LOCUS       NM_007452               1445 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus peroxiredoxin 3 (Prdx3), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_007452
VERSION     NM_007452.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1445)
  AUTHORS   Su,W., Guo,Y., Wang,Q., Ma,L., Zhang,Q., Zhang,Y., Geng,Y., Jin,T.,
            Guo,J., Yang,R., Niu,Z., Ren,L., Wang,Y., Ning,Z., Li,W., He,W.,
            Sun,J., Li,T., Li,Z., Shan,H. and Liang,H.
  TITLE     YAP1 inhibits the senescence of alveolar epithelial cells by
            targeting Prdx3 to alleviate pulmonary fibrosis
  JOURNAL   Exp Mol Med 56 (7), 1643-1654 (2024)
   PUBMED   38945958
  REMARK    GeneRIF: YAP1 inhibits the senescence of alveolar epithelial cells
            by targeting Prdx3 to alleviate pulmonary fibrosis.
REFERENCE   2  (bases 1 to 1445)
  AUTHORS   Huang,W., Wang,L., Huang,Z., Sun,Z. and Zheng,B.
  TITLE     Peroxiredoxin 3 has a crucial role in the macrophage polarization
            by regulating mitochondrial homeostasis
  JOURNAL   Respir Res 25 (1), 110 (2024)
   PUBMED   38431661
  REMARK    GeneRIF: Peroxiredoxin 3 has a crucial role in the macrophage
            polarization by regulating mitochondrial homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1445)
  AUTHORS   Schraps,N., Tirre,M., Pyschny,S., Reis,A., Schlierbach,H.,
            Seidl,M., Kehl,H.G., Schanzer,A., Heger,J., Jux,C. and
            Drenckhahn,J.D.
  TITLE     Cardiomyocyte maturation alters molecular stress response
            capacities and determines cell survival upon mitochondrial
            dysfunction
  JOURNAL   Free Radic Biol Med 213, 248-265 (2024)
   PUBMED   38266827
REFERENCE   4  (bases 1 to 1445)
  AUTHORS   Munoz-Gallardo,M.D.M., Garcia-Padilla,C., Vicente-Garcia,C.,
            Carvajal,J., Arenega,A. and Franco,D.
  TITLE     miR-195b is required for proper cellular homeostasis in the elderly
  JOURNAL   Sci Rep 14 (1), 810 (2024)
   PUBMED   38191655
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1445)
  AUTHORS   Cui,S., Ghai,A., Deng,Y., Li,S., Zhang,R., Egbulefu,C., Liang,G.,
            Achilefu,S. and Ye,J.
  TITLE     Identification of hyperoxidized PRDX3 as a ferroptosis marker
            reveals ferroptotic damage in chronic liver diseases
  JOURNAL   Mol Cell 83 (21), 3931-3939 (2023)
   PUBMED   37863053
  REMARK    GeneRIF: Identification of hyperoxidized PRDX3 as a ferroptosis
            marker reveals ferroptotic damage in chronic liver diseases.
REFERENCE   6  (bases 1 to 1445)
  AUTHORS   Kilpatrick,T.J. and Bartlett,P.F.
  TITLE     Cloned multipotential precursors from the mouse cerebrum require
            FGF-2, whereas glial restricted precursors are stimulated with
            either FGF-2 or EGF
  JOURNAL   J Neurosci 15 (5 Pt 1), 3653-3661 (1995)
   PUBMED   7751935
REFERENCE   7  (bases 1 to 1445)
  AUTHORS   Tsuji,K., Copeland,N.G., Jenkins,N.A. and Obinata,M.
  TITLE     Mammalian antioxidant protein complements alkylhydroperoxide
            reductase (ahpC) mutation in Escherichia coli
  JOURNAL   Biochem J 307 (Pt 2) (Pt 2), 377-381 (1995)
   PUBMED   7733872
REFERENCE   8  (bases 1 to 1445)
  AUTHORS   Chae,H.Z., Kim,I.H., Kim,K. and Rhee,S.G.
  TITLE     Cloning, sequencing, and mutation of thiol-specific antioxidant
            gene of Saccharomyces cerevisiae
  JOURNAL   J Biol Chem 268 (22), 16815-16821 (1993)
   PUBMED   8344960
REFERENCE   9  (bases 1 to 1445)
  AUTHORS   Nemoto,Y., Yamamoto,T., Takada,S., Matsui,Y. and Obinata,M.
  TITLE     Antisense RNA of the latent period gene (MER5) inhibits the
            differentiation of murine erythroleukemia cells
  JOURNAL   Gene 91 (2), 261-265 (1990)
   PUBMED   2210385
REFERENCE   10 (bases 1 to 1445)
  AUTHORS   Yamamoto,T., Matsui,Y., Natori,S. and Obinata,M.
  TITLE     Cloning of a housekeeping-type gene (MER5) preferentially expressed
            in murine erythroleukemia cells
  JOURNAL   Gene 80 (2), 337-343 (1989)
   PUBMED   2583515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY318475.1, AK002448.1 and BB372344.1.
            
            On Dec 19, 2006 this sequence version replaced NM_007452.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M28723.1, BC005626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                BY318475.1         4-70
            68-1437             AK002448.1         2-1371
            1438-1445           BB372344.1         301-308
FEATURES             Location/Qualifiers
     source          1..1445
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 56.52 cM"
     gene            1..1445
                     /gene="Prdx3"
                     /gene_synonym="Aop1; D0Tohi1; Ef2l; Mer5; Prx3; SP22;
                     TDXM"
                     /note="peroxiredoxin 3"
                     /db_xref="GeneID:11757"
                     /db_xref="MGI:MGI:88034"
     exon            1..107
                     /gene="Prdx3"
                     /gene_synonym="Aop1; D0Tohi1; Ef2l; Mer5; Prx3; SP22;
                     TDXM"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..845
                     /gene="Prdx3"
                     /gene_synonym="Aop1; D0Tohi1; Ef2l; Mer5; Prx3; SP22;
                     TDXM"
                     /EC_number="1.11.1.24"
                     /note="thioredoxin-dependent peroxide reductase,
                     mitochondrial; peroxiredoxin III; AOP-1; perioredoxin-3;
                     anti-oxidant protein 1; Prx III; mitochondrial Trx
                     dependent peroxide reductase; mitochondrial thioredoxin
                     dependent peroxide reductase; thioredoxin-dependent
                     peroxiredoxin 3"
                     /codon_start=1
                     /product="thioredoxin-dependent peroxide reductase,
                     mitochondrial precursor"
                     /protein_id="NP_031478.1"
                     /db_xref="CCDS:CCDS29944.1"
                     /db_xref="GeneID:11757"
                     /db_xref="MGI:MGI:88034"
                     /translation="MAAAAGRLLWSSVARHASAISRSISASTVLRPVASRRTCLTDIL
                     WSASAQGKSAFSTSSSFHTPAVTQHAPYFKGTAVVNGEFKELSLDDFKGKYLVLFFYP
                     LDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIT
                     LLSDITKQISRDYGVLLESAGIALRGLFIIDPNGVVKHLSVNDLPVGRSVEETLRLVK
                     AFQFVETHGEVCPANWTPESPTIKPSPTASKEYFEKVHQ"
     exon            108..243
                     /gene="Prdx3"
                     /gene_synonym="Aop1; D0Tohi1; Ef2l; Mer5; Prx3; SP22;
                     TDXM"
                     /inference="alignment:Splign:2.1.0"
     exon            244..385
                     /gene="Prdx3"
                     /gene_synonym="Aop1; D0Tohi1; Ef2l; Mer5; Prx3; SP22;
                     TDXM"
                     /inference="alignment:Splign:2.1.0"
     exon            386..521
                     /gene="Prdx3"
                     /gene_synonym="Aop1; D0Tohi1; Ef2l; Mer5; Prx3; SP22;
                     TDXM"
                     /inference="alignment:Splign:2.1.0"
     exon            522..625
                     /gene="Prdx3"
                     /gene_synonym="Aop1; D0Tohi1; Ef2l; Mer5; Prx3; SP22;
                     TDXM"
                     /inference="alignment:Splign:2.1.0"
     exon            626..791
                     /gene="Prdx3"
                     /gene_synonym="Aop1; D0Tohi1; Ef2l; Mer5; Prx3; SP22;
                     TDXM"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1445
                     /gene="Prdx3"
                     /gene_synonym="Aop1; D0Tohi1; Ef2l; Mer5; Prx3; SP22;
                     TDXM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prdx3"
                     /gene_synonym="Aop1; D0Tohi1; Ef2l; Mer5; Prx3; SP22;
                     TDXM"
                     /note="hexamer: AATAAA"
     polyA_site      1443
                     /gene="Prdx3"
                     /gene_synonym="Aop1; D0Tohi1; Ef2l; Mer5; Prx3; SP22;
                     TDXM"
                     /note="major polyA site"
ORIGIN      
        1 agaagcacac ccggcgtgct ccggctactc ctcggtatct ccgcctatcg tgcctcttgc
       61 gtgctctgaa gatggcggca gctgcgggaa ggttgctctg gtcctcggtt gctcgtcatg
      121 caagtgctat ttcccggagt atttctgcct caacagttct taggcctgtt gcttctagaa
      181 gaacctgttt gacagacata ctgtggtctg cctctgccca aggaaagtca gcctttagca
      241 ccagttcctc tttccacacc cctgctgtca cccagcacgc gccctatttt aaaggtactg
      301 ctgttgtcaa tggagagttc aaagagctga gtctcgacga ctttaaggga aaatacttgg
      361 tgcttttctt ctaccctttg gatttcacat ttgtgtgtcc tacagaaatt gttgctttca
      421 gtgacaaagc caatgaattt catgatgtaa actgtgaagt agttgcagtt tcagtggatt
      481 cccacttcag tcatcttgcc tggatcaaca caccaagaaa gaatggtggt ttgggccaca
      541 tgaacatcac actgttgtcg gatataacta agcagatatc ccgagactac ggagtgctgt
      601 tggaaagtgc tggcattgca ctcagaggtc tcttcattat tgaccctaat ggtgtcgtca
      661 agcacctgag tgtcaacgac cttccggtgg gccgcagtgt ggaagaaaca ctccgtttgg
      721 taaaggcgtt ccagtttgtg gagacccatg gagaagtctg cccagccaac tggacaccag
      781 agtcccctac gatcaagcca agtccaacag cttccaaaga gtactttgag aaggtccatc
      841 agtaggccat cctatgtctg caattacctg aagcttttca ggccaaaaaa gagccccagc
      901 tggaatcctt ccaatgcctt gaagattatt tatagaatgg caaaacctca ttatgtttgt
      961 gtttataagt actgctccac aggctttgta attttaagac aggttcaggc tctctaaagg
     1021 tggctagctg cttccatagc tgctcttact agggacttct tgatggctaa ccaattctcc
     1081 ccgagtgctt ggcccccatt tcttggatca tgtccttaga gggtaagcat tctttccctt
     1141 agcctgccct gaaccttggt ctacagtgaa gtagcacata gtgccagtac ttggtgaaat
     1201 gaagtagcac atagcaccag cacttaatgg aagcttctga tcaaggtcct aaaatttcct
     1261 cttgaatttt tgtgaattat gctgaatttc cctttttttt ttttttaaat tgtagtcatt
     1321 aactcacagt gtccttgtgt gttctgaggt attgaagagg tataatcatg aaggactatg
     1381 tctaatccat aagtcatttt cttcaagagc tggatatata gaataaaaat aaacattaaa
     1441 atatt
//
