LOCUS       NM_001163622            3830 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus prolyl endopeptidase-like (Prepl), transcript variant
            1, mRNA.
ACCESSION   NM_001163622
VERSION     NM_001163622.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3830)
  AUTHORS   Bhalla,K., Rosier,K., Monnens,Y., Meulemans,S., Vervoort,E.,
            Thorrez,L., Agostinis,P., Meier,D.T., Rochtus,A., Resnick,J.L. and
            Creemers,J.W.M.
  TITLE     Similar metabolic pathways are affected in both Congenital
            Myasthenic Syndrome-22 and Prader-Willi Syndrome
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167175 (2024)
   PUBMED   38626828
REFERENCE   2  (bases 1 to 3830)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3830)
  AUTHORS   Duarte,M.L., Wang,M., Gomes,I., Liu,C., Sharma,A., Fakira,A.K.,
            Gupta,A., Mack,S.M., Zhang,B. and Devi,L.A.
  TITLE     Multiomics Analyses Identify Proline Endopeptidase-Like Protein As
            a Key Regulator of Protein Trafficking, a Pathway Underlying
            Alzheimer's Disease Pathogenesis
  JOURNAL   Mol Pharmacol 104 (1), 1-16 (2023)
   PUBMED   37147110
  REMARK    GeneRIF: Multiomics Analyses Identify Proline Endopeptidase-Like
            Protein As a Key Regulator of Protein Trafficking, a Pathway
            Underlying Alzheimer's Disease Pathogenesis.
REFERENCE   4  (bases 1 to 3830)
  AUTHORS   Rosier,K., McDevitt,M.T., Smet,J., Floyd,B.J., Verschoore,M.,
            Marcaida,M.J., Bingman,C.A., Lemmens,I., Dal Peraro,M.,
            Tavernier,J., Cravatt,B.F., Gounko,N.V., Vints,K., Monnens,Y.,
            Bhalla,K., Aerts,L., Rashan,E.H., Vanlander,A.V., Van Coster,R.,
            Regal,L., Pagliarini,D.J. and Creemers,J.W.M.
  TITLE     Prolyl endopeptidase-like is a (thio)esterase involved in
            mitochondrial respiratory chain function
  JOURNAL   iScience 24 (12), 103460 (2021)
   PUBMED   34888501
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3830)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3830)
  AUTHORS   Morawski,M., Nuytens,K., Juhasz,T., Zeitschel,U., Seeger,G.,
            Waelkens,E., Regal,L., Schulz,I., Arendt,T., Szeltner,Z.,
            Creemers,J. and Rossner,S.
  TITLE     Cellular and ultra structural evidence for cytoskeletal
            localization of prolyl endopeptidase-like protein in neurons
  JOURNAL   Neuroscience 242, 128-139 (2013)
   PUBMED   23485813
REFERENCE   7  (bases 1 to 3830)
  AUTHORS   Radhakrishnan,K., Baltes,J., Creemers,J.W. and Schu,P.
  TITLE     Trans-Golgi network morphology and sorting is regulated by
            prolyl-oligopeptidase-like protein PREPL and the AP-1 complex
            subunit mu1A
  JOURNAL   J Cell Sci 126 (Pt 5), 1155-1163 (2013)
   PUBMED   23321636
  REMARK    GeneRIF: The data demonstrate PREPL as an AP-1 effector that takes
            part in the regulation of AP-1 membrane binding. PREPL is highly
            expressed in brain and at lower levels in muscle and kidney.
REFERENCE   8  (bases 1 to 3830)
  AUTHORS   Ferretti,E., Li,B., Zewdu,R., Wells,V., Hebert,J.M., Karner,C.,
            Anderson,M.J., Williams,T., Dixon,J., Dixon,M.J., Depew,M.J. and
            Selleri,L.
  TITLE     A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face
            morphogenesis by promoting epithelial apoptosis
  JOURNAL   Dev Cell 21 (4), 627-641 (2011)
   PUBMED   21982646
REFERENCE   9  (bases 1 to 3830)
  AUTHORS   Lone,A.M., Bachovchin,D.A., Westwood,D.B., Speers,A.E.,
            Spicer,T.P., Fernandez-Vega,V., Chase,P., Hodder,P.S., Rosen,H.,
            Cravatt,B.F. and Saghatelian,A.
  TITLE     A substrate-free activity-based protein profiling screen for the
            discovery of selective PREPL inhibitors
  JOURNAL   J Am Chem Soc 133 (30), 11665-11674 (2011)
   PUBMED   21692504
REFERENCE   10 (bases 1 to 3830)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY146774.1, AK028877.1, AK083070.1 and BU058006.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.284654.1,
                                           SRR1660815.134040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BY146774.1         3-45
            44-141              AK028877.1         1-98
            142-2777            AK028877.1         100-2735
            2778-3821           AK083070.1         2283-3326
            3822-3830           BU058006.1         481-489
FEATURES             Location/Qualifiers
     source          1..3830
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 55.19 cM"
     gene            1..3830
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /note="prolyl endopeptidase-like"
                     /db_xref="GeneID:213760"
                     /db_xref="MGI:MGI:2441932"
     exon            1..162
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     exon            163..698
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     CDS             486..2663
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /EC_number="3.4.21.-"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="prolyl endopeptidase-like isoform a"
                     /protein_id="NP_001157094.1"
                     /db_xref="CCDS:CCDS50202.1"
                     /db_xref="GeneID:213760"
                     /db_xref="MGI:MGI:2441932"
                     /translation="MLQTAKFSLRALKHSIPHLGNCMQKQSYRNVAGPYYSRVRLKKY
                     HLTKCLQNKPRIAGLARNIPSRSFSCKDLLPIKPESEKPISENMDAFEKVRTRLETQP
                     QEEYEVVNAEIKHGGFVYYQEGCCLVRSKDEEADSDNYEVLFNLEELKLDQPFIDCIR
                     VAPDEKYVAAKIRTEDSETSTLVVVKLSDQPVMEASFPNVSSFEWVKDEEDEDVLFYT
                     FQRNLRCHDVYRATFGDNKRNERFYTEKDPSYFVFLYLTKDSRFLTLNIMNKTTSEVW
                     LIDGLSPWDPPVLIQKRIHGMLYYVEHRDDELYILTNVGEPTEFKLMRTAADAPAIMN
                     WDLFFTMKRNTKVVDLDMFKDHCVLFLKHSNLLYVNVIGLADDSVRSLKLPPWACGFI
                     MDTNSDPKNCPFQLCSPIRPPKYYTYKFAEGKLFEETGHEDPITKTSRVLRIEAKSKD
                     GKLVPMTVFHKTDSEDLQRKPLLVHVYGAYGMDLKMNFRPEKRVLVDDGWILAYCHVR
                     GGGELGLQWHADGRLTKKLNGLADLVACIKTLHSQGFSQPSLTTLSAFSAGGVLVGAL
                     CNSKPELLRAVTLEAPFLDVLNTMLDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPC
                     QNIKPQHYPSVHITAYENDERVPLKGIVNYTEKLKEAVAEHTKGAGEGYQPPNIILDI
                     QPGGNHVIEDSHKKITTQMKFLYEELGLDSTDAFEALKKYLKF"
     exon            699..821
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     exon            822..888
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1095
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1231
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1448
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1634
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1832
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..2008
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2225
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2375
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2499
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2573
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..3830
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2757..2762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /note="hexamer: ATTATA"
     polyA_site      2779
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /note="major polyA site"
     regulatory      3777..3782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /note="hexamer: AGTAAA"
     regulatory      3795..3800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
                     /note="hexamer: TATAAA"
     polyA_site      3803
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
     polyA_site      3813
                     /gene="Prepl"
                     /gene_synonym="2810457N15Rik; 9530014L06Rik;
                     D030028O16Rik; mKIAA0436"
ORIGIN      
        1 aaactagctc tgggcggcgc gaggtaggtt gtctttcttg ctgggtgctg gaggctggct
       61 tcggctggac aaggctgagg tgactgcagc tccttctgga gagcttcggt ttctcgtatt
      121 tgtcttctct accttcgctc gtccagctgt ctttcgattt gctttgtcca tacgttctcc
      181 agagtcactg ctgcttagct tgtccctagg aaaactgact ttacagatga cgtgtttatt
      241 aagtcccgcc tgccaagaag tatgatctga atgaacttaa cgcatacaag gttttaaacg
      301 tgtttaacct aagttatcag atgtctacag taattggtaa cctaaggggc tcatgacgcc
      361 acaggggagg gatgagatgt ggggacctca aatgcactaa gatcccatga ctgtataatt
      421 atacgtatga aatcatccac gtgctggcag cccctaaggg agcaaaaacc agggactttg
      481 ccaccatgct gcagacggcc aaattctctc tccgagcttt gaagcatagt attcctcatc
      541 ttgggaactg catgcagaaa cagagttacc gtaacgtcgc tggtccttat tacagtagag
      601 taagattgaa aaagtaccac ctaaccaagt gtctgcagaa taaacccagg atagcaggat
      661 tagcaagaaa catcccaagt cggagcttct cgtgtaagga tcttctgcct attaagccag
      721 aaagtgaaaa gcccatttct gaaaacatgg atgcatttga aaaagtgaga acaagactgg
      781 aaacacagcc acaggaagag tacgaagtcg tcaatgcaga gattaaacat ggcggctttg
      841 tttattatca agaaggttgc tgcttggttc gttccaaaga cgaagaagct gacagtgata
      901 attatgaagt tttattcaac ctggaagaac ttaaattgga tcagcctttc attgattgca
      961 tcagagttgc tcctgatgag aaatacgtgg ctgccaagat aaggacggag gattctgaaa
     1021 cctccacctt agtagttgtg aagctcagtg accagcctgt aatggaagcg tcgttcccaa
     1081 acgtgtccag tttcgaatgg gtgaaggatg aagaagatga agatgtctta ttctacacct
     1141 tccaaaggaa ccttcgctgc cacgatgtgt atcgagccac atttggtgac aacaagcgca
     1201 atgaacggtt ctacacagag aaagacccaa gctattttgt cttcctctac cttacaaaag
     1261 acagtcgttt cctcacactg aatattatga acaagacgac ttccgaggtg tggttgatag
     1321 atggcctgag cccgtgggac ccaccagtcc ttattcagaa gaggatacac ggaatgcttt
     1381 actatgttga gcatcgagat gatgagttat acatcctgac gaatgttgga gaacctacag
     1441 aattcaagct gatgcggacg gcagctgatg cccctgctat tatgaattgg gatttatttt
     1501 tcacaatgaa gagaaatacc aaggttgtag acttggacat gtttaaggac cactgtgttc
     1561 tgttcctgaa acacagcaat ctcctctatg ttaatgtgat tggtctggcc gacgactcag
     1621 tgcgctccct aaagctcccg ccttgggcct gtggattcat aatggataca aattctgacc
     1681 caaagaactg cccctttcag ctttgctctc caataagacc cccaaaatat tacacataca
     1741 aatttgcaga aggcaaactg tttgaggaaa ctggtcacga agatccgatt acaaagacca
     1801 gccgtgtttt acgcatagaa gccaaaagca aggatggaaa gttagtgccc atgacagttt
     1861 ttcacaaaac cgattctgag gacctgcaga ggaagcctct cttggtgcac gtctatggag
     1921 cgtacggaat ggacctgaaa atgaatttca ggcctgaaaa gcgggtcttg gtggatgatg
     1981 gatggatctt agcttattgc catgttaggg gtggtggcga gctaggtctc cagtggcatg
     2041 ccgatggccg actaactaaa aagctcaatg gccttgctga cttagtggct tgcattaaga
     2101 cgcttcacag ccagggcttt tctcagccga gcctaacaac gctgagcgct ttcagtgctg
     2161 gaggtgtgct cgtgggagca ctgtgtaatt ctaagccaga gctcctgaga gccgtgaccc
     2221 tggaggcacc tttcttggat gtcctcaata ccatgttgga taccaccctt cctctgacac
     2281 tggaagagtt ggaagagtgg gggaacccgt catctgatga gaaacacaag aactacataa
     2341 agcgctactg tccctgccag aacattaagc ctcagcatta tccttcagtt cacatcacag
     2401 cctatgaaaa cgatgagcga gtgccgctga aaggaatcgt gaactacaca gagaagctta
     2461 aggaggccgt ggctgagcac accaagggag cgggtgaagg ctatcagccc cccaacatta
     2521 tcctagatat tcagcctggg gggaaccacg tgattgagga ttctcacaaa aagatcacaa
     2581 cccagatgaa attcctatat gaggaacttg gacttgacag cactgatgct ttcgaggcgc
     2641 tgaagaaata cctaaagttc tgaaatgctg cattcagctg ggaactggaa acacatggaa
     2701 ataataatta gttttgtttc cagttagttt agcaaaagtg aagttttttt taagttatta
     2761 tataattttt taaaagttgt ctctttgtgt aattttgctt aatacttgct catactgttc
     2821 ccaccagcac acaccccctg gcctaggaaa gtcgttttcc atcatgctcc tcagtaggat
     2881 gtagagaagg gagccagaag gactggggca ggagaacagg agaacgcctg gcctcccaat
     2941 cagtctttta acagaatttt acaattcaaa atccttcccc tttgctagtg aatatttgta
     3001 ggcgctgtgg ctgtgagtca ccttgcaatt tccacaactc cactttaaag aaaaggatag
     3061 cattcttcat atttaaatgc tttagtattt tggcataatc ttttaaacac tttaaaaaca
     3121 gtgcattcgt gctacagaaa tatctaagaa ttgatgccat tcatgagtct gctcagccct
     3181 gtgcgtacgt gatgttctgg gtggccatct cttagggagc ttccttccta acacgagcta
     3241 tagaggatgt ccagtgcact ggagtagcac gcccgactgg aaacaaagca tctgtctctg
     3301 aaagcggcct gctgatggag gggagccttc gtgctgtgct ccaagaccag gccctctccc
     3361 ttctccagag aaatggcacg ggtgtcaaca gcactgcctt tggaggctga gttggtactt
     3421 aaccttattc tcagctctgg aggaagatct gaaatgatcc cctgtagatt tagcacagtt
     3481 gatgattctc caaaattcag aaccacgagg aagacgttat ctatgccgtc cagctctctt
     3541 gtgtacacca cagagtgact gtcgtctctc aagaggcaaa accagccccg gctgaggacc
     3601 agctctgtgg catggagtag actcagatcc tgatacagcc tcagtgctga gctcggctgg
     3661 gtcttttgga cctgttttta aaaagaatat tgacataaat gtttgatttt aagaattatc
     3721 cacacccccc ccaaaaaaat cccttgcttc tgtttgccct ttacactgtc caagtaagta
     3781 aataactgcc caattataaa gcatttataa atagttggtc ctaaagtcaa
//
