LOCUS       NM_001302886            3955 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus PR domain containing 4 (Prdm4), transcript variant 2,
            mRNA.
ACCESSION   NM_001302886
VERSION     NM_001302886.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3955)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3955)
  AUTHORS   Hanaka,T., Kido,T., Noguchi,S., Yamada,S., Noguchi,H., Guo,X.,
            Nawata,A., Wang,K.Y., Oda,K., Takaki,T., Izumi,H., Ishimoto,H.,
            Yatera,K. and Mukae,H.
  TITLE     The overexpression of peroxiredoxin-4 affects the progression of
            idiopathic pulmonary fibrosis
  JOURNAL   BMC Pulm Med 19 (1), 265 (2019)
   PUBMED   31888585
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3955)
  AUTHORS   Song,N.J., Chang,S.H., Kim,S., Panic,V., Jang,B.H., Yun,U.J.,
            Choi,J.H., Li,Z., Park,K.M., Yoon,J.H., Kim,S., Yoo,J.H., Ling,J.,
            Thomas,K., Villanueva,C.J., Li,D.Y., Ahn,J.Y., Ku,J.M. and
            Park,K.W.
  TITLE     PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases
            energy expenditure, inhibits weight gain, and improves insulin
            resistance in diet-induced obese mice
  JOURNAL   Cell Death Dis 9 (9), 876 (2018)
   PUBMED   30158592
  REMARK    GeneRIF: The role of butein in obesity and metabolic diseases,
            further highlighting that adipose PI3Kalpha-Akt1-Prdm4 axis is a
            regulator of energy expenditure.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3955)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 3955)
  AUTHORS   Chittka,A.
  TITLE     Differential regulation of SC1/PRDM4 and PRMT5 mediated protein
            arginine methylation by the nerve growth factor and the epidermal
            growth factor in PC12 cells
  JOURNAL   Neurosci Lett 550, 87-92 (2013)
   PUBMED   23831350
REFERENCE   6  (bases 1 to 3955)
  AUTHORS   Chittka,A., Nitarska,J., Grazini,U. and Richardson,W.D.
  TITLE     Transcription factor positive regulatory domain 4 (PRDM4) recruits
            protein arginine methyltransferase 5 (PRMT5) to mediate histone
            arginine methylation and control neural stem cell proliferation and
            differentiation
  JOURNAL   J Biol Chem 287 (51), 42995-43006 (2012)
   PUBMED   23048031
  REMARK    GeneRIF: SC1 and PRMT5 are components of an epigenetic regulatory
            complex that maintains the 'stem-like' cellular state of the neural
            stem cells.
REFERENCE   7  (bases 1 to 3955)
  AUTHORS   Guo,X., Yamada,S., Tanimoto,A., Ding,Y., Wang,K.Y., Shimajiri,S.,
            Murata,Y., Kimura,S., Tasaki,T., Nabeshima,A., Watanabe,T.,
            Kohno,K. and Sasaguri,Y.
  TITLE     Overexpression of peroxiredoxin 4 attenuates atherosclerosis in
            apolipoprotein E knockout mice
  JOURNAL   Antioxid Redox Signal 17 (10), 1362-1375 (2012)
   PUBMED   22548251
REFERENCE   8  (bases 1 to 3955)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3955)
  AUTHORS   Orel,N. and Sendtner,M.
  TITLE     SC1/PRDM4 is a critical mediator for cell death, mitosis and
            differentiation of neural stem cells
  JOURNAL   J Stem Cells Regen Med 2 (1), 216-217 (2007)
   PUBMED   24693010
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3955)
  AUTHORS   Kendall,S.E., Ryczko,M.C., Mehan,M. and Verdi,J.M.
  TITLE     Characterization of NADE, NRIF and SC-1 gene expression during
            mouse neurogenesis
  JOURNAL   Brain Res Dev Brain Res 144 (2), 151-158 (2003)
   PUBMED   12935912
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD350319.1, AK028414.1 and
            BC057596.1.
            
            Summary: This gene encodes a member of the PR/SET family of zinc
            finger proteins. This protein has been shown to bind DNA in a
            sequence-specific manner and has been implicated in neural stem
            cell proliferation and differentiation. Pseudogenes have been
            identified on chromosomes 14 and X. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Nov 2014].
            
            Transcript Variant: This variant (2) contains a longer 5' UTR and
            uses an alternate in-frame splice site in the central coding
            region, compared to variant 1. This results in a shorter protein
            (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                CD350319.1         1-60
            61-1117             AK028414.1         3-1059
            1118-1650           BC057596.1         930-1462
            1651-3955           BC057596.1         1484-3788
FEATURES             Location/Qualifiers
     source          1..3955
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 41.75 cM"
     gene            1..3955
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /note="PR domain containing 4"
                     /db_xref="GeneID:72843"
                     /db_xref="MGI:MGI:1920093"
     exon            1..179
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            180..385
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..519
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..2777
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /note="isoform 2 is encoded by transcript variant 2; PR
                     domain zinc finger protein 4; PR domain-containing protein
                     4"
                     /codon_start=1
                     /product="PR domain zinc finger protein 4 isoform 2"
                     /protein_id="NP_001289815.1"
                     /db_xref="CCDS:CCDS88065.1"
                     /db_xref="GeneID:72843"
                     /db_xref="MGI:MGI:1920093"
                     /translation="MNDMNLSPVGMEQLSSSSVSNALPVSGSHLGLAASPSHSAIPAP
                     GLPVAIPNLGPSLSSLPSALSLMLPVGIGDRGVMCGLPERNYTLPPPPYPHLESSYFR
                     TILPGILSYLADRPPPQYIHPNSINVDGNTALSITNNPSALDPYQANGNVGLELGIVS
                     IDSRSVNTHGAQSLHPNDGHEVALDTTITMENVSRVTSPISTDGMAEELTMDGVTGEH
                     PQIPNGSRSHEPLSVDSVSNSLTAEAVGHGGVIPIHGNGLELPVVMETDHIANRVNGM
                     SDSTLSDSIHTVAMSTNSVSVALSTSHNLASLESVSLHEVGLSLEPVAVSSITQEVAM
                     GTGHVDVSSDSLSFVPSSLQMEDSNSNKENMATLFTIWCTLCDRAYPSDCPDHGPVTF
                     VPDTPIESRARLSLPKQLVLRQSIVGTDVGVWTAETIPVRTCFGPLIGQQSHSLEVAE
                     WTDKAVNHVWKIYHTGVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGKIYF
                     CTSQDIPPESELLFYYSRNYAQQIGVPEHPDVHLCNCGKECSSYSEFKAHLTSHIHNH
                     LPSQGHSSSHGPSHSKERKWKCSMCPQAFISPSKLHVHFMGHMGMKPHKCDFCSKAFS
                     DPSNLRTHLKIHTGQKNYRCTLCDKSFTQKAHLESHMVIHTGEKNLKCDYCDKLFMRR
                     QDLKQHVLIHTQERQIKCPKCDKLFLRTNHLKKHLNSHEGKRDYVCEKCTKAYLTKYH
                     LTRHLKTCKEPSSSSSAQEEEDDESEEEDLADSMRTEDCRMGSAVYSTDESLSAHK"
     exon            520..705
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..1500
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1650
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1769
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1855
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1983
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2298
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2467
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..3941
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3919..3924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /note="hexamer: ATTAAA"
     polyA_site      3941
                     /gene="Prdm4"
                     /gene_synonym="1700031E19Rik; 2810470D21Rik; SC-1; SC1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcccccga gggtgcggcc ccgtgaaggc ggcgggcctg accgggcggg gccgggcggg
       61 aaatgttagg agagctgtaa accgggcgcg gggtcccggg aggcaggagc gtccgggccg
      121 acgttcggcc cgatgacgag ccaggcggcc gggccagtgc tccccagcgc gggcctcagg
      181 tcggccagtc cggctgccag cgcttctggg aaaacagccc cgggcgccgc ccagcatgcc
      241 gggccctcgc cgcggagcgc agccgccggc cctcggagac gtcgggcagt gcggggaggc
      301 gcggccaccg gcgggatgtg gtagcacgtg acaccggccc catcgcgcac ctagcagccg
      361 ccggccccct gccctggacg tgcaggatga atgacatgaa cttgagccca gtggggatgg
      421 agcagctgtc ttcatcctct gtgagcaatg ccctgccagt ctcaggaagt cacctgggct
      481 tggctgcctc tccctctcac agtgccatcc ctgccccagg acttccagtg gcaattccaa
      541 acctgggtcc ctccctgagc tctctgcctt ctgccttgtc tcttatgctc cccgtgggca
      601 ttggagaccg aggagtgatg tgtgggctac ctgagaggaa ctacacccta cctccacctc
      661 cttaccctca cctagagagc agttacttca gaaccattct acctggcatt ttatcttatt
      721 tagctgacag accacctcct cagtatatcc accccaactc tataaatgtt gatggaaata
      781 cagcattatc tatcaccaac aacccttcag cactagatcc gtatcaggcc aatggaaatg
      841 ttggattaga actaggcatt gtttcaatag actctcgctc tgtaaacaca catggtgccc
      901 aaagtcttca tcctaatgat ggccacgaag tagcattgga cacaacaatc accatggaga
      961 atgtttctag ggttaccagc ccaatctcca cagatggaat ggcagaggag cttacaatgg
     1021 acggtgttac aggagagcat ccccaaatcc caaatggctc cagaagtcat gagcctctct
     1081 ctgtggattc tgtgagcaac agccttacag cagaagctgt aggacatggt ggtgtgatac
     1141 ccattcacgg gaatggtctg gagcttcctg tggtcatgga aactgaccac attgcaaacc
     1201 gggtcaatgg gatgtctgac agtaccctca gtgactccat ccacaccgtg gccatgagca
     1261 ccaactctgt aagcgtggca ctctctacct cacacaacct ggcctcccta gagtctgttt
     1321 ccctccatga agttggcctt agcctagagc ctgtggctgt ctcttctatc acgcaggagg
     1381 ttgccatggg gacaggtcat gtagatgtgt cctcagacag cttgtctttt gtaccatctt
     1441 cactgcaaat ggaagactcc aattcaaaca aggaaaacat ggcaaccttg tttacaattt
     1501 ggtgcactct ttgtgaccga gcctacccct cagattgccc tgatcatgga ccagtgactt
     1561 ttgttcctga cacaccaata gagagcagag caagactatc cctcccgaag cagcttgttc
     1621 tccgccagtc catcgtggga acagatgttg gtgtatggac tgcagaaacc attcctgtgc
     1681 ggacttgctt cggacctcta attggtcagc agagtcactc cttggaagta gcagagtgga
     1741 cagacaaggc agttaaccat gtctggaaga tataccacac tggtgtcctg gagttctgta
     1801 tcattacaac cgatgagaat gagtgtaatt ggatgatgtt tgtgcgcaaa gccaggaacc
     1861 gtgaagaaca gaatttggtg gcctatcccc atgatgggaa aatctatttc tgtacctcac
     1921 aagacatccc ccctgaaagt gagctgcttt tctattacag ccggaattac gctcaacaga
     1981 taggtgttcc tgaacaccca gatgtgcacc tctgtaactg tggcaaggag tgcagttcct
     2041 attcagagtt caaagctcat ctgaccagcc atatccacaa tcatctccct agccagggcc
     2101 acagcagcag ccatgggcca agccacagca aggaaaggaa gtggaagtgt tcaatgtgcc
     2161 cccaggcttt tatctcgcct tccaaactcc acgttcactt tatgggccac atgggtatga
     2221 agccccacaa gtgtgatttt tgtagcaagg cttttagtga tccaagcaac ctacggacac
     2281 acctcaaaat acatacaggt cagaaaaatt ataggtgtac tttgtgtgac aagtctttca
     2341 cgcagaaggc tcacctggag tctcacatgg tcatccacac gggtgagaag aatctcaagt
     2401 gtgattactg tgacaagctg ttcatgcgga gacaggacct caagcagcac gtgctcatcc
     2461 acacgcaaga acgccagatc aagtgtccga agtgtgataa actgttcttg agaacaaacc
     2521 acttgaagaa gcatctcaat tctcacgaag gaaaacgaga ttatgtctgc gaaaaatgta
     2581 caaaggctta tctaaccaag taccatctca ctcgccacct gaagacctgc aaagagccca
     2641 gctccagctc ctctgcacag gaggaagagg atgatgagtc ggaggaagaa gatctcgcag
     2701 actccatgag gacagaggac tgcaggatgg gcagtgctgt ttactcaaca gacgagtctc
     2761 tctccgcaca taaataggag gagagagcaa ctgctttgga cggaacacac attggtaaaa
     2821 caaaaccaac ccacggttag aagtggacgg agtggggaca gctaaagcac ttacagagga
     2881 atgtccagtg gattctttaa gatggactgg cagatgaggc atgcatctgt cctacttttc
     2941 agtaatgggt ggcaatgaga gggccaactt ttactatctg ttctttattt acatgtaatt
     3001 tgggagatgt atttatgctt gagtcaaagt gcccttttgt ccacacaaat cagatttctc
     3061 tcatattgct ccattttccc ccagccagcg tgacttgagc catcccactg catcccacac
     3121 attaagcact gatgtaaggt aaccgccgtg caagtgttag gaggcctgta attagttaaa
     3181 aaggaacacc tgcctacctt ctggctcctg ctgcctcagt ctcagcaggg gttgagaggg
     3241 caggtaaagc agcaggcgtg gatcagagga cagtgactga tagaggaaaa ggtccagaag
     3301 cccacctctg atagaagcca aggttagcca cgtggttatg tgtatgcaca tctttgtgat
     3361 ctagccttgt ctctttagga aagccttcag tctttcagag aggacctaga acattaacag
     3421 tgttgagata atacatgctg ggtagtctct agtcagcaag tgcacatggg ctcgcctgac
     3481 gagatcacga gatcggttct tctgcccaca ggaggaagga tcggaatgat ggtttgtttt
     3541 ctttctttct tttttgaaat gtaggtttac tttatgaaaa ccattaaaat gttgctagct
     3601 gaaagcaaca agtagttcca aatgcattgt gggtttcagt taggccttcc cagttgtctt
     3661 ccttgttgct gaaggtcctc accagctgag tgtagaggat accaaaggaa ttggaagatg
     3721 agaaggctta ttagtcactc cctgtgagca ggcacaccca gcttttctcc agaagcggac
     3781 accctgaact tgacaggatt gatggaacac gtcttcctgc tcaaaggctt gagtagagga
     3841 ctctgctggc aaggttttgc tgctaatgta tttatagaat gaatgtattt cattcaaacc
     3901 tgtattcctc taggaagaat taaaatcatt tttaatgaaa aaaaaaaaaa aaaaa
//
