LOCUS       NP_083801               1598 aa            linear   ROD 30-APR-2024
DEFINITION  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2
            protein isoform 1 [Mus musculus].
ACCESSION   NP_083801 XP_001475325
VERSION     NP_083801.1
DBSOURCE    REFSEQ: accession NM_029525.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1598)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1598)
  AUTHORS   Fu,Q., Huang,X., Wan,S., Li,Y., Li,X., Su,S., Xu,X. and Wu,Y.
  TITLE     P-Rex2 mediation of synaptic plasticity contributes to bone cancer
            pain
  JOURNAL   Mol Pain 18, 17448069221076460 (2022)
   PUBMED   35083941
  REMARK    GeneRIF: P-Rex2 mediation of synaptic plasticity contributes to
            bone cancer pain.
REFERENCE   3  (residues 1 to 1598)
  AUTHORS   Lissanu Deribe,Y.
  TITLE     Interplay between PREX2 mutations and the PI3K pathway and its
            effect on epigenetic regulation of gene expression in NRAS-mutant
            melanoma
  JOURNAL   Small GTPases 7 (3), 178-185 (2016)
   PUBMED   27111337
  REMARK    GeneRIF: complex signaling mechanisms that involve PREX2,
            PI3K/AKT/PTEN and downstream epigenetic machinery to deregulate
            expression of key cell cycle regulators
REFERENCE   4  (residues 1 to 1598)
  AUTHORS   Lissanu Deribe,Y., Shi,Y., Rai,K., Nezi,L., Amin,S.B., Wu,C.C.,
            Akdemir,K.C., Mahdavi,M., Peng,Q., Chang,Q.E., Hornigold,K.,
            Arold,S.T., Welch,H.C., Garraway,L.A. and Chin,L.
  TITLE     Truncating PREX2 mutations activate its GEF activity and alter gene
            expression regulation in NRAS-mutant melanoma
  JOURNAL   Proc Natl Acad Sci U S A 113 (9), E1296-E1305 (2016)
   PUBMED   26884185
REFERENCE   5  (residues 1 to 1598)
  AUTHORS   Mense,S.M., Barrows,D., Hodakoski,C., Steinbach,N., Schoenfeld,D.,
            Su,W., Hopkins,B.D., Su,T., Fine,B., Hibshoosh,H. and Parsons,R.
  TITLE     PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor
            cell invasion
  JOURNAL   Sci Signal 8 (370), ra32 (2015)
   PUBMED   25829446
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1598)
  AUTHORS   Jackson,C., Welch,H.C. and Bellamy,T.C.
  TITLE     Control of cerebellar long-term potentiation by P-Rex-family
            guanine-nucleotide exchange factors and phosphoinositide 3-kinase
  JOURNAL   PLoS One 5 (8), e11962 (2010)
   PUBMED   20694145
  REMARK    GeneRIF: PI3K/P-Rex/Rac pathway is required for late phase
            long-term potentiation in the mouse cerebellum
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 1598)
  AUTHORS   Donald,S., Humby,T., Fyfe,I., Segonds-Pichon,A., Walker,S.A.,
            Andrews,S.R., Coadwell,W.J., Emson,P., Wilkinson,L.S. and
            Welch,H.C.
  TITLE     P-Rex2 regulates Purkinje cell dendrite morphology and motor
            coordination
  JOURNAL   Proc Natl Acad Sci U S A 105 (11), 4483-4488 (2008)
   PUBMED   18334636
  REMARK    GeneRIF: P-Rex1 and P-Rex2 are important regulators of Purkinje
            cell morphology and cerebellar function
REFERENCE   8  (residues 1 to 1598)
  AUTHORS   Lickert,H., Cox,B., Wehrle,C., Taketo,M.M., Kemler,R. and
            Rossant,J.
  TITLE     Dissecting Wnt/beta-catenin signaling during gastrulation using RNA
            interference in mouse embryos
  JOURNAL   Development 132 (11), 2599-2609 (2005)
   PUBMED   15857914
REFERENCE   9  (residues 1 to 1598)
  AUTHORS   Donald,S., Hill,K., Lecureuil,C., Barnouin,R., Krugmann,S., John
            Coadwell,W., Andrews,S.R., Walker,S.A., Hawkins,P.T., Stephens,L.R.
            and Welch,H.C.
  TITLE     P-Rex2, a new guanine-nucleotide exchange factor for Rac
  JOURNAL   FEBS Lett 572 (1-3), 172-176 (2004)
   PUBMED   15304343
REFERENCE   10 (residues 1 to 1598)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138884.1, AC102631.9, AC102481.10, AC164600.5 and AI553603.1.
            
            On Apr 19, 2008 this sequence version replaced XP_001475325.1.
            
            Transcript Variant: This variant (1) represents the longer variant
            and it encodes the longer protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM109952.1, SRR10223969.48.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1598
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 2.57 cM"
     Protein         1..1598
                     /product="phosphatidylinositol
                     3,4,5-trisphosphate-dependent Rac exchanger 2 protein
                     isoform 1"
                     /note="phosphatidylinositol 3,4,5-trisphosphate-dependent
                     Rac exchanger 2 protein; DEP domain containing 2; DEP
                     domain-containing protein 2; ptdIns(3,4,5)-dependent Rac
                     exchanger 2"
                     /calculated_mol_wt=181587
     Region          19..204
                     /region_name="RhoGEF"
                     /note="RhoGEF domain; pfam00621"
                     /db_xref="CDD:459876"
     Region          210..356
                     /region_name="PH_Collybistin_ASEF"
                     /note="Collybistin/APC-stimulated guanine nucleotide
                     exchange factor pleckstrin homology (PH) domain; cd01224"
                     /db_xref="CDD:269931"
     Region          374..454
                     /region_name="DEP_1_P-Rex"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1
                     found in P-Rex-like proteins. The P-Rex family is the
                     guanine-nucleotide exchange factor (GEF) for the small
                     GTPase Rac that contains an N-terminal RhoGEF domain, two
                     DEP and PDZ domains. Rac-GEF...; cd04439"
                     /db_xref="CDD:239886"
     Region          466..558
                     /region_name="DEP_2_P-Rex"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2
                     found in P-Rex-like proteins. The P-Rex family is the
                     guanine-nucleotide exchange factor (GEF) for the small
                     GTPase Rac that contains an N-terminal RhoGEF domain, two
                     DEP and PDZ domains. Rac-GEF...; cd04440"
                     /db_xref="CDD:239887"
     Region          587..>636
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Region          668..743
                     /region_name="PDZ_RGS12-like"
                     /note="PDZ domain of regulator of G-protein signaling 12
                     (RGS12), and related domains; cd06710"
                     /db_xref="CDD:467194"
     Site            order(678..684,692,695,724,728,731..732)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467194"
     Region          1573..1598
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3LAC4.2)"
     CDS             1..1598
                     /gene="Prex2"
                     /gene_synonym="6230420N16Rik; C030045D06Rik; D430013K02;
                     Depdc2; P-Rex2"
                     /coded_by="NM_029525.1:329..5125"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS48217.1"
                     /db_xref="GeneID:109294"
                     /db_xref="MGI:MGI:1923385"
ORIGIN      
        1 msdesarevd kqlrlrvcvl selqkterdy vgtleflvsa flhrmnqcaa akvdknvtee
       61 tvkmlfsnie eilivhkefl kvveeclype psaqqevgac flhfkdkfri ydeycsnhek
      121 aqklllelnk irtirtflln cmllggrknt dvplegylvt piqrickypl llkellkrtp
      181 rrhsdytavm ealqamkavc snineakrqm eklevleewq ahiegwegsn itdtctemlm
      241 cgvlmkissg niqervfflf dnllvyckrk hrrlknskas tdgyryvfrg rintevmeve
      301 nvddgtadfh ssghivvngw kihntaknkw fvcmakspee khewfeailk ererrkglkl
      361 gmeqdtwvmi seqgeklykm mckqgnlikd rkrklttfpk cflgsefvsw lleigeihrp
      421 eegvhlgqal lengiihhvt dkhqfkpeqm lyrfryddgt fyprsemqdv iskgvrlycr
      481 lhslftpvvr dkdyhlrtyk svvmanklid wliaqgdcrt reeamifavg lcdngfmhhv
      541 leksefkdep llfrffadee megsnmkhrl mkhdlkvven viakslliks negsygfgle
      601 dknkvpiikl vekgsnaema gmevgkkifa ingdlvflrp fpevdcflks clnsrkplrv
      661 lvstkpretv kipdsadglg fqirgfgpsv vhavgrgtva aaaglhpgqc iikvnginvs
      721 kethasviah vtacrkykrp mkqdsiqwvy dslesaqedi qkshskppgd gagdafeckv
      781 edvidkfntm aiidgkkehv sltvdnvhle ygvvyeydst agtkcnvvek mvepkgffsl
      841 takilealak sdehfvqnct slnslnevia tdlqskftsm cseriehvch rissygrfsr
      901 vlknrawptf kqakpkispl hssdfcptnc hvnvmevsyp ktstslgsaf gvqldsrkhn
      961 shdkenksve pgklspmvyi qhtittmaap sglslghkdg hglqyllkee dletqdiyhk
     1021 llgklqtalk evemsvcqid dllssitysp klerkttecv tpmdsdnekg ernskrvcfn
     1081 vagdeqedsg hdtvsnrdsy sdcnsnrnsi asftsicssq cssyfhsdem dsgdelpisv
     1141 rishdkqdki htcleqlfsq idsiinllkg qavirafeqt kyltpgrglq efqqemeakl
     1201 scprrlrlhl kqdpwnlpss iqalaqsirk haeevkcril lalleysdse tqlrrdmvfc
     1261 qslvatvcaf seqlmaalnq mfdnskenem etceasrrwl dqianagvlf hfqsllspnl
     1321 kdeqamledt lvalfdlekv sfffkpseed plvanvplty qvegsrqalk vyfymdsyhf
     1381 eqlpqrlkng ggfkihpvlf sqalesmegy cyrdnisvee fqaqintasl ekvkqynqkl
     1441 rafyldksns ppnttskaay idklmkplna ldelyrlits firskriaac vntpcsasgv
     1501 gllsvsselc drlgachiim cssgvhrctl svtleqtitl arshglppry imqamdvmrk
     1561 qgarvqntak nlgvrdrtpq saprlyklce ppppvgee
//
