LOCUS       NM_016764                999 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus peroxiredoxin 4 (Prdx4), transcript variant 2, mRNA.
ACCESSION   NM_016764
VERSION     NM_016764.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 999)
  AUTHORS   Zou,X., Liang,X., Dai,W., Zhu,T., Wang,C., Zhou,Y., Qian,Y.,
            Yan,Z., Gao,C., Gao,L., Cui,Y., Liu,J. and Meng,Y.
  TITLE     Peroxiredoxin 4 deficiency induces accelerated ovarian aging
            through destroyed proteostasis in granulosa cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167334 (2024)
   PUBMED   38971505
  REMARK    GeneRIF: Peroxiredoxin 4 deficiency induces accelerated ovarian
            aging through destroyed proteostasis in granulosa cells.
REFERENCE   2  (bases 1 to 999)
  AUTHORS   Lu,Z., Tang,Y., Qin,R., Han,Z., Chen,H., Cao,L., Zhang,P., Yang,X.,
            Yu,W., Cheng,N. and Sun,Y.
  TITLE     Revealing Prdx4 as a potential diagnostic and therapeutic target
            for acute pancreatitis based on machine learning analysis
  JOURNAL   BMC Med Genomics 17 (1), 93 (2024)
   PUBMED   38641608
  REMARK    GeneRIF: Revealing Prdx4 as a potential diagnostic and therapeutic
            target for acute pancreatitis based on machine learning analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 999)
  AUTHORS   Xu,N., Jiang,X., Zhang,W., Shi,Y., Leak,R.K., Keep,R.F., Ye,Q.,
            Yang,T., Li,S., Hu,X., Stetler,R.A., Bennett,M.V.L. and Chen,J.
  TITLE     Endothelial peroxiredoxin-4 is indispensable for blood-brain
            barrier integrity and long-term functional recovery after ischemic
            stroke
  JOURNAL   Proc Natl Acad Sci U S A 121 (11), e2400272121 (2024)
   PUBMED   38437534
  REMARK    GeneRIF: Endothelial peroxiredoxin-4 is indispensable for
            blood-brain barrier integrity and long-term functional recovery
            after ischemic stroke.
REFERENCE   4  (bases 1 to 999)
  AUTHORS   Amatya,B., Yang,S., Yu,P., Vaz de Castro,P.A.S., Armando,I.,
            Zeng,C., Felder,R.A., Asico,L.D., Jose,P.A. and Lee,H.
  TITLE     Peroxiredoxin-4 and Dopamine D5 Receptor Interact to Reduce
            Oxidative Stress and Inflammation in the Kidney
  JOURNAL   Antioxid Redox Signal 38 (16-18), 1150-1166 (2023)
   PUBMED   36401517
  REMARK    GeneRIF: Peroxiredoxin-4 and Dopamine D5 Receptor Interact to
            Reduce Oxidative Stress and Inflammation in the Kidney.
REFERENCE   5  (bases 1 to 999)
  AUTHORS   Dai,W., Zou,X., Jia,H., Peng,Y., La,B., Yan,Z., Gao,L., Qin,L.,
            Diao,F., Ma,X., Meng,Y., Cui,Y. and Liu,J.
  TITLE     Peroxiredoxin 4 secreted by cumulus cells ameliorates the
            maturation of oocytes in vitro
  JOURNAL   Biochem Biophys Res Commun 636 (Pt 1), 155-161 (2022)
   PUBMED   36334439
  REMARK    GeneRIF: Peroxiredoxin 4 secreted by cumulus cells ameliorates the
            maturation of oocytes in vitro.
REFERENCE   6  (bases 1 to 999)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 999)
  AUTHORS   McGowan,K.M., Tong,X., Colucci-Guyon,E., Langa,F., Babinet,C. and
            Coulombe,P.A.
  TITLE     Keratin 17 null mice exhibit age- and strain-dependent alopecia
  JOURNAL   Genes Dev 16 (11), 1412-1422 (2002)
   PUBMED   12050118
REFERENCE   8  (bases 1 to 999)
  AUTHORS   Wong,C.M., Chun,A.C., Kok,K.H., Zhou,Y., Fung,P.C., Kung,H.F.,
            Jeang,K.T. and Jin,D.Y.
  TITLE     Characterization of human and mouse peroxiredoxin IV: evidence for
            inhibition by Prx-IV of epidermal growth factor- and p53-induced
            reactive oxygen species
  JOURNAL   Antioxid Redox Signal 2 (3), 507-518 (2000)
   PUBMED   11229364
REFERENCE   9  (bases 1 to 999)
  AUTHORS   Lee,T.H., Yu,S.L., Kim,S.U., Lee,K.K., Rhee,S.G. and Yu,D.Y.
  TITLE     Characterization of mouse peroxiredoxin I genomic DNA and its
            expression
  JOURNAL   Gene 239 (2), 243-250 (1999)
   PUBMED   10548725
REFERENCE   10 (bases 1 to 999)
  AUTHORS   Lyu,M.S., Rhee,S.G., Chae,H.Z., Lee,T.H., Adamson,M.C., Kang,S.W.,
            Jin,D.Y., Jeang,K.T. and Kozak,C.A.
  TITLE     Genetic mapping of six mouse peroxiredoxin genes and fourteen
            peroxiredoxin related sequences
  JOURNAL   Mamm Genome 10 (10), 1017-1019 (1999)
   PUBMED   10501973
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ079814.1, AK152255.1 and AW121558.1.
            
            On Aug 27, 2015 this sequence version replaced NM_016764.4.
            
            Transcript Variant: This variant (2) lacks contains an alternate
            exon in the 3' coding region compared to variant 1, that causes a
            frameshift. The resulting isoform (2) has a shorter and distinct
            C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019578.1, U96746.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                CJ079814.1         1-25
            26-980              AK152255.1         2-956
            981-999             AW121558.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..999
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 72.38 cM"
     gene            1..999
                     /gene="Prdx4"
                     /gene_synonym="AOE372; Prx-iv; Prx4; TRANK"
                     /note="peroxiredoxin 4"
                     /db_xref="GeneID:53381"
                     /db_xref="MGI:MGI:1859815"
     exon            1..348
                     /gene="Prdx4"
                     /gene_synonym="AOE372; Prx-iv; Prx4; TRANK"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..923
                     /gene="Prdx4"
                     /gene_synonym="AOE372; Prx-iv; Prx4; TRANK"
                     /EC_number="1.11.1.24"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; antioxidant enzyme AOE372; peroxiredoxin IV;
                     thioredoxin peroxidase AO372; thioredoxin-dependent
                     peroxide reductase A0372; Prx IV; thioredoxin-dependent
                     peroxiredoxin 4"
                     /codon_start=1
                     /product="peroxiredoxin-4 isoform 2 precursor"
                     /protein_id="NP_058044.1"
                     /db_xref="CCDS:CCDS30496.1"
                     /db_xref="GeneID:53381"
                     /db_xref="MGI:MGI:1859815"
                     /translation="MEARSKLLDGTTASRRWTRKLVLLLPPLLLFLLRTESLQGLESD
                     ERFRTRENECHFYAGGQVYPGEASRVSVADHSLHLSKAKISKPAPYWEGTAVINGEFK
                     ELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRIEEFKSINTEVVACSVDSQFTHL
                     AWINTPRRQGGLGPIRIPLLSDLNHQISKDYGVYLEDSGHTLRGLFIIDDKGVLRQIT
                     LNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN"
     exon            349..466
                     /gene="Prdx4"
                     /gene_synonym="AOE372; Prx-iv; Prx4; TRANK"
                     /inference="alignment:Splign:2.1.0"
     exon            467..583
                     /gene="Prdx4"
                     /gene_synonym="AOE372; Prx-iv; Prx4; TRANK"
                     /inference="alignment:Splign:2.1.0"
     exon            584..706
                     /gene="Prdx4"
                     /gene_synonym="AOE372; Prx-iv; Prx4; TRANK"
                     /inference="alignment:Splign:2.1.0"
     exon            707..837
                     /gene="Prdx4"
                     /gene_synonym="AOE372; Prx-iv; Prx4; TRANK"
                     /inference="alignment:Splign:2.1.0"
     exon            838..872
                     /gene="Prdx4"
                     /gene_synonym="AOE372; Prx-iv; Prx4; TRANK"
                     /inference="alignment:Splign:2.1.0"
     exon            873..983
                     /gene="Prdx4"
                     /gene_synonym="AOE372; Prx-iv; Prx4; TRANK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      957..962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prdx4"
                     /gene_synonym="AOE372; Prx-iv; Prx4; TRANK"
                     /note="hexamer: AATAAA"
     polyA_site      983
                     /gene="Prdx4"
                     /gene_synonym="AOE372; Prx-iv; Prx4; TRANK"
                     /note="major polyA site"
ORIGIN      
        1 ttggtcgcgc ggtctccagc gcgccgtttt agctggctgc ctggcggcag gggactctgt
       61 gctttagcag agggacgtgt tttcgcgctt gcttggtcat ggaggcgcgg tccaagctgc
      121 tggacgggac cacggcgtcc cgtcgctgga cccgaaagct ggtgttgctc ctgccgccgc
      181 tgctgctgtt cctgttgcgg accgaatctc tgcaaggctt ggagagtgat gaacggttcc
      241 ggacccgcga aaatgagtgc cacttctacg ctggtggaca agtgtacccc ggggaggcgt
      301 cccgggtttc agtcgcggat cactccctgc atctaagcaa agccaagatc tccaagccag
      361 caccttattg ggaaggaaca gctgtgatta acggagaatt caaggagctc aaactgactg
      421 actatcgtgg gaaatacttg gtttttttct tctacccact ggatttcacc tttgtgtgtc
      481 caactgaaat catcgctttt ggggatcgaa ttgaagaatt caaatctata aatactgaag
      541 tggtagcatg ctctgttgac tctcagttta cccacttggc ctggattaat acccctcgaa
      601 gacaaggagg actggggcca ataaggattc cacttctttc tgacctgaac catcagatct
      661 caaaggacta tggtgtatac cttgaagact caggacatac tcttagaggc ctctttatta
      721 tcgatgacaa aggagtcctg aggcagatta ctctgaatga ccttcctgtc ggaagatcag
      781 tggacgagac actgcgtttg gttcaagcct tccagtacac tgacaagcat ggagaagtct
      841 gccctgctgg ctggaaacct ggtagtgaaa caataatccc agatccagct ggaaaactga
      901 agtatttcga caagctaaac tgaaaagtac ttcagttatg atgtttggac cttctcaata
      961 aaggtcattg tgttattacc ataaaaaaaa aaaaaaaaa
//
