LOCUS       NP_473418                378 aa            linear   ROD 12-NOV-2024
DEFINITION  prolargin precursor [Mus musculus].
ACCESSION   NP_473418
VERSION     NP_473418.3
DBSOURCE    REFSEQ: accession NM_054077.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 378)
  AUTHORS   Yamauchi,Y., Mieno,H., Suetsugu,H., Watanabe,H. and Nakaya,M.
  TITLE     Elevated PRELP expression in heart and liver fibrosis promotes
            collagen production
  JOURNAL   Biochem Biophys Res Commun 734, 150785 (2024)
   PUBMED   39369540
  REMARK    GeneRIF: Elevated PRELP expression in heart and liver fibrosis
            promotes collagen production.
REFERENCE   2  (residues 1 to 378)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 378)
  AUTHORS   Davaapil,H., Hopkins,J., Bonnin,N., Papadaki,V., Leung,A.,
            Kosuge,H., Tashima,T., Nakakido,M., Sekido,R., Tsumoto,K.,
            Sagoo,M.S. and Ohnuma,S.I.
  TITLE     PRELP secreted from mural cells protects the function of blood
            brain barrier through regulation of endothelial cell-cell integrity
  JOURNAL   Front Cell Dev Biol 11, 1147625 (2023)
   PUBMED   37936982
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 378)
  AUTHORS   Lipp,S.N., Jacobson,K.R., Colling,H.A., Tuttle,T.G., Miles,D.T.,
            McCreery,K.P. and Calve,S.
  TITLE     Mechanical loading is required for initiation of extracellular
            matrix deposition at the developing murine myotendinous junction
  JOURNAL   Matrix Biol 116, 28-48 (2023)
   PUBMED   36709857
REFERENCE   5  (residues 1 to 378)
  AUTHORS   Zhang,Y., Fu,C., Zhao,S., Jiang,H., Li,W. and Liu,X.
  TITLE     PRELP promotes myocardial fibrosis and ventricular remodelling
            after acute myocardial infarction by the wnt/beta-catenin
            signalling pathway
  JOURNAL   Cardiovasc J Afr 33 (5), 228-233 (2022)
   PUBMED   35788244
  REMARK    GeneRIF: PRELP promotes myocardial fibrosis and ventricular
            remodelling after acute myocardial infarction by the
            wnt/beta-catenin signalling pathway.
REFERENCE   6  (residues 1 to 378)
  AUTHORS   Ahrens,M.J., Li,Y., Jiang,H. and Dudley,A.T.
  TITLE     Convergent extension movements in growth plate chondrocytes require
            gpi-anchored cell surface proteins
  JOURNAL   Development 136 (20), 3463-3474 (2009)
   PUBMED   19762422
REFERENCE   7  (residues 1 to 378)
  AUTHORS   Tarunina,M., Alger,L., Chu,G., Munger,K., Gudkov,A. and Jat,P.S.
  TITLE     Functional genetic screen for genes involved in senescence: role of
            Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in
            senescence and cell survival
  JOURNAL   Mol Cell Biol 24 (24), 10792-10801 (2004)
   PUBMED   15572682
REFERENCE   8  (residues 1 to 378)
  AUTHORS   Ross,M.D., Bruggeman,L.A., Hanss,B., Sunamoto,M., Marras,D.,
            Klotman,M.E. and Klotman,P.E.
  TITLE     Podocan, a novel small leucine-rich repeat protein expressed in the
            sclerotic glomerular lesion of experimental HIV-associated
            nephropathy
  JOURNAL   J Biol Chem 278 (35), 33248-33255 (2003)
   PUBMED   12796502
REFERENCE   9  (residues 1 to 378)
  AUTHORS   Grover,J. and Roughley,P.J.
  TITLE     Characterization and expression of murine PRELP
  JOURNAL   Matrix Biol 20 (8), 555-564 (2001)
   PUBMED   11731272
  REMARK    GeneRIF: expressed in cartilage throughout both fetal development
            and post-natal life
REFERENCE   10 (residues 1 to 378)
  AUTHORS   Takanosu,M., Boyd,T.C., Le Goff,M., Henry,S.P., Zhang,Y.,
            Bishop,P.N. and Mayne,R.
  TITLE     Structure, chromosomal location, and tissue-specific expression of
            the mouse opticin gene
  JOURNAL   Invest Ophthalmol Vis Sci 42 (10), 2202-2210 (2001)
   PUBMED   11527931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047480.1 and AK037150.1.
            
            On May 8, 2009 this sequence version replaced NP_473418.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019775.1, AK047480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..378
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.02 cM"
     Protein         1..378
                     /product="prolargin precursor"
                     /note="prolargin; proline-arginine-rich end leucine-rich
                     repeat protein"
                     /calculated_mol_wt=40964
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2347
     mat_peptide     22..378
                     /product="Prolargin. /id=PRO_0000032745"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK53.2)"
                     /calculated_mol_wt=40964
     Region          22..62
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK53.2)"
     Region          68..103
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          91..110
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK53.2)"
     Region          100..123
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <102..>337
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          111..134
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK53.2)"
     Site            120
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JK53.2)"
     Region          124..147
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          135..158
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK53.2)"
     Region          148..168
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          159..179
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK53.2)"
     Region          169..192
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          180..203
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK53.2)"
     Region          193..218
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          204..229
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK53.2)"
     Region          219..239
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          230..250
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK53.2)"
     Region          240..263
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          251..274
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK53.2)"
     Region          264..288
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          275..299
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK53.2)"
     Site            285
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JK53.2)"
     Region          300..319
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK53.2)"
     Region          309..347
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            316
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JK53.2)"
     Region          320..358
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK53.2)"
     Site            323
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JK53.2)"
     Region          359..378
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK53.2)"
     CDS             1..378
                     /gene="Prelp"
                     /gene_synonym="7330409J17Rik; SLRR2A"
                     /coded_by="NM_054077.4:164..1300"
                     /db_xref="CCDS:CCDS15300.1"
                     /db_xref="GeneID:116847"
                     /db_xref="MGI:MGI:2151110"
ORIGIN      
        1 mrasffwllp lllilasvaq gqptrpkpgi rrkpkprptp rfpqapepae ptdlppplpp
       61 gppsvfpdcp recycppdfp salycdsrnl rrvpvippri hylylqnnfi telplesfqn
      121 atglrwvnld nnrirkvdqr vlgklpslaf lymeknqlee vpsalprnle qlrlsqnlis
      181 rippgvfskl enlllldlqh nrlsdgvfka dtfqglknlm qlnlahnilr kmppkvpqai
      241 hqlyldsnki etipngyfkd fpnlafirmn ynklsdrglp knsfnisnll vlhlshnkis
      301 nvpaisnkle hlylnnnsie kingtqicpn nlvafhdfss dlenvphlry lrldgnflkp
      361 pipldlmmcf rllqsvvi
//
