LOCUS       NM_011073               2054 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus perforin 1 (pore forming protein) (Prf1), mRNA.
ACCESSION   NM_011073
VERSION     NM_011073.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Mann,J., Runge,S., Schell,C., Grawe,K., Thoulass,G., Lao,J.,
            Ammann,S., Grun,S., Konig,C., Berger,S.A., Hild,B., Aichele,P.,
            Rosshart,S.P. and Ehl,S.
  TITLE     The Microbiome Modifies Manifestations of Hemophagocytic
            Lymphohistiocytosis in Perforin-Deficient Mice
  JOURNAL   Eur J Immunol 55 (1), e202451061 (2025)
   PUBMED   39548906
REFERENCE   2  (bases 1 to 2054)
  AUTHORS   Zhang,Y., Naderi Yeganeh,P., Zhang,H., Wang,S.Y., Li,Z., Gu,B.,
            Lee,D.J., Zhang,Z., Ploumakis,A., Shi,M., Wu,H., Greer,E.L.,
            Hide,W. and Lieberman,J.
  TITLE     Tumor editing suppresses innate and adaptive antitumor immunity and
            is reversed by inhibiting DNA methylation
  JOURNAL   Nat Immunol 25 (10), 1858-1870 (2024)
   PUBMED   39169233
REFERENCE   3  (bases 1 to 2054)
  AUTHORS   Kogl,T., Chang,H.F., Staniek,J., Chiang,S.C.C., Thoulass,G.,
            Lao,J., Weissert,K., Dettmer-Monaco,V., Geiger,K., Manna,P.T.,
            Beziat,V., Momenilandi,M., Tu,S.M., Keppler,S.J., Pattu,V.,
            Wolf,P., Kupferschmid,L., Tholen,S., Covill,L.E., Ebert,K.,
            Straub,T., Gross,M., Gather,R., Engel,H., Salzer,U., Schell,C.,
            Maier,S., Lehmberg,K., Cornu,T.I., Pircher,H., Shahrooei,M.,
            Parvaneh,N., Elling,R., Rizzi,M., Bryceson,Y.T., Ehl,S., Aichele,P.
            and Ammann,S.
  TITLE     Patients and mice with deficiency in the SNARE protein SYNTAXIN-11
            have a secondary B cell defect
  JOURNAL   J Exp Med 221 (7) (2024)
   PUBMED   38722309
  REMARK    Erratum:[J Exp Med. 2024 Jul 1;221(7):e2022112205142024c. doi:
            10.1084/jem.2022112205142024c. PMID: 38771261]
REFERENCE   4  (bases 1 to 2054)
  AUTHORS   Keenan,C., Albeituni,S., Oak,N., Stroh,A., Tillman,H.S., Wang,Y.,
            Freeman,B.B. 3rd, Aleman-Arteaga,S., Meyer,L.K., Woods,R.,
            Verbist,K.C., Zhou,Y., Cheng,C. and Nichols,K.E.
  TITLE     Differential effects of itacitinib, fedratinib, and ruxolitinib in
            mouse models of hemophagocytic lymphohistiocytosis
  JOURNAL   Blood 143 (23), 2386-2400 (2024)
   PUBMED   38446698
REFERENCE   5  (bases 1 to 2054)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2054)
  AUTHORS   Lichtenheld,M.G. and Podack,E.R.
  TITLE     Structure and function of the murine perforin promoter and upstream
            region. Reciprocal gene activation or silencing in perforin
            positive and negative cells
  JOURNAL   J Immunol 149 (8), 2619-2626 (1992)
   PUBMED   1401900
REFERENCE   7  (bases 1 to 2054)
  AUTHORS   Fink,T.M., Zimmer,M., Weitz,S., Tschopp,J., Jenne,D.E. and
            Lichter,P.
  TITLE     Human perforin (PRF1) maps to 10q22, a region that is syntenic with
            mouse chromosome 10
  JOURNAL   Genomics 13 (4), 1300-1302 (1992)
   PUBMED   1505959
REFERENCE   8  (bases 1 to 2054)
  AUTHORS   Kawasaki,A., Shinkai,Y., Yagita,H. and Okumura,K.
  TITLE     Expression of perforin in murine natural killer cells and cytotoxic
            T lymphocytes in vivo
  JOURNAL   Eur J Immunol 22 (5), 1215-1219 (1992)
   PUBMED   1577064
REFERENCE   9  (bases 1 to 2054)
  AUTHORS   Trapani,J.A. and Dupont,B.
  TITLE     Novel putative promoter/enhancer sequences are shared by the mouse
            and human perforin (Pfp) genes
  JOURNAL   Tissue Antigens 36 (5), 228-234 (1990)
   PUBMED   2095003
REFERENCE   10 (bases 1 to 2054)
  AUTHORS   Kozak,C.A., Peyser,M., Krall,M., Mariano,T.M., Kumar,C.S.,
            Pestka,S. and Mock,B.A.
  TITLE     Molecular genetic markers spanning mouse chromosome 10
  JOURNAL   Genomics 8 (3), 519-524 (1990)
   PUBMED   1981053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC132300.1.
            
            On Mar 28, 2009 this sequence version replaced NM_011073.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132300.1, M23182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2054              BC132300.1         1-2054
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.18 cM"
     gene            1..2054
                     /gene="Prf1"
                     /gene_synonym="Pfn; Pfp; Prf-1"
                     /note="perforin 1 (pore forming protein)"
                     /db_xref="GeneID:18646"
                     /db_xref="MGI:MGI:97551"
     exon            1..19
                     /gene="Prf1"
                     /gene_synonym="Pfn; Pfp; Prf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            20..591
                     /gene="Prf1"
                     /gene_synonym="Pfn; Pfp; Prf-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1720
                     /gene="Prf1"
                     /gene_synonym="Pfn; Pfp; Prf-1"
                     /note="perforin-1; P1; cytolysin; lymphocyte pore-forming
                     protein; pore forming protein"
                     /codon_start=1
                     /product="perforin-1 precursor"
                     /protein_id="NP_035203.3"
                     /db_xref="CCDS:CCDS23875.1"
                     /db_xref="GeneID:18646"
                     /db_xref="MGI:MGI:97551"
                     /translation="MATCLFLLGLFLLLPRPVPAPCYTATRSECKQKHKFVPGVWMAG
                     EGMDVTTLRRSGSFPVNTQRFLRPDRTCTLCKNSLMRDATQRLPVAITHWRPHSSHCQ
                     RNVAAAKVHSTEGVAREAAANINNDWRVGLDVNPRPEANMRASVAGSHSKVANFAAEK
                     TYQDQYNFNSDTVECRMYSFRLVQKPPLHLDFKKALRALPRNFNSSTEHAYHRLISSY
                     GTHFITAVDLGGRISVLTALRTCQLTLNGLTADEVGDCLNVEAQVSIGAQASVSSEYK
                     ACEEKKKQHKMATSFHQTYRERHVEVLGGPLDSTHDLLFGNQATPEQFSTWTASLPSN
                     PGLVDYSLEPLHTLLEEQNPKREALRQAISHYIMSRARWQNCSRPCRSGQHKSSHDSC
                     QCECQDSKVTNQDCCPRQRGLAHLVVSNFRAEHLWGDYTTATDAYLKVFFGGQEFRTG
                     VVWNNNNPRWTDKMDFENVLLSTGGPLRVQVWDADYGWDDDLLGSCDRSPHSGFHEVT
                     CELNHGRVKFSYHAKCLPHLTGGTCLEYAPQGLLGDPPGNRSGAVW"
     exon            592..2054
                     /gene="Prf1"
                     /gene_synonym="Pfn; Pfp; Prf-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcttggtg ggacttcagc tttccagagt ttatgactac tgtgcctgca gcatcatggc
       61 cacgtgcctg ttcctcctgg gccttttcct gctgctgcca cgacctgtcc ctgctccctg
      121 ctacactgcc actcggtcag aatgcaagca gaagcacaag ttcgtgccag gtgtatggat
      181 ggctggggaa ggcatggatg tgactaccct ccgccgctcc ggctccttcc cagtgaacac
      241 acagaggttc ctgaggcctg accgcacctg caccctctgt aaaaactccc taatgagaga
      301 cgccacacag cgcctacctg tggcaatcac ccactggcgg cctcacagct cacactgcca
      361 gcgtaatgtg gccgcagcca aggtccactc cacggagggt gtggcccggg aggcagctgc
      421 taatatcaat aacgactggc gtgtggggct ggatgtgaac cctaggccag aggcaaacat
      481 gcgcgcctcc gtggctggct cccactccaa ggtagccaat tttgcagctg agaagaccta
      541 tcaggaccag tacaacttta atagcgacac agtagagtgt cgcatgtaca gttttcgcct
      601 ggtacaaaaa cctccactcc accttgactt caaaaaggcg ctcagagccc tcccccgcaa
      661 ctttaacagc tccacagagc atgcttacca caggctcatc tcctcctatg gcacgcactt
      721 tatcacggct gtggacctcg gtggccgcat ctcggtcctt acagccctgc gtacctgtca
      781 gctgaccctg aatgggctca cagctgatga ggtaggagac tgcctgaacg tggaggccca
      841 ggtcagcatc ggtgcccaag ccagcgtctc cagtgaatac aaagcttgtg aggagaagaa
      901 gaaacagcac aaaatggcca cctctttcca ccagacctac cgtgagcgtc acgtcgaagt
      961 acttggtggc cctctggact ccacgcatga tctgctcttc gggaaccaag ctacaccaga
     1021 gcagttctca acctggacag cctcactgcc cagcaaccct ggtctggtgg actacagcct
     1081 ggagcccctg cacacattac tggaagaaca gaacccgaag cgggaggctc tgagacaggc
     1141 tatcagccat tatataatga gcagagcccg gtggcagaac tgtagcaggc cctgcaggtc
     1201 aggccagcat aagagtagcc atgattcatg ccagtgtgag tgccaggatt caaaggtcac
     1261 caaccaggac tgctgcccac gacagagggg cttggcccat ttggtggtaa gcaatttccg
     1321 ggcagaacat ctgtggggag actacaccac agctactgat gcctacctaa aggtcttctt
     1381 tggtggccag gagttcagga ccggtgtcgt gtggaacaat aacaatcccc ggtggactga
     1441 caagatggac tttgagaatg tgctcctgtc cacaggggga cccctcaggg tgcaggtctg
     1501 ggatgccgac tacggctggg atgatgacct tcttggttct tgtgacaggt ctccccactc
     1561 tggtttccat gaggtgacat gtgagctaaa ccacggcagg gtgaaattct cctaccatgc
     1621 caagtgtctg ccccatctca ctggagggac ctgcctggag tatgcccccc aggggcttct
     1681 gggagatcct ccaggaaacc gcagtggggc tgtgtggtaa cataataaca acaataacat
     1741 gcctgagagc tgggtgtagt agcacacgcc tttaatccca gcatttggga ggcagagaca
     1801 ggtggatatc tatgagttcg aggccagcct gggtctacag ggtctcaaaa aaaaaaagca
     1861 aacaacaaaa ctggaatgtt caactggctt ctccctgggg atctgcaatg gcttactatg
     1921 catagagagg ccactagagt ggctgagttt ttacaataga gcatccctga ctttcccttc
     1981 cacactgcct cagccctgca atgcccgaaa gcttggcaac tactgccacg aagcgtaaac
     2041 atgggccagg agcc
//
