LOCUS       NM_001081209            2593 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus PR domain containing 14 (Prdm14), mRNA.
ACCESSION   NM_001081209 XM_357091
VERSION     NM_001081209.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2593)
  AUTHORS   Allegre N, Chauveau S, Dennis C, Renaud Y, Meistermann D, Estrella
            LV, Pouchin P, Cohen-Tannoudji M, David L and Chazaud C.
  TITLE     NANOG initiates epiblast fate through the coordination of
            pluripotency genes expression
  JOURNAL   Nat Commun 13 (1), 3550 (2022)
   PUBMED   35729116
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2593)
  AUTHORS   Vos ESM, Valdes-Quezada C, Huang Y, Allahyar A, Verstegen MJAM,
            Felder AK, van der Vegt F, Uijttewaal ECH, Krijger PHL and de Laat
            W.
  TITLE     Interplay between CTCF boundaries and a super enhancer controls
            cohesin extrusion trajectories and gene expression
  JOURNAL   Mol Cell 81 (15), 3082-3095 (2021)
   PUBMED   34197738
  REMARK    GeneRIF: Interplay between CTCF boundaries and a super enhancer
            controls cohesin extrusion trajectories and gene expression.
REFERENCE   3  (bases 1 to 2593)
  AUTHORS   Kobayashi T, Goto T, Oikawa M, Sanbo M, Yoshida F, Terada R,
            Niizeki N, Kajitani N, Kazuki K, Kazuki Y, Hochi S, Nakauchi H,
            Surani MA and Hirabayashi M.
  TITLE     Blastocyst complementation using Prdm14-deficient rats enables
            efficient germline transmission and generation of functional mouse
            spermatids in rats
  JOURNAL   Nat Commun 12 (1), 1328 (2021)
   PUBMED   33637711
  REMARK    GeneRIF: Blastocyst complementation using Prdm14-deficient rats
            enables efficient germline transmission and generation of
            functional mouse spermatids in rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2593)
  AUTHORS   Chen M, Wang Y, Lin L, Dong F, Wu H, Bao S and Gao F.
  TITLE     PRMT7 is involved in regulation of germ cell proliferation during
            embryonic stage
  JOURNAL   Biochem Biophys Res Commun 533 (4), 938-944 (2020)
   PUBMED   33008598
REFERENCE   5  (bases 1 to 2593)
  AUTHORS   Kobayashi T, Kobayashi H, Goto T, Takashima T, Oikawa M, Ikeda H,
            Terada R, Yoshida F, Sanbo M, Nakauchi H, Kurimoto K and
            Hirabayashi M.
  TITLE     Germline development in rat revealed by visualization and deletion
            of Prdm14
  JOURNAL   Development 147 (4) (2020)
   PUBMED   32001439
  REMARK    GeneRIF: the crucial role of Prdm14 in primordial germ cell
            specification is conserved between rat and mice
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2593)
  AUTHORS   Ma Z, Swigut T, Valouev A, Rada-Iglesias A and Wysocka J.
  TITLE     Sequence-specific regulator Prdm14 safeguards mouse ESCs from
            entering extraembryonic endoderm fates
  JOURNAL   Nat Struct Mol Biol 18 (2), 120-127 (2011)
   PUBMED   21183938
  REMARK    GeneRIF: Prdm14 safeguards mouse embryonic stem cells maintenance
            by preventing induction of extraembryonic endoderm fates.
REFERENCE   7  (bases 1 to 2593)
  AUTHORS   Kurimoto K, Yamaji M, Seki Y and Saitou M.
  TITLE     Specification of the germ cell lineage in mice: a process
            orchestrated by the PR-domain proteins, Blimp1 and Prdm14
  JOURNAL   Cell Cycle 7 (22), 3514-3518 (2008)
   PUBMED   19001867
  REMARK    GeneRIF: launch of the germ cell lineage in mice is orchestrated by
            Blimp1 and Prdm14
REFERENCE   8  (bases 1 to 2593)
  AUTHORS   Yamaji M, Seki Y, Kurimoto K, Yabuta Y, Yuasa M, Shigeta M,
            Yamanaka K, Ohinata Y and Saitou M.
  TITLE     Critical function of Prdm14 for the establishment of the germ cell
            lineage in mice
  JOURNAL   Nat Genet 40 (8), 1016-1022 (2008)
   PUBMED   18622394
  REMARK    GeneRIF: Study provides genetic evidence that Prdm14, with
            exclusive expression in the germ cell lineage and pluripotent cell
            lines, is critical for the reacquisition of potential pluripotency
            and successful epigenetic reprogramming.
REFERENCE   9  (bases 1 to 2593)
  AUTHORS   Kinameri E, Inoue T, Aruga J, Imayoshi I, Kageyama R, Shimogori T
            and Moore AW.
  TITLE     Prdm proto-oncogene transcription factor family expression and
            interaction with the Notch-Hes pathway in mouse neurogenesis
  JOURNAL   PLoS One 3 (12), e3859 (2008)
   PUBMED   19050759
REFERENCE   10 (bases 1 to 2593)
  AUTHORS   Dettman EJ and Justice MJ.
  TITLE     The zinc finger SET domain gene Prdm14 is overexpressed in
            lymphoblastic lymphomas with retroviral insertions at Evi32
  JOURNAL   PLoS One 3 (11), e3823 (2008)
   PUBMED   19043588
  REMARK    GeneRIF: study implicates Prdm14 as a proto-oncogene involved in
            lymphoblastic lymphoma formation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134292.1, AK141218.1 and BB283625.1.
            
            [WARNING] On Jan 10, 2024 this sequence was replaced by
            NM_001081209.3.
            
            On Dec 21, 2007 this sequence version replaced NM_001081209.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164134
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-353               AK134292.1         2-354
            354-1051            AK141218.1         132-829
            1052-1052           AK134292.1         1053-1053
            1053-2459           AK141218.1         831-2237
            2460-2564           AK134292.1         2484-2588
            2565-2593           BB283625.1         494-522
FEATURES             Location/Qualifiers
     source          1..2593
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 4.1 cM"
     gene            1..2593
                     /gene="Prdm14"
                     /note="PR domain containing 14"
                     /db_xref="GeneID:383491"
                     /db_xref="MGI:MGI:3588194"
     exon            1..54
                     /gene="Prdm14"
                     /inference="alignment:Splign:2.1.0"
     exon            55..745
                     /gene="Prdm14"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1761
                     /gene="Prdm14"
                     /note="PR domain-containing protein 14"
                     /codon_start=1
                     /product="PR domain zinc finger protein 14"
                     /protein_id="NP_001074678.2"
                     /db_xref="CCDS:CCDS48221.1"
                     /db_xref="GeneID:383491"
                     /db_xref="MGI:MGI:3588194"
                     /translation="MALPPSGETQSQDKANYLPQSNPHHLTTYYAHAPGYSHFRNLAT
                     TEEEFQPWKLAAAVLESQAMAPLDAFRMTAPLLNPGLAVQSEPLYNLPWYKLSPWNRI
                     PQFTPEVPRFLDSTEHRSSGSSNQNLVLGGGGGQISGQRWEAENLLLPSPVIASLLPD
                     GIKSSQSISVPQTLNQEGKLPFCGFNFTEEELSFVLYGAIASPEHPTDLQHAISGILV
                     PTESSGSNHLHKTLDKDSLQLPEGLCLMQTSFGDVPHFGVFCSDFIAKGVRFGPFRGR
                     VVNASEVKAHRDNSRMWEIFEDGHLSHFIDGKGSGNWMSYVNCARFPKEQNLLAVQHQ
                     GQIFYESCRDIQRNQELLVWYGNGYEKFLGVPMNLRVTEQGGQQLSESSEESAEGYRC
                     ERCGKVFTYKYYRDKHLKYTPCVDKGDRKFPCSLCQRSFEKRDRLRIHILHVHERHRP
                     YLCSTCGKSFSQSSSLNKHMRVHSGDRPYQCVYCTKKFTASSILRTHIRQHSGEKPFK
                     CKHCGKAFASHAAHDSHVRRSHKDNGRSSCDICGKGFLDQEAFYAHMRLHKTC"
     exon            746..799
                     /gene="Prdm14"
                     /inference="alignment:Splign:2.1.0"
     exon            800..957
                     /gene="Prdm14"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1228
                     /gene="Prdm14"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1431
                     /gene="Prdm14"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1533
                     /gene="Prdm14"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..2593
                     /gene="Prdm14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagaagtct agggtcccga gacccagcgg gtgccgccct agccttggcc tgagatccgc
       61 aaaactcagc ttgcgatggc cttaccgccc tctggtgaga cccagtccca ggacaaggcg
      121 aactacctgc cccagagcaa ccctcaccac ctgactacct actacgcgca tgccccaggc
      181 tacagtcact ttaggaacct cgccaccacc gaggaggagt ttcaaccttg gaaactggca
      241 gctgcagtgc ttgagtccca ggcgatggcc cctcttgatg cttttcggat gactgctccc
      301 ttgttgaacc cgggtctggc tgttcagagc gagccgctct acaatctgcc ctggtacaaa
      361 ttgtcaccat ggaaccgaat tcctcaattc actcccgaag taccacgatt tctagacagc
      421 actgagcata ggagcagcgg ttccagcaac caaaatttgg tcctcggcgg cggcggtggc
      481 caaatcagtg gtcagaggtg ggaagctgaa aatttacttc tgccatcccc ggtaattgct
      541 tccctactac ctgatggaat taagtcgtcc cagtcaatat ctgtccccca aaccttgaat
      601 caagagggga agctgccgtt ttgcggcttc aacttcacag aggaggaact gagcttcgtt
      661 ctgtatggag ccatcgctag tccggagcac ccaaccgact tacagcatgc aatttcaggc
      721 atcctggttc ccacagagag ttctgggtct aatcatcttc ataaaaccct ggacaaagac
      781 tccctccagc ttccggaagg tctctgcctc atgcagacct catttggtga tgtgccacac
      841 tttggcgtgt tctgcagcga cttcattgcc aaaggagtga gatttggacc ctttcgaggt
      901 agagtggtca atgccagcga agtgaaggca cacagggaca actctcggat gtgggaaatt
      961 tttgaagatg gtcacctgag ccattttatc gacggcaaag gttctgggaa ctggatgtcc
     1021 tatgtcaact gtgctcggtt ccccaaggag cagaacctgc tggccgtgca gcaccaaggg
     1081 cagatatttt atgagagttg tagagacatc cagcggaacc aggaactgct tgtgtggtac
     1141 ggaaatggct atgagaagtt cctgggcgtt cccatgaacc tccgtgtcac tgagcaagga
     1201 ggccagcagc tgtctgagtc ctctgaagag tctgcagaag gttacagatg tgaacgctgt
     1261 ggaaaggtgt ttacctacaa atactacaga gataagcacc tgaagtacac gccctgtgtg
     1321 gacaaggggg acaggaagtt tccgtgttct ctctgccaaa gatcctttga aaagcgcgac
     1381 cgcctccgga tccatattct tcacgtccat gagaggcacc ggccctacct gtgttcaacc
     1441 tgtgggaaaa gtttttctca gtcttccagc ctgaacaagc acatgagagt ccactctgga
     1501 gacaggccat accagtgcgt gtactgtaca aagaagttca ctgcctccag catactccga
     1561 acacacatca gacagcactc aggagagaag cccttcaagt gcaagcattg tggtaaagcc
     1621 tttgcatctc atgctgccca cgacagccac gtccggcgct cacacaagga caatggccgt
     1681 agctcctgcg atatttgtgg gaaaggcttc ctggatcaag aggctttcta tgcccacatg
     1741 aggcttcata aaacctgcta ggtctttgaa agcaaagcca gttacaaacc aagaacgctg
     1801 actctcattc ctgctttgtc tgtgtcgcgt gggcatggtt gaagtgttca gtgagaatct
     1861 ggagaatgga gtagttgatc tgaagctcca aaccttatgg aatccattca gaccaggagt
     1921 gagaataaag tcctgggtct tgtgattaaa gaagaaaagg ttccccctct cctgtctgcc
     1981 ttgaacaccc cgttatacgg tgtctgtagc cagcgactat gtgcatgagt gttcgccgcg
     2041 ggcatgtttc tgtgctgcat gcgtgtggag gcccaaggaa gacatcagat cctctggggc
     2101 tgtatttacg gatagttgta agccactgtg tgggtaccgg gaattgaacc caggtcctct
     2161 gctagtgctg ctaggactta actgctaaac catctcacca gctcctgctt tctatttggt
     2221 tttggtggtg gtgttttggt ctctctctct ttctctccca cccccaagct ggctttaaat
     2281 ttgtcctata gctgaaaatg accttgaatt acaggattaa gttaccacag ccaagcaatt
     2341 tgcactacct agagatttgg tatgttataa ctaagtcttc tgccgtgtat tagtgttcca
     2401 tcttaatttg agctcatttc tctcctcact gagcaatgaa aatgccaggt aatacaccta
     2461 gtatcagaaa gaatcatttc cagggcagga agactggcaa ttcttgttga tgtctaactt
     2521 ttaccaacag agaaggaaaa ttatatctga ataaagacag gctgaaaata aacacttatg
     2581 ctactctggt ttt
//
