LOCUS       NM_001407995            3335 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus PR domain containing 8 (Prdm8), transcript variant 3,
            mRNA.
ACCESSION   NM_001407995 XM_030254902
VERSION     NM_001407995.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3335)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3335)
  AUTHORS   Deska-Gauthier,D., Borowska-Fielding,J., Jones,C., Zhang,H.,
            MacKay,C.S., Michail,R., Bennett,L.A., Bikoff,J.B. and Zhang,Y.
  TITLE     Embryonic temporal-spatial delineation of excitatory spinal V3
            interneuron diversity
  JOURNAL   Cell Rep 43 (1), 113635 (2024)
   PUBMED   38160393
REFERENCE   3  (bases 1 to 3335)
  AUTHORS   Filova,I., Pysanenko,K., Tavakoli,M., Vochyanova,S., Dvorakova,M.,
            Bohuslavova,R., Smolik,O., Fabriciova,V., Hrabalova,P.,
            Benesova,S., Valihrach,L., Cerny,J., Yamoah,E.N., Syka,J.,
            Fritzsch,B. and Pavlinkova,G.
  TITLE     ISL1 is necessary for auditory neuron development and contributes
            toward tonotopic organization
  JOURNAL   Proc Natl Acad Sci U S A 119 (37), e2207433119 (2022)
   PUBMED   36074819
REFERENCE   4  (bases 1 to 3335)
  AUTHORS   Decourtye,L., McCallum-Loudeac,J.A., Zellhuber-McMillan,S.,
            Young,E., Sircombe,K.J. and Wilson,M.J.
  TITLE     Characterization of a novel Lbx1 mouse loss of function strain
  JOURNAL   Differentiation 123, 30-41 (2022)
   PUBMED   34906895
REFERENCE   5  (bases 1 to 3335)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3335)
  AUTHORS   Ross,S.E., Mardinly,A.R., McCord,A.E., Zurawski,J., Cohen,S.,
            Jung,C., Hu,L., Mok,S.I., Shah,A., Savner,E.M., Tolias,C.,
            Corfas,R., Chen,S., Inquimbert,P., Xu,Y., McInnes,R.R., Rice,F.L.,
            Corfas,G., Ma,Q., Woolf,C.J. and Greenberg,M.E.
  TITLE     Loss of inhibitory interneurons in the dorsal spinal cord and
            elevated itch in Bhlhb5 mutant mice
  JOURNAL   Neuron 65 (6), 886-898 (2010)
   PUBMED   20346763
REFERENCE   7  (bases 1 to 3335)
  AUTHORS   Eom,G.H., Kim,K., Kim,S.M., Kee,H.J., Kim,J.Y., Jin,H.M., Kim,J.R.,
            Kim,J.H., Choe,N., Kim,K.B., Lee,J., Kook,H., Kim,N. and Seo,S.B.
  TITLE     Histone methyltransferase PRDM8 regulates mouse testis
            steroidogenesis
  JOURNAL   Biochem Biophys Res Commun 388 (1), 131-136 (2009)
   PUBMED   19646955
  REMARK    GeneRIF: PRDM8 repressed the expression of steroidogenic markers,
            p450c17c and LHR, which indicates its regulatory role in mouse
            testis development.
REFERENCE   8  (bases 1 to 3335)
  AUTHORS   Komai,T., Iwanari,H., Mochizuki,Y., Hamakubo,T. and Shinkai,Y.
  TITLE     Expression of the mouse PR domain protein Prdm8 in the developing
            central nervous system
  JOURNAL   Gene Expr Patterns 9 (7), 503-514 (2009)
   PUBMED   19616129
  REMARK    GeneRIF: These results show that Prdm8 expression is tightly
            regulated in a spatio-temporal manner during neural development and
            mainly restricted to postmitotic neurons, except in the spinal
            cord.
REFERENCE   9  (bases 1 to 3335)
  AUTHORS   Kinameri,E., Inoue,T., Aruga,J., Imayoshi,I., Kageyama,R.,
            Shimogori,T. and Moore,A.W.
  TITLE     Prdm proto-oncogene transcription factor family expression and
            interaction with the Notch-Hes pathway in mouse neurogenesis
  JOURNAL   PLoS One 3 (12), e3859 (2008)
   PUBMED   19050759
REFERENCE   10 (bases 1 to 3335)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121929.2 and AC125073.4.
            
            On Jun 8, 2022 this sequence version replaced XM_030254902.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2226890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC121929.2         7987-8104           c
            119-321             AC121929.2         4923-5125           c
            322-454             AC125073.4         39241-39373
            455-675             AC125073.4         41550-41770
            676-904             AC125073.4         42722-42950
            905-3335            AC125073.4         43285-45715
FEATURES             Location/Qualifiers
     source          1..3335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 47.77 cM"
     gene            1..3335
                     /gene="Prdm8"
                     /gene_synonym="4930565F05Rik; PFM5"
                     /note="PR domain containing 8"
                     /db_xref="GeneID:77630"
                     /db_xref="MGI:MGI:1924880"
     exon            1..118
                     /gene="Prdm8"
                     /gene_synonym="4930565F05Rik; PFM5"
                     /inference="alignment:Splign:2.1.0"
     exon            119..321
                     /gene="Prdm8"
                     /gene_synonym="4930565F05Rik; PFM5"
                     /inference="alignment:Splign:2.1.0"
     exon            322..454
                     /gene="Prdm8"
                     /gene_synonym="4930565F05Rik; PFM5"
                     /inference="alignment:Splign:2.1.0"
     exon            455..675
                     /gene="Prdm8"
                     /gene_synonym="4930565F05Rik; PFM5"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..2523
                     /gene="Prdm8"
                     /gene_synonym="4930565F05Rik; PFM5"
                     /note="PR domain-containing protein 8"
                     /codon_start=1
                     /product="PR domain zinc finger protein 8"
                     /protein_id="NP_001394924.1"
                     /db_xref="GeneID:77630"
                     /db_xref="MGI:MGI:1924880"
                     /translation="MEDSGIQRGIWDGDAKAVQQCLTDIFTSVYTTCDIPENAIFGPC
                     VLSHTSLYDSIAFVALKSTDKRTVPYIFRVDTSAANGSSEGLMWLRLVQSARDKEEQN
                     LEAYIKNGQLFYRSLRRIAKDEELLVWYGKELTELLLLCPSRAHKMNGSSPYTCLECS
                     QRFQFEFPYVAHLRFRCPKRLHSTDANPQDEQGGGLGTKDHGGGGGGKEQQQQQQQQQ
                     QEAPLIPGPKFCKAGPIHHYPASSPEASNPPGSAGAGSAKPSTDFHNLARELENSRGS
                     SSCVAAPGVGSGGSGHQEAELSPDGVATGGCKGKRRFPEEAAAEGGGAGLAGGRARFS
                     ERPLATSKEELVCTPQQYRAAGSYFGLEENGRLFAPPSPETGEAKRSAFVEVKKAGRA
                     VGLQEEAAATDGAGGTAEDPDAGGGVAGGGSNGSSTPAAGSPGAPEKLLAPRPGGSLP
                     GRLEGGSPARGSAFTSVSQLGGGGGAGTAGTAGGSGGGQTAASDERKSAFSQPARSFS
                     QLSPLVLGQKLGALEPCHPGDGVGPTRLYPAAADPLAVKLQGAADLNGACGPLASGGG
                     GGLPKQSPFLYATAFWPKSSAAAAAAAAAAAGPLQLQLPSALTLLPPSFTSLCLPAQN
                     WCAKCNASFRMTSDLVYHMRSHHKKEYAMEPLVKRRREEKLKCPICNESFRERHHLSR
                     HMTSHN"
     exon            676..904
                     /gene="Prdm8"
                     /gene_synonym="4930565F05Rik; PFM5"
                     /inference="alignment:Splign:2.1.0"
     exon            905..3335
                     /gene="Prdm8"
                     /gene_synonym="4930565F05Rik; PFM5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3192..3197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prdm8"
                     /gene_synonym="4930565F05Rik; PFM5"
                     /note="hexamer: AATACA"
     polyA_site      3219
                     /gene="Prdm8"
                     /gene_synonym="4930565F05Rik; PFM5"
                     /note="major polyA site"
     regulatory      3266..3271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prdm8"
                     /gene_synonym="4930565F05Rik; PFM5"
                     /note="hexamer: ATTAAA"
     polyA_site      3291
                     /gene="Prdm8"
                     /gene_synonym="4930565F05Rik; PFM5"
     regulatory      3308..3313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prdm8"
                     /gene_synonym="4930565F05Rik; PFM5"
                     /note="hexamer: AATAAA"
     polyA_site      3335
                     /gene="Prdm8"
                     /gene_synonym="4930565F05Rik; PFM5"
ORIGIN      
        1 gcagaagagc ccagtacgga tcggaaagcc taggctggga taccggccgg accgcggttt
       61 cagagcgagg gacttcagag gtcggctcgc ccggattgag cgcccccaca ttccgcagca
      121 ttttttagtc aggatctgcg tggagcctgc accgagagcc agaagtttat gaaagacccc
      181 aggttgcgga tgctgcttca gcacgggctc accccggggt gacaagcaga aggacgcgct
      241 cttaaaggct gttggaggcc ctgttttcct gtctgtcttg ctgagctgag cgaggcttcc
      301 ttgctggtta tcctattatc gaacccacaa gactgacacc gacacctctt gacatggaga
      361 tacactaatg taataggcag gaaggaacac tggcttgcac cccgttggtt ccaggtggcc
      421 ttatttgggc gactcggtcc tgaccttatt tctgtgatgg aggattcagg catccagaga
      481 ggcatctggg atggagatgc caaggctgtc caacagtgtc tgacagacat ttttaccagt
      541 gtatatacaa cctgcgacat cccagagaac gccatattcg gtccctgtgt actgagccat
      601 acttccctgt atgacagcat agccttcgta gccctcaagt ccacggacaa gagaacagta
      661 ccttacatct tccgggtaga cacttcggcg gcaaatggtt cctcagaagg tctcatgtgg
      721 ctgcggctgg tccaatcagc ccgagataag gaagaacaga atctcgaagc ttatataaaa
      781 aatggacagc tgttctaccg ctctctccgc aggattgcca aagatgaaga gttactagtt
      841 tggtacggga aagaactgac tgaattgctc ttgctctgcc cgtctagagc tcacaaaatg
      901 aacgggtcgt ctccttacac atgcctggaa tgcagccaac gtttccagtt tgagttcccc
      961 tatgtggcac atctgcgatt ccgctgcccc aagagacttc acagcactga tgcgaatccc
     1021 caagacgagc aagggggcgg cttgggcact aaggaccacg gcggcggcgg cggtggtaaa
     1081 gagcaacagc agcagcaaca gcagcagcaa caggaggcgc cgttgatccc gggccccaag
     1141 ttctgcaaag ccggccccat acaccactac cccgcgtcat ccccggaggc gagcaacccg
     1201 ccgggctccg cgggtgccgg cagcgccaag ccgtccacgg acttccacaa cttggctcgg
     1261 gaactggaaa actcccgggg aagcagcagt tgcgtagcgg ccccgggcgt cggcagtggc
     1321 ggcagcggcc accaggaggc ggagctgagt cccgacggcg tcgccaccgg cggctgcaaa
     1381 ggcaagaggc ggttcccaga ggaggcggcg gcggagggcg gcggcgcggg gctggcgggc
     1441 ggccgtgcgc gcttctccga gaggccgctg gcgacctcca aggaggagtt ggtgtgcacg
     1501 ccgcagcagt accgcgccgc cggcagctac ttcggcctgg aggagaacgg ccggctcttc
     1561 gcgccgccca gcccggagac tggcgaggcg aagcgcagcg ccttcgtgga ggtgaagaag
     1621 gcgggccgcg cggtgggctt gcaggaggag gcggcggcga cagacggcgc agggggcacg
     1681 gccgaggacc ccgacgcggg aggcggtgtc gccggcggcg gcagcaacgg ctcgtccacc
     1741 cccgcggcgg ggtcgcctgg ggcccccgag aagttgctgg ctccgcgtcc cggaggctct
     1801 ctgcccggac ggctggaggg cgggagcccc gcgcgcggca gcgccttcac ctcggtgtcg
     1861 cagctgggcg gcggtggcgg cgcggggacc gcggggactg cggggggctc ggggggcggc
     1921 caaacggccg catcggacga gcggaagagc gccttctcgc agcccgcgcg ctccttctcg
     1981 cagctgtccc cgttggtcct cggccagaag ctgggcgctc tcgagccgtg tcacccggga
     2041 gacggcgtgg gtcccaccag actctacccg gccgccgccg atccgctggc tgtgaagctg
     2101 cagggggcag cggacctgaa cggagcctgc gggcccctgg cgagcggcgg tggcggtggc
     2161 ttgcccaagc agagcccctt cctctacgcc accgccttct ggcccaagag ctcggctgcg
     2221 gcggcagcgg cggcggcggc cgccgccggg cccctgcagc tgcaactgcc ctccgcgctc
     2281 accctgctgc cgccctcctt cacttcgctg tgtctgcccg cgcagaactg gtgcgccaaa
     2341 tgcaacgcct ccttccgcat gacctccgac ctggtgtacc atatgcggtc tcaccacaaa
     2401 aaggagtatg ccatggagcc cctggtgaag cggcggcggg aggagaaact caagtgcccc
     2461 atttgcaacg agtccttcag ggagcgtcac cacctgtccc ggcacatgac ctcgcataat
     2521 taattgttgc gtaaaagact ccggctttcc acgcgtgtgc acgcacagtc aagccacctg
     2581 caggagcaga cacgcgagga tgacatccac cactacctta tgcccccaaa cactgcaacc
     2641 aaacacgtgc acacacaggt ccctcccctc gccaggagcc tcatcatcca aatgtttaat
     2701 ttcacacaca cacacacaca cacacacaca cacacacaca cacacgcacg cacgaacgca
     2761 cacacggacg cacgcacacg atgcacagga tggtggattt tggattgggt gggttgtttg
     2821 agcggggttt tcttttgaat gcacgaattt tcactttccc aaaaacaaaa gtacattttt
     2881 aaaaaaatgt catatattgc aacatattga tgcatttgtc atacgtttct acttaaatta
     2941 ttaagcactt atggtttaga tgtaataatt atatgtaagg acaaagttta ttttagatat
     3001 aaagtaatgg aggaagagga gatgcgttct gcatttcctg atgacagctg tgttcttaca
     3061 aaaataaaca aaatggataa aaaggggggc gccattcggt ttaagtttcc agggggaagt
     3121 gcatgtatca tgaaatgatt atggacttca gtgaagaatg tcatcaatga tgtaaatatg
     3181 tattcccttt taatacaaag tgtaattttg tgccagtgac atggagtctg aatagttatg
     3241 tgtttcttct atccctaaga gatttattaa acggtatagt ttatccaggt atgttggatg
     3301 ctttgacaat aaataactat tttcctcaaa gcaaa
//
