LOCUS       NM_012021               1271 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus peroxiredoxin 5 (Prdx5), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_012021
VERSION     NM_012021.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1271)
  AUTHORS   Wang,R., Mi,Y., Ni,J., Wang,Y., Ding,L., Ran,X., Sun,Q., Tan,S.Y.,
            Koeffler,H.P., Feng,N. and Chen,Y.Q.
  TITLE     Identification of PRDX5 as A Target for The Treatment of
            Castration-Resistant Prostate Cancer
  JOURNAL   Adv Sci (Weinh) 11 (9), e2304939 (2024)
   PUBMED   38115765
  REMARK    GeneRIF: Identification of PRDX5 as A Target for The Treatment of
            Castration-Resistant Prostate Cancer.
REFERENCE   2  (bases 1 to 1271)
  AUTHORS   Munoz-Gallardo,M.D.M., Garcia-Padilla,C., Vicente-Garcia,C.,
            Carvajal,J., Arenega,A. and Franco,D.
  TITLE     miR-195b is required for proper cellular homeostasis in the elderly
  JOURNAL   Sci Rep 14 (1), 810 (2024)
   PUBMED   38191655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1271)
  AUTHORS   Shin,H.J., Lee,S.W., Kim,M.H., Park,Y.H., Lee,H.J. and Lee,D.S.
  TITLE     Mitochondrial peroxiredoxin 5 overexpression suppresses
            insulin-induced adipogenesis by downregulating the phosphorylation
            of p38
  JOURNAL   Biosci Biotechnol Biochem 87 (7), 696-706 (2023)
   PUBMED   37024271
  REMARK    GeneRIF: Mitochondrial peroxiredoxin 5 overexpression suppresses
            insulin-induced adipogenesis by downregulating the phosphorylation
            of p38.
REFERENCE   4  (bases 1 to 1271)
  AUTHORS   Cho,E., Che,X., Ang,M.J., Cheon,S., Lee,J., Kim,K.S., Lee,C.H.,
            Lee,S.Y., Yang,H.Y., Moon,C., Park,C., Choi,J.Y. and Lee,T.H.
  TITLE     Peroxiredoxin 5 regulates osteogenic differentiation through
            interaction with hnRNPK during bone regeneration
  JOURNAL   Elife 12, e80122 (2023)
   PUBMED   36735291
  REMARK    GeneRIF: Peroxiredoxin 5 regulates osteogenic differentiation
            through interaction with hnRNPK during bone regeneration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1271)
  AUTHORS   Xu,Z., Qiao,S., Qian,W., Zhu,Y., Yan,W., Shen,S. and Wang,T.
  TITLE     Card9 protects fungal peritonitis through regulating Malt1-mediated
            activation of autophagy in macrophage
  JOURNAL   Int Immunopharmacol 110, 108941 (2022)
   PUBMED   35850054
REFERENCE   6  (bases 1 to 1271)
  AUTHORS   Knoops,B., Goemaere,J., Van der Eecken,V. and Declercq,J.P.
  TITLE     Peroxiredoxin 5: structure, mechanism, and function of the
            mammalian atypical 2-Cys peroxiredoxin
  JOURNAL   Antioxid Redox Signal 15 (3), 817-829 (2011)
   PUBMED   20977338
  REMARK    Review article
REFERENCE   7  (bases 1 to 1271)
  AUTHORS   Zhou,Y., Kok,K.H., Chun,A.C., Wong,C.M., Wu,H.W., Lin,M.C.,
            Fung,P.C., Kung,H. and Jin,D.Y.
  TITLE     Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits
            p53-induced apoptosis
  JOURNAL   Biochem Biophys Res Commun 268 (3), 921-927 (2000)
   PUBMED   10679306
REFERENCE   8  (bases 1 to 1271)
  AUTHORS   Knoops,B., Clippe,A., Bogard,C., Arsalane,K., Wattiez,R.,
            Hermans,C., Duconseille,E., Falmagne,P. and Bernard,A.
  TITLE     Cloning and characterization of AOEB166, a novel mammalian
            antioxidant enzyme of the peroxiredoxin family
  JOURNAL   J Biol Chem 274 (43), 30451-30458 (1999)
   PUBMED   10521424
REFERENCE   9  (bases 1 to 1271)
  AUTHORS   Yamashita,H., Avraham,S., Jiang,S., London,R., Van Veldhoven,P.P.,
            Subramani,S., Rogers,R.A. and Avraham,H.
  TITLE     Characterization of human and murine PMP20 peroxisomal proteins
            that exhibit antioxidant activity in vitro
  JOURNAL   J Biol Chem 274 (42), 29897-29904 (1999)
   PUBMED   10514471
REFERENCE   10 (bases 1 to 1271)
  AUTHORS   Lyu,M.S., Rhee,S.G., Chae,H.Z., Lee,T.H., Adamson,M.C., Kang,S.W.,
            Jin,D.Y., Jeang,K.T. and Kozak,C.A.
  TITLE     Genetic mapping of six mouse peroxiredoxin genes and fourteen
            peroxiredoxin related sequences
  JOURNAL   Mamm Genome 10 (10), 1017-1019 (1999)
   PUBMED   10501973
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC120557.12, AK009858.1,
            AK003332.2 and AA208558.1.
            
            On Dec 1, 2017 this sequence version replaced NM_012021.2.
            
            Summary: This gene encodes a member of the peroxiredoxin family of
            antioxidant enzymes, which reduce hydrogen peroxide and alkyl
            hydroperoxides. The encoded protein plays an antioxidant protective
            role in different tissues under normal conditions and during
            inflammatory processes. The use of alternate transcription start
            sites may result in use of alternate in-frame translation start
            codons that generate alternate isoforms that are targeted to the
            mitochondrion or peroxisome/cytoplasm. [provided by RefSeq, Nov
            2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008174.1, AF124994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC120557.12        88872-88901
            31-496              AK009858.1         2-467
            497-1257            AK003332.2         2-762
            1258-1271           AA208558.1         298-311
FEATURES             Location/Qualifiers
     source          1..1271
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.08 cM"
     gene            1..1271
                     /gene="Prdx5"
                     /gene_synonym="AOEB166; AOPP; PLP; Pmp20; Prdx6; PrxV"
                     /note="peroxiredoxin 5"
                     /db_xref="GeneID:54683"
                     /db_xref="MGI:MGI:1859821"
     exon            1..648
                     /gene="Prdx5"
                     /gene_synonym="AOEB166; AOPP; PLP; Pmp20; Prdx6; PrxV"
                     /inference="alignment:Splign:2.1.0"
     CDS             490..1122
                     /gene="Prdx5"
                     /gene_synonym="AOEB166; AOPP; PLP; Pmp20; Prdx6; PrxV"
                     /EC_number="1.11.1.24"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; peroxiredoxin-5, mitochondrial; thioredoxin
                     reductase; antioxidant enzyme B166; thioredoxin peroxidase
                     PMP20; peroxisomal antioxidant enzyme; liver tissue
                     2D-page spot 2D-0014IV; peroxiredoxin 6; peroxiredoxin V;
                     peroxisomal membrane protein 20; thioredoxin-dependent
                     peroxiredoxin 5"
                     /codon_start=1
                     /product="peroxiredoxin-5, mitochondrial isoform 1
                     precursor"
                     /protein_id="NP_036151.1"
                     /db_xref="CCDS:CCDS29507.1"
                     /db_xref="GeneID:54683"
                     /db_xref="MGI:MGI:1859821"
                     /translation="MLQLGLRVLGCKASSVLRASTCLAGRAGRKEAGWECGGARSFSS
                     SAVTMAPIKVGDAIPSVEVFEGEPGKKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLP
                     GFVEQAGALKAKGAQVVACLSVNDVFVIEEWGRAHQAEGKVRLLADPTGAFGKATDLL
                     LDDSLVSLFGNRRLKRFSMVIDNGIVKALNVEPDGTGLTCSLAPNILSQL"
     exon            649..783
                     /gene="Prdx5"
                     /gene_synonym="AOEB166; AOPP; PLP; Pmp20; Prdx6; PrxV"
                     /inference="alignment:Splign:2.1.0"
     exon            784..915
                     /gene="Prdx5"
                     /gene_synonym="AOEB166; AOPP; PLP; Pmp20; Prdx6; PrxV"
                     /inference="alignment:Splign:2.1.0"
     exon            916..954
                     /gene="Prdx5"
                     /gene_synonym="AOEB166; AOPP; PLP; Pmp20; Prdx6; PrxV"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1016
                     /gene="Prdx5"
                     /gene_synonym="AOEB166; AOPP; PLP; Pmp20; Prdx6; PrxV"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1271
                     /gene="Prdx5"
                     /gene_synonym="AOEB166; AOPP; PLP; Pmp20; Prdx6; PrxV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1237..1242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prdx5"
                     /gene_synonym="AOEB166; AOPP; PLP; Pmp20; Prdx6; PrxV"
                     /note="hexamer: AATAAA"
     polyA_site      1262
                     /gene="Prdx5"
                     /gene_synonym="AOEB166; AOPP; PLP; Pmp20; Prdx6; PrxV"
                     /note="major polyA site"
ORIGIN      
        1 gttgaactct tcgccggacc ggaagtggcc gacttagggg accttttggg gggcttggcg
       61 gcagccgaga tcggaaggac tgtgttgggt cacgtcctgg taccggaagc gtttctcggg
      121 gagactgcaa aggcttacgc cgaatcccgc tcgctgaaga gagtacacac tatgcaagtc
      181 acgtgtaaac cggctgcgtt acggcgcagg taaaacgaac acatttgagg ctcagccaga
      241 tcatccccga cctctgtttg cggctatggg tcacgaactg tcacgtcggt aaaccaggca
      301 cctctttctg cgattgaaga aggtgtgcga gccctgagag ccccgccgcg tcgtagtgcg
      361 tcacggccct gcccctctaa gccggcgctg tggctgcgac gtgggacgtg cggcgtgggc
      421 ggagctgtcc ctgcatccac ctcctgtggg cagagccatc tgcgggtggg ctgcggcagc
      481 ggggcgggta tgctacagct ggggcttcga gtcctgggct gcaaagccag ttctgtgctc
      541 cgtgcatcga cgtgcttggc aggcagagca ggccggaaag aagcaggttg ggagtgtggc
      601 ggagcccgca gcttcagcag ctccgcggtg accatggccc cgatcaaggt gggagatgcc
      661 attccctcag tggaggtatt tgaaggggaa ccgggaaaga aggtgaactt ggcagagctg
      721 ttcaagggca agaaaggtgt tttgtttgga gtccctgggg catttacacc tggctgttct
      781 aagacccacc tgcctgggtt tgtggagcaa gctggagctc tgaaggccaa gggagcgcag
      841 gtggtggcct gtctgagcgt taatgacgtc tttgtgattg aagagtgggg tcgagcccac
      901 caggcagaag gcaaggttcg gctcctggct gaccccactg gagcctttgg gaaggcgaca
      961 gacttattat tggatgattc tttggtgtct ctctttggga atcgtcggct gaaaaggttc
     1021 tccatggtga tagacaacgg catagtgaag gcactgaacg tggagccaga tggcacaggc
     1081 ctcacctgca gcctggcccc caacatcctc tctcaactct gaggccctgg ccagatgtcc
     1141 tctgactctc ccatctctcc cacccggctc taggccaaaa ggctcggtac ctccttactg
     1201 ggagccacgt aaatggaacc ttgaccatat ttctgcaata aacagtttaa tttgtgtctt
     1261 taccactggt a
//
