LOCUS       NM_177782               6530 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
            exchange factor 1 (Prex1), mRNA.
ACCESSION   NM_177782 NM_001081380 XM_485102 XM_902963 XM_902964 XM_902965
            XM_902966 XM_902967 XM_902969 XM_914522 XM_923276 XM_923283
            XM_923288 XM_923292 XM_923299 XM_923308 XM_983285
VERSION     NM_177782.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6530)
  AUTHORS   Pan,J., Liu,M., Su,H., Hu,H., Chen,H. and Ma,L.
  TITLE     Pharmacological Inhibition of P-Rex1/Rac1 Axis Blocked Angiotensin
            II-Induced Cardiac Fibrosis
  JOURNAL   Cardiovasc Drugs Ther 38 (5), 861-872 (2024)
   PUBMED   36892683
  REMARK    GeneRIF: Pharmacological Inhibition of P-Rex1/Rac1 Axis Blocked
            Angiotensin II-Induced Cardiac Fibrosis.
REFERENCE   2  (bases 1 to 6530)
  AUTHORS   Machin,P.A., Johnsson,A.E., Massey,E.J., Pantarelli,C.,
            Chetwynd,S.A., Chu,J.Y., Okkenhaug,H., Segonds-Pichon,A.,
            Walker,S., Malliri,A., Fukui,Y. and Welch,H.C.E.
  TITLE     Dock2 generates characteristic spatiotemporal patterns of Rac
            activity to regulate neutrophil polarisation, migration and
            phagocytosis
  JOURNAL   Front Immunol 14, 1180886 (2023)
   PUBMED   37383235
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6530)
  AUTHORS   Floerchinger,A., Murphy,K.J., Latham,S.L., Warren,S.C.,
            McCulloch,A.T., Lee,Y.K., Stoehr,J., Melenec,P., Guaman,C.S.,
            Metcalf,X.L., Lee,V., Zaratzian,A., Da Silva,A., Tayao,M., Rolo,S.,
            Phimmachanh,M., Sultani,G., McDonald,L., Mason,S.M., Ferrari,N.,
            Ooms,L.M., Johnsson,A.E., Spence,H.J., Olson,M.F., Machesky,L.M.,
            Sansom,O.J., Morton,J.P., Mitchell,C.A., Samuel,M.S.,
            Croucher,D.R., Welch,H.C.E., Blyth,K., Caldon,C.E., Herrmann,D.,
            Anderson,K.I., Timpson,P. and Nobis,M.
  TITLE     Optimizing metastatic-cascade-dependent Rac1 targeting in breast
            cancer: Guidance using optical window intravital FRET imaging
  JOURNAL   Cell Rep 36 (11), 109689 (2021)
   PUBMED   34525350
REFERENCE   4  (bases 1 to 6530)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6530)
  AUTHORS   Srijakotre,N., Liu,H.J., Nobis,M., Man,J., Yip,H.Y.K., Papa,A.,
            Abud,H.E., Anderson,K.I., Welch,H.C.E., Tiganis,T., Timpson,P.,
            McLean,C.A., Ooms,L.M. and Mitchell,C.A.
  TITLE     PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary
            tumor initiation and metastasis
  JOURNAL   Proc Natl Acad Sci U S A 117 (45), 28056-28067 (2020)
   PUBMED   33097662
  REMARK    GeneRIF: PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1)
            promotes mammary tumor initiation and metastasis.
REFERENCE   6  (bases 1 to 6530)
  AUTHORS   Donald,S., Humby,T., Fyfe,I., Segonds-Pichon,A., Walker,S.A.,
            Andrews,S.R., Coadwell,W.J., Emson,P., Wilkinson,L.S. and
            Welch,H.C.
  TITLE     P-Rex2 regulates Purkinje cell dendrite morphology and motor
            coordination
  JOURNAL   Proc Natl Acad Sci U S A 105 (11), 4483-4488 (2008)
   PUBMED   18334636
REFERENCE   7  (bases 1 to 6530)
  AUTHORS   Dong,X., Mo,Z., Bokoch,G., Guo,C., Li,Z. and Wu,D.
  TITLE     P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in
            mouse neutrophils
  JOURNAL   Curr Biol 15 (20), 1874-1879 (2005)
   PUBMED   16243036
  REMARK    GeneRIF: P-Rex1 is a primary Rac2 guanine nucleotide exchange
            factor in mouse neutrophils.
REFERENCE   8  (bases 1 to 6530)
  AUTHORS   Welch,H.C., Condliffe,A.M., Milne,L.J., Ferguson,G.J., Hill,K.,
            Webb,L.M., Okkenhaug,K., Coadwell,W.J., Andrews,S.R., Thelen,M.,
            Jones,G.E., Hawkins,P.T. and Stephens,L.R.
  TITLE     P-Rex1 regulates neutrophil function
  JOURNAL   Curr Biol 15 (20), 1867-1873 (2005)
   PUBMED   16243035
  REMARK    GeneRIF: P-Rex1 is an important regulator of neutrophil function by
            mediating a subset of Rac-dependent neutrophil responses.
REFERENCE   9  (bases 1 to 6530)
  AUTHORS   Yoshizawa,M., Kawauchi,T., Sone,M., Nishimura,Y.V., Terao,M.,
            Chihama,K., Nabeshima,Y. and Hoshino,M.
  TITLE     Involvement of a Rac activator,P-Rex1, in neurotrophin-derived
            signaling and neuronal migration
  JOURNAL   J Neurosci 25 (17), 4406-4419 (2005)
   PUBMED   15858067
REFERENCE   10 (bases 1 to 6530)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK173168.1.
            
            On or before Feb 8, 2007 this sequence version replaced
            XM_485102.4, XM_902969.2, XM_902963.2, XM_902967.2, XM_902966.2,
            XM_902965.2, XM_914522.2, XM_923308.2, XM_923283.2, XM_923276.2,
            XM_923299.2, XM_923292.2, XM_923288.2, XM_983285.1, NM_001081380.1,
            NM_177782.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173168.1, BC157940.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6530              AK173168.1         1-6530
FEATURES             Location/Qualifiers
     source          1..6530
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 87.09 cM"
     gene            1..6530
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /note="phosphatidylinositol-3,4,5-trisphosphate-dependent
                     Rac exchange factor 1"
                     /db_xref="GeneID:277360"
                     /db_xref="MGI:MGI:3040696"
     exon            1..318
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..5067
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /note="ptdIns(3,4,5)-dependent Rac exchanger 1; SET domain
                     containing 6"
                     /codon_start=1
                     /product="phosphatidylinositol
                     3,4,5-trisphosphate-dependent Rac exchanger 1 protein"
                     /protein_id="NP_808450.2"
                     /db_xref="CCDS:CCDS38334.1"
                     /db_xref="GeneID:277360"
                     /db_xref="MGI:MGI:3040696"
                     /translation="MEAPGSGGGDGGGDPGGDGAHPDARGPVSGPCAAARDSERQLRL
                     RLCVLNEILGTERDYVGTLRFLQSAFLQRIRQNVADSVEKGLTEENVKVLFSNIEDIL
                     EVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKV
                     PAVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHTAV
                     QSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTELLLQGNLLKI
                     SAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVE
                     NVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDALIREREQRESL
                     KLGMERDAYVMIAEKGEKLYHMMMSKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIG
                     EISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSK
                     GVRLYCRLHSLYAPVIKDRDYHLKTYKSVVPGSKLVDWLLAQGDCQTREEAVALGVGL
                     CNNGFMHHVLEKSEFKDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLIP
                     PQEDDYGFDLEEKNKAVVVKSVQRGSLAEMAGLQAGRKIYSINEDLVFLRPFSEVETI
                     LNQFFCSRRPLRLLVATKAKETIKVPDHPEALSFQIRGTAPPCVFAVGRGSEAVAAGL
                     CAGQCILKVNGTSVANDGALEVLEHFQAFRNHREEALGLYQWVYHSHEDAQLARASQG
                     APDEDPQEDDQPDSALPLLSLGPQLSLHEDSAVVSLTLDNVHLEHGVVYEYMSTAGAK
                     CHVLEKIVEPRGCFRLAAKILEAFAVDDSIFVQNCGRLMAMSSAIVTMSHYEFHNICD
                     TKLESIGQRIACYQEFAAQLKSRVSPPFKQASLEPHPLCGLDFCPTNCHVNLMEVSYP
                     KTTPSVGRSFSIRFGRKPSLIGLDPEQGLNPMAYTQHCITTMAAPSWKCSPAVDEDSQ
                     GQGLNDSSYGSASGAPSQQDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQ
                     INRLLSTITEPTSAAPAPCDPSLVEETSSSPPVSEESEVDRTDHSGIKKVCFKVSEDE
                     QEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSD
                     KQDKLHGCLEHLFNQVDSIHALLKGPVMSRAFEETRHFPMKHSWQEFKQKEECTVRGR
                     NLIQISIQEDPWNLPSSIRTLVDNIQQYVEDGKNQLLLALLKCTDTELQLRRDAVFCQ
                     ALVAAVCTFSEQLLAALDYRYNNNGEYEESSRDASRKWLEQVAATGVLLHWQSLLAPA
                     SVKEERTMLEDIWVTLSELDNVTFSFKQLDENSVANTNVFYHIEGSRQALKVVFYLDG
                     FHFSRLPSRLEGGASLRLHTVLFTKALESVEGPPPPGNQAAEELQQEINAQSLEKVQQ
                     YYRKLRAFYLERSNLPTDAGATAVKIDQLIRPINALDELYRLMKTFVHPKAGAAGSLG
                     AGLIPVSSELCYRLGACQITMCGTGMQRSTLSVSLEQAAILARSHGLLPKCVMQATDI
                     MRKQGPRVEILAKNLRIKDPMPQGAPRLYQLCQPPVDGDL"
     exon            319..390
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            391..513
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            514..618
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            619..720
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            721..882
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1016
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1135
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1285
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1433
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1534
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1638
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1688
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1764
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1837
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1980
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2073
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2222
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2308
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2445
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2551
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2739
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2901
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3112
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3386
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3599
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            3600..3688
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            3689..3771
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..3862
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            3863..3991
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            3992..4033
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            4034..4254
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            4255..4354
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            4355..4498
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            4499..4613
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            4614..4680
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            4681..4853
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            4854..4956
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            4957..5024
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
     exon            5025..6530
                     /gene="Prex1"
                     /gene_synonym="G630042G04; P-REX1; Setd6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcccccgct ccgcctgccc cgggcccgct gagcggcgcc tgtccgggat gcggagcccg
       61 gacgcctaag ccgcggcgcg acctcggcgc gggaagttcg ggcgccgcgc ggctatggag
      121 gcacccggca gcggtggtgg tgacggcggc ggggacccag gcggggacgg tgcgcatccc
      181 gatgctcgcg gccccgtctc cgggccgtgc gcggccgccc gcgactcgga gcgccagctg
      241 cgcctccgtc tgtgcgtact caacgagatc ctgggcaccg agcgcgacta cgtgggcacc
      301 ttgcgtttcc tgcagtcggc cttcctacag cggatccggc agaatgtggc cgactctgtg
      361 gagaagggcc tcacagaaga gaatgtcaag gtcctcttct ccaacattga ggacatcctg
      421 gaagtccata aggattttct ggctgccctg gagtactgct tacaccccga gcctcagtct
      481 cagcacgaac ttgggaatgt tttcttgaaa tttaaggaca agttctgtgt gtatgaggag
      541 tactgcagca accacgagaa ggccctgcgc ctgttggtgg agctcaacaa ggtccctgct
      601 gtgcgtgcct tcctcctgag ctgcatgctt ctggggggcc ggaagaccac tgacattcct
      661 ctggaaggct acctgctgtc cccgatccag agaatctgca agtacccgct cctgctcaag
      721 gagttggcca agaggacccc cggcaagcac cctgaccaca ccgcggtaca gagtgccctg
      781 caggccatga agactgtctg ctccaacatc aatgagacta agaggcagat ggagaagctg
      841 gaggccctgg agcagctgca gtctcacatt gaaggctggg agggctccaa cctcacagac
      901 atctgcaccg agctcctcct tcagggcaac ctgctgaaga tctctgcggg caacatccaa
      961 gagagagcct tcttcctctt tgacaacctg cttgtctact gcaagcggaa gtctagggtc
     1021 actgggagca agaaatctac caaaaggacc aagtccatca acggctccct gtacatcttt
     1081 aggggtcgga tcaacactga ggtcatggaa gtggagaatg tggaggatgg gacagccgat
     1141 taccacagca atggctacac tgtcaccaat ggctggaaga tccacaacac cgccaaaaac
     1201 aagtggttcg tgtgtatggc caagacggcg gaggagaaac agaagtggct ggatgccctg
     1261 atccgagagc gggagcagcg agagagcctg aagctgggca tggagcgtga cgcgtacgtc
     1321 atgattgcgg agaaggggga gaagctgtat cacatgatga tgagcaagaa ggtgaacttg
     1381 atcaaggacc gccggcggaa gctgagcacc gtccccaagt gcttccttgg caatgagttt
     1441 gttgcctggc tcctggaaat tggtgagatc agcaagacgg aagaaggcgt caacttgggc
     1501 caagccctgc tggagaatgg tatcatccac catgtctctg acaagcacca gttcaagaac
     1561 gagcaggtga tgtaccgctt ccgctacgac gacggcactt acaaagcgcg cagcgagctg
     1621 gaggatatca tgtccaaggg cgtgagactc tactgccggc tgcacagcct gtacgcccct
     1681 gtgatcaagg accgtgatta ccacctgaag acctacaagt ccgtggtccc cgggagcaag
     1741 ctggtagact ggctactggc acagggggac tgccagacac gggaggaggc cgtggcgctt
     1801 ggtgtgggcc tgtgcaacaa cggttttatg caccatgttc tggagaagag cgaattcaag
     1861 gatgagtccc agtacttccg cttccatgct gatgaggaga tggaggggac cagcagcaag
     1921 aacaaacagc ttcgcaatga cttcaagctg gtggagaaca tcctggcaaa gcgactgctg
     1981 atcccgccac aggaggacga ctatggcttc gaccttgagg agaagaacaa ggctgtggta
     2041 gtgaagtctg tgcagagggg ctcgctggct gagatggctg gcctgcaggc tgggaggaag
     2101 atttactcca tcaacgagga cctggtgttc ctgcgtccct tctctgaggt ggagaccatc
     2161 ctcaaccagt tcttctgctc ccgccgcccg ctccgcctcc tggtggccac caaggccaaa
     2221 gagaccatca aagtccctga ccacccagag gccctgtcct tccagattcg aggaacagcc
     2281 ccgccgtgtg tctttgctgt gggcagaggc tctgaggctg tggctgccgg gctctgcgcg
     2341 ggccaatgca tcctgaaagt caacggcacc agcgtggcga atgatggcgc cctggaggtt
     2401 ctcgagcact tccaggcttt ccgcaaccac agggaggagg ccctgggtct ttaccagtgg
     2461 gtctaccaca gccacgagga tgcccagctg gcacgagcca gccagggtgc ccctgatgag
     2521 gacccccagg aagatgacca gcctgactca gccctgcccc tgctgtccct gggtccccag
     2581 ctgagtctgc atgaggacag cgctgtggtc agcctgacgc tggacaatgt tcacttggag
     2641 cacggtgtgg tttacgaata catgagcact gcaggagcca agtgtcacgt gctggagaag
     2701 atcgtggagc cccgaggctg tttccgcctt gctgccaaga tccttgaggc ctttgctgtg
     2761 gacgacagca tcttcgtgca gaactgtggg cggctcatgg ccatgagcag tgccattgtc
     2821 accatgtccc actacgagtt ccataacatc tgtgacacca agctggagag catcggccag
     2881 aggatcgcct gctaccagga gtttgcagcc cagctgaaga gtagggtcag cccccccttc
     2941 aagcaggcat ccctggagcc ccacccgctg tgtggccttg acttctgccc caccaactgt
     3001 cacgtcaacc tcatggaagt gtcctacccc aagaccacac cttcggtggg caggtccttc
     3061 agcatccgct tcggacgcaa accctccctc atcggccttg acccagaaca aggcctgaac
     3121 cccatggcct atacccagca ctgtatcacc accatggctg ccccgtcctg gaagtgctca
     3181 cctgctgtag acgaggactc ccaaggccag ggtctcaatg acagcagcta tgggtcagcc
     3241 agtggtgccc cgagccagca agaccgcggc ctgagctttc tgctcaaaca ggaagaccgt
     3301 gagatccagg acgcatacct gcagctcttc actaagctgg acgtggccct caaggagatg
     3361 aagcagtatg tcacccagat taacaggctg ctgtcaacca tcacagagcc cacatcagct
     3421 gcccctgcgc cctgtgaccc atccttggtg gaggagacct catcttcccc accggtcagt
     3481 gaggagagtg aagtggaccg gactgaccac agcggcatca agaaagtgtg cttcaaggtg
     3541 tcggaggacg agcaggaaga ctcgggccac gacaccatga gctaccgcga ctcctacagt
     3601 gagtgtaaca gcaatcggga ctctgtcctg tcctacacca gcgtgagaag caacagttcg
     3661 tacctgggta gtgacgagat gggctcaggg gatgagctgc cctgtgacat gcgcatcccg
     3721 tccgacaagc aggacaaact tcacggctgc ctggaacatc tctttaacca ggtcgattcc
     3781 atccatgccc tgctcaaggg gcctgtgatg agcagggcat ttgaggagac caggcatttc
     3841 cccatgaagc acagctggca agagttcaaa cagaaagagg aatgcacggt ccgagggcgg
     3901 aacttgattc agatcagtat ccaggaggac ccttggaacc tgcccagctc catcaggacc
     3961 ctggtggaca acatccagca atacgtggaa gatggaaaga accagctgct tctggctctg
     4021 ctcaagtgca cagacacgga gctgcagctg cgcagggatg ctgtcttctg tcaggctctg
     4081 gtggccgccg tgtgcacttt ctcggagcag ctgctggccg cccttgacta ccgctacaac
     4141 aacaacggcg agtatgaaga gagcagcaga gatgccagcc gcaagtggct ggagcaggtg
     4201 gcggctacag gtgtcctgct gcactggcag tctctgctgg caccagcctc cgtgaaggag
     4261 gaacggacca tgctggagga catctgggtg acgctgtcgg agctggacaa tgtcaccttc
     4321 tcctttaagc agctggatga gaattctgtg gccaacacca atgtcttcta ccacatcgag
     4381 ggcagtaggc aggcactgaa ggtagtcttc tacctcgatg gcttccactt ctccaggctg
     4441 ccctctcgcc tagagggtgg ggccagcctc aggctgcaca cggtgctctt cacaaaagca
     4501 ctggagagcg tggaagggcc cccgccccct ggaaaccagg cagcagaaga gctgcagcag
     4561 gagatcaacg cacagtccct ggagaaggtg cagcagtact atagaaagct cagggcgttc
     4621 tacctggagc ggtccaacct gcccacggat gctggcgcca cagctgtgaa gattgaccag
     4681 ctgattcgtc ccatcaatgc cctggatgag ctctaccgcc tcatgaagac cttcgtgcac
     4741 cccaaagcgg gtgctgctgg gagcctgggt gctggtctca tccccgtctc ctccgagctc
     4801 tgctatcgcc tgggggcgtg tcagatcacc atgtgtggca ccggcatgca gcggagcacc
     4861 ctgagcgtgt ccttggaaca agcagccatc ttggcacgga gtcacggcct gttgcccaag
     4921 tgtgtcatgc aggccacaga catcatgcgc aagcagggcc cccgagtgga gattctggcc
     4981 aaaaacctcc gcatcaagga ccccatgccc caaggtgcac cacgcctcta ccagctctgc
     5041 cagcctccgg tggatggaga cctctgaaca ccaacatgtt ccctgcttgg tcactgcctc
     5101 aagcagctgc ggtgtgagag gacacggagg gtctgcaagg gcacccgagg cttctgccat
     5161 tgctgtgtca agacctaccc agatgacccc gctgccactg tctgggacaa gcctctgcgc
     5221 acatcctctc tctggactgg ctgatcactg ctgggctggc aggttctcca tacttatgcc
     5281 taaagcctga gagctgcttg ggggggcccc ccagagctca tgaatgtagc tggggcctgg
     5341 atgcctgcac tcacccaggt cccctacaca gggaaaggtc acagggtcta gcaggtggag
     5401 gcctgcagac cccgctcctc agatggccaa gctgcacttt gaacctgggt tcctcccggg
     5461 gccacattcc aggggactgt acctatttcc tgagctggct gaagcttccg gacatgcctc
     5521 ctgcccctta ctaactggct cagctgactc gggacagcct ggcctctgcc aggagaggac
     5581 actgggccat cactctgtga acacttgtgt gcccggctgg cttctaacac ccaccgccat
     5641 tggaatttga gctgtcagct ctgggcgcca gattggctct gatgctaatt tatatgacac
     5701 aacatctctg tggtttatgt tttatttttc tttcttactg tcattgttag tgttgtcaag
     5761 agttttcccc ctccccgtaa cgtttttgtc attatgtctt tgacgcttta aatttcagag
     5821 aagagtatat tgcctaatgg gaccaacata aagtagttat caacaacttt attcagctct
     5881 actaaaaaac aaaaggaact aaattattga aaaggtttaa gaggtcatta tttccgtgtt
     5941 aaaatctaaa ggctgtgaga tgtgcctcac aggcttcact gctccttccc ctgcctcagc
     6001 acccgcgagt ccggcccacg ttggacttgg ttgtgtcaac gactggacca gagtttgaga
     6061 ggtgctcagt tgtggcttag ggccgggctg cgtgttcttt attttgatgt catcatctca
     6121 gaacagggtc agagaaccgg agagatagga acctgttgtc ctaccttctg agtcggcggc
     6181 tgcacgtggg gacccctggg ctgtttgtcc tccagcttct gaacatctat agggaaccgc
     6241 tggcatgtag gagcgggaag ggcatgcctt ctcacctata aggctgtaag gctgggtttg
     6301 ggagtatggt cccctcggtc cctcggggcc acctttctct tggtatcggg ccatctttgt
     6361 tgatgtgttt tgttcatcca gagaaccagg gcccctgtta accctgctga gggggacggg
     6421 gaagggcccc gagggccagg gcagcatacc tggtttattt taaatgtaca gattcttttc
     6481 attaaattca tgatagattt tttattatta ttaaagtcgg tatataatac
//
