LOCUS       NM_027547               2182 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus PR domain containing 5 (Prdm5), transcript variant 1,
            mRNA.
ACCESSION   NM_027547
VERSION     NM_027547.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2182)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2182)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2182)
  AUTHORS   Xu,W., Li,H., Wang,L., Zhang,J., Liu,C., Wan,X., Liu,X., Hu,Y.,
            Fang,Q., Xiao,Y., Bu,Q., Wang,H., Tian,J., Zhao,Y. and Cen,X.
  TITLE     Endocannabinoid signaling regulates the reinforcing and
            psychostimulant effects of ketamine in mice
  JOURNAL   Nat Commun 11 (1), 5962 (2020)
   PUBMED   33235205
  REMARK    GeneRIF: Endocannabinoid signaling regulates the reinforcing and
            psychostimulant effects of ketamine in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2182)
  AUTHORS   Ko,H.R., Hwang,I., Jin,E.J., Yun,T., Ryu,D., Kang,J.S., Park,K.W.,
            Shin,J.H., Cho,S.W., Lee,K.H., Ye,K. and Ahn,J.Y.
  TITLE     Roles of ErbB3-binding protein 1 (EBP1) in embryonic development
            and gene-silencing control
  JOURNAL   Proc Natl Acad Sci U S A 116 (49), 24852-24860 (2019)
   PUBMED   31748268
REFERENCE   5  (bases 1 to 2182)
  AUTHORS   Wang,L., Ding,Q.Q., Gao,S.S., Yang,H.J., Wang,M., Shi,Y.,
            Cheng,B.F., Bi,J.J. and Feng,Z.W.
  TITLE     PRDM5 promotes the proliferation and invasion of murine melanoma
            cells through up-regulating JNK expression
  JOURNAL   Cancer Med 5 (9), 2558-2566 (2016)
   PUBMED   27485778
  REMARK    GeneRIF: PRDM5 promotes the proliferation and invasion of murine
            melanoma cells through up-regulating JNK expression and strategies
            targeting PRDM5 may be promising for the therapy of melanoma.
REFERENCE   6  (bases 1 to 2182)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 2182)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 2182)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   9  (bases 1 to 2182)
  AUTHORS   Kinameri,E., Inoue,T., Aruga,J., Imayoshi,I., Kageyama,R.,
            Shimogori,T. and Moore,A.W.
  TITLE     Prdm proto-oncogene transcription factor family expression and
            interaction with the Notch-Hes pathway in mouse neurogenesis
  JOURNAL   PLoS One 3 (12), e3859 (2008)
   PUBMED   19050759
REFERENCE   10 (bases 1 to 2182)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY014014.1, AK014501.1, BX511446.1 and BG070775.2.
            
            On Jan 30, 2007 this sequence version replaced NM_027547.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014501.1, BC138901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                BY014014.1         2-78
            78-1730             AK014501.1         2-1654
            1731-1734           BX511446.1         234-237
            1735-2178           AK014501.1         1659-2102
            2179-2182           BG070775.2         1-4                 c
FEATURES             Location/Qualifiers
     source          1..2182
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.32 cM"
     gene            1..2182
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /note="PR domain containing 5"
                     /db_xref="GeneID:70779"
                     /db_xref="MGI:MGI:1918029"
     exon            1..232
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1939
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /note="isoform 1 is encoded by transcript variant 1; PR
                     domain zinc finger protein 5; PR domain-containing protein
                     5"
                     /codon_start=1
                     /product="PR domain zinc finger protein 5 isoform 1"
                     /protein_id="NP_081823.2"
                     /db_xref="CCDS:CCDS20208.1"
                     /db_xref="GeneID:70779"
                     /db_xref="MGI:MGI:1918029"
                     /translation="MLGMYVPDRFALKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRM
                     PEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRFVHEAPSQERKNLAAIQEG
                     ENIFYLAVDDIETDTELLIGYLDSDVEAEEEEQQALTMTKEGKVDHSKGQLAAGSKGH
                     LGCEEDFACPQCESSFPSEEVLTEHLQSLHQKPTGEKEFKCENCGKKFPVRQALQRHF
                     EQHRKACRGEARFVCKADSCGKRLKSKDALRRHQENVHTGDPKRKLICSVCNRKCTSV
                     SSLQEHRKIHEIFDCQECMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRLDQVGA
                     HKVIHSEDKPYQCKLCGKGFAHRNVYKNHKKTHSEERPFQCDACKALFRTPFSLQRHL
                     LIHNSERTFKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPSVLRSHKK
                     THTGEKEKVCPYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTH
                     TREKPYQCSECSKAFSQKRGLDEHKRTHTGEKPFQCDVCDLAFSLKKMLIRHKMTHNP
                     NRPMAECHFCHKKFTRNDYLKVHMDNIHGVADS"
     exon            233..316
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            317..439
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..614
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..789
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..911
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            912..991
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1076
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1234
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1328
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1489
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1583
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1669
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1774
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..2182
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2163..2168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /note="hexamer: ATTAAA"
     polyA_site      2181
                     /gene="Prdm5"
                     /gene_synonym="4432417F03Rik; 6530401I24Rik;
                     E130112L17Rik; PFM2"
                     /note="major polyA site"
ORIGIN      
        1 gaggaggggc ctggccgcgg ggagccgagg agggaggtgg ggattctggg agccgagctc
       61 atttcctcct cccggccgcc ccaggcccgc accccatctc cacgtgcggc gcctccggag
      121 cgcggccgag ccacggagga tgctgggcat gtacgtacca gacaggttcg ccctgaagtc
      181 gtcccgggtc caggacggga tggggctcta cacggcccgc cgcgtgcgca agggtgaaaa
      241 atttggaccc ttcgctgggg agaagcgaat gcctgaagac ttggatgaaa atatggacta
      301 cagactgatg tgggaggtac gtgggagcaa gggagaagtt ctgtatattt tggatgctac
      361 caacccaaga cactccaact ggcttcgctt tgttcacgag gcaccatctc aggagcggaa
      421 gaacctggct gccattcaag aaggagaaaa tattttctac ttggcagttg atgatataga
      481 aacagataca gagcttttga ttggctacct ggacagtgat gtggaggcag aggaggagga
      541 gcaacaagct ctgaccatga ccaaagaagg caaagttgac cactctaagg gacagttggc
      601 agctggaagt aaaggtcacc ttggctgtga agaggacttt gcctgtccac agtgtgaatc
      661 gagctttccc agtgaggaag tccttactga gcaccttcag agcttgcacc agaagcccac
      721 aggggagaaa gagttcaaat gcgagaactg cgggaagaaa ttccctgtga ggcaggcctt
      781 gcagagacat tttgagcagc accggaaggc ttgccgaggg gaggccaggt ttgtgtgcaa
      841 agccgacagc tgcgggaaga ggctgaaaag caaggatgcc ctgcgaaggc accaggaaaa
      901 tgtccacacc ggtgatccta agagaaaact catatgctcg gtgtgcaata gaaaatgtac
      961 ctcagtgtca agcctgcagg agcacaggaa gattcatgag atatttgatt gtcaagaatg
     1021 tatgaaaaag tttatttctg ctaatcagct gaagcgtcac atgattaccc actcagaaaa
     1081 gcggccttat aactgtgaga tctgtaacaa gtccttcaag aggctcgatc aagtgggcgc
     1141 ccacaaagtg atccacagtg aggacaaacc ctaccagtgc aagctctgtg gcaagggctt
     1201 tgctcacaga aacgtttaca agaaccacaa gaagacccac tccgaggaga gacctttcca
     1261 gtgtgatgca tgtaaagcct tgttccgcac gcccttttct ctgcagagac acctgttaat
     1321 ccacaacagt gagaggactt ttaagtgtca ccactgtgat gccacattta aaaggaagga
     1381 tacattaaac gttcatgtcc aggtggtcca tgaaagacac aagaagtacc gatgtgagct
     1441 gtgcaataag gcctttgtca caccttcagt gcttaggagt cataagaaga cacacacagg
     1501 agaaaaggag aaagtctgcc catattgtgg ccagaaattt gccagcagtg ggaccctgag
     1561 agttcacatc cggagccaca caggtgagcg cccctatcaa tgcccgtact gtgaaaaagg
     1621 tttcagtaaa aatgacggac tgaagatgca cattcgtact cacaccaggg agaagcccta
     1681 ccagtgctca gagtgcagca aggccttcag ccagaagcgg ggcctcgatg aacacaagag
     1741 gacacacaca ggagaaaagc cttttcagtg tgacgtatgt gacttggctt ttagcctgaa
     1801 gaaaatgctt attcgacaca agatgacaca caatcctaac cgtccgatgg cagagtgcca
     1861 tttctgccat aagaagttta caagaaatga ctacctcaaa gtgcacatgg acaacatcca
     1921 tggggtagct gacagctaag aggagcggca aggaaccaca ccatgtgaaa gagcttctac
     1981 tatgaatccc agattcttct cacctgatcg gcttaacaga aatagccaca aaggattcat
     2041 tgatctgaca gtgtttatgt gcctatcttt gtaatctata gatgcaaaaa aaatcctttt
     2101 accaaaaata aattcaaaat agaaaacaat aatactttgt agattacaga gtattctggc
     2161 tgattaaaaa ttaaatacag ag
//
