LOCUS       NM_007453               2378 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus peroxiredoxin 6 (Prdx6), transcript variant 1, mRNA.
ACCESSION   NM_007453 NM_011788 XM_917034
VERSION     NM_007453.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2378)
  AUTHORS   Ito,J., Nakamura,T., Toyama,T., Chen,D., Berndt,C., Poschmann,G.,
            Mourao,A.S.D., Doll,S., Suzuki,M., Zhang,W., Zheng,J., Trumbach,D.,
            Yamada,N., Ono,K., Yazaki,M., Kawai,Y., Arisawa,M., Ohsaki,Y.,
            Shirakawa,H., Wahida,A., Proneth,B., Saito,Y., Nakagawa,K.,
            Mishima,E. and Conrad,M.
  TITLE     PRDX6 dictates ferroptosis sensitivity by directing cellular
            selenium utilization
  JOURNAL   Mol Cell 84 (23), 4629-4644 (2024)
   PUBMED   39547222
REFERENCE   2  (bases 1 to 2378)
  AUTHORS   Torres-Velarde,J.M., Allen,K.N., Salvador-Pascual,A., Leija,R.G.,
            Luong,D., Moreno-Santillan,D.D., Ensminger,D.C. and
            Vazquez-Medina,J.P.
  TITLE     Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells
  JOURNAL   Free Radic Biol Med 218, 82-93 (2024)
   PUBMED   38579937
REFERENCE   3  (bases 1 to 2378)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2378)
  AUTHORS   Munoz-Gallardo,M.D.M., Garcia-Padilla,C., Vicente-Garcia,C.,
            Carvajal,J., Arenega,A. and Franco,D.
  TITLE     miR-195b is required for proper cellular homeostasis in the elderly
  JOURNAL   Sci Rep 14 (1), 810 (2024)
   PUBMED   38191655
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2378)
  AUTHORS   Bidooki,S.H., Sanchez-Marco,J., Martinez-Beamonte,R.,
            Herrero-Continente,T., Navarro,M.A., Rodriguez-Yoldi,M.J. and
            Osada,J.
  TITLE     Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9
            to Regulate Glutathione Metabolism and Lipid Peroxidation in the
            Hepatic AML12 Cell Line
  JOURNAL   Int J Mol Sci 24 (24), 17131 (2023)
   PUBMED   38138960
  REMARK    GeneRIF: Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6
            and HSPA9 to Regulate Glutathione Metabolism and Lipid Peroxidation
            in the Hepatic AML12 Cell Line.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2378)
  AUTHORS   Douville,P.J. and Carbonetto,S.
  TITLE     Genetic linkage analysis in recombinant inbred mice of P40, a
            putative clone for the high-affinity laminin receptor
  JOURNAL   Mamm Genome 3 (8), 438-446 (1992)
   PUBMED   1353694
REFERENCE   7  (bases 1 to 2378)
  AUTHORS   Siracusa,L.D., Rosner,M.H., Vigano,M.A., Gilbert,D.J., Staudt,L.M.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of the octamer transcription factors, Otf-1,
            Otf-2, and Otf-3, defines multiple Otf-3-related sequences
            dispersed in the mouse genome
  JOURNAL   Genomics 10 (2), 313-326 (1991)
   PUBMED   1676977
REFERENCE   8  (bases 1 to 2378)
  AUTHORS   Hsieh,C.L., Sturm,R., Herr,W. and Francke,U.
  TITLE     The gene for the ubiquitous octamer-binding protein Oct-1 is on
            human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on
            mouse chromosome 1
  JOURNAL   Genomics 6 (4), 666-672 (1990)
   PUBMED   2341156
REFERENCE   9  (bases 1 to 2378)
  AUTHORS   Paigen,B., Albee,D., Holmes,P.A. and Mitchell,D.
  TITLE     Genetic analysis of murine strains C57BL/6J and C3H/HeJ to confirm
            the map position of Ath-1, a gene determining atherosclerosis
            susceptibility
  JOURNAL   Biochem Genet 25 (7-8), 501-511 (1987)
   PUBMED   3128974
REFERENCE   10 (bases 1 to 2378)
  AUTHORS   Seldin,M.F., Morse,H.C. 3rd, D'Hoostelaere,L., Britten,J.L. and
            Steinberg,A.D.
  TITLE     Mapping of alpha-spectrin on distal mouse chromosome 1
  JOURNAL   Cytogenet Cell Genet 45 (1), 52-54 (1987)
   PUBMED   2885153
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC115751.6, AK157820.1 and
            AK030413.1.
            
            On Dec 31, 2014 this sequence version replaced NM_007453.3.
            
            Summary: This gene encodes a member of the peroxiredoxin family of
            peroxidases. The encoded protein is a bifunctional enzyme that has
            glutathione peroxidase and phospholipase activities. This protein
            is an antioxidant that reduces peroxidized membrane phospholipids
            and plays an important role in phospholipid homeostasis based on
            its ability to generate lysophospholipid substrate for the
            remodeling pathway of phospholipid synthesis. Mice lacking this
            gene are sensitive to oxidant stress, have altered lung
            phospholipid metabolism and susceptible to skin tumorigenesis.
            Alternate splicing of this gene results in multiple transcript
            variants. A pseudogene of this gene is found on chromosome 4.
            [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030413.1, BC061181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC115751.6         105839-105865
            28-1475             AK157820.1         2-1449
            1476-2378           AK030413.1         1433-2335
FEATURES             Location/Qualifiers
     source          1..2378
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 69.75 cM"
     gene            1..2378
                     /gene="Prdx6"
                     /gene_synonym="1-Cys Prx; 1-cysPrx; 9430088D19Rik; aiPLA2;
                     Aop2; Brp-12; CP-3; GPx; LPCAT-5; Ltw-4; Ltw4; Lvtw-4;
                     NSGPx; ORF06; Prdx5"
                     /note="peroxiredoxin 6"
                     /db_xref="GeneID:11758"
                     /db_xref="MGI:MGI:894320"
     exon            1..189
                     /gene="Prdx6"
                     /gene_synonym="1-Cys Prx; 1-cysPrx; 9430088D19Rik; aiPLA2;
                     Aop2; Brp-12; CP-3; GPx; LPCAT-5; Ltw-4; Ltw4; Lvtw-4;
                     NSGPx; ORF06; Prdx5"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..769
                     /gene="Prdx6"
                     /gene_synonym="1-Cys Prx; 1-cysPrx; 9430088D19Rik; aiPLA2;
                     Aop2; Brp-12; CP-3; GPx; LPCAT-5; Ltw-4; Ltw4; Lvtw-4;
                     NSGPx; ORF06; Prdx5"
                     /EC_number="3.1.1.4"
                     /EC_number="2.3.1.23"
                     /EC_number="1.11.1.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxiredoxin 6, related sequence 3; anti-oxidant protein
                     2, related sequence 3; peroxiredoxin 5, related sequence
                     3; 1-Cys peroxiredoxin; antioxidant protein 2;
                     non-selenium glutathione peroxidase; acidic
                     calcium-independent phospholipase A2; LPC acyltransferase
                     5; lyso-PC acyltransferase 5; lysophosphatidylcholine
                     acyltransferase 5; glutathione-dependent peroxiredoxin"
                     /codon_start=1
                     /product="peroxiredoxin-6 isoform 1"
                     /protein_id="NP_031479.1"
                     /db_xref="CCDS:CCDS15415.1"
                     /db_xref="GeneID:11758"
                     /db_xref="MGI:MGI:894320"
                     /translation="MPGGLLLGDEAPNFEANTTIGRIRFHDFLGDSWGILFSHPRDFT
                     PVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNGETPTEKLPFPI
                     IDDKGRDLAILLGMLDPVEKDANNMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEI
                     LRVVDSLQLTGTKPVATPVDWKKGESVMVVPTLSEEEAKQCFPKGVFTKELPSGKKYL
                     RYTPQP"
     exon            190..346
                     /gene="Prdx6"
                     /gene_synonym="1-Cys Prx; 1-cysPrx; 9430088D19Rik; aiPLA2;
                     Aop2; Brp-12; CP-3; GPx; LPCAT-5; Ltw-4; Ltw4; Lvtw-4;
                     NSGPx; ORF06; Prdx5"
                     /inference="alignment:Splign:2.1.0"
     exon            347..493
                     /gene="Prdx6"
                     /gene_synonym="1-Cys Prx; 1-cysPrx; 9430088D19Rik; aiPLA2;
                     Aop2; Brp-12; CP-3; GPx; LPCAT-5; Ltw-4; Ltw4; Lvtw-4;
                     NSGPx; ORF06; Prdx5"
                     /inference="alignment:Splign:2.1.0"
     exon            494..640
                     /gene="Prdx6"
                     /gene_synonym="1-Cys Prx; 1-cysPrx; 9430088D19Rik; aiPLA2;
                     Aop2; Brp-12; CP-3; GPx; LPCAT-5; Ltw-4; Ltw4; Lvtw-4;
                     NSGPx; ORF06; Prdx5"
                     /inference="alignment:Splign:2.1.0"
     exon            641..2378
                     /gene="Prdx6"
                     /gene_synonym="1-Cys Prx; 1-cysPrx; 9430088D19Rik; aiPLA2;
                     Aop2; Brp-12; CP-3; GPx; LPCAT-5; Ltw-4; Ltw4; Lvtw-4;
                     NSGPx; ORF06; Prdx5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1461..1466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prdx6"
                     /gene_synonym="1-Cys Prx; 1-cysPrx; 9430088D19Rik; aiPLA2;
                     Aop2; Brp-12; CP-3; GPx; LPCAT-5; Ltw-4; Ltw4; Lvtw-4;
                     NSGPx; ORF06; Prdx5"
                     /note="hexamer: AATAAA"
     polyA_site      1481
                     /gene="Prdx6"
                     /gene_synonym="1-Cys Prx; 1-cysPrx; 9430088D19Rik; aiPLA2;
                     Aop2; Brp-12; CP-3; GPx; LPCAT-5; Ltw-4; Ltw4; Lvtw-4;
                     NSGPx; ORF06; Prdx5"
                     /note="major polyA site"
ORIGIN      
        1 actcggccag cactgatcta ggtctccgca ggagcccgcc cgctgctcac tgctgcggct
       61 gcgcctcctt gttctcagcg tcaccactgc cgccatgccc ggagggttgc ttctcgggga
      121 cgaagccccc aactttgagg ccaataccac catcggccgc atccgcttcc acgatttcct
      181 gggagattca tggggcattc tcttttccca cccacgggac tttaccccag tgtgcaccac
      241 agaacttggc agagctgcaa agctggcgcc agagtttgcc aagaggaatg ttaagttgat
      301 tgctctttca atagacagtg ttgaggatca tcttgcctgg agcaaggaca tcaatgctta
      361 caatggtgaa acacccacgg aaaagttgcc atttcccatc attgatgata agggcaggga
      421 ccttgccatc cttttgggca tgttggatcc agtcgagaag gacgctaaca acatgcctgt
      481 gacggcccgt gtggtgttca tttttggccc tgacaagaaa ctgaagctgt ctatcctcta
      541 ccctgccacc acgggcagga actttgatga gattctcaga gtggttgact ctctccagct
      601 gacaggcaca aagccggttg ccaccccagt tgactggaag aagggagaga gcgtgatggt
      661 agttcccacc ctctccgaag aggaagccaa acaatgtttc cctaaaggag tcttcaccaa
      721 agagctcccg tctggcaaaa aatacctccg ttatacaccc cagccttaag tctttgcgga
      781 aattggggct gcatctgcac atccagtact ggggcctgag gatgtcagct ggcagccgtg
      841 ggtccttgca gcaggtccgt agaaagatcg tggcatgatc acagccggtc ctgtagatcg
      901 ctcgctatac tactgggtca ttaaatggaa atggcaccaa aaccttctcg ggattcttta
      961 ctctgtgcct tcgccagcat tctgcccctc tgcctgtcac agtgccctac tgactggctc
     1021 tctttgaaac gaattatgta ttgaagattc cttaggtctc tgtagggtct ttgatcagca
     1081 aacaaggtag tgtcagtgtg ggctctgtgc tagaatgatg aaacaccttt tgtatctttc
     1141 cgaactgaat cttctgttac ccattttgga gagcactgac atagggagaa gctttcgatt
     1201 ctgtattttt agtaaataaa aagtggggac agccgggaga attcttacag ggaatctatt
     1261 gtaagtttct atcgaagtgg gctcagaaag cctttcgcct cccaagagtg cgcatgtacc
     1321 tcctagagtt tccacatctg ctctctggtg atgtctgcct gtgaacgcac cttataaaag
     1381 acgggcggtg acagtgtttt accactcagt gtcctagtag tgggtggcca tttctgaatt
     1441 ctgctttttg aggttcaaca aataaaatcc tgatcagaaa accgttgtca tgttttaaag
     1501 tactactatc ttagactcta gcatgtctat tgcacaggca tgcttccttc ttgctgggaa
     1561 tagcatgggt atgtttctcc aacaacatga gtctccgcat gaactggaag ccactgaagg
     1621 atgaattcct acatgtatgt taggctaatt ccttggttcc tgttctccta agtcttgtga
     1681 acaggtgtgc accttctcag aggttctcaa cttgtggctc ataacctctt tggtcaccaa
     1741 ggaccaatgg aaaatattta cattacagtt cataacgata gcgaatttac agttaggaag
     1801 cagaaacaaa aataatttta tgtttagggg tcaccgcaac attaggaagg ttgagaacca
     1861 ctaatggtta ggtagtctgg cctcattagt gtaagctctg agatagtggt atattttgtt
     1921 tttctactct gaactgaatg gtttcattcc aacttagata cagtgctact agtccaagtc
     1981 attgtgagtc ttagtctagg ttgtaacaaa gatgcctggc ttgagcatgg gatgtttatt
     2041 tctaggtgtc aagctggaga gttaaattca aggcagtggt gggtcctagg tcatcctcct
     2101 cctaggaggc acctcactgc ttgctctttt ccattacaca cgtaattact ttggtccctg
     2161 cttttaatgg gaagtctggc ttccagttcc tgttgaggcg tttctggttt ttgtgtgttt
     2221 atgatactgg cttgttttgt atgtagccca ggctagacct gaaatctttc ctgctgccac
     2281 agctccccag gggctcagat tacaaatgtt accatcatgc cctatgccat cagctttgat
     2341 gacaaaagtt caaaatctaa actgccattg ttgatcat
//
