LOCUS       NM_054077               3602 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus proline arginine-rich end leucine-rich repeat (Prelp),
            mRNA.
ACCESSION   NM_054077
VERSION     NM_054077.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3602)
  AUTHORS   Yamauchi,Y., Mieno,H., Suetsugu,H., Watanabe,H. and Nakaya,M.
  TITLE     Elevated PRELP expression in heart and liver fibrosis promotes
            collagen production
  JOURNAL   Biochem Biophys Res Commun 734, 150785 (2024)
   PUBMED   39369540
  REMARK    GeneRIF: Elevated PRELP expression in heart and liver fibrosis
            promotes collagen production.
REFERENCE   2  (bases 1 to 3602)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3602)
  AUTHORS   Davaapil,H., Hopkins,J., Bonnin,N., Papadaki,V., Leung,A.,
            Kosuge,H., Tashima,T., Nakakido,M., Sekido,R., Tsumoto,K.,
            Sagoo,M.S. and Ohnuma,S.I.
  TITLE     PRELP secreted from mural cells protects the function of blood
            brain barrier through regulation of endothelial cell-cell integrity
  JOURNAL   Front Cell Dev Biol 11, 1147625 (2023)
   PUBMED   37936982
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3602)
  AUTHORS   Lipp,S.N., Jacobson,K.R., Colling,H.A., Tuttle,T.G., Miles,D.T.,
            McCreery,K.P. and Calve,S.
  TITLE     Mechanical loading is required for initiation of extracellular
            matrix deposition at the developing murine myotendinous junction
  JOURNAL   Matrix Biol 116, 28-48 (2023)
   PUBMED   36709857
REFERENCE   5  (bases 1 to 3602)
  AUTHORS   Zhang,Y., Fu,C., Zhao,S., Jiang,H., Li,W. and Liu,X.
  TITLE     PRELP promotes myocardial fibrosis and ventricular remodelling
            after acute myocardial infarction by the wnt/beta-catenin
            signalling pathway
  JOURNAL   Cardiovasc J Afr 33 (5), 228-233 (2022)
   PUBMED   35788244
  REMARK    GeneRIF: PRELP promotes myocardial fibrosis and ventricular
            remodelling after acute myocardial infarction by the
            wnt/beta-catenin signalling pathway.
REFERENCE   6  (bases 1 to 3602)
  AUTHORS   Ahrens,M.J., Li,Y., Jiang,H. and Dudley,A.T.
  TITLE     Convergent extension movements in growth plate chondrocytes require
            gpi-anchored cell surface proteins
  JOURNAL   Development 136 (20), 3463-3474 (2009)
   PUBMED   19762422
REFERENCE   7  (bases 1 to 3602)
  AUTHORS   Tarunina,M., Alger,L., Chu,G., Munger,K., Gudkov,A. and Jat,P.S.
  TITLE     Functional genetic screen for genes involved in senescence: role of
            Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in
            senescence and cell survival
  JOURNAL   Mol Cell Biol 24 (24), 10792-10801 (2004)
   PUBMED   15572682
REFERENCE   8  (bases 1 to 3602)
  AUTHORS   Ross,M.D., Bruggeman,L.A., Hanss,B., Sunamoto,M., Marras,D.,
            Klotman,M.E. and Klotman,P.E.
  TITLE     Podocan, a novel small leucine-rich repeat protein expressed in the
            sclerotic glomerular lesion of experimental HIV-associated
            nephropathy
  JOURNAL   J Biol Chem 278 (35), 33248-33255 (2003)
   PUBMED   12796502
REFERENCE   9  (bases 1 to 3602)
  AUTHORS   Grover,J. and Roughley,P.J.
  TITLE     Characterization and expression of murine PRELP
  JOURNAL   Matrix Biol 20 (8), 555-564 (2001)
   PUBMED   11731272
  REMARK    GeneRIF: expressed in cartilage throughout both fetal development
            and post-natal life
REFERENCE   10 (bases 1 to 3602)
  AUTHORS   Takanosu,M., Boyd,T.C., Le Goff,M., Henry,S.P., Zhang,Y.,
            Bishop,P.N. and Mayne,R.
  TITLE     Structure, chromosomal location, and tissue-specific expression of
            the mouse opticin gene
  JOURNAL   Invest Ophthalmol Vis Sci 42 (10), 2202-2210 (2001)
   PUBMED   11527931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047480.1 and AK037150.1.
            
            On May 8, 2009 this sequence version replaced NM_054077.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019775.1, AK047480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3585              AK047480.1         2-3586
            3586-3602           AK037150.1         3564-3580
FEATURES             Location/Qualifiers
     source          1..3602
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.02 cM"
     gene            1..3602
                     /gene="Prelp"
                     /gene_synonym="7330409J17Rik; SLRR2A"
                     /note="proline arginine-rich end leucine-rich repeat"
                     /db_xref="GeneID:116847"
                     /db_xref="MGI:MGI:2151110"
     exon            1..147
                     /gene="Prelp"
                     /gene_synonym="7330409J17Rik; SLRR2A"
                     /inference="alignment:Splign:2.1.0"
     exon            148..1124
                     /gene="Prelp"
                     /gene_synonym="7330409J17Rik; SLRR2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1300
                     /gene="Prelp"
                     /gene_synonym="7330409J17Rik; SLRR2A"
                     /note="prolargin; proline-arginine-rich end leucine-rich
                     repeat protein"
                     /codon_start=1
                     /product="prolargin precursor"
                     /protein_id="NP_473418.3"
                     /db_xref="CCDS:CCDS15300.1"
                     /db_xref="GeneID:116847"
                     /db_xref="MGI:MGI:2151110"
                     /translation="MRASFFWLLPLLLILASVAQGQPTRPKPGIRRKPKPRPTPRFPQ
                     APEPAEPTDLPPPLPPGPPSVFPDCPRECYCPPDFPSALYCDSRNLRRVPVIPPRIHY
                     LYLQNNFITELPLESFQNATGLRWVNLDNNRIRKVDQRVLGKLPSLAFLYMEKNQLEE
                     VPSALPRNLEQLRLSQNLISRIPPGVFSKLENLLLLDLQHNRLSDGVFKADTFQGLKN
                     LMQLNLAHNILRKMPPKVPQAIHQLYLDSNKIETIPNGYFKDFPNLAFIRMNYNKLSD
                     RGLPKNSFNISNLLVLHLSHNKISNVPAISNKLEHLYLNNNSIEKINGTQICPNNLVA
                     FHDFSSDLENVPHLRYLRLDGNFLKPPIPLDLMMCFRLLQSVVI"
     exon            1125..3602
                     /gene="Prelp"
                     /gene_synonym="7330409J17Rik; SLRR2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3571..3576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prelp"
                     /gene_synonym="7330409J17Rik; SLRR2A"
                     /note="hexamer: AATAAA"
     polyA_site      3598
                     /gene="Prelp"
                     /gene_synonym="7330409J17Rik; SLRR2A"
                     /note="major polyA site"
ORIGIN      
        1 agaagaaaag tcaggcagac acacgcagac acgcaccaac tgggagacca gaacttctag
       61 ctggctctct gctgccacag ctccagcaaa gggtggggag gaacagaaga gtgccccaga
      121 gtccagagga gaggcaggtg tgtgcaggta catcacctgg atcatgaggg catccttctt
      181 ctggctcctc ccacttctcc tcatcttggc ctcagtggcc caaggccaac cgacaagacc
      241 aaaacctggg attaggcgta aacccaagcc gaggcccaca cccagatttc ctcaggcccc
      301 cgagccagca gagccgacag acctgcctcc acctcttcct cccggccctc catctgtctt
      361 ccctgactgt ccacgggaat gctactgccc ccctgacttc ccgtcagccc tctactgtga
      421 cagccgaaac ctgcgaaggg tccccgtcat cccaccccga atccattacc tttacttgca
      481 gaacaacttc atcactgagc ttcctctgga atctttccag aatgccacgg gcctgaggtg
      541 ggtcaacctg gacaacaacc gaattcgcaa ggtggaccag agagtgctgg ggaagctccc
      601 cagcctggca ttcctctaca tggagaagaa ccagctggaa gaggtgccat cagctctgcc
      661 ccggaacttg gaacagctga ggctgagcca gaacctcatt tccaggatcc cgcccggagt
      721 gttcagcaag ctggagaacc tgctgctcct ggatctgcag cacaatcggc tgagcgacgg
      781 cgtcttcaag gccgacacct tccagggcct caaaaacctc atgcagctca atctagccca
      841 caacatcctg agaaagatgc cccccaaagt cccccaagcc atccaccagc tctacctgga
      901 tagcaacaag atcgagacca tccccaacgg gtacttcaag gacttcccca acctggcctt
      961 catccgcatg aactacaaca aactgtcaga tcgcgggctc cccaagaact ccttcaacat
     1021 ctccaacttg ctggtgctcc acctgtctca caacaagatc agcaacgtgc cggccatcag
     1081 caacaagctg gaacacctgt acctcaacaa caatagcata gagaaaatca acgggaccca
     1141 gatttgcccc aacaacctag tggccttcca tgacttctcc tcggatctgg aaaacgtgcc
     1201 ccacctgcgc tacctgcggc tggatggaaa ttttctgaag cctcccatcc cactggacct
     1261 catgatgtgc ttccgcctcc tgcagtccgt ggtcatctag gctgtgccca gagctggacc
     1321 tcctctgaca gcacttgaag gctggtggcc caagctctgg ggtccactgt ttttatctgt
     1381 ctccctctct cgctcccagc cctgcccttc ctctcgtccc ttcgtgagga tggtaaatac
     1441 tgtataacct gctccggctc taaagcaaga ttccccaccc agcccaaaga caccctgcca
     1501 gccaagacct ctgctcttct ttggtctccc tttgcttcag aaacacaggt gtacgccaac
     1561 agacatatcc cctctcttcc cccacaccac gagtctctca tgggtaaggc tgggccatgg
     1621 actgacatct tattttagtc ttagccgagt cagaagcaga agtcattcca gaggtgaacc
     1681 ctggaaagtt cctccattga gaactccccc atttgggtaa ctgtctcaag aaggccgaca
     1741 aatccaggtc tcctaggcct gagatccctt ccaaagctgt cctctgccac tgtttcctga
     1801 caccagacag atgtcaccct gttccctact gtctcgagtt cttcagaaag gaagtgtggg
     1861 ggatgactaa ggtggggtgg agggtcaggg tttccccaca acttccagcc tttcctccgc
     1921 ttcccatctc cctcctttgg ggcaaacaca gtacacaccc tcttggctgg gcctcagaaa
     1981 ggaacagcca gggacaaagt ggtgcaagga actagacttt ggctaatagg agggtagctg
     2041 tggggtcaga gcccaaaact gggcctatgt ggatgtcgcc aagccctgca atctccctta
     2101 cccaaacttg acaatggagg gccaagaggc atcacaccac ttcatctgct ctctattatg
     2161 tgtgagactc agtcgagtca tcccacccca agggcagttc ttgagaaaca gaggaagagg
     2221 tggagcacct gggaatctcc cagaagcctc ttccatactg gggattagcc tctacctcta
     2281 aggccgactc atcagcgaca tctggtggct ggtggcatga tactgcaatt ccctgattcc
     2341 ctaggggaag agggccatgg gctttctcct actgggtctg aaggaaaggg cagaggctgg
     2401 gggttcattc ctatcaggag tgattgtgaa tgagaagtct ttgagagtct aagggaagct
     2461 agtttgacag aggccttgcc agggctcatt ttgctctcgg cttccacatc tgtaaactga
     2521 gtccctccca gagctcctgt ttgtgcaccc tcttctagag cacacctagc gcaggacaag
     2581 tggcatcacc cattctccct ctgcagttaa tttattccct gcatagagtg tccctccccc
     2641 gcagacttgc taccctcctt tcctagccca ggtgagcagc ttggcgggtt tccaagaacc
     2701 tgggctccct gcctttctct tcttcccttc tcctccctca ccggaaggct gcctttgccc
     2761 tgccacactt gcctgggtgg agaaggatgt ggagatgaat gttctagaag tgagtgaggc
     2821 acaggaccaa ttctccttag gctgggggag tctctggagg ctttttcctc tccccaagat
     2881 ggtgtcacac aactgtttta aaacattgga ttaggctggg ccctatagtc cagaaacccc
     2941 atttatattc cccatcacct ttctcgcatt gaaaatagag cccacttcac acaacctctt
     3001 ttccctgctg tgcaacttcc tcaccctagt tgcagctggt ttctccaagg ctcctgctta
     3061 agtcaatgta tcattacggc tgaaagcaac ctggtgctac agcctggaca agccccttct
     3121 gcacctatga caacctgcaa cttttgcccc tttcaggagg cccacaggga tcacagctcc
     3181 tgtggctgct agggatgggg gcaggcactg atcctgcaaa cctgaactag catcccacca
     3241 tcagcatccc attatccaac cgtggacctt gccagcttcc tccactgctc tctgcagcca
     3301 tcagctagag ggacaagagt taaactggct ttacaggaaa cacacacagt gctggttacc
     3361 ttgaggttta gaaagcccct cctcacacaa gtttattcaa tcagtgccat tagcatttat
     3421 acatgcaggt gcatgtgtgt gcatatgtgt gtgcatatgt gtgtgcgcgt gcatgcgcca
     3481 gctctcaccc tgtacatctt atctattctc caaaagacca tgttaactct gatacagcgt
     3541 ccgcattcca gcaagcttca cagcagagga aataaagtca tatggaaaac acccagcaca
     3601 aa
//
