LOCUS       NM_011563               1481 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus peroxiredoxin 2 (Prdx2), transcript variant 1, mRNA.
ACCESSION   NM_011563
VERSION     NM_011563.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1481)
  AUTHORS   Du,Y., Wang,J., Zhang,J., Li,N., Li,G., Liu,X., Lin,Y., Wang,D.,
            Kang,K., Bian,L. and Zhao,X.
  TITLE     Intracerebral hemorrhage-induced brain injury in mice: The role of
            peroxiredoxin 2-Toll-like receptor 4 inflammatory axis
  JOURNAL   CNS Neurosci Ther 30 (3), e14681 (2024)
   PUBMED   38516845
  REMARK    GeneRIF: Intracerebral hemorrhage-induced brain injury in mice: The
            role of peroxiredoxin 2-Toll-like receptor 4 inflammatory axis.
REFERENCE   2  (bases 1 to 1481)
  AUTHORS   Munoz-Gallardo,M.D.M., Garcia-Padilla,C., Vicente-Garcia,C.,
            Carvajal,J., Arenega,A. and Franco,D.
  TITLE     miR-195b is required for proper cellular homeostasis in the elderly
  JOURNAL   Sci Rep 14 (1), 810 (2024)
   PUBMED   38191655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1481)
  AUTHORS   Xu,G.L., Ye,X.L., Vashisth,M.K. and Zhao,W.Z.
  TITLE     Correlation between PRDX2 and spermatogenesis under oxidative
            stress
  JOURNAL   Biochem Biophys Res Commun 656, 139-145 (2023)
   PUBMED   36963350
  REMARK    GeneRIF: Correlation between PRDX2 and spermatogenesis under
            oxidative stress.
REFERENCE   4  (bases 1 to 1481)
  AUTHORS   Jin,M.H., Yu,N.N., Jin,Y.H., Mao,Y.Y., Feng,L., Liu,Y., Wang,A.G.,
            Sun,H.N., Kwon,T. and Han,Y.H.
  TITLE     Peroxiredoxin II with dermal mesenchymal stem cells accelerates
            wound healing
  JOURNAL   Aging (Albany NY) 13 (10), 13926-13940 (2021)
   PUBMED   34030134
  REMARK    GeneRIF: Peroxiredoxin II with dermal mesenchymal stem cells
            accelerates wound healing.
REFERENCE   5  (bases 1 to 1481)
  AUTHORS   Nunoue,T., Yamaguchi,S., Teshigawara,S., Katayama,A., Nakatsuka,A.,
            Eguchi,J., Niki,T. and Wada,J.
  TITLE     Lgals9 deficiency ameliorates obesity by modulating redox state of
            PRDX2
  JOURNAL   Sci Rep 11 (1), 5991 (2021)
   PUBMED   33727589
  REMARK    GeneRIF: Lgals9 deficiency ameliorates obesity by modulating redox
            state of PRDX2.
            Erratum:[Sci Rep. 2021 Sep 14;11(1):18611. doi:
            10.1038/s41598-021-98293-1.. PMID: 34521981]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1481)
  AUTHORS   Rodriguez,J., Agudo,M., Van Damme,J., Vandekerckhove,J. and
            Santaren,J.F.
  TITLE     Polypeptides differentially expressed in imaginal discs define the
            peroxiredoxin family of genes in Drosophila
  JOURNAL   Eur J Biochem 267 (2), 487-497 (2000)
   PUBMED   10632718
REFERENCE   7  (bases 1 to 1481)
  AUTHORS   Lyu,M.S., Rhee,S.G., Chae,H.Z., Lee,T.H., Adamson,M.C., Kang,S.W.,
            Jin,D.Y., Jeang,K.T. and Kozak,C.A.
  TITLE     Genetic mapping of six mouse peroxiredoxin genes and fourteen
            peroxiredoxin related sequences
  JOURNAL   Mamm Genome 10 (10), 1017-1019 (1999)
   PUBMED   10501973
REFERENCE   8  (bases 1 to 1481)
  AUTHORS   Gladyshev,V.N., Factor,V.M., Housseau,F. and Hatfield,D.L.
  TITLE     Contrasting patterns of regulation of the antioxidant
            selenoproteins, thioredoxin reductase, and glutathione peroxidase,
            in cancer cells
  JOURNAL   Biochem Biophys Res Commun 251 (2), 488-493 (1998)
   PUBMED   9792801
REFERENCE   9  (bases 1 to 1481)
  AUTHORS   Lim,M.J., Chae,H.Z., Rhee,S.G., Yu,D.Y., Lee,K.K. and Yeom,Y.I.
  TITLE     The type II peroxiredoxin gene family of the mouse: molecular
            structure, expression and evolution
  JOURNAL   Gene 216 (1), 197-205 (1998)
   PUBMED   9714804
REFERENCE   10 (bases 1 to 1481)
  AUTHORS   Ichimiya,S., Davis,J.G., O'Rourke,D.M., Katsumata,M. and
            Greene,M.I.
  TITLE     Murine thioredoxin peroxidase delays neuronal apoptosis and is
            expressed in areas of the brain most susceptible to hypoxic and
            ischemic injury
  JOURNAL   DNA Cell Biol 16 (3), 311-321 (1997)
   PUBMED   9115640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005225.1, AK008433.1 and CD773819.1.
            
            On Dec 3, 2015 this sequence version replaced NM_011563.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005225.1, AK011963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK005225.1         2-25
            25-26               AK005225.1         27-28
            27-968              AK008433.1         6-947
            969-1481            CD773819.1         1-513               c
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.4 cM"
     gene            1..1481
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /note="peroxiredoxin 2"
                     /db_xref="GeneID:21672"
                     /db_xref="MGI:MGI:109486"
     exon            1..141
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /inference="alignment:Splign:2.1.0"
     exon            142..246
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..740
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /EC_number="1.11.1.24"
                     /note="thiol-specific antioxidant protein;
                     thioredoxin-dependent peroxide reductase 1; Calpromotin;
                     thioredoxin peroxidase 1; Prx II-1; thioredoxin reductase;
                     Trx dependent peroxide reductase 1; protector protein;
                     thioredoxin-dependent peroxiredoxin 2"
                     /codon_start=1
                     /product="peroxiredoxin-2"
                     /protein_id="NP_035693.3"
                     /db_xref="CCDS:CCDS40416.1"
                     /db_xref="GeneID:21672"
                     /db_xref="MGI:MGI:109486"
                     /translation="MASGNAQIGKSAPDFTATAVVDGAFKEIKLSDYRGKYVVLFFYP
                     LDFTFVCPTEIIAFSDHAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIP
                     LLADVTKSLSQNYGVLKNDEGIAYRGLFIIDAKGVLRQITVNDLPVGRSVDEALRLVQ
                     AFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN"
     exon            247..400
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /inference="alignment:Splign:2.1.0"
     exon            401..523
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /inference="alignment:Splign:2.1.0"
     exon            524..654
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /inference="alignment:Splign:2.1.0"
     exon            655..1466
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      949..954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /note="hexamer: AATAAA"
     polyA_site      972
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /note="major polyA site"
     polyA_site      1462
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
ORIGIN      
        1 gcccacctcc ccgcgcactg cctggtgtgg tttgggccac gcataaaagg ttctccggcc
       61 tagggctctc tcggttttga gatctctttc ctgtctctac ccgtgtctgg acgtccgtgt
      121 gtccggctct tgctcacgca gtcatggcct ccggcaacgc gcaaatcgga aagtcggctc
      181 ctgacttcac ggccacagcg gtggtggatg gtgccttcaa ggaaatcaag ctttcggact
      241 acagagggaa gtacgtggtc ctctttttct acccactgga cttcactttt gtttgcccca
      301 cggagatcat cgcttttagc gaccatgctg aggacttccg aaagctaggc tgcgaggtgc
      361 tgggagtgtc tgtggactct cagttcaccc acctggcgtg gatcaatacc ccacggaagg
      421 agggaggctt gggccccctg aatatccctc tgcttgctga cgtgactaaa agcttgtccc
      481 agaattacgg cgtgttgaaa aatgatgagg gcattgctta caggggtctc tttatcatcg
      541 atgccaaggg tgtccttcgc cagatcacag tcaatgacct acctgtggga cgctctgtag
      601 acgaggctct ccgcctagtc caggcctttc agtatacaga cgagcatggg gaagtctgcc
      661 ctgctggctg gaagcccggc agtgacacca tcaagcccaa tgtggatgac agcaaggaat
      721 acttctccaa acacaactga gatgggtaaa catgggtgag cctgaagctt ggatttcacc
      781 tgtgccccaa cctggatgtc ctgtgctggc ccagaaaatg ctagattttc ctccactctc
      841 tgaaggggct ggagtctagg ctgaggtttt ctcattaccc acctggaatc tggtgaatag
      901 tgatcctgcc ctgagcacac ctagctgggc ccaggtctat aggaaaccaa taaagtatta
      961 gggacagtgt aagtctgtgt tggtgtgtgt ttagtagttt tagtagttta cactctggct
     1021 tgtgcaactg actctgtagt tatgcctctt caccacaagg tggaggcatt acctcattca
     1081 cgccatggtc tgagcatggt gggacacagt gagaccaaat aattactagg cctggaggga
     1141 ttctttaaga gctctttatg tttctcctga agatccaggt tccattcctg gagcttacat
     1201 agttgcttac aaccctcttt aacgccagat ccaacacctt cgtctgatcc tccagcacca
     1261 ggcatgcacg tgaacatggg cagaacgtgc atagacatga aataaatact tctgtaaaaa
     1321 aaaaaaaata ggggtcggca gtttacttct ggattctggc tcttagacca gtgtccatat
     1381 cttaccatta actatataaa atgatatgta acagctggat cttcactggg tttttacatt
     1441 ggatgggaat aaaaactaaa gtcaaaaaaa aaaaaaaaaa a
//
