LOCUS       NM_001317385            1446 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus peroxiredoxin 2 (Prdx2), transcript variant 2, mRNA.
ACCESSION   NM_001317385 XM_006530835
VERSION     NM_001317385.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1446)
  AUTHORS   Du,Y., Wang,J., Zhang,J., Li,N., Li,G., Liu,X., Lin,Y., Wang,D.,
            Kang,K., Bian,L. and Zhao,X.
  TITLE     Intracerebral hemorrhage-induced brain injury in mice: The role of
            peroxiredoxin 2-Toll-like receptor 4 inflammatory axis
  JOURNAL   CNS Neurosci Ther 30 (3), e14681 (2024)
   PUBMED   38516845
  REMARK    GeneRIF: Intracerebral hemorrhage-induced brain injury in mice: The
            role of peroxiredoxin 2-Toll-like receptor 4 inflammatory axis.
REFERENCE   2  (bases 1 to 1446)
  AUTHORS   Munoz-Gallardo,M.D.M., Garcia-Padilla,C., Vicente-Garcia,C.,
            Carvajal,J., Arenega,A. and Franco,D.
  TITLE     miR-195b is required for proper cellular homeostasis in the elderly
  JOURNAL   Sci Rep 14 (1), 810 (2024)
   PUBMED   38191655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1446)
  AUTHORS   Xu,G.L., Ye,X.L., Vashisth,M.K. and Zhao,W.Z.
  TITLE     Correlation between PRDX2 and spermatogenesis under oxidative
            stress
  JOURNAL   Biochem Biophys Res Commun 656, 139-145 (2023)
   PUBMED   36963350
  REMARK    GeneRIF: Correlation between PRDX2 and spermatogenesis under
            oxidative stress.
REFERENCE   4  (bases 1 to 1446)
  AUTHORS   Jin,M.H., Yu,N.N., Jin,Y.H., Mao,Y.Y., Feng,L., Liu,Y., Wang,A.G.,
            Sun,H.N., Kwon,T. and Han,Y.H.
  TITLE     Peroxiredoxin II with dermal mesenchymal stem cells accelerates
            wound healing
  JOURNAL   Aging (Albany NY) 13 (10), 13926-13940 (2021)
   PUBMED   34030134
  REMARK    GeneRIF: Peroxiredoxin II with dermal mesenchymal stem cells
            accelerates wound healing.
REFERENCE   5  (bases 1 to 1446)
  AUTHORS   Nunoue,T., Yamaguchi,S., Teshigawara,S., Katayama,A., Nakatsuka,A.,
            Eguchi,J., Niki,T. and Wada,J.
  TITLE     Lgals9 deficiency ameliorates obesity by modulating redox state of
            PRDX2
  JOURNAL   Sci Rep 11 (1), 5991 (2021)
   PUBMED   33727589
  REMARK    GeneRIF: Lgals9 deficiency ameliorates obesity by modulating redox
            state of PRDX2.
            Erratum:[Sci Rep. 2021 Sep 14;11(1):18611. doi:
            10.1038/s41598-021-98293-1.. PMID: 34521981]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1446)
  AUTHORS   Rodriguez,J., Agudo,M., Van Damme,J., Vandekerckhove,J. and
            Santaren,J.F.
  TITLE     Polypeptides differentially expressed in imaginal discs define the
            peroxiredoxin family of genes in Drosophila
  JOURNAL   Eur J Biochem 267 (2), 487-497 (2000)
   PUBMED   10632718
REFERENCE   7  (bases 1 to 1446)
  AUTHORS   Lyu,M.S., Rhee,S.G., Chae,H.Z., Lee,T.H., Adamson,M.C., Kang,S.W.,
            Jin,D.Y., Jeang,K.T. and Kozak,C.A.
  TITLE     Genetic mapping of six mouse peroxiredoxin genes and fourteen
            peroxiredoxin related sequences
  JOURNAL   Mamm Genome 10 (10), 1017-1019 (1999)
   PUBMED   10501973
REFERENCE   8  (bases 1 to 1446)
  AUTHORS   Gladyshev,V.N., Factor,V.M., Housseau,F. and Hatfield,D.L.
  TITLE     Contrasting patterns of regulation of the antioxidant
            selenoproteins, thioredoxin reductase, and glutathione peroxidase,
            in cancer cells
  JOURNAL   Biochem Biophys Res Commun 251 (2), 488-493 (1998)
   PUBMED   9792801
REFERENCE   9  (bases 1 to 1446)
  AUTHORS   Lim,M.J., Chae,H.Z., Rhee,S.G., Yu,D.Y., Lee,K.K. and Yeom,Y.I.
  TITLE     The type II peroxiredoxin gene family of the mouse: molecular
            structure, expression and evolution
  JOURNAL   Gene 216 (1), 197-205 (1998)
   PUBMED   9714804
REFERENCE   10 (bases 1 to 1446)
  AUTHORS   Ichimiya,S., Davis,J.G., O'Rourke,D.M., Katsumata,M. and
            Greene,M.I.
  TITLE     Murine thioredoxin peroxidase delays neuronal apoptosis and is
            expressed in areas of the brain most susceptible to hypoxic and
            ischemic injury
  JOURNAL   DNA Cell Biol 16 (3), 311-321 (1997)
   PUBMED   9115640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005225.1, CX238307.1, DV051712.1, BC086783.1 and AC163703.4.
            
            On Dec 3, 2015 this sequence version replaced XM_006530835.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV051712.1, DV661745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK005225.1         2-25
            25-39               AK005225.1         27-41
            40-72               CX238307.1         1-33
            73-228              DV051712.1         20-175
            229-553             BC086783.1         1-325
            554-554             AC163703.4         189949-189949       c
            555-1446            BC086783.1         327-1218
FEATURES             Location/Qualifiers
     source          1..1446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.4 cM"
     gene            1..1446
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /note="peroxiredoxin 2"
                     /db_xref="GeneID:21672"
                     /db_xref="MGI:MGI:109486"
     exon            1..141
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /inference="alignment:Splign:2.1.0"
     exon            142..334
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..828
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /EC_number="1.11.1.24"
                     /note="thiol-specific antioxidant protein;
                     thioredoxin-dependent peroxide reductase 1; Calpromotin;
                     thioredoxin peroxidase 1; Prx II-1; thioredoxin reductase;
                     Trx dependent peroxide reductase 1; protector protein;
                     thioredoxin-dependent peroxiredoxin 2"
                     /codon_start=1
                     /product="peroxiredoxin-2"
                     /protein_id="NP_001304314.1"
                     /db_xref="CCDS:CCDS40416.1"
                     /db_xref="GeneID:21672"
                     /db_xref="MGI:MGI:109486"
                     /translation="MASGNAQIGKSAPDFTATAVVDGAFKEIKLSDYRGKYVVLFFYP
                     LDFTFVCPTEIIAFSDHAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIP
                     LLADVTKSLSQNYGVLKNDEGIAYRGLFIIDAKGVLRQITVNDLPVGRSVDEALRLVQ
                     AFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN"
     exon            335..488
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /inference="alignment:Splign:2.1.0"
     exon            489..611
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /inference="alignment:Splign:2.1.0"
     exon            612..742
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1416
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1037..1042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /note="hexamer: AATAAA"
     polyA_site      1060
                     /gene="Prdx2"
                     /gene_synonym="Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1;
                     Torin; TPx; TPx-B; TR; TSA"
                     /note="major polyA site"
ORIGIN      
        1 gcccacctcc ccgcgcactg cctggtgtgg tttgggccac gcataaaagg ttctccggcc
       61 tagggctctc tcggttttga gatctctttc ctgtctctac ccgtgtctgg acgtccgtgt
      121 gtccggctct tgctcacgca gacttagcac caaaagtgac cttggaaagg caagacaaag
      181 gatcttctaa ggctctaaag accaagcttg tgtgggtctc tgatttcagt catggcctcc
      241 ggcaacgcgc aaatcggaaa gtcggctcct gacttcacgg ccacagcggt ggtggatggt
      301 gccttcaagg aaatcaagct ttcggactac agagggaagt acgtggtcct ctttttctac
      361 ccactggact tcacttttgt ttgccccacg gagatcatcg cttttagcga ccatgctgag
      421 gacttccgaa agctaggctg cgaggtgctg ggagtgtctg tggactctca gttcacccac
      481 ctggcgtgga tcaatacccc acggaaggag ggaggcttgg gccccctgaa tatccctctg
      541 cttgctgacg tgactaaaag cttgtcccag aattacggcg tgttgaaaaa tgatgagggc
      601 attgcttaca ggggtctctt tatcatcgat gccaagggtg tccttcgcca gatcacagtc
      661 aatgacctac ctgtgggacg ctctgtagac gaggctctcc gcctagtcca ggcctttcag
      721 tatacagacg agcatgggga agtctgccct gctggctgga agcccggcag tgacaccatc
      781 aagcccaatg tggatgacag caaggaatac ttctccaaac acaactgaga tgggtaaaca
      841 tgggtgagcc tgaagcttgg atttcacctg tgccccaacc tggatgtcct gtgctggccc
      901 agaaaatgct agattttcct ccactctctg aaggggctgg agtctaggct gaggttttct
      961 cattacccac ctggaatctg gtgaatagtg atcctgccct gagcacacct agctgggccc
     1021 aggtctatag gaaaccaata aagtattagg gacagtgtaa gtctgtgttg gtgtgtgttt
     1081 agtagtttta gtagtttaca ctctggcttg tgcaactgac tctgtagtta tgcctcttca
     1141 ccacaaggtg gaggcattac ctcattcacg ccatggtctg agcatggtgg gacacagtga
     1201 gaccaaataa ttactaggcc tggagggatt ctttaagagc tctttatgtt tctcctgaag
     1261 atccaggttc cattcctgga gcttacatag ttgcttacaa ccctctttaa cgccagatcc
     1321 aacaccttcg tctgatcctc cagcaccagg catgcacgtg aacatgggca gaacgtgcat
     1381 agacatgaaa taaatacttc tgtaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaa
//
