version replaced NM_008920.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010901.1, BY710298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AL935159.11        64941-64980
            41-110              AL935159.11        65806-65875
            111-421             AL935159.11        66486-66796
            422-553             AL935159.11        67069-67200
            554-665             AL935159.11        67643-67754
            666-838             AL935159.11        67940-68112
FEATURES             Location/Qualifiers
     source          1..838
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     gene            1..838
                     /gene="Prg2"
                     /gene_synonym="EMBP; MBP; mMBP; mMBP-1"
                     /note="proteoglycan 2, bone marrow"
                     /db_xref="GeneID:19074"
                     /db_xref="MGI:MGI:103294"
     exon            1..40
                     /gene="Prg2"
                     /gene_synonym="EMBP; MBP; mMBP; mMBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            41..110
                     /gene="Prg2"
                     /gene_synonym="EMBP; MBP; mMBP; mMBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            111..421
                     /gene="Prg2"
                     /gene_synonym="EMBP; MBP; mMBP; mMBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..553
                     /gene="Prg2"
                     /gene_synonym="EMBP; MBP; mMBP; mMBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..665
                     /gene="Prg2"
                     /gene_synonym="EMBP; MBP; mMBP; mMBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..838
                     /gene="Prg2"
                     /gene_synonym="EMBP; MBP; mMBP; mMBP-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagccagct ttgcaaactt gacaagaccc aggagggcct gacaaagcca agatgaaatt
       61 ccctctactt ctggctcttc tagtcggggg agcgtctgct cttcatctga gctctgaaac
      121 ttctgactcc aaaagcccat tgatggatga gaacttgcct agggatgcag agatatcagg
      181 accagaagga gaagagtgtc ctccagggga agagctaatg ccactggagg gggagaagga
      241 agaaggttct ggaagtgaag gtgttcctgg ggatgaagga gctgtctcag gtcaggatgt
      301 gacagacgtg gaccttcagt gccccaagga agaggacaca acaagtctta tgggtgactc
      361 tggatgcaag acctgtcgct acctcctagt caggagggct gaatgctttg acaaagctca
      421 gtcagtttgc cggcgctgct accggggcac cctcgcctcc atccacagtt tcagtgttaa
      481 cttcggaatc cagtccgctg tcaggggaat caaccagggt caagtctgga ttggaggcag
      541 gatcaagggc tggggccgat gcaaacgctt tcgatgggtt gatggaagtt cttggaattt
      601 tgcatactgg gctgctgggc agccttgccc tggtggtggc agatgtgtga ccctgtgtac
      661 tcaaggaggc cactggcgtc tatctcactg tgtcaagaga cgtcccttca tctgttcgta
      721 ttgagctggt tccagctggg agttcaaatt catgctttcc tgggtaactg cctcttcttt
      781 cctgccagat gtccccgttc tttcccctcc ctaaaataaa gccgctttac ttaaacag
//
