LOCUS       NM_001081355            7323 bp    mRNA    linear   ROD 17-APR-2022
DEFINITION  Mus musculus PR domain containing 2, with ZNF domain (Prdm2),
            transcript variant 1, mRNA.
ACCESSION   NM_001081355 XM_898822
VERSION     NM_001081355.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7323)
  AUTHORS   Xie X, Man X, Zhu Z, Yuan D and Huang S.
  TITLE     Tumor suppressor RIZ1 in obesity and the PI3K/AKT/mTOR pathway
  JOURNAL   Obesity (Silver Spring) 24 (2), 389-397 (2016)
   PUBMED   26709097
  REMARK    GeneRIF: RIZ1 is an important regulator of both Akt3 transcription
            and AKT phosphorylation and suggest a role for RIZ1 in HF-induced
            obesity and the AKT pathway
REFERENCE   2  (bases 1 to 7323)
  AUTHORS   Wada S, Ideno H, Shimada A, Kamiunten T, Nakamura Y, Nakashima K,
            Kimura H, Shinkai Y, Tachibana M and Nifuji A.
  TITLE     H3K9MTase G9a is essential for the differentiation and growth of
            tenocytes in vitro
  JOURNAL   Histochem Cell Biol 144 (1), 13-20 (2015)
   PUBMED   25812847
REFERENCE   3  (bases 1 to 7323)
  AUTHORS   Ideno H, Shimada A, Imaizumi K, Kimura H, Abe M, Nakashima K and
            Nifuji A.
  TITLE     Predominant expression of H3K9 methyltransferases in
            prehypertrophic and hypertrophic chondrocytes during mouse growth
            plate cartilage development
  JOURNAL   Gene Expr Patterns 13 (3-4), 84-90 (2013)
   PUBMED   23333759
REFERENCE   4  (bases 1 to 7323)
  AUTHORS   Noman AS, Koide N, Iftakhar-E-Khuda I, Dagvadorj J, Tumurkhuu G,
            Naiki Y, Komatsu T, Yoshida T and Yokochi T.
  TITLE     Retinoblastoma protein-interacting zinc finger 1, a tumor
            suppressor, augments lipopolysaccharide-induced proinflammatory
            cytokine production via enhancing nuclear factor-kappaB activation
  JOURNAL   Cell Immunol 264 (2), 114-118 (2010)
   PUBMED   20557878
  REMARK    GeneRIF: prevents lipopolysaccharide-induced proinflammatory
            cytokine production via enhancing nuclear factor-kappaB activation
REFERENCE   5  (bases 1 to 7323)
  AUTHORS   Carling T, Kim KC, Yang XH, Gu J, Zhang XK and Huang S.
  TITLE     A histone methyltransferase is required for maximal response to
            female sex hormones
  JOURNAL   Mol Cell Biol 24 (16), 7032-7042 (2004)
   PUBMED   15282304
  REMARK    GeneRIF: Data suggest that the histone methyltransferase RIZ1 is
            required for estrogen response in female reproductive tissues and
            that estrogen-bound estrogen receptors may turn a transcriptional
            repressor into a coactivator.
REFERENCE   6  (bases 1 to 7323)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 7323)
  AUTHORS   Steele-Perkins G, Fang W, Yang XH, Van Gele M, Carling T, Gu J,
            Buyse IM, Fletcher JA, Liu J, Bronson R, Chadwick RB, de la
            Chapelle A, Zhang X, Speleman F and Huang S.
  TITLE     Tumor formation and inactivation of RIZ1, an Rb-binding member of a
            nuclear protein-methyltransferase superfamily
  JOURNAL   Genes Dev 15 (17), 2250-2262 (2001)
   PUBMED   11544182
REFERENCE   8  (bases 1 to 7323)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 7323)
  AUTHORS   Mock BA, Coleman MP and Huang S.
  TITLE     Riz maps to distal chromosome 4 near genes involved in
            tumorigenesis and nerve degeneration
  JOURNAL   Mamm Genome 7 (8), 637 (1996)
   PUBMED   8679000
REFERENCE   10 (bases 1 to 7323)
  AUTHORS   Buyse IM, Shao G and Huang S.
  TITLE     The retinoblastoma protein binds to RIZ, a zinc-finger protein that
            shares an epitope with the adenovirus E1A protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4467-4471 (1995)
   PUBMED   7538672
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087820.1, AL606915.12, CN537770.1, BY232351.1 and AI850024.1.
            
            On Aug 27, 2008 this sequence version replaced NM_001081355.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               AK087820.1         2-362
            362-388             AL606915.12        146880-146906       c
            389-644             AK087820.1         363-618
            645-713             CN537770.1         17-85
            714-832             BY232351.1         112-230
            833-5169            AL606915.12        99302-103638        c
            5170-5313           AL606915.12        79226-79369         c
            5314-7089           AL606915.12        75202-76977         c
            7090-7323           AI850024.1         1-234               c
FEATURES             Location/Qualifiers
     source          1..7323
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 76.84 cM"
     gene            1..7323
                     /gene="Prdm2"
                     /gene_synonym="4833427P12Rik; E330024L24Rik; Gm1033;
                     Gm19732; KMT8; Riz; Riz1; Znfpr1c1"
                     /note="PR domain containing 2, with ZNF domain"
                     /db_xref="GeneID:110593"
                     /db_xref="MGI:MGI:107628"
     exon            1..95
                     /gene="Prdm2"
                     /gene_synonym="4833427P12Rik; E330024L24Rik; Gm1033;
                     Gm19732; KMT8; Riz; Riz1; Znfpr1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            96..169
                     /gene="Prdm2"
                     /gene_synonym="4833427P12Rik; E330024L24Rik; Gm1033;
                     Gm19732; KMT8; Riz; Riz1; Znfpr1c1"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..5290
                     /gene="Prdm2"
                     /gene_synonym="4833427P12Rik; E330024L24Rik; Gm1033;
                     Gm19732; KMT8; Riz; Riz1; Znfpr1c1"
                     /EC_number="2.1.1.354"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="PR domain zinc finger protein 2 isoform a"
                     /protein_id="NP_001074824.3"
                     /db_xref="CCDS:CCDS38942.2"
                     /db_xref="GeneID:110593"
                     /db_xref="MGI:MGI:107628"
                     /translation="MHQNTESVAVTETLAEVPEHVLRGLPEEVRLLPSAVDKTRIGVW
                     ATKPILKGKKFGPFVGDKKKRSQVRNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVN
                     WACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARS
                     KRSSPKSRRGKKKSQENKNKGVRTQAAARKASELDSTSANMRGSAEGPKEEDERPLAS
                     APEQPALLPEVVSQDAVPQVAIPLPACESQPGADGKQEVTDCEVNNMKEEEEEEEEEL
                     EEEEEEEELGEDGEEEADMPNESSVKEPEIRCEEKPEDLLEEPRSVPTETSEGSPGAT
                     PPPHAPRAREEANGEGLETFMFPCQHCERKFATKQGLERHMHIHISTINHAFKCKYCG
                     KPFGTQINRRRHERRHETGLKRRPSMALQSSEDPDDGKGENVTSKDESSPPQLGQDCL
                     ILNSEKTSQEILNSSFVEENGEVKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKG
                     VRRKGGLLEEPQPPAEQAPPSQNVYVPSTEPEEDGDADDVYIMDISSNISENLNYYID
                     GKIQTNNSTSDCDVIEMESNSAHLYGIDCLLTPVTVEITQNIKSTQGSVTDDLLKESP
                     SSTNCESKKRRTASPPVLPKIKAETDSDSTAPSCSLSLPLSISTTEVVSFHKEKGVYL
                     SSKLKQLLQTQDKLTPPAGISTAEIPKLGPVCVSAPASMLAVTSSRFKRRTSSPPSSP
                     QHSPALRDFGKQSDGKAAWTDTALTSKKPKLESRSDSPAWSLSGRDERETGSPPCFDE
                     YKISKEWAASSTFSSVCNQQPLDLSSGVKQKSEGTGKTPVPWESVLDLSVHKKPCDSE
                     GKEFKENHLAQPAAKKKKPTTCMLQKVLLNEYNGVSLPTESTPEATRSPSPCKSPDTQ
                     PDPELATDSSCSAPTAESPPEVVGPSSPPLQAASLSSGQLPPLLIPTEPSSPPPCPPV
                     LTVATPPPPLLPTVPLPNPSCDASPQQCPSPFSNATAQSPLPILSPTVSPSPSPIPPV
                     EPLMSAASPGPPTLSSSSSSSSSSSFSSSSCSSSSPSPPPLSAVSSVVSSGDNLEASL
                     PAITLKQEESESEGLKRKEEAPAAGGQSAVQETFSRNFVCNVCASPFLSIKDLTKHLS
                     VHAEEWPFKCEFCVQLFKGKTDLSEHRFLLHGVGNIFVCSVCKKEFAFLCNLQQHQRD
                     LHPDELCTHHEFESGTLRPQNFTDPSKAHVEHMPSLPEEPAEASREEELNDSSEELYT
                     TIKIMASGIKTKEPDVRLGLNQHYPSFKPPPFQYHHRNPMGIGVTATNFTTHNIPQTF
                     TTAIRCTKCGKSVDNMPELHKHILACASASDKKRYTPKKNPVPLRQTVQPKNGVLVLD
                     NSGKNAFRRMGQPKRLSFNVELSKMSPNKLKLNALKKKNQLVQKAILQKNRSAKQKAD
                     LRDTSEASSHICPYCDREFTYIGSLNKHAAFSCPKKPLSPSKRKVSHSSKKGGHTSSA
                     SSDRNSSSNPRRRTADTEIKMQSMQAPLGKTRARSTGPAQASLPSSSFRSRQNVKFAA
                     SVKSKKASSSSLRNSSPVRMAKITHVEGKKSKAVAKSHSTQLSSKASRSLHVKVQKSK
                     AVLQSKTALASKKRTDRFIVKSRERSGGPITRSLQLAAAADLSESRREDSSARHELKD
                     LSYSLRLASRCASSTAPYITRQCRKVKAAAATQFQGPFFKE"
     exon            170..284
                     /gene="Prdm2"
                     /gene_synonym="4833427P12Rik; E330024L24Rik; Gm1033;
                     Gm19732; KMT8; Riz; Riz1; Znfpr1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..388
                     /gene="Prdm2"
                     /gene_synonym="4833427P12Rik; E330024L24Rik; Gm1033;
                     Gm19732; KMT8; Riz; Riz1; Znfpr1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..541
                     /gene="Prdm2"
                     /gene_synonym="4833427P12Rik; E330024L24Rik; Gm1033;
                     Gm19732; KMT8; Riz; Riz1; Znfpr1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..668
                     /gene="Prdm2"
                     /gene_synonym="4833427P12Rik; E330024L24Rik; Gm1033;
                     Gm19732; KMT8; Riz; Riz1; Znfpr1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..779
                     /gene="Prdm2"
                     /gene_synonym="4833427P12Rik; E330024L24Rik; Gm1033;
                     Gm19732; KMT8; Riz; Riz1; Znfpr1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..5169
                     /gene="Prdm2"
                     /gene_synonym="4833427P12Rik; E330024L24Rik; Gm1033;
                     Gm19732; KMT8; Riz; Riz1; Znfpr1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            5170..5313
                     /gene="Prdm2"
                     /gene_synonym="4833427P12Rik; E330024L24Rik; Gm1033;
                     Gm19732; KMT8; Riz; Riz1; Znfpr1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            5314..7308
                     /gene="Prdm2"
                     /gene_synonym="4833427P12Rik; E330024L24Rik; Gm1033;
                     Gm19732; KMT8; Riz; Riz1; Znfpr1c1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagccaag atggcggcgg cgcggccgcg ggcgccagag cgacggcggc ggctgcggct
       61 ctgggctcgc tgaagcgttg gcacgtcgcg ctctgggctc atgtaatcaa agaagtttct
      121 ttgttgtgtg tatctttaca gaacacaaca ggaattgaaa atgcatcaga acactgagtc
      181 tgtggcagtc actgagactc tggctgaggt acctgaacac gtgcttcgag gacttccaga
      241 ggaagtaaga cttttaccat ctgcggtcga caagactcgg attggtgtct gggccactaa
      301 accaatttta aaagggaaaa agtttgggcc atttgttggt gataagaaga agagatccca
      361 ggttaggaat aatgtataca tgtgggaggt gtactaccca aatttggggt ggatgtgcat
      421 tgatgccact gatccggaga agggcaactg gctccgctat gtgaactggg cttgctcagg
      481 agaagaacag aatttatttc cactggaaat caacagagcc atttactata aaaccttaaa
      541 gccaatcgcg cctggcgagg agctcctggt ctggtacaat ggggaagaca accccgagat
      601 agcagctgcg attgaggaag agcgagccag cgcccggagc aagcggagct ccccgaagag
      661 ccggagaggg aagaagaaat cacaggagaa taaaaacaaa ggcgtcagaa cccaggctgc
      721 agcgcggaag gcgagcgagc tggactccac ctctgcaaac atgaggggct ctgcagaagg
      781 tccaaaagaa gaggatgaga ggcctttggc ttctgcacct gagcagccag cccttctgcc
      841 agaggtggta agccaggatg cagttccaca ggtggccatc cctcttcctg cctgcgagtc
      901 acagccaggg gcagatggga aacaagaagt cacagactgt gaggtcaaca atatgaagga
      961 agaggaggag gaggaggagg aggagctgga agaggaagaa gaggaggagg agttgggaga
     1021 agatggggag gaagaagcag acatgccgaa tgaaagctct gtgaaagaac cagaaatacg
     1081 gtgtgaagaa aagccagaag atttactgga agagccacgg agtgtgccaa ctgaaacttc
     1141 tgaaggctcc ccaggcgcca cccctcctcc ccacgctccc agggctagag aggaggccaa
     1201 cggcgagggg cttgaaacat tcatgtttcc atgtcagcat tgtgaaagga aatttgcaac
     1261 gaagcagggg ctagaacgtc acatgcacat ccacatttct acaatcaacc acgctttcaa
     1321 gtgcaagtac tgtgggaaac catttggcac acagatcaac aggaggcggc atgaaaggcg
     1381 ccacgaaaca gggttgaaga gaagacccag catggcatta caatcctcag aggacccaga
     1441 cgatggcaag ggggaaaatg ttacttctaa agatgagtcg agtccacctc aacttgggca
     1501 agactgtttg atattgaact cagagaaaac ctcacaggaa atactgaatt catcttttgt
     1561 ggaagagaat ggtgaagtta aagaacttca cccatgcaaa tactgcaaaa aggtatttgg
     1621 aactcacacc aatatgagac gacatcagcg tagagttcac gaacgccacc tgattcccaa
     1681 aggtgtccgg cgaaaaggag gcctcctaga agagccgcag ccacctgcag agcaggcccc
     1741 gccctcccag aatgtctatg taccaagcac agagcccgag gaggacgggg acgcagatga
     1801 tgtgtatatc atggacattt ctagcaacat ctctgagaac ctaaattact atattgatgg
     1861 taagattcag accaacaaca gcactagtga ttgtgatgtg attgagatgg agtctaactc
     1921 tgcacacttg tatggcatag actgtctgct cactccagta actgtagaga ttactcaaaa
     1981 cataaagagc actcagggct ctgtgacaga tgatcttctt aaagagtctc ccagtagcac
     2041 aaattgcgag tctaagaaac ggaggactgc cagtccacct gtactcccta aaattaaagc
     2101 agagacagat tctgattcca cggcaccctc gtgttcctta agtctgcctc tgagcatatc
     2161 aacaacagag gtggtgtctt tccataaaga gaagggtgtc tatttgtctt caaagctcaa
     2221 gcagcttctt cagacccagg acaaactgac tcctcctgca gggatttcaa cagctgagat
     2281 tcctaagtta ggtcccgtgt gtgtatctgc tcctgcatcc atgttagctg tgacttctag
     2341 taggtttaag agacgcacca gctctccccc cagttctcca cagcacagcc ctgcccttcg
     2401 agactttggg aaacagagtg atgggaaagc agcatggaca gacacagctc tgacttccaa
     2461 gaaaccgaag ttagaaagtc gtagtgactc accagcgtgg agtttgtctg ggagagatga
     2521 gagagaaact ggaagccctc cttgttttga tgaatacaaa atatcaaaag aatgggcagc
     2581 cagttctact ttcagcagcg tgtgcaacca acagccgttg gatttatcca gcggtgtcaa
     2641 acagaagtca gagggcacag gcaagactcc agtcccatgg gaatctgtat tggatctcag
     2701 tgtgcataaa aagccttgtg attctgaagg caaggaattc aaagagaacc atttggcaca
     2761 gccggctgca aagaagaaaa aaccaaccac ctgcatgcta caaaaggttc ttctcaatga
     2821 atataatggt gttagcttac ctacagaaag cacaccagag gcgaccagga gcccaagtcc
     2881 ttgtaaatca ccagacacac agccagatcc tgaacttgct actgactcga gttgctcagc
     2941 ccccactgct gagtctccac ctgaggttgt tggcccttca tcaccccctc tccaggcagc
     3001 ctccctgtcc tctggtcagc tgcctcctct cttgatcccc acagagcctt cttcccctcc
     3061 gccctgccct cctgtgttaa ctgttgccac tccaccacct cccctccttc cgactgtccc
     3121 tctccccaac ccctcttgtg atgcctctcc tcaacagtgc ccctctccat tctcaaatgc
     3181 cactgctcag tctcctcttc cgattctctc cccaacagtg tccccctctc cctctcctat
     3241 tcctcctgta gagccactca tgtctgctgc ttcccctggt cctccgacac tttcctcctc
     3301 ttcctcctcc tcttcctcct cttccttctc ttcctcttca tgttcctcct cctccccctc
     3361 accaccccct ctctcagcag tgtcatctgt ggtgtcctct ggggacaacc tggaagcatc
     3421 tctccctgca ataactctca aacaggagga gtcagagagt gaaggtctga aacgcaagga
     3481 agaggcccca gctgcaggtg ggcagagcgc tgtccaagag acattcagca gaaacttcgt
     3541 ctgcaatgtg tgcgcatcac cttttctttc cattaaagac ctaaccaaac atttgtctgt
     3601 ccatgctgaa gaatggccct tcaaatgtga gttttgtgtg cagcttttta agggtaagac
     3661 cgatctatca gagcaccgat ttctgcttca tggagtcgga aatatctttg tgtgttctgt
     3721 atgtaagaaa gaatttgcct tcttatgcaa tttacagcag catcagcgtg atctccaccc
     3781 agatgagtta tgcacacacc acgagtttga aagtgggacc ctgaggcccc agaacttcac
     3841 agaccccagc aaggcccatg tggagcatat gccgagtttg ccagaagagc ctgcggaagc
     3901 ttctagagag gaggagttaa atgactcctc tgaagagctt tacacgacca tcaaaataat
     3961 ggcttccgga ataaagacga aagagccaga tgttcgactt ggtctcaacc agcattaccc
     4021 gagctttaag ccacctccat ttcagtacca ccatcgaaac cctatgggga ttggggtaac
     4081 agccacaaac ttcaccaccc acaatatccc acagactttc actactgcca tccgctgcac
     4141 aaagtgtggc aagagtgttg ataacatgcc tgagctgcat aagcacatct tggcgtgtgc
     4201 atctgcaagt gacaagaaga ggtacactcc taagaaaaac ccagtgccgc tgagacagac
     4261 ggtgcagccc aaaaatggag tgctggtttt agacaactct gggaaaaatg ccttcagacg
     4321 gatggggcag cctaagagac tgagcttcaa tgttgaactc agcaaaatgt ctccaaataa
     4381 gctcaagcta aatgcattga agaaaaaaaa tcagctggta cagaaagcga tccttcagaa
     4441 gaacagatct gcgaagcaga aggcagacct gagggacact tccgaggcgt cctcacatat
     4501 ctgcccttac tgtgacaggg agttcacgta catcggcagc ctgaataagc atgctgcttt
     4561 cagctgtcct aaaaaacccc tttctccttc caaaagaaaa gtttctcatt catctaagaa
     4621 aggtggccac acatcatctg ccagcagtga cagaaacagt agtagcaatc cccggaggcg
     4681 caccgcagat acggagatca agatgcagag catgcaggca cccttgggca agacccgagc
     4741 tcggagtaca ggccctgccc aagcctcgct gccctcctca tccttcagat ccagacagaa
     4801 tgtcaagttt gcagcttcag tcaagtccaa aaaagcaagc tcttcatcct tgaggaattc
     4861 tagtcccgta agaatggcta agattactca tgttgagggc aaaaaatcca aagctgttgc
     4921 caagagtcat tctactcagc tctcaagcaa agcatcccga agcctgcacg tgaaggtgca
     4981 gaagagcaaa gctgttctac aaagcaagac tgccctggcc agcaagaaaa gaacagaccg
     5041 gttcatagta aaatctagag agcggagcgg gggcccaatc acccgaagcc ttcagctggc
     5101 agctgctgcg gacctgagtg aaagcaggag agaggacagc agtgccaggc atgagctgaa
     5161 ggacttgagc tacagcctcc gcctggcatc gcgatgcgcc tcatcaacag ccccttatat
     5221 caccagacaa tgcagaaagg tcaaggctgc agcagcaact cagttccagg gacccttctt
     5281 caaagagtag gcactttgtc tgctccttaa cagcacctga agtgacctgg aatcagtgaa
     5341 gccaaaggga ccagcagtct gccctgcaga gagcactgac ctctcccagt tgtgagagtg
     5401 agagagtgag catgagagag gatcagagag agagagagag agagagagag agagagagag
     5461 agagagagga gagcgcatgt gtgcatgtat gtgtgtgctg gtgcatgtgt gtggtcccag
     5521 cctcaggagc aggaccttca tgtcatcctc tggatgatcc ttggacatgg cccagaaccg
     5581 tgctctgtgg tgcagccatc ctgcccggga ggggcgtctc cttctatgca attttttaaa
     5641 agagttcctt ggccctgctt cgtgcttctt gagctgtgcg tttgccatcg ctgggacttt
     5701 gatctggccc cgaggggtgg ggaggggtcc tagctaagga tgacctttca gaggtcaagc
     5761 tgcccctcat gccacccctc cccaccgccc ccaccgacct tttcctcaca ctgtctctgg
     5821 gaatcaatag caaatagcat atagatccat cagggctgag cctgagcctt ggccctagca
     5881 ctaggaaacc ccaccccctt ttctccctaa gcaactggag ctgccagctt tcaagtcatt
     5941 tcctcctttg aggttcagga gtccactgct ctgaagtctc cactgggaac cccggagccc
     6001 acgcgctcag gatgcagcct ccgcggccgt tctcagacct ggtctctcat ttagtagaag
     6061 cagtgtctag ggacgctggg gtggagatgt gactctcctg tgcccttctt tgtctcccat
     6121 ggtgggaccc actacaccat tagcatctga cccttgcaag ttagctgcaa agtgaagcaa
     6181 aggaaaaaaa ataataaaaa gggaaataaa aagtatatgg atgggttcaa acaaacaaaa
     6241 accaggagga tttgaacggg tgattttcag atgccataaa accgcttgcc aggggagggc
     6301 agggctgacc tctgacctct gctgtggtgg acagttggag cccggcagaa acacggacct
     6361 tgctcactga ggtccttggg ttttgtgcct ttggggcgga ggatgcctga gacgattttg
     6421 gtaatgtttc ctcagctccg atctggtccc tacctgtcaa agtgggagga cagaacttgg
     6481 gagagttgtc acacaagaga ggggctgtct ttttcagggc tactatggtt gatattgcaa
     6541 ctctgtagat atgtatgtag acacttttaa aagcacgtat ttatggaccc tgctgtaaat
     6601 gccccatttt taaagtttta taacatgtgt tatttaatta atcagttgac tggctgcagt
     6661 aaggggactg actggtccag gaaaaagggt ccctggagac cctcacatgg gcaggaaaac
     6721 atccatcaac gtccagtgtc acagttttcc gatttaccca cccagccaga ctctggcgtg
     6781 cccctctttt atttcttcaa ctggaatttt ctccttctac gcaccctgca gttagtcctc
     6841 gaaagcatgg actcatggct gtcgccaacc ccactgacac agtctgtcct acagctggtc
     6901 gcgtgcactg tatcccagcc acgccctgca gccgggaaaa accgcacgaa cccaaagcct
     6961 tagcaaactg ctttcagtca aacttggaaa atgttgctgg gctcgtgggg gattctctct
     7021 ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct ctctctctcc
     7081 ctccctccct ccctccctcc ctccctctct ttgcatgtgc aaactgtgct gggtcaccct
     7141 tcaacacttc ccagattgtc aggaaaacaa agagaaagtt ttgtcagacg aggtgtttcc
     7201 tggtcagtgg cggtcttccc aagctagcgg atttccgtcc cagtgaagaa gattcagtat
     7261 tctgccatgt gaagacagtg aacaataaaa gtgctgagcg attgtgaaaa aaaaaaaaaa
     7321 aaa
//
