LOCUS       NM_011034               1416 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus peroxiredoxin 1 (Prdx1), mRNA.
ACCESSION   NM_011034
VERSION     NM_011034.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1416)
  AUTHORS   Shen,Y., You,Z., Li,L., Tang,X. and Shan,X.
  TITLE     The interaction of PRDX1 with Cofilin promotes oral squamous cell
            carcinoma metastasis
  JOURNAL   Int J Cancer 155 (7), 1290-1302 (2024)
   PUBMED   38738971
  REMARK    GeneRIF: The interaction of PRDX1 with Cofilin promotes oral
            squamous cell carcinoma metastasis.
REFERENCE   2  (bases 1 to 1416)
  AUTHORS   Song,Y., Wang,X., Sun,Y., Yu,N., Tian,Y., Han,J., Qu,X. and Yu,X.
  TITLE     PRDX1 inhibits ferroptosis by binding to Cullin-3 as a molecular
            chaperone in colorectal cancer
  JOURNAL   Int J Biol Sci 20 (13), 5070-5086 (2024)
   PUBMED   39430237
  REMARK    GeneRIF: PRDX1 inhibits ferroptosis by binding to Cullin-3 as a
            molecular chaperone in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1416)
  AUTHORS   Du,J., Zhou,W., Sun,Z., Zhang,W., Luo,W. and Liu,S.
  TITLE     Peroxiredoxin 1 promotes proliferation and inhibits differentiation
            of MC3T3-E1 cells via AKT1 / NF-kappaB signaling pathway
  JOURNAL   J Oral Biosci 66 (2), 403-411 (2024)
   PUBMED   38663496
  REMARK    GeneRIF: Peroxiredoxin 1 promotes proliferation and inhibits
            differentiation of MC3T3-E1 cells via AKT1 / NF-kappaB signaling
            pathway.
REFERENCE   4  (bases 1 to 1416)
  AUTHORS   Li,L., Li,J., Lu,Y., Li,W., Yang,J., Wang,M., Miao,C., Tian,Z.,
            Zhang,M. and Tang,X.
  TITLE     Conditional knockout mouse model reveals a critical role of
            peroxiredoxin 1 in oral leukoplakia carcinogenesis
  JOURNAL   Heliyon 10 (10), e31227 (2024)
   PUBMED   38818156
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1416)
  AUTHORS   He,J., Hou,X., Wu,J., Wang,K., Qi,X., Wei,Z., Sun,Y., Wang,C.,
            Yao,H. and Liu,K.
  TITLE     Hspb1 protects against severe acute pancreatitis by attenuating
            apoptosis and ferroptosis via interacting with Anxa2 to restore the
            antioxidative activity of Prdx1
  JOURNAL   Int J Biol Sci 20 (5), 1707-1728 (2024)
   PUBMED   38481805
  REMARK    GeneRIF: Hspb1 protects against severe acute pancreatitis by
            attenuating apoptosis and ferroptosis via interacting with Anxa2 to
            restore the antioxidative activity of Prdx1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1416)
  AUTHORS   Takenaka,M., Imai,E., Kaneko,T., Ito,T., Moriyama,T., Yamauchi,A.,
            Hori,M., Kawamoto,S. and Okubo,K.
  TITLE     Isolation of genes identified in mouse renal proximal tubule by
            comparing different gene expression profiles
  JOURNAL   Kidney Int 53 (3), 562-572 (1998)
   PUBMED   9507200
REFERENCE   7  (bases 1 to 1416)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   8  (bases 1 to 1416)
  AUTHORS   Kawai,S., Takeshita,S., Okazaki,M., Kikuno,R., Kudo,A. and Amann,E.
  TITLE     Cloning and characterization of OSF-3, a new member of the MER5
            family, expressed in mouse osteoblastic cells
  JOURNAL   J Biochem 115 (4), 641-643 (1994)
   PUBMED   8089076
REFERENCE   9  (bases 1 to 1416)
  AUTHORS   Shau,H., Butterfield,L.H., Chiu,R. and Kim,A.
  TITLE     Cloning and sequence analysis of candidate human natural
            killer-enhancing factor genes
  JOURNAL   Immunogenetics 40 (2), 129-134 (1994)
   PUBMED   8026862
REFERENCE   10 (bases 1 to 1416)
  AUTHORS   Ishii,T., Yamada,M., Sato,H., Matsue,M., Taketani,S., Nakayama,K.,
            Sugita,Y. and Bannai,S.
  TITLE     Cloning and characterization of a 23-kDa stress-induced mouse
            peritoneal macrophage protein
  JOURNAL   J Biol Chem 268 (25), 18633-18636 (1993)
   PUBMED   8360158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831786.7.
            
            On Jun 27, 2022 this sequence version replaced NM_011034.4.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083243.1, AK151459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AL831786.7         59581-59642
            63-179              AL831786.7         61389-61505
            180-333             AL831786.7         65758-65911
            334-456             AL831786.7         66865-66987
            457-587             AL831786.7         67699-67829
            588-1416            AL831786.7         73153-73981
FEATURES             Location/Qualifiers
     source          1..1416
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.28 cM"
     gene            1..1416
                     /gene="Prdx1"
                     /gene_synonym="MSP23; NkefA; OSF-3; OSF3; PAG; Paga;
                     PrdxI; prx1; PrxI; Tdpx2; TDX2; TPxA"
                     /note="peroxiredoxin 1"
                     /db_xref="GeneID:18477"
                     /db_xref="MGI:MGI:99523"
     exon            1..62
                     /gene="Prdx1"
                     /gene_synonym="MSP23; NkefA; OSF-3; OSF3; PAG; Paga;
                     PrdxI; prx1; PrxI; Tdpx2; TDX2; TPxA"
                     /inference="alignment:Splign:2.1.0"
     exon            63..179
                     /gene="Prdx1"
                     /gene_synonym="MSP23; NkefA; OSF-3; OSF3; PAG; Paga;
                     PrdxI; prx1; PrxI; Tdpx2; TDX2; TPxA"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..673
                     /gene="Prdx1"
                     /gene_synonym="MSP23; NkefA; OSF-3; OSF3; PAG; Paga;
                     PrdxI; prx1; PrxI; Tdpx2; TDX2; TPxA"
                     /EC_number="1.11.1.24"
                     /note="thioredoxin peroxidase 2; osteoblast-specific
                     factor 3; macrophage 23 kDa stress protein;
                     thioredoxin-dependent peroxide reductase 2; macrophage
                     23kDa stress protein; macrophase stress protein 22kDa;
                     proliferation-associated gene A; macrophage 23 Kd stress
                     protein; macrophase stress protein 23 kd; Trx dependent
                     peroxide reductase 2; thioredoxin-dependent peroxiredoxin
                     1"
                     /codon_start=1
                     /product="peroxiredoxin-1"
                     /protein_id="NP_035164.1"
                     /db_xref="CCDS:CCDS18515.1"
                     /db_xref="GeneID:18477"
                     /db_xref="MGI:MGI:99523"
                     /translation="MSSGNAKIGYPAPNFKATAVMPDGQFKDISLSEYKGKYVVFFFY
                     PLDFTFVCPTEIIAFSDRADEFKKLNCQVIGASVDSHFCHLAWINTPKKQGGLGPMNI
                     PLISDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITINDLPVGRSVDEIIRLV
                     QAFQFTDKHGEVCPAGWKPGSDTIKPDVNKSKEYFSKQK"
     exon            180..333
                     /gene="Prdx1"
                     /gene_synonym="MSP23; NkefA; OSF-3; OSF3; PAG; Paga;
                     PrdxI; prx1; PrxI; Tdpx2; TDX2; TPxA"
                     /inference="alignment:Splign:2.1.0"
     exon            334..456
                     /gene="Prdx1"
                     /gene_synonym="MSP23; NkefA; OSF-3; OSF3; PAG; Paga;
                     PrdxI; prx1; PrxI; Tdpx2; TDX2; TPxA"
                     /inference="alignment:Splign:2.1.0"
     exon            457..587
                     /gene="Prdx1"
                     /gene_synonym="MSP23; NkefA; OSF-3; OSF3; PAG; Paga;
                     PrdxI; prx1; PrxI; Tdpx2; TDX2; TPxA"
                     /inference="alignment:Splign:2.1.0"
     exon            588..1416
                     /gene="Prdx1"
                     /gene_synonym="MSP23; NkefA; OSF-3; OSF3; PAG; Paga;
                     PrdxI; prx1; PrxI; Tdpx2; TDX2; TPxA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      912..917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prdx1"
                     /gene_synonym="MSP23; NkefA; OSF-3; OSF3; PAG; Paga;
                     PrdxI; prx1; PrxI; Tdpx2; TDX2; TPxA"
                     /note="hexamer: ATTAAA"
     polyA_site      932
                     /gene="Prdx1"
                     /gene_synonym="MSP23; NkefA; OSF-3; OSF3; PAG; Paga;
                     PrdxI; prx1; PrxI; Tdpx2; TDX2; TPxA"
                     /note="major polyA site"
     regulatory      1396..1401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prdx1"
                     /gene_synonym="MSP23; NkefA; OSF-3; OSF3; PAG; Paga;
                     PrdxI; prx1; PrxI; Tdpx2; TDX2; TPxA"
                     /note="hexamer: ATTAAA"
     polyA_site      1416
                     /gene="Prdx1"
                     /gene_synonym="MSP23; NkefA; OSF-3; OSF3; PAG; Paga;
                     PrdxI; prx1; PrxI; Tdpx2; TDX2; TPxA"
ORIGIN      
        1 gggcgacctc ttcctgcgtt ctcacggctc tttctgtttg tgagacctgt ggctcgaccc
       61 tgctgatagc aagatgtctt caggaaatgc aaaaattggg tatcctgctc ccaacttcaa
      121 agctacagct gttatgccag atggacaatt caaagatatc agcctaagtg aatacaaagg
      181 aaaatatgtt gtgttcttct tttaccctct tgactttact tttgtgtgtc ccacggagat
      241 cattgctttc agtgatagag ccgatgaatt taagaaactc aactgccaag tgattggcgc
      301 ttctgtggat tctcacttct gtcatctggc atggattaac acacccaaga aacaaggagg
      361 attgggaccc atgaacattc ccttaatatc agatcccaag cgcaccattg ctcaggatta
      421 tggagtctta aaggctgatg aaggtatctc tttcaggggc ctttttatta ttgatgataa
      481 aggtatcctt cgacagataa caataaacga tcttcccgtt ggccgctctg tggatgagat
      541 tatacgacta gtccaggcct tccagttcac tgacaaacat ggtgaagtgt gtccagctgg
      601 ctggaaacct ggcagtgata ccatcaagcc tgatgtcaat aagagcaaag agtatttctc
      661 taagcagaag tgagcactgg accatttttc tgccaggcag cattgagcag ccagaagaaa
      721 ctcttgtact ctactcgtgc ttaaacacat gatgtggtgt gattccagat aagcctttcc
      781 tacagggctg gggatggata gcctttcttc cactattggt aatggtctga gctgtgtttt
      841 gggcagacca atcttctatc agtcacagaa aacaacctgt taattctttt ttcttctttt
      901 tttaagtatc tattaaacgt gaattctgag aacttggtga ttcattcttt aaaggcaaca
      961 ttggaatttt aaaaaggact ttattttcat gagtaggtaa aagtgtttga gtgttgttta
     1021 tcttttttaa aaagaatgtt tccccagcat gtgtaccatt tacctgcctg ttggataccc
     1081 tgggaccatg tgggtgctgg gaattgaacc tgggtcttct ataagagcaa cggggttcct
     1141 aaccattgag ctgtctctcc agtctcttaa cttttgagac aggatctctc actgatctag
     1201 aacttgatgt atatgtgagg ctagtaagct ctcaggatct acttttctag tgctggtttt
     1261 ataagcatgg attaccatag ttggcctttt gtttttcgag acagggtttc tctgtgtaac
     1321 agccctggct gtcctggaac tctgtagact aggctggcct ctgaaagatc tacctgccta
     1381 tttaatctgc caggaattaa aagtgtgtgc caccac
//
