LOCUS       NM_001033281            2601 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus PR domain containing 6 (Prdm6), mRNA.
ACCESSION   NM_001033281 XM_128908 XM_912379
VERSION     NM_001033281.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2601)
  AUTHORS   Zou,M., Mangum,K.D., Magin,J.C., Cao,H.H., Yarboro,M.T.,
            Shelton,E.L., Taylor,J.M., Reese,J., Furey,T.S. and Mack,C.P.
  TITLE     Prdm6 drives ductus arteriosus closure by promoting ductus
            arteriosus smooth muscle cell identity and contractility
  JOURNAL   JCI Insight 8 (5), e163454 (2023)
   PUBMED   36749647
  REMARK    GeneRIF: Prdm6 drives ductus arteriosus closure by promoting ductus
            arteriosus smooth muscle cell identity and contractility.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2601)
  AUTHORS   Hong,L., Li,N., Gasque,V., Mehta,S., Ye,L., Wu,Y., Li,J.,
            Gewies,A., Ruland,J., Hirschi,K.K., Eichmann,A., Hendry,C., van
            Dijk,D. and Mani,A.
  TITLE     Prdm6 controls heart development by regulating neural crest cell
            differentiation and migration
  JOURNAL   JCI Insight 7 (4), e156046 (2022)
   PUBMED   35108221
  REMARK    GeneRIF: Prdm6 controls heart development by regulating neural
            crest cell differentiation and migration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2601)
  AUTHORS   Li,N., Subrahmanyan,L., Smith,E., Yu,X., Zaidi,S., Choi,M.,
            Mane,S., Nelson-Williams,C., Behjati,M., Kazemi,M., Hashemi,M.,
            Fathzadeh,M., Narayanan,A., Tian,L., Montazeri,F., Mani,M.,
            Begleiter,M.L., Coon,B.G., Lynch,H.T., Olson,E.N., Zhao,H.,
            Ruland,J., Lifton,R.P. and Mani,A.
  TITLE     Mutations in the Histone Modifier PRDM6 Are Associated with
            Isolated Nonsyndromic Patent Ductus Arteriosus
  JOURNAL   Am J Hum Genet 98 (6), 1082-1091 (2016)
   PUBMED   27181681
  REMARK    Erratum:[Am J Hum Genet. 2016 Oct 6;99(4):1000. doi:
            10.1016/j.ajhg.2016.09.003. PMID: 27716515]
REFERENCE   4  (bases 1 to 2601)
  AUTHORS   Mohar,I., Stamper,B.D., Rademacher,P.M., White,C.C., Nelson,S.D.
            and Kavanagh,T.J.
  TITLE     Acetaminophen-induced liver damage in mice is associated with
            gender-specific adduction of peroxiredoxin-6
  JOURNAL   Redox Biol 2, 377-387 (2014)
   PUBMED   24563856
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2601)
  AUTHORS   Gewies,A., Castineiras-Vilarino,M., Ferch,U., Jahrling,N.,
            Heinrich,K., Hoeckendorf,U., Przemeck,G.K., Munding,M., Gross,O.,
            Schroeder,T., Horsch,M., Karran,E.L., Majid,A., Antonowicz,S.,
            Beckers,J., Hrabe de Angelis,M., Dodt,H.U., Peschel,C., Forster,I.,
            Dyer,M.J. and Ruland,J.
  TITLE     Prdm6 is essential for cardiovascular development in vivo
  JOURNAL   PLoS One 8 (11), e81833 (2013)
   PUBMED   24278461
  REMARK    GeneRIF: identified Prdm6 as a factor that is essential for the
            physiological control of cardiovascular development
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2601)
  AUTHORS   Kirchhof,P., Kahr,P.C., Kaese,S., Piccini,I., Vokshi,I.,
            Scheld,H.H., Rotering,H., Fortmueller,L., Laakmann,S., Verheule,S.,
            Schotten,U., Fabritz,L. and Brown,N.A.
  TITLE     PITX2c is expressed in the adult left atrium, and reducing Pitx2c
            expression promotes atrial fibrillation inducibility and complex
            changes in gene expression
  JOURNAL   Circ Cardiovasc Genet 4 (2), 123-133 (2011)
   PUBMED   21282332
REFERENCE   7  (bases 1 to 2601)
  AUTHORS   Yi,L., Domyan,E.T., Lewandoski,M. and Sun,X.
  TITLE     Fibroblast growth factor 9 signaling inhibits airway smooth muscle
            differentiation in mouse lung
  JOURNAL   Dev Dyn 238 (1), 123-137 (2009)
   PUBMED   19097117
REFERENCE   8  (bases 1 to 2601)
  AUTHORS   Wu,Y., Ferguson,J.E. 3rd, Wang,H., Kelley,R., Ren,R., McDonough,H.,
            Meeker,J., Charles,P.C., Wang,H. and Patterson,C.
  TITLE     PRDM6 is enriched in vascular precursors during development and
            inhibits endothelial cell proliferation, survival, and
            differentiation
  JOURNAL   J Mol Cell Cardiol 44 (1), 47-58 (2008)
   PUBMED   17662997
  REMARK    GeneRIF: These data indicate that PRDM6 is expressed by vascular
            precursors, has differential effects in endothelial cells and
            smooth muscle cells, and may play a role in vascular precursor
            differentiation and survival.
REFERENCE   9  (bases 1 to 2601)
  AUTHORS   Kinameri,E., Inoue,T., Aruga,J., Imayoshi,I., Kageyama,R.,
            Shimogori,T. and Moore,A.W.
  TITLE     Prdm proto-oncogene transcription factor family expression and
            interaction with the Notch-Hes pathway in mouse neurogenesis
  JOURNAL   PLoS One 3 (12), e3859 (2008)
   PUBMED   19050759
REFERENCE   10 (bases 1 to 2601)
  AUTHORS   Davis,C.A., Haberland,M., Arnold,M.A., Sutherland,L.B.,
            McDonald,O.G., Richardson,J.A., Childs,G., Harris,S., Owens,G.K.
            and Olson,E.N.
  TITLE     PRISM/PRDM6, a transcriptional repressor that promotes the
            proliferative gene program in smooth muscle cells
  JOURNAL   Mol Cell Biol 26 (7), 2626-2636 (2006)
   PUBMED   16537907
  REMARK    GeneRIF: PRISM acts as a novel epigenetic regulator of Smooth
            Muscle Cells (SMC) phenotypic plasticity by suppressing
            differentiation and maintaining the proliferative potential of
            vascular SMCs.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC164620.5 and
            AC116597.3.
            
            On May 2, 2007 this sequence version replaced NM_001033281.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133910.1, BC139295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-617               AC164620.5         94478-95094         c
            618-925             AC164620.5         85912-86219         c
            926-1053            AC164620.5         22901-23028         c
            1054-1178           AC164620.5         19318-19442         c
            1179-1521           AC164620.5         7251-7593           c
            1522-1698           AC116597.3         140336-140512       c
            1699-2601           AC116597.3         132811-133713       c
FEATURES             Location/Qualifiers
     source          1..2601
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 29.04 cM"
     gene            1..2601
                     /gene="Prdm6"
                     /gene_synonym="Gm92; PRISM"
                     /note="PR domain containing 6"
                     /db_xref="GeneID:225518"
                     /db_xref="MGI:MGI:2684938"
     exon            1..617
                     /gene="Prdm6"
                     /gene_synonym="Gm92; PRISM"
                     /inference="alignment:Splign:2.1.0"
     exon            618..925
                     /gene="Prdm6"
                     /gene_synonym="Gm92; PRISM"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1053
                     /gene="Prdm6"
                     /gene_synonym="Gm92; PRISM"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1178
                     /gene="Prdm6"
                     /gene_synonym="Gm92; PRISM"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1521
                     /gene="Prdm6"
                     /gene_synonym="Gm92; PRISM"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1698
                     /gene="Prdm6"
                     /gene_synonym="Gm92; PRISM"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..2601
                     /gene="Prdm6"
                     /gene_synonym="Gm92; PRISM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcccagctc gaggcgtcgg acatgctgaa gccgggggat cccggcggct cggccttcct
       61 caaagtggac ccagcttacc tgcagcactg gcagcaactc ttcccgcacg gaggcggcgg
      121 cggcggcccg ctcaaagcca gtggcgccgc gctcgccctg ggcgccccac agcccctgca
      181 gccaccgcca ccgccgccgc ctcctcctcc cgagcgcgcc gagcctcctc cagacggcct
      241 gcggccgcgg cctgcctcgc tctcgtccac cccggctcct tcctccacct ctgcctcttc
      301 tgcctcttcc tgcgccgcag ccgcggccgc cgctgcgctg gcgggtctct cggccctgcc
      361 ggtggcacag atgccggtgt tcgctcctct agctgctgct gctgtggccg cggagccact
      421 gcccccaaag gacctgtgcc tcggcgcctc cgccggcccc gggccggcca agtgcggcgg
      481 cggcggtggc agcgtggggg acggccgtgg cgtcccacgt ttccgctgca gcgcggagga
      541 gctggactat tacctgtacg ggcagcagcg catggaaatc atcccgctca accagcacac
      601 cagcgacccc aacaaccgtt gcgatatgtg cgcggacaac cgtaacgggg agtgccccat
      661 gcacgggcca ctgcactcgc tgcgccggct cgtgggcacc agcagcgcgg ccgccgctgc
      721 acccccgccg gagctgcccg agtggcttcg ggatctgccg cgggaggtgt gcctgtgtac
      781 cagcacggtg ccaggcctgg cgtatggcat ctgtgccgcg cagaggatcc agcagggcac
      841 ctggattggg cccttccagg gcgtgcttct gtccccggag aaagtgcaga ccggcgtagt
      901 gaggaacacg cagcatctct gggagatata tgaccaagat gggacacttc agcactttat
      961 tgatggtggg gagcctagta agtcgagctg gatgaggtat atccgatgtg caaggcactg
     1021 tggagaacag aatctaacag tagttcagta caggtcgaat atattctacc gagcctgtat
     1081 agatatcccc aggggcaccg agctcctggt gtggtacaat gacagctata catctttctt
     1141 tgggatccct ttacaatgca ttgcccagga tgaaaacttg aacgtccctt ccaccgtaat
     1201 ggaagccatg tgccgacagg atgccctgca gcccttcaac aaaagcagca agctttctcc
     1261 ctcgggccag cagcgctccg tggttttccc acagactccc tgcagcagga atttctccct
     1321 cttggataaa tctgggccca tggaggcagg atttaaccaa atcaacgtga agaatcagag
     1381 ggtcctggcg agcccaacct caaccagcca gctgcactcg gagttcagcg actggcatct
     1441 ctggaagtgc ggccagtgct ttaagacttt cacgcagcgc attctcctgc agatgcatgt
     1501 gtgcacgcag aaccccgaca gaccctacca gtgtggccac tgctcacagt ccttttccca
     1561 gccgtcagaa ctgaggaacc acgtagtcac tcactccagt gaccggcctt tcaagtgcgg
     1621 ctactgtggc cgtgcgtttg ccggagccac caccctcaac aaccacatcc ggacccacac
     1681 tggagaaaag cccttcaagt gcgagaggtg cgaaaggagc ttcacccagg ccacgcagct
     1741 gagtcgacac cagcgcatgc ccaatgagtg caagccgata accgagagcc cggaatcaat
     1801 cgaagtggat taactgattg actggccgga attaaacagc aaggaaagtc atgattaaat
     1861 gtcacggaca cttaagcaaa accaaagatt tcctctgaac aactttcaat cagtcccaga
     1921 aaaccaaaag cagtaataaa ataagtaaga tgttaagaga tattgatcct ggcgtggaag
     1981 tcagaccagg caagagatta tttatttatg actagggatg agacagattt ccgtggacag
     2041 ctcacctggg atggctcgtg tttccagtcc caaccgtgtg tttgctttat ttctaaaaaa
     2101 gctttttaaa aactgttatt taataccaaa gggagatttc tctgccctca gctgtaagaa
     2161 cgcacaggga cttgactctc gtcgcacctt ttttttctag tagcatgttt caaggggacc
     2221 cgttctatgg ccttcctcct gtggaggcct ggctcgcccg atgttggtta ccccagcaag
     2281 gaaggcttga ggcccaagca agaacccggc tgaagcagca ccgccgctgc ctgtagcctt
     2341 agaggcagcc cagttccaca gtttcgctcc tgatgcactt tgatggggct cttcccaccc
     2401 cgcagcctgg aactgaagct ggaaaaggaa gaaaatggtt tcagacgcaa acgcaaagga
     2461 cgaacgagga ggacttgctt tgtcctgtcc ggatctcaca cacatttaaa gtgtacggag
     2521 cttcataata caatatatat tgttctgaag cagctagtcg agaaaaaaaa atgttggttt
     2581 caataacatt ttagcttaag g
//
