LOCUS       NM_011156               6494 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus prolyl endopeptidase (Prep), mRNA.
ACCESSION   NM_011156
VERSION     NM_011156.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6494)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6494)
  AUTHORS   Santillo,A., Falvo,S., Venditti,M., Di Maio,A., Chieffi Baccari,G.,
            Errico,F., Usiello,A., Minucci,S. and Di Fiore,M.M.
  TITLE     D-Aspartate Depletion Perturbs Steroidogenesis and Spermatogenesis
            in Mice
  JOURNAL   Biomolecules 13 (4), 621 (2023)
   PUBMED   37189369
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6494)
  AUTHORS   Palacios-Acedo,A.L., Mezouar,S., Mege,D., Crescence,L., Dubois,C.
            and Panicot-Dubois,L.
  TITLE     P2RY12-Inhibitors Reduce Cancer-Associated Thrombosis and Tumor
            Growth in Pancreatic Cancers
  JOURNAL   Front Oncol 11, 704945 (2021)
   PUBMED   34589424
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6494)
  AUTHORS   Jiang,D., Zhang,J., Lin,S., Wang,Y., Chen,Y. and Fan,J.
  TITLE     Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and
            Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat
            Diet
  JOURNAL   Front Cell Dev Biol 9, 628143 (2021)
   PUBMED   34095107
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6494)
  AUTHORS   Jiang,D.X., Zhang,J.B., Li,M.T., Lin,S.Z., Wang,Y.Q., Chen,Y.W. and
            Fan,J.G.
  TITLE     Prolyl endopeptidase gene disruption attenuates high fat
            diet-induced nonalcoholic fatty liver disease in mice by improving
            hepatic steatosis and inflammation
  JOURNAL   Ann Transl Med 8 (5), 218 (2020)
   PUBMED   32309365
REFERENCE   6  (bases 1 to 6494)
  AUTHORS   Odaka,C., Mizuochi,T., Shirasawa,T., Morain,P. and Checler,F.
  TITLE     Murine T cells expressing high activity of prolyl endopeptidase are
            susceptible to activation-induced cell death
  JOURNAL   FEBS Lett 512 (1-3), 163-167 (2002)
   PUBMED   11852073
  REMARK    GeneRIF: Murine T cells expressing high activity of prolyl
            endopeptidase are susceptible to activation-induced cell death.
REFERENCE   7  (bases 1 to 6494)
  AUTHORS   Kimura,A., Matsui,H. and Takahashi,T.
  TITLE     Expression and localization of prolyl oligopeptidase in mouse
            testis and its possible involvement in sperm motility
  JOURNAL   Zoolog Sci 19 (1), 93-102 (2002)
   PUBMED   12025410
REFERENCE   8  (bases 1 to 6494)
  AUTHORS   Kimura,A., Yoshida,I., Takagi,N. and Takahashi,T.
  TITLE     Structure and localization of the mouse prolyl oligopeptidase gene
  JOURNAL   J Biol Chem 274 (34), 24047-24053 (1999)
   PUBMED   10446174
REFERENCE   9  (bases 1 to 6494)
  AUTHORS   Borsani,G., DeGrandi,A., Ballabio,A., Bulfone,A., Bernard,L.,
            Banfi,S., Gattuso,C., Mariani,M., Dixon,M., Donnai,D., Metcalfe,K.,
            Winter,R., Robertson,M., Axton,R., Brown,A., van Heyningen,V. and
            Hanson,I.
  TITLE     EYA4, a novel vertebrate gene related to Drosophila eyes absent
  JOURNAL   Hum Mol Genet 8 (1), 11-23 (1999)
   PUBMED   9887327
REFERENCE   10 (bases 1 to 6494)
  AUTHORS   Ishino,T., Ohtsuki,S., Homma,Ki. and Natori,S.
  TITLE     cDNA cloning of mouse prolyl endopeptidase and its involvement in
            DNA synthesis by Swiss 3T3 cells
  JOURNAL   J Biochem 123 (3), 540-545 (1998)
   PUBMED   9538240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076257.1, AK163774.1, AC153535.4 and BP759584.1.
            
            On Jun 23, 2018 this sequence version replaced NM_011156.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161528.1, AK133875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1122              AK076257.1         2-1123
            1123-3810           AK163774.1         1-2688
            3811-5983           AC153535.4         118085-120257       c
            5984-6494           BP759584.1         26-536              c
FEATURES             Location/Qualifiers
     source          1..6494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.27 cM"
     gene            1..6494
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /note="prolyl endopeptidase"
                     /db_xref="GeneID:19072"
                     /db_xref="MGI:MGI:1270863"
     exon            1..160
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2248
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /EC_number="3.4.21.26"
                     /note="post-proline cleaving enzyme; prolyl
                     oligopeptidase"
                     /codon_start=1
                     /product="prolyl endopeptidase"
                     /protein_id="NP_035286.1"
                     /db_xref="CCDS:CCDS23826.1"
                     /db_xref="GeneID:19072"
                     /db_xref="MGI:MGI:1270863"
                     /translation="MLSFQYPDVYRDETSVQEYHGHKICDPYSWLEDPDSEQTKAFVE
                     AQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYV
                     QDSLEGEARVFLDPNTLSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDG
                     AKELPDVLERVKFTCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLCYHVLGTD
                     QSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIWEGCDPVNRLWYCDLQQEPNGITGI
                     LKWVKLIDNFEGEYDYVTNEGTVFTFKTNRNSPNYRLINIDFTDPDESKWKVLVPEHE
                     KDVLEWVACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSVVGYSGRKKDS
                     EIFYQFTSFLSPGVIYHCDLTKEELEPMVFREVTVKGIDAADYQTIQIFYPSKDGTKI
                     PMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGVLAVANIRGGG
                     EYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQ
                     RPDLFGCVIAQVGVMDMLKFHKFTIGHAWTTDYGCSDTKQHFEWLLKYSPLHNVKLPE
                     ADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGA
                     GKPTAKVIEEVSDMFAFIARCLNIEWIQ"
     exon            161..235
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     exon            236..369
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     exon            370..500
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     exon            501..710
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     exon            711..832
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     exon            833..938
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1130
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1328
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1432
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1569
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1664
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1796
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1953
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..6473
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2657..2662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /note="hexamer: AATAAA"
     regulatory      2697..2702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /note="hexamer: AATAAA"
     polyA_site      2698
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /note="major polyA site"
     polyA_site      2720
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /note="major polyA site"
     regulatory      2776..2781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /note="hexamer: AATAAA"
     polyA_site      2800
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
     regulatory      3680..3685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
                     /note="hexamer: ATTAAA"
     polyA_site      3703
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
     polyA_site      3812
                     /gene="Prep"
                     /gene_synonym="D10Wsu136e; PE; PEP; Pop"
ORIGIN      
        1 gagtccgccc gtgcacgccg gctgtccgct cgcccgctcg cacgccgccc tccgccgcag
       61 tccgcgccca gcctcgcccg cacttccccc cttcagcccg cgcccggatc cggccatgct
      121 gtccttccag taccccgacg tgtaccgcga cgagacctcc gtgcaggagt atcatggaca
      181 taaaatttgt gacccgtatt cttggcttga agacccagac agcgagcaga ctaaggcttt
      241 cgtggaggca caaaacaaga ttactgtgcc atttcttgag caatgtccaa tcagaggttt
      301 atacaaggag agaatgactg agctgtacga ctaccccaag tacagctgcc acttcaagaa
      361 aggaaagcgg tacttttatt tttacaatac aggtttgcag aaccaacgcg tgttatatgt
      421 gcaagactcc ttagaggggg aggccagagt gttcctggac cccaacacac tgtcggatga
      481 tggtacagtg gcactccgag gttatgcctt cagtgaagat ggcgaatact ttgcctatgg
      541 tctgagcgcc agcggctccg actgggtgac gatcaagttc atgaaggtcg atggtgccaa
      601 agagctcccg gatgtgctgg agagagtcaa gttcacctgc atggcctgga cgcatgacgg
      661 gaagggaatg ttctataact catacccgca gcaggacggg aagagcgatg gcacagagac
      721 atccaccaat ctccaccaaa agctctgcta ccacgtcttg gggacggatc agtcagaaga
      781 tattttgtgt gctgagttcc ccgatgagcc taaatggatg ggaggagctg agctatccga
      841 cgatggccgg tacgtcttgt tatccatctg ggagggatgt gatccagtaa accgactgtg
      901 gtactgtgac ctccagcaag aacccaatgg tatcaccgga atcctgaagt gggtaaaact
      961 gatagacaac tttgaaggag aatacgacta cgtaaccaac gagggcacag tgttcacatt
     1021 caagacgaac cgcaattctc ccaattatcg gctgatcaat atcgacttca cggaccctga
     1081 cgagtccaag tggaaagtgc tcgtaccgga gcacgagaag gatgtcttag aatgggtggc
     1141 ttgtgtcagg tccaacttcc tggtcttgtg ctacctccat gacgtgaaga acattctaca
     1201 gcttcacgac ctgacgactg gtgctctcct caagaccttc cccctggatg tgggcagcgt
     1261 ggtgggctac agtgggcgca agaaggactc tgagatcttc taccagttca catccttcct
     1321 atctccaggt gtcatttacc actgcgatct taccaaagag gaactggagc ccatggtttt
     1381 ccgagaggtg acggtgaagg gaatcgatgc tgctgattac cagacaatcc agattttcta
     1441 ccctagcaag gatggcacca agattcccat gtttattgtg cataaaaaag gcataaagct
     1501 ggatggctca caccctgctt tcttatatgg ctacgggggc ttcaacatct ccattacacc
     1561 caactacagc gtgtccaggc tcatttttgt gagacatatg ggcggcgtcc tcgcggtggc
     1621 taacatcaga ggcggcggtg aatacggaga gacgtggcac aaaggtggta tcttggccaa
     1681 caaacagaac tgttttgatg acttccagtg tgctgctgag tacctcatca aggaaggtta
     1741 cacatctccc aagaggctca cgatcaacgg aggctccaac ggcggcctct tagtagctgc
     1801 ttgcgcaaat cagcgtccag acctcttcgg ctgtgttatt gcccaggttg gagtgatgga
     1861 catgttgaag ttccacaaat ttactatcgg ccatgcatgg accactgatt acgggtgctc
     1921 cgacactaaa caacactttg aatggcttct caaatactcg ccactacaca atgtgaagct
     1981 tccggaggca gacgacatcc agtacccgtc catgcttctc ctcacggctg accacgacga
     2041 ccgcgtggtc ccgctgcact cactgaagtt cattgccacc cttcagtaca tcgtgggccg
     2101 cagccggaag cagagcaacc ccctgctcat ccacgtggac accaaggccg gccacggggc
     2161 cgggaaaccc accgccaaag tgatagaaga agtctcggat atgtttgcgt tcatagcacg
     2221 gtgcctgaac atcgagtgga tccagtaaat gggatttcca gttcctccca ccaaacacag
     2281 aaaacctcaa gggctttcac accatcctga ccaagaaacc actgggcaga gtgctgccct
     2341 acgtgagcac tgtgcctccg ctcacagaca gcaagccgct gagcagaact gccacgggga
     2401 ttttatcttt tctaggcttc atctttctag caagcccttg atgttttggg ttggtttttt
     2461 ttttcccact ctctccaggc acatatcttt aaaaggggga aaggggggca tgtttgtata
     2521 agaaactaaa aggcagtgaa catgttgtga atattagact cctgaattcg taagggatct
     2581 aataaggtca tagttgggca tacccatata taatagctca atgaagttac ttctctaacc
     2641 atagcatata aacttaaata aatgggagac ctcaagggag tctccactgc aatactaata
     2701 aatgctattt aagagtggga ggctttagtt ttggttcctt tgagaggcag ccctccaaat
     2761 gcagatgact atcagaataa agaatgtagt ctttatgcaa caggttagtt tccaacaatg
     2821 agaatcttag caccactgaa aagaggcgga gtctatccac ctcgtctggc ttcgatggat
     2881 gcagctgtgg gagactgctt gccatcacca ctgtcaccca tccaggtaaa gataggattc
     2941 tggtttggat gcctcgtgga caagagaact tgctctgcac acctgaggac tgccgagttt
     3001 gaataacagc acgtgtatag catgctgggc acaggctact tgtgcctgtg atcccctgca
     3061 gtgggggcgg cagtaggcag gtcctgagca ctcagtggcc agccaagtta gccggaaatg
     3121 gtgagcttct ggttcattga gagacagtgt ctcaaggcag taaggtgggt ggggacagag
     3181 aaaggcatgg ggcatcctgt ctccatgtac acgtgcacaa atgggcaaac cggcacacgc
     3241 atgcttgcat catgcacaga atccacatac agacacagaa actatggact tgaaaattaa
     3301 gatgattcac ctgtttgccc gtgtattgac ttggttacag agtatttgta gaaatgaaac
     3361 aacgcaagta aactgcccaa atagaggcgt ttacccaatc tcccattata acctggggcc
     3421 agcagcattt cccaagcttt gtccctccca ggttacgttc ccaggaatgc aatcacactg
     3481 tacagaaatc atgttcccat gtgctctacc ccagcctgct aatctttgag ggaacaatac
     3541 aaactcctca aacctaggct ttagaaatta tgttctgggt gtgttttaac atctcacaac
     3601 atgccgttcc tttagctatc agtttgggaa tggtgatatc tagtttataa ggaaaagatg
     3661 tgttacttta tcagatgtga ttaaaaggaa taccttcact gtacgcagag ttgcaacaca
     3721 gatcgtcccg gtgactgcgt ccagatcaca tacatacgcc ttttgcccat tgttgctcct
     3781 tgaattttta tcaaattgtg atctgagacc tagatacagc attttctttc tcgcctgcta
     3841 aggcatacca aacaccgctc aacactgggg cggggtttgt gcttcctgct ccggaaccgg
     3901 gctgtccctg accatcagac tctaacatgc caccagcctg caggtcacac tgaggctgaa
     3961 agcagcaacc ttcatcacag cctgttgaca gcatggctgc aaggacaagg agtgtgtttg
     4021 cgcatcgaag ccagaggcag cctctgctgg cctgcctaag tcatttgaag ggagatatct
     4081 gagcagttcc caccagggca tctccagctc acgcagaatc tgatcacctt cccactaagg
     4141 tctcctgcac agcaaaagtg ggagtgtaac tcgcagggtc tgctgcagtg cgagacctgt
     4201 gtccaaagcc cagggcccac tggaggccat gatgagagac agggcagtat gtgtatgagt
     4261 tcccagcaca cgtcacttct ctgtcccagc ctaagctgct tatctgtata tctgttgcat
     4321 atccgcagcc acagacagaa cattgctgtc ttcacgtttt aagctttaaa ctgagcagta
     4381 attagtggtc agagcacctg ccaccaagcc agtagagttc agcacccaca tggcaaaagg
     4441 gaggaactga ctcctgcagg ttgtgtcctc tgcctataac atgcatgtac aggaagtcaa
     4501 taaacactag agctgtttta attaggaact ccctaagact gaaggccagg gcttcccaga
     4561 gccgtctccc cattcctcac tacctttctg tccccgcact gcccttcacc tgtctctcaa
     4621 tgccagtgac atttgctggc atgtgttggg gtgggggttg ggggtgcctg ctatacacat
     4681 gatctagatg ccatgccctc agagcatctt cgccttagca agatagtgac atttgtggca
     4741 tttaatgtgt tcatacatgg acgattgtga aatcctgcag ttattcgtca ggcagctaca
     4801 ttgaaatagt ggtactagtt tgaaaagcaa ccgtgacaac aagctctctc tacagtttgg
     4861 tgagggtttt agcaaccatg ggtaactttc tggagaagac cacacaacca atactcagaa
     4921 cagggtgcag atacccaagg gttggcttat ggtaggtaag aaagctgggt agggaggtgt
     4981 ttagaaagag gccaagaaaa aaattcagga cgttcaggca aatggaatga ggacaagggc
     5041 tgatggagca aagccgtatt ctaggtcttg tagatatgga aaacccttct ttcatcaaat
     5101 agatcctccc aaggaggata atgtctggtg ttttccctgc cccatgcttc attaaccacc
     5161 ctgtgtttga atgtttgttc tcatgcagcc ctatgcagca tgtgccacac ccttactcca
     5221 cttacttagc aaaggcccag gatttccccg ctagggggta tacagaacca caaccctagc
     5281 aattggacct tagggacagt tacaatctga acaacttatt tccccctaaa acttaagaat
     5341 tacaatctga gctctcaaag tcatagcatt aggtggggcc tctggggatt aggtcagtgt
     5401 cttaggtttt tactgctgtg aacagacacc atgattaagg caagtcttat aaagggcaac
     5461 atttaattgg gcctgcctta caggttcaga tattcagttc attattatca aggcaacatc
     5521 caggcaggca tggtgcagga ggagctgaga gttctacatc ttcatctgaa ggccactagg
     5581 agaagactga cttccaggca gttaggatga gggttgtaaa acccaagccc acagtgacac
     5641 gcctattcat acaaggcctc acctccaaat agtgccactc cctggaccaa gcatattcaa
     5701 gccatgacag tcaggaatgg ggttggtgcc ttttttaagc cagccttatc ccttccaccc
     5761 ggtctgggca aaccagagct gtcatttcta agttggagcc acccagtgtg tggtgtttca
     5821 ttacaacagc cggaatggtt gaaggtactc actctcctga taagtcagtg tacacaaaat
     5881 acagtttcag gaattaagag cattggagag acaagtccgg acagatgaac agttgataac
     5941 aagaagtgct gtttcagtga atgtaaagag accacatttc agcaaagccc tgggacaaac
     6001 agcattggtg tgaatgcaga gctggaggca ggaaacagcc aagcccccaa ggaagtgtgg
     6061 ggagcaaggc agagtagggg acaggctgaa aagtagagtg aacccatgag aaaccactgg
     6121 agtgggactg agaagtgacc ccaaaggagc cagggtaaag caagaaggcc acttagagca
     6181 ggtaatccta acgccacgaa gggagctcgg ggctaagagc agcagaaacc tgtaaatcaa
     6241 ctggcacact gaatcgtaga agaacctcca tgacatgcta tgggaaaagc caggctcaaa
     6301 caaccatggg aagtatattc cactacatga aatgtcagtt cagtggctgt ttggggtagg
     6361 atagggatag aggttaactg tttagagata aaggttgtta ctgggtcgtg aaatttccag
     6421 cgttgtatta aggtgaaggt tgatccaccc agtaaattta tgacatcatt gaaaaaaaaa
     6481 aaaaaaaaaa aaaa
//
