LOCUS       NM_144789               6346 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus PR domain containing 15 (Prdm15), transcript variant
            1, mRNA.
ACCESSION   NM_144789 XM_622716 XM_907577
VERSION     NM_144789.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6346)
  AUTHORS   Mzoughi S, Fong JY, Papadopoli D, Koh CM, Hulea L, Pigini P, Di
            Tullio F, Andreacchio G, Hoppe MM, Wollmann H, Low D, Caldez MJ,
            Peng Y, Torre D, Zhao JN, Uchenunu O, Varano G, Motofeanu CM,
            Lakshmanan M, Teo SX, Wun CM, Perini G, Tan SY, Ong CB, Al-Haddawi
            M, Rajarethinam R, Hue SS, Lim ST, Ong CK, Huang D, Ng SB,
            Bernstein E, Hasson D, Wee KB, Kaldis P, Jeyasekharan A,
            Dominguez-Sola D, Topisirovic I and Guccione E.
  TITLE     PRDM15 is a key regulator of metabolism critical to sustain B-cell
            lymphomagenesis
  JOURNAL   Nat Commun 11 (1), 3520 (2020)
   PUBMED   32665551
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6346)
  AUTHORS   Mzoughi S, Di Tullio F, Low DHP, Motofeanu CM, Ong SLM, Wollmann H,
            Wun CM, Kruszka P, Muenke M, Hildebrandt F, Dunn NR, Messerschmidt
            DM and Guccione E.
  TITLE     PRDM15 loss of function links NOTCH and WNT/PCP signaling to
            patterning defects in holoprosencephaly
  JOURNAL   Sci Adv 6 (2), eaax9852 (2020)
   PUBMED   31950080
  REMARK    GeneRIF: PRDM15 loss of function links NOTCH and WNT/PCP signaling
            to patterning defects in holoprosencephaly.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6346)
  AUTHORS   Mzoughi S, Zhang J, Hequet D, Teo SX, Fang H, Xing QR, Bezzi M,
            Seah MKY, Ong SLM, Shin EM, Wollmann H, Wong ESM, Al-Haddawi M,
            Stewart CL, Tergaonkar V, Loh YH, Dunn NR, Messerschmidt DM and
            Guccione E.
  TITLE     PRDM15 safeguards naive pluripotency by transcriptionally
            regulating WNT and MAPK-ERK signaling
  JOURNAL   Nat Genet 49 (9), 1354-1363 (2017)
   PUBMED   28740264
  REMARK    GeneRIF: Findings indicate that PR domain containing 15 protein
            (PRDM15) is important in both mouse and human induced pluripotent
            stem cells (iPSCs) reprogramming.
REFERENCE   4  (bases 1 to 6346)
  AUTHORS   Burton A, Muller J, Tu S, Padilla-Longoria P, Guccione E and
            Torres-Padilla ME.
  TITLE     Single-cell profiling of epigenetic modifiers identifies PRDM14 as
            an inducer of cell fate in the mammalian embryo
  JOURNAL   Cell Rep 5 (3), 687-701 (2013)
   PUBMED   24183668
REFERENCE   5  (bases 1 to 6346)
  AUTHORS   Kinameri E, Inoue T, Aruga J, Imayoshi I, Kageyama R, Shimogori T
            and Moore AW.
  TITLE     Prdm proto-oncogene transcription factor family expression and
            interaction with the Notch-Hes pathway in mouse neurogenesis
  JOURNAL   PLoS One 3 (12), e3859 (2008)
   PUBMED   19050759
REFERENCE   6  (bases 1 to 6346)
  AUTHORS   Reymond A, Marigo V, Yaylaoglu MB, Leoni A, Ucla C, Scamuffa N,
            Caccioppoli C, Dermitzakis ET, Lyle R, Banfi S, Eichele G,
            Antonarakis SE and Ballabio A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   7  (bases 1 to 6346)
  AUTHORS   Reymond A, Camargo AA, Deutsch S, Stevenson BJ, Parmigiani RB, Ucla
            C, Bettoni F, Rossier C, Lyle R, Guipponi M, de Souza S, Iseli C,
            Jongeneel CV, Bucher P, Simpson AJ and Antonarakis SE.
  TITLE     Nineteen additional unpredicted transcripts from human chromosome
            21
  JOURNAL   Genomics 79 (6), 824-832 (2002)
   PUBMED   12036297
REFERENCE   8  (bases 1 to 6346)
  AUTHORS   Davisson MT, Bechtel LJ, Akeson EC, Fortna A, Slavov D and Gardiner
            K.
  TITLE     Evolutionary breakpoints on human chromosome 21
  JOURNAL   Genomics 78 (1-2), 99-106 (2001)
   PUBMED   11707078
REFERENCE   9  (bases 1 to 6346)
  AUTHORS   Akeson EC, Lambert JP, Narayanswami S, Gardiner K, Bechtel LJ and
            Davisson MT.
  TITLE     Ts65Dn -- localization of the translocation breakpoint and trisomic
            gene content in a mouse model for Down syndrome
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 270-276 (2001)
   PUBMED   11528125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121560.17.
            
            [WARNING] On Jan 18, 2024 this sequence was replaced by
            NM_144789.3.
            
            On or before Apr 14, 2009 this sequence version replaced
            XM_907577.3, XM_622716.4, NM_144789.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.18794.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC121560.17        156522-156698       c
            178-223             AC121560.17        145394-145439       c
            224-317             AC121560.17        144726-144819       c
            318-471             AC121560.17        143045-143198       c
            472-724             AC121560.17        141049-141301       c
            725-826             AC121560.17        135082-135183       c
            827-1069            AC121560.17        127239-127481       c
            1070-1199           AC121560.17        123683-123812       c
            1200-1396           AC121560.17        122320-122516       c
            1397-1491           AC121560.17        122007-122101       c
            1492-1579           AC121560.17        121577-121664       c
            1580-1747           AC121560.17        118029-118196       c
            1748-1842           AC121560.17        116528-116622       c
            1843-1974           AC121560.17        114126-114257       c
            1975-2109           AC121560.17        113193-113327       c
            2110-2273           AC121560.17        112480-112643       c
            2274-2353           AC121560.17        111946-112025       c
            2354-2473           AC121560.17        111516-111635       c
            2474-2605           AC121560.17        109181-109312       c
            2606-2689           AC121560.17        105025-105108       c
            2690-2865           AC121560.17        104525-104700       c
            2866-2946           AC121560.17        103168-103248       c
            2947-3156           AC121560.17        101121-101330       c
            3157-6346           AC121560.17        96938-100127        c
FEATURES             Location/Qualifiers
     source          1..6346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 57.66 cM"
     gene            1..6346
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /note="PR domain containing 15"
                     /db_xref="GeneID:114604"
                     /db_xref="MGI:MGI:1930121"
     exon            1..177
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..3633
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 298; PR domain-containing protein 15; PR
                     domain zinc finger protein 15"
                     /codon_start=1
                     /product="PR domain zinc finger protein 15 isoform 1"
                     /protein_id="NP_659038.2"
                     /db_xref="CCDS:CCDS49926.1"
                     /db_xref="GeneID:114604"
                     /db_xref="MGI:MGI:1930121"
                     /translation="MCPPTIWEKGGQVGARWSLRAPEVSAMAEDGSEEIMFIWCEDCS
                     QYHDSECPELGPVVMVKDSFVLSRARSSLPSNLEIRRLDDGAEGVFAVTQLVKRTQFG
                     PFESRRVAKWEKESAFPLKVFQKDGHPVCFDTSNEDDCNWMMLVRPALEPGHQNLTAY
                     QHGSDVYFTTSKDIPAGTELRVWYAAFYAKKMDKPMLKQACSSVQAAGTPEPSVSVEP
                     ERGQWVCKVCSNTFLELQLLNEHLLGHLEQAKSLPAGGQQHEAASEKEPDAPRMEPPT
                     AAESKSIQSVMVTKEPKKKPRRGRKPKASKVEQPLVIIKDKEPSEHVAEIITEIPPDE
                     PVSATPDERIMELVLGKLAAPTNEASSVPKFPHHPSSTIALKRGLVLSSRHGVRRKLV
                     RQLGEHKRIHQCGTCSKVFQNSSNLSRHVRSHGECAHGDKLFKCEECSKLFSRKESLK
                     QHVSYKHSRNEVDGEYRYRCGSCGKTFRMESALEFHNCRTDDKTFQCEMCFRFFSTNS
                     NLSKHKKKHGDKKFACEVCSKMFYRKDVMLDHQRRHLDGVRRVKREDLEASGESLVRY
                     KKEPSGCPVCGKVFSCRSNMNKHLLTHGDKKYTCEICGRKFFRVDVLRDHIHVHFKDI
                     ALMDDHQREEFIGKIGISSEENDDNSDESADSEPHKYSCKRCQLTFGRGKEYLKHIME
                     VHKEKGHGCSICHRRFALKATYHAHMVIHRENLPDPNVQKYIHPCEICGRIFNSIGNL
                     ERHKLIHTGVKSHACEQCGKSFARKDMLKEHMRVHDNIREYLCAECGKGMKTKHALRH
                     HMKLHKGIKEYECKECHRKFAQKVNMLKHYKRHTGIKDFMCELCGKTFSERNTMETHK
                     LIHTVGKQWTCSVCDKKYVTEYMLQKHVQLTHDKVEAQSCQLCGTKVSTRASMSRHMR
                     RKHPEVLAVRIDDLDHLPETTTIDASSIGIVQPALGLEQEELAEGKHGKAAKRSHKRK
                     QKPEEEAGAPVPEDTTFSEYPEKEPEFTGSVGDETNSAVQSIQQVVVTLGDPNVTAPS
                     SSVGLTNITVTPITTAAGTQFTNLQPVAVGHLTNPDRQLQLDNSILTVTFDTVSGSAM
                     LHNRQNDVQIHPQPEATNPQSVAHFINLTTLVNSITPLGNQLSEQHPLTWRAVPQTDV
                     LQPPQAPAAPQQAVQPQVQNEQQQMYSY"
     exon            178..223
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            224..317
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            318..471
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            472..724
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            725..826
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1069
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1199
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1396
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1491
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1579
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1747
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1842
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1974
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2109
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2273
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2353
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2473
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2605
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2689
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2865
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..2946
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3156
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..6346
                     /gene="Prdm15"
                     /gene_synonym="C21orf83; E130018M06Rik; ORF62; Zfp298"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtttaag aaagtccgag gctgtgccgt ggctcccagg ccctggcgcc tcactcgtct
       61 ctaccttttg gtggcccagg gaccacagtg gcaagacagg ctggagacat gtgcccacct
      121 actatctggg aaaagggtgg acaggtgggg gccaggtgga gcctgcgtgc tcctgaggta
      181 tcagcaatgg ctgaagatgg tagtgaggag atcatgttta tctggtgtga agactgcagc
      241 cagtaccatg actcggagtg tcctgaactg ggacctgtgg tcatggtcaa ggactccttt
      301 gtgctgagca gggcaaggtc ctccctcccc tctaacctgg agatcaggcg cctggatgac
      361 ggggctgaag gcgtgtttgc agtgacccag ctagtcaagc gcacacaatt tggtccgttt
      421 gagtccagga gagtcgccaa gtgggagaaa gagtcggcat ttcctctgaa ggtatttcag
      481 aaggacgggc atcctgtgtg cttcgacact tccaatgagg atgactgcaa ctggatgatg
      541 ctagtgcgac cagcactgga gcctgggcac cagaacctga cagcctacca acatggcagt
      601 gacgtgtatt tcaccacctc aaaggacatt cctgcaggca ctgaactgcg tgtgtggtat
      661 gctgcctttt atgccaagaa gatggacaag cccatgctaa agcaggcctg ctccagtgtt
      721 caggctgcag gcacccctga gcccagtgtc tctgtggaac ctgagcgtgg ccaatgggtg
      781 tgtaaggtgt gctccaacac cttcctggag cttcagctcc tgaacgagca tctcttgggc
      841 catctggagc aagccaaaag cctccctgca ggtggccagc agcatgaggc agcttctgag
      901 aaggagcctg atgcacccag gatggagcct cccacagcag ccgagagcaa gagcatccag
      961 agtgtcatgg tcaccaaaga gccaaagaaa aagcctcgaa gagggaggaa acccaaagca
     1021 tccaaggttg agcagcctct ggtcattatc aaagacaagg agccttcaga gcatgtggca
     1081 gagatcataa ctgagatccc cccagatgag cctgtgagtg caacaccaga tgaacggatc
     1141 atggagttag tcttggggaa gctggccgcc cccacaaatg aagccagctc agtgccaaag
     1201 ttcccacatc atccaagcag caccattgcc ctcaagaggg gcttggttct gtccagcaga
     1261 catggcgtcc ggcggaagct cgtccgtcag ctgggtgagc ataaacgcat ccatcagtgt
     1321 ggcacctgca gcaaggtctt ccagaacagc agcaacctga gccggcacgt gcgctcgcac
     1381 ggtgagtgcg cgcacgggga caagctgttt aaatgtgagg aatgttcgaa actgttcagc
     1441 cgtaaggaaa gtctaaagca gcatgtttcc tacaagcaca gccggaatga ggtggacggt
     1501 gagtaccgct accgctgtgg cagctgtggg aagacattcc gaatggagag tgcactggag
     1561 ttccacaact gtaggacaga tgacaagacg ttccaatgtg agatgtgttt cagattcttc
     1621 tccaccaaca gcaacctctc taagcacaag aagaaacatg gggacaagaa gtttgcctgt
     1681 gaggtctgca gtaagatgtt ctaccgcaag gatgttatgc tggaccacca gaggcgacac
     1741 ttggatggtg tgcggcgggt gaagagagaa gacttggagg ccagcgggga aagcctggtt
     1801 cgttacaaga aggaaccttc tggatgccca gtgtgtggca aggtgttctc ctgtcggagc
     1861 aacatgaaca agcacctgct gacccacggt gacaagaagt acacctgcga gatctgtggg
     1921 cgcaagttct tccgagtgga cgtactcagg gaccacatcc atgtccactt caaggacatc
     1981 gcgctaatgg atgaccacca gcgggaggag ttcattggca aaattgggat ctcctcagag
     2041 gagaatgatg acaactctga tgagagcgca gactctgagc cacacaagta cagctgcaag
     2101 aggtgccagc tcactttcgg ccgtgggaag gaatacctga agcacatcat ggaggtgcac
     2161 aaggagaagg gccacggctg cagcatctgc caccgacgct tcgcactcaa ggccacctac
     2221 catgcccaca tggtcatcca ccgggagaac ctgcctgacc ccaacgtgca gaagtacatt
     2281 cacccctgtg agatctgtgg gaggatattc aacagcattg ggaacttgga gcgccacaaa
     2341 ctcatccaca caggtgtgaa aagccacgcc tgtgagcagt gtgggaagtc ctttgccagg
     2401 aaggacatgc tgaaagagca catgcgtgtg catgacaaca tccgggagta cctgtgcgcc
     2461 gagtgtggga aaggtatgaa gaccaagcat gcactgcgcc accatatgaa gctgcacaaa
     2521 ggcatcaagg agtatgagtg caaggaatgt caccgcaagt ttgcacagaa ggtcaacatg
     2581 ctcaagcact acaaacggca cacaggaatt aaagacttca tgtgtgaatt gtgtgggaag
     2641 acattcagtg agaggaacac aatggagaca cacaagctca tccacacagt aggcaagcag
     2701 tggacttgtt ccgtgtgtga caagaagtac gtcacagagt acatgcttca gaaacacgtc
     2761 cagctcactc atgacaaggt ggaagcacag agttgccaac tatgtggcac caaagtgtca
     2821 acccgggcct ccatgagcag acatatgcga cgcaagcacc ccgaggtcct cgctgttcgg
     2881 attgacgatc tggaccacct ccccgagacc accaccatcg atgcatcttc catcggcatt
     2941 gtccagcctg cgctgggcct ggagcaggaa gaactggcag aaggtaagca tggaaaggct
     3001 gccaagcgca gccacaagag aaagcagaag ccagaggaag aggcaggggc tccagtgcct
     3061 gaggatacca ccttcagtga ataccccgaa aaggagccag agttcacagg cagtgtgggt
     3121 gacgagacaa attctgctgt acagagtatc caacaggtgg tggtgaccct aggggacccc
     3181 aatgtgactg ctccatcaag ctcagttggt ctaaccaaca tcaccgtgac ccccatcacc
     3241 actgcagctg gaactcagtt taccaattta cagccagtgg ctgttggaca tcttaccaac
     3301 cctgatcgcc agctacagct agataactcc atcctgactg tgacctttga tactgtcagt
     3361 ggctccgcca tgttgcacaa ccggcaaaat gatgtccaga tccacccaca gccagaagcc
     3421 acaaaccctc agtcagtggc ccactttatc aaccttacca cactggtaaa ctccatcaca
     3481 cccttgggga accaactcag tgagcagcac ccactcacct ggcgagcagt gccccagaca
     3541 gatgtgctgc agccgccaca ggcccctgca gccccgcagc aggcggtgca accccaggta
     3601 cagaatgagc agcagcagat gtacagctac tgatctgtgg ctgcagaata ggctgagctg
     3661 cagcagtggg gttctgaggt cttgaggtgt ttgctggata ccaaacagga agagtttgca
     3721 aatgtcaaga tcactgagat tagcattaca gagctaccta tcagctttgc tggtggtatg
     3781 gctttggcaa gcaggagctt ctgccatgtg ttttcccaag gtgttgcagc ctggccagac
     3841 cacagtgtca ccctcagagg tctgtaattg tcatggggct cagggataca gataacagga
     3901 tcctagaagc aggcgtgata ttccaaggac cagggagatt tgatctgttt tctttagcac
     3961 tccagtgaca ataactgaaa tatggctagc cttctgtggc aacacacaga agcaaacgca
     4021 ggtttctcct tgctcctgga ttcacaagca gggagaagtc attctgaagt ctcagttctt
     4081 acgtcacaga gctgtggcct gaggcctcct gtgagaagta tcatgaggcc cccagctcag
     4141 gcacagaaga catcttggga acatctatag actgattttt atgaagagtc tgttttattt
     4201 cataaccacg ttatgtatta tggccctctc gtggtcaata ttgatttctt ttaatatgat
     4261 aaagtcgttt gcactgtagg gtgtcagtcc ctgtccagtt gtgcacagat gccttgtgtg
     4321 aggccacaca cagttgtgtg caaagtgagc cctcacgctt gaatcccgat gctcctctgg
     4381 agctatctca ggactctgcc atccaaacat gtattatggt gcagcttagc cacatccctg
     4441 aatgaaggat ggggagtgaa ccatgtttcc tttctgtgta agccttaatt ccaaaggtgg
     4501 ttatgtctga aaaccaattt cctatgaaat acagaggttc agctctgtag gagagaagtg
     4561 tagctagtga tttacgaagc ccgagaggtg cttccatgtg gtggtgagag cagtagaggt
     4621 cctcgtgaca gaatacaaac tggccacccc cagctctgag ggaacatggc tggcacaaac
     4681 ccgtgctatc cccatggtaa caggccaggc tgccatcata gggtccatag tccagcacag
     4741 ggacatgaag aggcaaggtg aggacagagt ttggtctagc tcttctgatt agtttttaat
     4801 gtcacacaaa agaacttaaa gatgaacttg ccttacttcg tccttggtcc tgtgtttcct
     4861 ggaagtattc aaatatgggc agccatcctg cagagatgga tactaaccag cagtggacaa
     4921 gggaagttac agtgtgatgt cagacatgat gctgctactc ggcacctcct tccagagagc
     4981 gagctttgag gatgaggctg gagcttctgt tacacagatg gagcataagg aagagatggc
     5041 acttgaggac aagtctgcag gtctgtgggt cgcctgaccc acaccctttc cacatccaca
     5101 caggtctcac ctcttggcag atggcatgct gggagttctt ggacttctta atttatgaca
     5161 gtttttttta tgttatttat gtgtataatt aactactttg tatgcagtac ccttatgaaa
     5221 tgaacttggc ctaggggtga actgttttct aaaacatagc ctttgttctc caaataaaac
     5281 tattccagga aaccatggaa aaaatgggca ggcaatccat agccctaatc tattttttaa
     5341 aaattcaacc gcagttcctc tttgccttta tagcctctca aagatgaatg agctgagccc
     5401 aaatgagcac tgggctcaat caaacatcac tagcatttga cttttattct cttctcacta
     5461 aaataaagac ctttgaaatc acatttttta ttttttaaag atgtattttt gtgcctatac
     5521 ccaggttgtt aaatcctgtt gaaagacgga gcttaggttg tacagtctct cctgctgcca
     5581 ctgtttgctt aaatatacag aggcatctac ttcctgctgt tataagcagg aattcagata
     5641 aaaccagcct ttctccccaa gtgtctgtga cacatggtct ccccagtcat tggctgaagc
     5701 aagcaggttg tctcaccata gttacagctc ccctgcagat agcaactgga tagcaaaaca
     5761 aaggcacctc tacactccag gtaccccaca tacataaacc attgttgatc cgtaggaaat
     5821 gttcaggttg ttttgttttt ttttttaaac tggtctaaat cggtcatagc tatgtgtcca
     5881 acaagccctg tgactatgtc taggttcgca taaataaatg tatcagactt tgtttacacc
     5941 ttgtgaatgg taatgctata gggtcacatg tcataacaag atggatctca tagttgcagc
     6001 acaggattcc accctctggg atggtgttag ccagtgataa gttctcagga aaagggtctg
     6061 taccagatgc cctctcctat gtcgggcatg aaagcctgct ggagaatggt ctcatgaaag
     6121 gcagatcttt gctccttcac accattctca gtcagtatcc aaaggcagaa gcagtgcctg
     6181 tgactaccat agattctgag gtttgtggag accattctgt aactctgagg gtgtttcatg
     6241 tcacatctgt ttgtatggtg ataaataaag gtgctgtgac ctgtgttttt caattgctgg
     6301 ccctctgctc tcctgcccat gataaagttg tacctggtaa tctttg
//
